COVID-19 Coronavirus Research Articles

Study On Mathematical Model For Forecasting of Novel Coronavirus in India

This paper reveals that the new coronavirus (Covid-19) is the biggest challenge for the whole world. The World Health Organization (WHO) has declared it an epidemic. The data was collected from 209 different individual WHO situation reports for COVID-19 in India. First, prognostic models were compared based on minimum AIC, MAPE, and MAE. Then the best forecasting models were used on the epidemiologic data of India to predict the epidemiologic pattern of prevalence. New and Total Covid-19 Deaths and Incidence ARIMA and SARIMA have been found suitable and predicted for September 1, 2020. Also, the prophet model is used for accuracy and prediction of the total number of coronavirus cases in India. The predicted values are checked against the past observed values so that the two values are very close. Using such time series models we can forecast for the next 15-20 days and plan accordingly. This kind of projection helps in planning for the future.

Somatic and neurological comorbidities in COVID-19 with fatal outcome

Introduction. Although the risk of emerging coronavirus infection may seem to have disappeared at first glance, SARS-COV-2 has complex and poorly understood effects on many organ systems, including the nervous system. Disease progression and unfavorable outcome COVID-19 are not only due to lung damage, elderly age, concomitant pathology: hypertension, diabetes mellitus, etc. have a significant impact.Aim. To study the structure of mortality in a new coronavirus infection COVID-19, caused by delta strain of coronavirus SARS- CoV-2, taking into account the nature of concomitant therapeutic and neurological pathology, the degree of comorbidity, fatal complications, and sex and age characteristics.Materials and methods. A postmortem analysis of pathological and anatomical conclusions of 209 patients with COVID-19 with comorbid somatic and neurological pathology who received inpatient treatment in covid hospitals of the Republic of Mordovia in 2021 was performed. The severity of the underlying disease, concomitant therapeutic and neurological pathology, and comorbidity were analysed. The coincidence of the final clinical and pathological diagnoses, fatal complications were assessed. The presented data allowed to identify the main factors of unfavourable outcome.Results and discussion. In unfavourable outcome of the disease, concomitant pathology is represented by hypertension, ischemic heart disease, chronic heart failure, chronic cerebral ischemia. In women, cases of diabetes mellitus and atherosclerosis were more frequent, in men - hypertension and chronic heart failure.Conclusions. New coronavirus COVID-19 infection associated with delta strain of SARS-COV-2 virus is characterised by severe and extremely severe course in elderly patients with comorbid somatic and neurological pathology.

Features of acute coronary syndrome after a COVID-19 in the aspect of pulmonary hypertension

BACKGROUND: After recovery from COVID-19 patients may develop new risk factors that lead to changes in cardiopulmonary interactions, i.e. an increase in the afterload on the right ventricle due to increased pressure in the pulmonary artery and change in pulmonary vascular resistance. It can be assumed that the presence of such a spectrum of problems can influence the severity of dyspnea and the development of pathogenetic events (pulmonary hypertension, right ventricular failure, subendocardial ischemia), which in turn can determine the outcome. AIM: To identify the characteristics of acute coronary syndrome after a COVID-19, taking into account angiographic data on coronary artery lesions and hemodynamic manifestations. MATERIALS AND METHODS: A comparative analysis of the clinical and hemodynamic consequences of the COVID-19 and the development of acute coronary syndrome in 157 patients was carried out. The group 1 included 69 patients who had had COVID-19 (vaccinated — 24.6%) during the 6 months preceding acute coronary syndrome; group 2 — 88 patients without a history of COVID-19 (vaccinated — 42%). The 12-lead electrocardiogram has been used in the diagnosis of subendocardial ischemia in acute coronary syndrome. The ST segment displacement in lead aVR was analyzed. RESULTS: After COVID-19, dispnoe occurred in 52% of the patients and in 14.8% without previous infection. Echocardiographic signs of right ventricular overload were present in 42% of the patients in group 1 and 10.2% in group 2. The mean pressure in the pulmonary artery was increased after COVID-19 in 58% of the patients in group 1 and in 10.2% of group 2 in the range from 20 to 24 mm Hg and in the range from 25 to 36 mm Hg in 29% of the patients in group 1 and 2.3% of the patients in group 2. The average value of left ventricular ejection fraction in the patients who had had COVID-19 was 55.9 ± 14%, which was less than in the patients in the control group (63.2 ± 5.5%; p 0.001). ST segment elevation in lead aVr indicated high incidence of subendocardial ischemia. 40.6% in group 1, and 11.4% in group 2 (χ2 = 17.9; p 0.001); in group 1 vaccinated — 17.6%, and not vaccinated — 48.1% (χ2 = 4.9; p = 0.027), in group 2 vaccinated — 8.1%, and not vaccinated — 13.7% (χ2 = 0.7; p = 0.41). All the patients had drug-eluting stents implanted in the infarct-related artery. After stenting, no recurrence of pain or further increase in chest pain was observed. CONCLUSIONS: After coronavirus infection COVID-19, 58% of patients have increased mean pressure in the pulmonary artery in the range from 20 to 24 mm Hg and in the range from 25 to 36 mm Hg in 29%. Atherothrombosis is the main mechanism of acute coronary syndrome after COVID-19 coronavirus infection. The main feature of acute coronary syndrome after a coronavirus infection COVID-19 is increased pressure in the pulmonary artery after a lung injury, which must be taken into account when planning surgical treatment tactics and management tactics in the postoperative period.

CLINICAL COURSE OF SEVERE AND CRITICAL CORONAVIRUS INFECTION COVID-19 AMONG PREGNANT WOMEN

Background. The COVID-19 pandemic, which spread in 2020, is a global problem that humanity has faced. Women during gestation are 3 times more likely to be admitted to the intensive care unit, 2.9 times more likely to need invasive ventilation, 2.4 times more likely to need extracorporeal membrane oxygenation, and 1.7 times more likely to have fatal outcomes than non-pregnant women Materials and methods. We conducted a retrospective analysis of the birth histories of 92 pregnant women and postpartum women with COVID-19 coronavirus infection at the clinical sites of the Scientific Center for Obstetrics, Gynecology and Perinatology, perinatal centers in the space of 2020. Results. All patients with coronavirus infection COVID-19 were young pregnant women from the age of 20 to 42 years, at a gestational age of 12 to 41 weeks, of which at full term (38-41 weeks) — 17 (18.5%), at a period of 30-37 weeks — 45 (48.9%), 21-29 weeks — 25 (27.2%), at 12-17 weeks — 5 (5.4%). One-way analysis of variance (ANOVA) has shown that there are statistically relevant differences in the days of hospitalization among the patients, depending on the parity of births (p<0.05). Complications during pregnancy on the part of the fetus were: a threatening state of the fetus was observed among 5 (5.4%), intrauterine fetal death - in 22 (23.9%), premature separation of the normally located placenta (PSNLP) was observed among 3 (3.3%), miscarriage among 2 (2.2%), therapeutic abortion - 1 (1.1%); 28 children (34.2%) were born prematurely, with birth weight from 510g (at 22 weeks) to 3100g (at 37 weeks). Conclusions. Thus, pregnant women with severe and critically severe forms of COVID-19 were predominantly urban residents, at a gestational age of 30 to 37 weeks, and were multiparous. The risk of complications did not depend on the number of previous births, highlighting the need for special attention to this patient category regardless of their obstetric history.

Social support, happiness, work–family conflict, and state anxiety among single mothers during the covid-19 pandemic

Israel has been greatly affected by the coronavirus (Covid-19), which the World Health Organization defined as a pandemic in March 2020. This study explored state anxiety, social support, work–family conflict, and happiness among mothers who are single by choice. This population’s experiences have not been examined during crises such as a global pandemic. Using snowball sampling, we recruited 386 single mothers by choice to complete an online questionnaire. Correlation analysis revealed a negative relationship between income and state anxiety (r = −0.12, p < 0.05). Social support (r = −0.35, p < 0.01) and level of happiness (r = −0.58, p < 0.01) also had negative correlations with state anxiety. A positive and significant relationship was found between work–family conflict and state anxiety (r = 0.42, p < 0.01). Stepwise regression analysis showed that happiness explained 34% of the variance in state anxiety. Future studies could compare mothers in relationships and how single mothers by choice coped in other countries. This would shed light on state anxiety among mothers with varying relationship statuses and in differing locations.

Recombinant SARS-CoV-2 Delta/Omicron BA.5 emerging in an immunocompromised long-term infected COVID-19 patient.

The emergence of the SARS-CoV-2 virus led to a global pandemic, prompting extensive research efforts to understand its molecular biology, transmission dynamics, and pathogenesis. Recombination events have been increasingly recognized as significant contributor to the virus's diversity and evolution, potentially leading to the emergence of novel strains with altered biological properties. Indeed, recombinant lineages such as the XBB variant and its descendants have subsequently dominated globally. Therefore, continued surveillance and monitoring of viral genome diversity are crucial to identify and understand the emergence and spread of novel strains. Through routine genomic surveillance of SARS-CoV-2 cases in Norway, we discovered a SARS-CoV-2 recombination event in a long-term infected immunocompromised COVID-19 (coronavirus disease) patient. A deeper investigation showed several recombination events between two distinct lineages of the virus, namely AY.98.1 and BA.5, that resulted in a single novel recombinant viral strain with a unique genetic signature. Our data is consistent with the presence of several concomitant recombinants in the patient, suggesting that these events occur frequently in vivo. This study underscores the importance of continued tracking of viral diversity and the potential impact of recombination events on the evolution of the SARS-CoV-2 virus.

Characterization of Collaborative Cross mouse founder strain CAST/EiJ as a novel model for lethal COVID-19

Mutations in SARS-CoV-2 variants of concern (VOCs) have expanded the viral host range beyond primates, and a few other mammals, to mice, affording the opportunity to exploit genetically diverse mouse panels to model the broad spectrum of responses to infection in patient populations. Here we surveyed responses to VOC infection in genetically diverse Collaborative Cross (CC) founder strains. Infection of wild-derived CC founder strains produced a broad range of viral burden, disease susceptibility and survival, whereas most other strains were resistant to disease despite measurable lung viral titers. In particular, CAST/EiJ, a wild-derived strain, developed high lung viral burdens, more severe lung pathology than seen in other CC strains, and a dysregulated cytokine profile resulting in morbidity and mortality. These inbred mouse strains may serve as a valuable platform to evaluate therapeutic countermeasures against severe COVID-19 and other coronavirus pandemics in the future.

Ethical Considerations of Establishing Social Restrictions in the Prevention and Control of the Corona Epidemic from the Point of View of Medical Students of Kermanshah University of Medical Sciences

Background: Covid-19 (coronavirus), with its different dimensions, has created a serious international crisis in the world and has presented mankind with a new challenge. Among these, it can be claimed that the most difficult challenge in the Corona crisis is the moral challenge. Objectives: Considering the significance of ethical considerations and the crucial role students play in conveying these concepts to society, we decided to examine their perspectives. Methods: The present study was a cross-sectional descriptive study, and the statistical population was medical students in the basic sciences of Kermanshah Medical School. The sample size was 205 people based on Cochran's formula (d = 0.05), and the sampling method was random sampling. To collect data, a researcher-made questionnaire was designed based on current issues and approved by several professors (25 questions with a 5-point Likert scale from "very much" to "very little"). The reliability coefficient (0.83 Cronbach's Alpha) was satisfactory for the questionnaire. After completion and collection, the data was entered into SPSS-21 software. Then, it was subjected to statistical analysis with descriptive statistics (prevalence, mean, and standard deviation) and inferential statistics (due to the non-normality of the data distribution, non-parametric tests were used to analyze and compare the answers). Results: The average age was 20.58 ± 2.41 years, 115 people (56.1%) were male, and 198 people (96.6%) were single. Natives accounted for 63.2%. The effective factors in interventions were, in order: Use of different media for information, appropriate, accurate, and timely information, appropriate and sufficient training, preparation and provision of conditions before the above interventions, presentation of decisions and programs in simple and practical language, and fair distribution of protective equipment. Conclusions: According to our results, it was found that the role of using different media for informing, training, preparing, and providing conditions before interventions is very important. Therefore, policymakers and health planners should have the necessary preparation in these matters to control future epidemics.

Retraction Note: Association of the corona virus (Covid-19) epidemic with environmental risk factors.

Retraction Note: Association of the corona virus (Covid-19) epidemic with environmental risk factors.

Employment, labor and social protection in a hybrid enforcement regime

The features of the hybrid law enforcement regime in the field of employment, labor and social protection are considered. Russia and the whole world have entered an era of turbulence, when customary and even emergency legal regimes that have been developed over decades do not allow us to respond effectively to challenges, regulate public relations and protect the rights and freedoms of legal entities in response to changes in the current situation. The traditional systematic approach to legal regulation using blocks of legislation formed in advance as a reaction to the situation changing in one direction or another often does not justify itself and each time requires a creative and individual, rather than template, approach from the law enforcement officer to the selection of used tools and norms of different legal regimes , which requires active rule-making to fill emerging gaps. Avoiding complex legal regulation adds originality to rulemaking and law enforcement in the early 2020s, the general direction of which is to accelerate the creation of rules of conduct in the field of labor, employment and social protection by increasing the role of the Government, speeding up the lawmaking process, expanding regional rulemaking, and giving greater legitimacy to the instructions of officials in comparison with documented acts. The legislator has consistently optimized the legal technique of preparing and adopting laws that meet the needs of operational support of a special military operation with labor legal means. The growth of regional rule-making in the field of social protection requires the elimination of shortcomings and unification at the federal level. A noticeable phenomenon was in a number of cases the replacement of written administrative acts with instructions from a senior official. The legal regimes formed in this way - aimed at countering the spread of the coronavirus COVID-19, accompanying the conduct of a special military operation, etc., can be called hybrid or constructed – assembled from various legal elements and do not form systems sufficient to achieve an integration-entropy balance. Moreover, for this design, elements of normatively established special legal regimes are used, which, however, have undergone significant transformation - a self-isolation regime instead of mandatory quarantine measures, special measures in the economic sphere instead of special economic measures established by presidential decree; mobilization – but partial. All this points to the 2020s as a period of hybrid law enforcement, when elements of other emergency regimes are used to construct the current law enforcement regime, but not in combination, while avoiding measures that entail a radical and total violation of civil rights and freedoms. At the same time, accelerated law-making clearly indicates that the array of norms that have been created over decades is insufficient to regulate the current agenda.

‘We Really Thrive on Interactions’ – How Consumers Experience and React to Sudden Constraints of Sociality in Everyday Neighborhood Places

This research investigates how consumers experience and deal with the constrained sociality of everyday places in their neighborhood (shops, parks, etc.) in times of crisis, using the coronavirus (Covid-19) pandemic as a revelatory context. Everyday neighborhood places outside the home or workplace do not only satisfy functional needs; they also serve people’s social life and enhance well-being. However, a gap exists in the literature about the impact of sudden consumer agency constraints on the felt sociality of such places, which hinders knowledge and advice on how service managers can effectively address consumer needs in such times. Drawing from semi-structured interviews with consumers and service providers in French and German urban environments, we find that the enacted restrictions changed how people related to the self, to others, and to the environment. Using ‘sense of place’ as a theoretical lens, we show that constrained sociality modifies the dialectical relationships between people and places: while consumers attributed new meaning to natural environments and re-valued the social resources of their neighborhood, the public restrictions made them increasingly concerned about their own agency. Since consumers thrive on everyday sociality, we discuss different ways service managers can enhance the experience of everyday places during public crises.

Time-varying effects of structural oil price shocks on financial market uncertainty

This study employed the structural oil price decomposition method proposed by Ready (2018) to decompose oil price shocks into oil risk shocks, demand shocks, and supply shocks. By using the Diebold and Yilmaz (DY) spillover index and rolling window methods, the static and dynamic spillovers of structural oil price shocks on financial market uncertainty were examined. The findings suggest that oil risk shocks exhibited the strongest spillover effects on financial market uncertainty (except for South Africa), followed by oil demand shocks, while oil supply shocks had virtually no impact. Second, the effects of structural oil price shocks on financial market uncertainty were time-varying. Third, significant differences in the spillover effects of structural oil price shocks on financial market uncertainty were found across countries, and the spillover effect of oil risk shocks on the financial market uncertainty in the United States was the largest in all periods. Fourth, the spillover effects of oil demand shocks on financial market uncertainty were larger in the high than in the low oil price period (except for Japan). Finally, during the COVID-19 (coronavirus disease) pandemic compared with the pre-epidemic period, the spillover effects of oil risk shocks on the financial market uncertainty in China significantly decreased, while simultaneously, the spillover effects of oil supply shocks on the financial market uncertainty in Australia substantially increased.

In Silico Evaluation of HIV Protease and RNA Polymerase Inhibitors as Potential COVID-19 Therapeutics.

The COVID-19 coronavirus, also known as the acute respiratory syndrome coronavirus, emerged as a significant global health concern. First identified in Wuhan, China, in December 2019, the virus rapidly spread to over 187 countries due to its high transmissibility. Until an effective treatment or vaccine is developed, preventive measures remain the only mandatory strategy to curb person-to-person transmission. The study aimed to explore potential therapeutic options for COVID-19 by repurposing existing drugs. Specifically, the objective was to evaluate a library of clinically approved or investigational antiviral compounds through docking studies to identify candidates with high binding affinity to COVID-19 proteins. The study employed molecular docking techniques using the Maestro interface (Schrodinger Suite, LLC, NY) to assess the interaction of selected compounds with various COVID-19 protein targets. A total of 15 compounds were analyzed for their binding potential to multiple forms of the virus's proteins. The docking studies revealed that several compounds, particularly HIV protease inhibitors and RNA-dependent RNA polymerase inhibitors, demonstrated strong binding affinities to key COVID-19 enzymes. These interactions suggest their potential as therapeutic candidates for COVID-19 treatment. The findings from this drug repurposing study highlight the potential of certain existing antiviral agents in the treatment of COVID-19. The identified compounds could serve as promising candidates for further investigation in the ongoing battle against the coronavirus pandemic.

A prospective analysis of the distribution of diseases of the oral mucosa in the “pre-covid” and COVID-19 periods

Over the past decades, cases of diseases of the oral mucosa (MSM) and the red border of the lips (RLB) have become significantly more frequent, and the severity of the course of diseases has increased markedly. Some diseases of SOP are prone to relapses, their treatment is not always successful. These diseases often lead to serious complications, including malignant ones. The outbreak of COVID-19 coronavirus infection was also one of the reasons that influenced the increase in the volume and variety of manifestations of MSM diseases. The purpose. To study the structure of MSM diseases in the “pre-epidemic” period and against the background of the pandemic of the new coronavirus infection COVID-19. Material and methods. The research was conducted on the basis of the therapeutic and prophylactic department of the clinic of the Federal State Budgetary Institution of the Ministry of Health of the Russian Federation. As part of the consultation, 988 patients with various diseases of MSM were examined from 2018 to 2022. The most common nosological forms of MSM diseases were identified. The patients were divided into 2 groups: group 1 – patients examined during the “pre-covid” period and group 2 – patients examined during the COVID-19 pandemic. All patients underwent the generally accepted methods of examination in the clinic (collection of complaints, anamnesis, examination of the litter, palpation). According to the indications, the presence of galvanism phenomena in the mouth (in the presence of orthopedic structures) was determined, bacterioscopic examination was performed and, in some cases, mainly for differential diagnosis, cytological examination and examination of the mucous membrane in the rays of a Wood lamp. Results and discussion. Analyzing the data obtained, we concluded that the overall increase in the number of patients who applied for MSM diseases in 2020-2022 increased the number of young patients aged 20 to 35 years. In the structure of diseases, the number of patients with such diseases as lichen planus (RLP), desquamative glossitis and glossalgia has increased. In the structure of dental lesions, cases of combined pathology of MSM diseases have become more frequent. Conclusions. In the complex of diagnostic studies of patients with MSM disease on the background of a coronavirus infection, in addition to a standard examination, it is necessary to introduce a general clinical examination by specialists such as a gastroenterologist, immunologist, neurologist, psychotherapist, dermatologist and others. Based on the etiology and clinic of MSM diseases in this category of patients, in addition to the prescribed generally accepted treatment regimens, it is necessary to prescribe drugs with effects on the autonomic and central nervous systems, as well as drugs that restore the intestinal and oral microflora.

Four Years of Anti-COVID-19 Regulations in Greece: Overview of the Legislative and Regulatory Process and of an Exemplary Administrative Codification

Abstract In the 25th of February 2024, four years since the first Act of Legislative Content of the Greek Government concerning the prevention and limitation of the spreading of coronavirus COVID-19 were completed. The regulatory production of this period is huge and has a series of unique characteristics with prevailing one the use of means of extraordinary legislation as foreseen in the Greek Constitution. All these measures are presented in a consolidated form in the “Special Administrative Codification of urgent regulatory measures to prevent and limit the spreading of coronavirus COVID-19 and to deal with relevant problems” under the short name of PANDEKTIS, conducted by the Department of Administrative Codifications – Raptarchis of the Secretariat General for Legal and Parliamentary Affairs of the Presidency of the Greek Government. The study of this monumental work gives rise to very interesting findings, about the way Hellenic Government handled the Pandemic crisis. This article presents the law-making process and the process of issuing secondary legislation during the Pandemic, its quantitative and qualitative characteristics with special comment on the fulfillment of the rules and principles of Better Regulation and discusses the use of administrative codification as a means of reflecting an holistic picture of the regulatory production during a period of crisis.

Impact of COVID-19 Coronavirus on Industry Standards 4.0 and 5.0

Impact of COVID-19 Coronavirus on Industry Standards 4.0 and 5.0

Последствия распространения коронавируса COVID-19 и новых штаммов для развития агропромышленного комплекса и потребительского рынка

The COVID-19 pandemic has become an example of the implementation of global biological threats, which are positioned as challenges to the economy, including the agricultural sector. The subject of the study was changes in food production and in the consumer market for agricultural products amid the consequences of the spread of the COVID-19 coronavirus and potentially dangerous new strains. Since the volume and structure of agricultural exports can serve as indicators of overcoming the challenge to the agro-industrial complex from the consequences of the COVID-19 pandemic, including in conjunction with the influence of the sanctions policies of Western countries, the object of the study was changes in the main indicators of exports of the agro-industrial complex of the Russian Federation at the federal and regional levels for first quarter of 2023 compared to the same period in 2022. Changes in the main indicators of exports of agricultural products were studied both at the federal and regional levels, using the example of agricultural enterprises in the Voronezh region, for the first quarter of 2023 compared to the same period in 2022. As a background for studying the subject field of indicators for overcoming the challenge to the agro-industrial sector from the consequences of the COVID-19 pandemic, changes in the field of food production and in the consumer market for agricultural products were identified and studied. An overview of the main exporting companies in the Voronezh region is presented for the following types of products: grains (wheat, corn, barley); meat and dairy products (pork and pork by-products, beef, butter); products of the oil and fat industry (sunflower oil, cakes, mustard oil). The priority trend for the Russian Federation is the development of deep processing of crop products, in particular grain crops. The basis is the trend of growing consumer demand for food products of plant origin, including those that imitate traditional meat and dairy products. A trend has been noted for the production and consumption of organic products, the implementation of which will contribute to the growth of the competitiveness of domestic agricultural products in the domestic and foreign markets. An important factor in increasing the competitiveness of domestic food in the global and domestic markets is the expansion of production of organic crop and livestock products based on a single unified database of agricultural land that meets the legally established requirements for this category of products.

Cheminformatics Screening of Phytochemicals Targeting Diverse Potential Receptors to Elicit Antiviral Properties

Objective: Recently, the COVID-19 (coronavirus disease) pandemic caused by SARSCoV-2 (severe acute respiratory syndrome coronavirus) gave rise to a public health emergency worldwide. Similarly, other viruses like HIV (Human Immunodeficiency Virus)/AIDS (acquired immunodeficiency syndrome), Zika, Ebola, and Influenza and their mutants have called for an urgent need for a Broad-spectrum antiviral drug, inhibiting the infection by targeting the common essential components of different viruses. Methods: Based on ancient medicinal knowledge, we made an attempt through molecular docking analysis to explore different phytochemical compounds against well-recognized viral receptors. Results: A total of 29 phytochemicals were virtually examined against 4 targets essential in the life cycle of viral infection: CD147 (Cluster of Differentiation 147), CD209L (Cluster of Differentiation 209 Lectin), eIF4A (Eukaryotic Initiation Factor 4A), and RdRp (RNA-dependent RNA polymerase). Providentially, Berbamine was identified as the best-hit lead molecule based on binding energies, conventional hydrogen bonding numbers, and non-covalent interactions. It exhibited binding energies as -8.3 kcal/mol with CD147, -8.2 kcal/mol with CD209L, -9.5 kcal/mol with eIF4A, and - 10.5 kcal/mol with RdRp. Additionally, in-silico drug likeliness (Lipinski’s rule) and ADME studies depict high bioavailability and gastrointestinal absorption and follow Lipinski’s rule. Conclusion: The data presented by our study exemplify phytochemicals from the selected plants that could target conserved viral components shared across multiple viruses. Berbamine can be designed as a possible drug to target Broad-Spectrum viruses, limiting the effectiveness of different viruses.

The effect of value orientations of physicians on satisfaction of patients with medical care quality in conditions of uncertainty

The COVID-19 coronavirus pandemic significantly impacted processes of medical care support and medical personnel and managers. The article presents analysis of results of three-year (2019-2022) studying level of loyalty of legal representatives of patients of one of Moscow children polyclinics. The study covered both legal representatives of patients (more than 190,000 assessments collected over entire observation period) and randomly selected district pediatricians (n=31). It is established that value-intentional consistency of district pediatricians (ratio between individual priorities of medical specialist and his ideas about proper behavior e.g. general medical or corporate values and norms), i.e. degree of interpersonal conflict, significantly affects loyalty of patients to them during uncertainty phase that covered first months of coronavirus pandemic. The physicians with moderate level of consistency between individual priorities and normative ideals demonstrated higher rates of loyalty on part of patients as compared with specialists who had value-intentional inconsistency. It is concluded that in order to increase and maintain this indicator, regular monitoring of social psychological status of medical workers, their material and non-material support and stimulation, development of mentoring system in medical organization and training of medical managers to use social psychological tools for building favorable corporate climate and culture of relations between employees of medical organization and patients are necessary.

Боковой амиотрофический склероз и его маски, коморбидная патология с быстрым летальным исходом: клинический случай

INTRODUCTION. Despite the fact that more than 150 years have passed since the first mention of amyotrophic lateral sclerosis (ALS), the issues of etiology, pathogenesis, diagnosis and treatment of this disease are still not fully resolved. However, the results of recent research in the field of genetics with the identification of genes associated with ALS, understanding the mechanisms of disease development and, as a result, the creation of effective drugs give hope that in the near future the disease will cease to be fatal. AIM. To analyze domestic and foreign publications on the etiology, pathogenesis, diagnosis and treatment of amyotrophic lateral sclerosis. To present a clinical case of a patient with amyotrophic lateral sclerosis. MATERIAL AND METHODS. The analysis of domestic and foreign publications for the period 1997-2024 is carried out. The sources of the Russian scientific electronic library eLibrary, RSCI databases, PubMed were used. CASE PRESENTATION. A patient is presented who, at the age of 56, developed mixed paresis of the right hand, followed by the development of mixed tetraparesis and simultaneously bulbar syndrome within 3 months. Differential diagnosis was performed between spondylogenic cervical myelopathy, endocrinopathy and ALS. Based on anamnestic data, clinical picture, rate of progression of symptoms, results of electroneuromyography, lack of improvement against the background of therapy, the main diagnosis was made: amyotrophic lateral sclerosis, a primary generalized form with mixed tetraparesis, bulbar syndrome. 2 weeks after discharge from the hospital in a stable condition, the patient was diagnosed with COVID-19 coronavirus infection, with a rapid fatal outcome from respiratory failure (7 months after the debut of ALS). CONCLUSION. A feature of the described ALS case is a rather rare primary generalized form of the disease (having such unfavorable prognosis factors as the development of bulbar syndrome at the beginning of the disease, a short time period from the appearance of the first symptoms to diagnosis), the presence of masking pathology in the form of spondylogenic myelopathy and the addition of COVID-19 with a rapid fatal outcome. With all the severity of ALS and an unfavorable prognosis, the presence of comorbid pathology can make the course of the disease even more dramatic. KEYWORDS: amyotrophic lateral sclerosis, comorbid pathology, coronavirus infection (COVID-19)