A self-piercing riveting process is used to join a thermoplastic composite sheet of PA6.6-GF50 with an aluminum alloy sheet 5182 O. Two shapes of self-piercing rivet are tested: the countersunk rivet and the button head rivet. Non-destructive inspections by pulse thermography and post-mortem cross-section observations are made to assess the damage that might have occurred during the rivet piercing process. The manufacturing defects are characterized and the possible causes for their emergence are explained. Then, single-lap joint tests were carried out to determine the best joint in terms of its mechanical strength. These tests were also instrumented by various monitoring techniques such as passive thermography, digital image correlation, and acoustic emission to clarify the joint damaging behavior. Non-destructive inspections by pulse thermography are finally correlated with the thermal fields acquired by passive thermography during the mechanical test to improve the understanding of the damage mechanisms and their criticality.