Under the background of educational reform, large-unit teaching strategy is of great significance to improve the quality of middle school mathematics teaching and promote students' deep learning. Based on the integration of pedagogy theory and practice, this paper deeply analyzes the challenges and opportunities faced by middle school mathematics teachers in Anyang when implementing large-unit teaching strategies, and puts forward targeted professional development strategies for teachers at different stages, such as rookie, backbone and senior. At the same time, this paper also discusses how to combine teachers' internal motivation and external support to build an effective strategy system. These research results not only provide concrete guidance for middle school mathematics teachers to implement large-unit teaching strategies, but also provide in-depth insights and references for educators to promote the sustainable development and innovation of middle school mathematics education.