Count Rate Linearity Research Articles

First experimental evaluation of count-rate performance for micrometre resolution deep silicon detector

Objective. An ultra-fine-pitch deep silicon detector has been developed for clinical photon-counting computed tomography (CT). With a small pixel size of 14 × 650 μm2, it has shown potential to reach micrometre spatial resolution in previous simulation studies. A detector prototype with such geometry has been manufactured, and we report on the first experimental evaluation of its count-rate performance. Approach. The measurement was carried out at MAX IV synchrotron laboratory with 35 keV monochromatic x-rays. By inserting tungsten attenuators of 50, 75, 100, 150, 200, 225, 325 μ m-thicknesses into the beam, the response of the detector to fluence rates from 3.3 × 107 to 1.3 × 1011 mm−2 s−1 was characterized. Main results. The measurement result showed that the detector exhibited count rate linearity up to 6.66 × 108 mm−2 s−1 with 13% count loss and was still functional at count rate up to 2.9 × 1010 mm−2 s−1. A semi-nonparalyzable dead-time model was fitted to the count-rate behaviour of the detector, showing great agreement with the measured data, with an estimated nonparalyzable dead time of 2.9 ns. Significance. This is the first experimental evaluation of the count-rate performance for a deep silicon detector with such small pixel geometry. The results suggest that this type of detector shows the potential to be used at fluence rates encountered in clinical CT with little count loss due to pile-up.

Large area hybrid detectors based on Medipix3RX: commissioning and characterization at Sirius beamlines

Hybrid pixel detectors are inherently modular and typically operate at relative low noise levels, while providing high spatial resolution, easing the assembling of large area detectors. This report summarizes the procedures and results regarding the characterization studies performed on the Medipix3RX ASIC based detector, known as PIMEGA, which was developed and is deployed at Sirius synchrotron facility at the Brazilian Synchrotron Light Laboratory. They consist of modular constructions that reach up to 170 × 170 mm2 of active area, with 300 µm thick silicon sensors, and pixel size of 55 × 55 µm2. We investigated the spatial and energy resolutions, structural noise properties, and count-rate linearity up to large fluxes from the synchrotron beamlines. The Modulation Transfer Function presents a considerably slow decay rate as a function of the spatial frequency, reaching 30% at 10.5 lp/mm, for an operation with a threshold setting equivalent to half of the incident energy. We have also found that the energy resolutions of the two highest gain modes are around 15% for 17.5 keV incident photons. In particular, we have found that, for a noise-suppressing set of configurations, the detector presents a dead time of 460 ± 10 ns. Additionally, the pile-up effect leads to a 10% loss of linearity at input fluxes of 2.3 × 105 photons/pixel.s. These results open the possibility for operating these devices with in-depth knowledge of their performance, allowing various scientific experiments, such as X-ray diffraction, computed controlled tomography, and ptychography.

Personal Dosimetry in Direct Pulsed Photon Fields With the Dosepix Detector

First investigations regarding dosimetric properties of the hybrid, pixelated, photon-counting Dosepix detector in the direct beam of a pulsed photon field (RQR8) for the personal dose equivalent $H\mathrm{_p(10)}$ are presented. The influence quantities such as pulse duration and dose rate were varied, and their responses were compared to the legal limits provided in PTB-A 23.2. The variation of pulse duration at a nearly constant dose rate of about 3.7$\,$Sv/h shows a flat response around 1.0 from 3.6$\,$s down to 2$\,$ms. A response close to 1.0 is achieved for dose rates from 0.07$\,$Sv/h to 35$\,$Sv/h for both pixel sizes. Above this dose rate, the large pixels (220$\,\mu$m edge length) are below the lower limit. The small pixels (55$\,\mu$m edge length) stay within limits up to 704$\,$Sv/h. The count rate linearity is compared to previous results, confirming the saturating count rate for high dose rates.

Two-channel combination methods for count-loss correction in radiation measurements at high rates and with pulsed sources

Pile-up effects due to the overlap of signals within the system dead-time (τ) influence the counting capability of radiation detection devices, necessitating the use of correction algorithms to compensate for the count-losses at high radiation rates. Count-rate linearity is especially critical for clinical applications like X-ray imaging or beam monitoring in particle therapy. In particular, in proton therapy the number of delivered particles must be measured online during the treatment session with a maximum error of 1 % up to an average input beam flux of about 1010cm−2s−1. For a segmented detector used to identify and count the single beam particles, assuming a channel area of 1 mm2 and a dead-time τ=2ns, a maximum counting inefficiency of 1 % is required up to τ.fin=0.2 for each detector channel, where fin represents the input rate. Moreover, the beam is often delivered in bunches with higher instantaneous particle rates, and the saturation model of the detector and electronic chain could not be easily determined. Similar considerations are applicable for pixelated detectors used for photon counting.Two methods are proposed to mitigate counting inefficiencies with radiation sources of variable time-structures. Both methods are based on the collection of logic signals provided by two independent detector channels exposed to the same radiation field after discriminating the detector analog outputs with a fixed threshold, assuming that the duration of the discriminator output signal corresponds to the system dead-time. The correction algorithms employ the measurements of the time durations, the number of signals from the two channels and of their AND/OR combinations. The methods provide count-loss corrections without the need to know the dead-time model.The performances of the proposed algorithms are evaluated by using simulations of ideal boxcar signals of fixed duration τ, distributed randomly in time to emulate the dead-time behavior of the system. Both methods provide an effective count-loss correction with a maximum deviation of 1% for different input rates up to τ.fin=1, assuming a uniform random time distribution of input events for both paralyzable and non-paralyzable systems. The simulations of pulsed radiation fluxes provide the same results as a function of the instantaneous input rates.These results are similar to those obtainable by the standard live-time correction algorithm. However, the latter algorithm can only be applied to continuous particle fluxes, while the proposed algorithms work also for pulsed beams, without any hypothesis on the bunch duration or frequency. The robustness of the algorithms with respect to the resolution of the time measurement is studied and the potential limitations in more realistic systems are discussed.The algorithms can be easily implemented in standard logical circuits with multiple input signals provided by segmented detectors. Even if the methods are intended for real-time correction in beam particle counting, they could be applied in a wider range of applications of radiation measurements.

Medipix3 proton and carbon ion measurements across full energy ranges and at clinical flux rates in MedAustron IR1

The Medipix3, a hybrid pixel detector with a silicon sensor, has been evaluated as a beam instrumentation device with proton and carbon ion measurements in the non-clinical research room (IR1) of MedAustron Ion Therapy Center. Protons energies are varied from 62.4 to 800 MeV with 104 to 108 protons per second impinging on the detector surface. For carbon ions, energies are varied from 120 to 400 MeV/amu with 107 to 108 carbon ions per second. Measurements include simultaneous high resolution, beam profile and beam intensity with various beam parameters at up to 1000 FPS (frames per second), count rate linearity and an assessment of radiation damage after the measurement day using an x-ray tube to provide a homogeneous radiation measurement. The count rate linearity is found to be linear within the uncertainties (dominated by accelerator related sources due to special setup) for the measurements without degraders. Various frequency components are identified within the beam intensity over time firstly including 49.98 Hz with standard deviation, σ = 0.29, secondly 30.55 Hz σ = 0.55 and thirdly 252.51 Hz σ = 0.83. A direct correlation between the number of zero counting and noisy pixels is observed in the measurements with the highest flux. No conclusive evidence of long term radiation damage was found as a result of these measurements over one day.

Medipix3 for dosimetry and real-time beam monitoring: first tests at a 60 MeV proton therapy facility

Charged particle therapy (CPT) is an advanced modality of radiation therapy which has grown rapidly worldwide, driven by recent developments in technology and methods of delivery. To ensure safe and high quality treatments, various instruments are used for a range of different measurements such as for quality assurance, monitoring and dosimetry purposes. With the emergence of new and enhanced delivery techniques, systems with improved capabilities are needed to exceed existing performance limitations of conventional tools. The Medipix3 is a hybrid pixel detector able to count individual protons with millisecond time resolution at clinical flux with near instant readout and count rate linearity. The system has previously demonstrated use in medical and other applications, showing wide versatility and potential for particle therapy. In this work we present measurements of the Medipix3 detector in the 60 MeV ocular proton therapy beamline at the Clatterbridge Cancer Centre, U.K. The beam current and lateral beam profiles were evaluated at multiple positions in the treatment line and compared with EBT3 Gafchromic film. The recorded count rate linearity and temporal analysis of the beam structure was measured with Medipix3 across the full range of available beam intensities, up to 3.12 × 1010 protons/s. We explore the capacity of Medipix3 to provide non-reference measurements and its applicability as a tool for dosimetry and beam monitoring for CPT. This is the first known time the performance of the Medipix3 detector technology has been tested within a clinical, high proton flux environment.

Characterization of stilbene and EJ-276 scintillators coupled with a large area SiPM array for a fast neutron dose rate detector

A 1-inch stilbene and EJ-276 (plastic) organic scintillators were characterized in view of their use in a portable survey meter for fast neutron detection and dose rate measurements in radiation protection. They were coupled with a large area Silicon Photomultiplier (SiPM) array and characterized in terms of neutron/γ–ray (n/γ) discrimination capability, count rate linearity, count rate saturation effects, temperature stability and neutron detection efficiency. A Pile-Up Rejection (PUR) algorithm was developed and tested to increase their count rate linearity with increasing dose rate. Results show that the stilbene exhibits better performance compared to the plastic in terms of: Pulse Shape Discrimination (PSD) with a Figure Of Merit (FOM) of 1.5 vs. 1.1, energy resolution (15% vs 20% at 662 keV) and fast neutron efficiency (12% vs. 9% with an AmBe source). For both scintillators, the dose rate response is linear up to 1 mSv/h with a 137Cs γ-ray source. With a neutron source, the response is linear, and the FOM is almost constant for dose rates up to 1.5 mSv/h. The PUR reduces the false neutron events by one order of magnitude when the detectors are irradiated with a γ-ray source up to 10 mSv/h, and it correctly works when irradiated with an AmBe source at 1.5 mSv/h together with a 137Cs source up to 60 μSv/h. The proposed PUR algorithm is promising but needs to be tested with a higher intensity mixed n/γ field. The temperature stability of both detectors was also studied in the temperature range from −10 °C to ＋40 °C. The light yield increases by around 25% for both detectors when reducing the temperature. The variation of the neutron count rate is around 10% in the same temperature range. This work provides a complete overview of the performance of these detectors and a coherent comparison between the two types of scintillators with the same experimental setup.

Evaluation of a one-dimensional position-sensitive quartz optical fiber sensor based on the time-of-flight method for high radiation dose rate applications

For the measurement of radiation distribution inside the Fukushima Daiichi Nuclear Power Station (FDNPS) buildings, the evaluation of a small-diameter quartz optical fiber as a one-dimensional position-sensitive sensor was conducted. The sensor determines the incident position of radiation into the fiber using the time-of-flight information from the Cerenkov photons generated in the optical fiber. Compared with a conventional sensor using plastic scintillating fiber, the quartz optical fiber has a much higher position resolution, which may be the result of the improvement of timing characteristics due to the prompt emission mechanism of the Cerenkov radiation. Additionally, the response of the quartz fiber sensor under high radiation field was evaluated. A count rate linearity up to a dose rate of at least 20 mSv/h was confirmed using a 10m-long quartz fiber with a diameter of 0.4 mm. Furthermore, the radiation tolerance of the sensor up to an accumulated dose of 1 kGy was evaluated.

Performance assessment of the ALBIRA II pre-clinical SPECT S102 system for 99mTc imaging.

The performance characteristics of the SPECT sub-system S102 of the ALBIRA II PET/SPECT/CT are analyzed for the 80mm field of view (FOV) to evaluate the potential in-vivo imaging in rats, based on measurements of the system response for the commonly used Technetium-99m (99mTc) in small animal imaging. The ALBIRA II tri-modal µPET/SPECT/CT pre-clinical system (Bruker BioSpin, Ettlingen, Germany) was used. The SPECT modality is made up of two opposite gamma cameras (Version S102) with Sodium doped Cesium Iodide (CsI(Na)) single continuous crystal detectors coupled to position-sensitive photomultipliers (PSPMTs). Imaging was performed with the NEMA NU-4 image quality phantom (Data Spectrum Corporation, Durham, USA). Measurements were performed with a starting activity concentration of 4.76MBq/mL 99mTc. An energy window of 20% at 140keV was selected in this study. The system offers a 20mm, 40mm, 60mm and an 80mm field of view (FOV) and in this study the 80mm FOV was used for all the acquisitions. The data were reconstructed with an ordered subset expectation maximization (OSEM) algorithm. Sensitivity, spatial resolution, count rate linearity, convergence of the algorithm and the recovery coefficients (RC) were analyzed. All analyses were performed with PMOD and MATLAB software. The sensitivities measured at the center of the 80mm FOV with the point source were 23.1 ± 0.3 cps/MBq (single pinhole SPH) and 105.6 ± 5.5 cps/MBq (multi pinhole MPH). The values for the axial, tangential and radial full width at half maximum (FWHM) were 2.51, 2.54, and 2.55mm with SPH and 2.35, 2.44 and 2.32mm with MPH, respectively. The corresponding RC values for the 5mm, 4mm, 3mm and 2mm rods were 0.60 ± 0.28, 0.61 ± 0.24, 0.29 ± 0.11 and 0.20 ± 0.06 with SPH and 0.56 ± 0.20, 0.50 ± 0.18, 0.38 ± 0.09 and 0.23 ± 0.06 with MPH. To obtain quantitative imaging data, the image reconstructions should be performed with 12 iterations. The ALBIRA II preclinical SPECT sub-system S102 has a favorable sensitivity and spatial resolution for the 80mm FOV setting for both the SPH and MPH configurations and is a valuable tool for small animal imaging.

Large Magellanic Cloud Cepheid Standards Provide a 1% Foundation for the Determination of the Hubble Constant and Stronger Evidence for Physics beyond ΛCDM

Abstract We present an improved determination of the Hubble constant from Hubble Space Telescope (HST) observations of 70 long-period Cepheids in the Large Magellanic Cloud (LMC). These were obtained with the same WFC3 photometric system used to measure extragalactic Cepheids in the hosts of SNe Ia. Gyroscopic control of HST was employed to reduce overheads while collecting a large sample of widely separated Cepheids. The Cepheid period–luminosity relation provides a zero-point-independent link with 0.4% precision between the new 1.2% geometric distance to the LMC from detached eclipsing binaries (DEBs) measured by Pietrzyński et al. and the luminosity of SNe Ia. Measurements and analysis of the LMC Cepheids were completed prior to knowledge of the new DEB LMC distance. Combined with a refined calibration of the count-rate linearity of WFC3-IR with 0.1% precision, these three improved elements together reduce the overall uncertainty in the geometric calibration of the Cepheid distance ladder based on the LMC from 2.5% to 1.3%. Using only the LMC DEBs to calibrate the ladder, we find H 0 = 74.22 ± 1.82 km s−1 Mpc−1 including systematic uncertainties, 3% higher than before for this particular anchor. Combining the LMC DEBs, masers in NGC 4258, and Milky Way parallaxes yields our best estimate: H 0 = 74.03 ± 1.42 km s−1 Mpc−1, including systematics, an uncertainty of 1.91%–15% lower than our best previous result. Removing any one of these anchors changes H 0 by less than 0.7%. The difference between H 0 measured locally and the value inferred from Planck CMB and ΛCDM is 6.6 ± 1.5 km s−1 Mpc−1 or 4.4σ (P = 99.999% for Gaussian errors) in significance, raising the discrepancy beyond a plausible level of chance. We summarize independent tests showing that this discrepancy is not attributable to an error in any one source or measurement, increasing the odds that it results from a cosmological feature beyond ΛCDM.

X-ray spectrometer with a low-cost SiC photodiode

A low-cost Commercial-Off-The-Shelf (COTS) 4H-SiC 0.06 mm2 UV p-n photodiode was coupled to a low-noise charge-sensitive preamplifier and used as photon counting X-ray spectrometer. The photodiode/spectrometer was investigated at X-ray energies from 4.95 keV to 21.17 keV: a Mo cathode X-ray tube was used to fluoresce eight high-purity metal foils to produce characteristic X-ray emission lines which were used to characterise the instrument. The energy resolution (full width at half maximum, FWHM) of the spectrometer was found to be 1.6 keV to 1.8 keV, across the energy range. The energy linearity of the detector/spectrometer (i.e. the detector’s charge output per photon as a function of incident photon energy across the 4.95 keV to 21.17 keV energy range), as well as the count rate linearity of the detector/spectrometer (i.e. number of detected photons as a function of photon fluence at a specific energy) were investigated. The energy linearity of the detector/spectrometer was linear with an error <± 0.7 %; the count rate linearity of the detector/spectrometer was linear with an error <± 2 %. The use of COTS SiC photodiodes as detectors for X-ray spectrometers is attractive for nanosatellite/CubeSat applications (including solar flare monitoring), and for cost sensitive industrial uses.

Investigation of the imaging characteristics of the ALBIRA II small animal PET system for 18F, 68Ga and 64Cu

AimIn this study the performance characteristics of the Albira II PET sub-system and the response of the system for the following radionuclides 18F, 68Ga and 64Cu was analyzed. Materials and methodsThe Albira II tri-modal system (Bruker BioSpin MRI GmbH, Ettlingen, Germany) is a pre-clinical device for PET, SPECT and CT. The PET sub-system uses single continuous crystal detectors of lutetium yttrium orthosilicate (LYSO). The detector assembly consists of three rings of 8 detector modules. The transaxial field of view (FOV) has a diameter of 80mm and the axial FOV is 148mm. A NEMA NU-4 image quality phantom (Data Spectrum Corporation, Durham, USA) having five rods with diameters of 1, 2, 3, 4 and 5mm and a uniform central region was used. Measurements with 18F, 68Ga and 64Cu were performed in list mode acquisition over 10h. Data were reconstructed using a maximum-likelihood expectation-maximization (MLEM) algorithm with iteration numbers between 5 and 50. System sensitivity, count rate linearity, convergence and recovery coefficients were analyzed. ResultsThe sensitivities for the entire FOV (non-NEMA method) for 18F, 68Ga and 64Cu were (3.78±0.05)%, (3.97±0.18)% and (3.79±0.37)%, respectively. The sensitivity based on the NEMA protocol using the 22Na point source yielded (5.53±0.06)%. Dead-time corrected true counts were linear for activities ≤7MBq (18F and 68Ga) and ≤17MBq (64Cu) in the phantom. The radial, tangential and axial full widths at half maximum (FWHMs) were 1.52, 1.47 and 1.48mm. Recovery coefficients for the uniform region with a total activity of 8MBq in the phantom were (0.97±0.05), (0.98±0.06), (0.98±0.06) for 18F, 68Ga and 64Cu, respectively. ConclusionThe Albira II pre-clinical PET system has an adequate sensitivity range and the system linearity is suitable for the range of activities used for pre-clinical imaging. Overall, the system showed a favorable image quality for pre-clinical applications.

Characterizing energy dependence and count rate performance of a dual scintillator fiber-optic detector for computed tomography.

Kilovoltage (kV) x-rays pose a significant challenge for radiation dosimetry. In the kV energy range, even small differences in material composition can result in significant variations in the absorbed energy between soft tissue and the detector. In addition, the use of electronic systems in light detection has demonstrated measurement losses at high photon fluence rates incident to the detector. This study investigated the feasibility of using a novel dual scintillator detector and whether its response to changes in beam energy from scatter and hardening is readily quantified. The detector incorporates a tissue-equivalent plastic scintillator and a gadolinium oxysulfide scintillator, which has a higher sensitivity to scatter x-rays. The detector was constructed by coupling two scintillators: (1) small cylindrical plastic scintillator, 500 μm in diameter and 2 mm in length, and (2) 100 micron sheet of gadolinium oxysulfide 500 μm in diameter, each to a 2 m long optical fiber, which acts as a light guide to transmit scintillation photons from the sensitive element to a photomultiplier tube. Count rate linearity data were obtained from a wide range of exposure rates delivered from a radiological x-ray tube by adjusting the tube current. The data were fitted to a nonparalyzable dead time model to characterize the time response. The true counting rate was related to the reference free air dose air rate measured with a 0.6 cm(3) Radcal(®) thimble chamber as described in AAPM Report No. 111. Secondary electron and photon spectra were evaluated using Monte Carlo techniques to analyze ionization quenching and photon energy-absorption characteristics from free-in-air and in phantom measurements. The depth/energy dependence of the detector was characterized using a computed tomography dose index QA phantom consisting of nested adult head and body segments. The phantom provided up to 32 cm of acrylic with a compatible 0.6 cm(3) calibrated ionization chamber to measure the reference air kerma. Each detector exhibited counting losses of 5% when irradiated at a dose rate of 26.3 mGy/s (Gadolinium) and 324.3 mGy/s (plastic). The dead time of the gadolinium oxysulfide detector was determined to be 48 ns, while the dead time of the plastic scintillating detector was unable to accurately be calculated due to poor counting statistics from low detected count rates. Noticeable depth/energy dependence was observed for the plastic scintillator for depths greater than 16 cm of acrylic that was not present for measurements using the gadolinium oxysulfide scintillator, leading us to believe that quenching may play a larger role in the depth dependence of the plastic scintillator than the incident x-ray energy spectrum. When properly corrected for dead time effects, the energy response of the gadolinium oxysulfide scintillator is consistent with the plastic scintillator. Using the integrated dual detector method was superior to each detector individually as the depth-dependent measure of dose was correctable to less than 8% between 100 and 135 kV. The dual scintillator fiber-optic detector accommodates a methodology for energy dependent corrections of the plastic scintillator, improving the overall accuracy of the dosimeter across the range of diagnostic energies.

Count rate linearity and spectral response ofthe Medipix3RX chip coupled to a 300μm silicon sensor under high flux conditions

For clinical X-ray imaging, the detector performance under high flux conditions is very important, with typical flux rates for modern CT systems reaching 109 photons s−1 mm−2 in the direct beam. In addition, for spectral imaging a good energy resolution under these conditions is needed. This poses difficulties, since pulse pileup in the pixel electronics does not only affect the count rate, leading to a deviation from the otherwise linear behavior, but also degrades the spectral response of the detector, making k-edge subtraction and other contrast enhancement techniques less efficient. In this paper, we investigate the count rate capabilities and the energy response of the Medipix3RX chip under high flux conditions using 10 keV monochromatic photons.

Investigating the feasibility of photon‐counting K‐edge imaging at high x‐ray fluxes using nonlinearity corrections

Pulse pileup occurring at high x-ray fluxes can severely degrade the energy resolution provided by a photon counting detector, which can represent a problem in spectroscopic CT when performing quantitative material discrimination tasks. As the effects of pileup can be most easily seen as a degradation of a detector's count rate linearity at high fluxes, it has been proposed previously to quantify and correct these nonlinearities. While this strategy has been applied successfully to materials without K-edges, it is currently unknown if this still prevails when using medical contrast agents. The purpose of this study is to close this gap. A Medipix2MXR Hexa detector was employed, featuring a pixel pitch of 165 [micro sign]m and a 1 mm thick CdTe sensor. A phantom containing various concentrations of iodine and gadolinium contrast agents was subject to energy selective CT acquisitions, using a pulsable x-ray source operated at 70 kVp. These acquisitions were obtained at low and high photon fluxes of 1.0 × 10(6) and 1.3 × 10(7) mm(-2) s(-1), respectively. Nonlinearity corrections were applied to the high-flux projections and for each pixel separately. The results were compared to the results at low photon fluxes. At high fluxes, a general reduction of the reconstructed attenuation coefficients was observed, which could be partially recovered using the correction strategy applied. The spectroscopic separation of iodine from the phantom material, however, degraded with increasing x-ray flux. In contrast to this, gadolinium could still be discriminated almost as well as in the low flux case. Nonlinearity corrections applied to high flux measurements can help to recover attenuation coefficients normally obtained at low fluxes for low-Z materials, which do not exhibit an absorption edge in the relevant energy range. However, as a result of a significant change of the x-ray spectrum, the spectroscopic contrast normally observed for iodine was found to vanish with increasing x-ray flux. In other words, the authors' results indicate that nonlinearity corrections may be feasible only when the K-edge of interest is sufficiently high compared to the mean photon energy, and that spectroscopic CT at high x-ray fluxes may suffer from less limitations when using high-Z materials as contrast agents. A future study should aim to confirm these findings under clinical conditions.

Manganese‐52 positron emission tomography tracer characterization and initial results in phantoms and in vivo

Manganese(II) is employed as a contrast agent with magnetic resonance imaging (MRI) for study of neuronal activation in rats and mice. However, at the concentrations required for MRI, Mn may induce pharmacological or toxic effects. Positron emission tomography (PET) imaging of (52)MnCl2 at tracer doses has the potential to allow similar Mn studies as manganese-enhanced MRI while providing quantitative results and avoiding toxic effects. In this work, (52)MnCl2 is produced and characterized as a PET tracer in phantoms and in rats. (52)MnCl2 was produced by proton irradiation of natural Cr foil and separated by column chromatography. Images were acquired on a Siemens Focus 120 small animal PET scanner. Phantom images were acquired to assess uniformity, resolution, cascade background correction, and count rate linearity. Images of rats were also acquired after systemic and intracerebroventricular (ICV) administration of (52)MnCl2 to investigate Mn(II) distribution in vivo. Irradiation yield was 74.6 ± 8.5 kBq/μA min (52)Mn at end of bombardment with initial specific activity of at least 3.5 MBq/nmol. (52)Mn PET images show similar uniformity and resolution to (18)F. (18)F based detector efficiency normalization is adequate for (52)Mn imaging. Subtraction of a rescaled random events distribution from sinogram data is effective for cascade correction of (52)Mn PET data. After systemic injection, (52)Mn appears in structures throughout the body of rats, including bones, liver, intestines, and the pituitary gland, but does not appear detectably throughout the brain. After ICV injection, (52)Mn remains in the brain and spinal cord. (52)Mn is a promising tracer for small animal PET imaging, yielding image quality comparable to (18)F. Potential applications include studies similar to Mn-enhanced neuronal MRI, and in other organ systems including bones, spinal cord, and the digestive tract.

Phantom study of a new hand-held γ-imaging probe for radio-guided surgery

In recent years, hand-held mini γ-cameras have been increasingly used to perform scintigraphic imaging during surgery. The aim of the present work was to evaluate the physical characteristics of a new high-sensitivity hand-held mini γ-camera through specific phantom measurements. To characterize the performances of the imaging probe Guardian2 hand-held γ-camera, we measured its sensitivity and depth transmission curve, the extrinsic spatial resolution and spatial linearity, the spatial uniformity, and the count-rate linearity. We also estimated its whole image quality through the contrast-to-noise ratio of four hot spheres (internal diameters ranging from 4.9 to 9.8 mm). The sensitivity of the imaging probe Guardian2 γ-camera was 204 counts/s/MBq; it had a high spatial resolution (2.5 mm FWHM at contact) and optimal linearity of counts (Pearson's coefficient, R=0.999). The integral uniformity was 12.0% in the useful field of view (FOV) and 8.8% in the central FOV, whereas the differential uniformity was 5.7% in the useful FOV and 4.0% in the central FOV. The system was able to detect and distinguish all four small spheres used for the whole quality test. The contrast-to-noise ratio was evaluated both at contact with the collimator and with a 5-cm-thick interposed Plexiglas slab. The γ-imaging probe that we evaluated demonstrated good performance, confidently allowing its use for specific clinical applications in radio-guided surgery.

Quantification with a dedicated breast PET/CT scanner

Dedicated breast PET/CT is expected to have utility in local staging, surgical planning, monitoring of therapy response, and detection of residual disease for breast cancer. Quantitative metrics will be integral to several such applications. The authors present a validation of fully 3D data correction schemes for a custom built dedicated breast PET/CT (DbPET/CT) scanner via (18)F-FDG phantom scans. A component-based normalization was implemented, live-time was estimated with a multicomponent model, and a variance reduced randoms estimate was computed from delayed coincidences. Attenuation factors were calculated by using a CT based segmentation scheme while scatter was computed using a Monte Carlo (MC) simulation method. As no performance standard currently exists for breast PET systems, custom performance tests were created based on prior patient imaging results. Count-rate linearity for live-time and randoms corrections was measured with a decay experiment for a solid polyethylene cylinder phantom with an offset line source. A MC simulation was used to validate attenuation correction, a multicompartment phantom with asymmetric activity distribution provided an assessment of scatter correction, and image uniformity after geometric and detector normalization was measured from a high count scan of a uniform cylinder phantom. Raw data were reconstructed with filtered back projection (FBP) after Fourier rebinning. To quantify performance absolute activity concentrations, contrast recovery coefficients and image uniformity were calculated through region of interest analysis. The most significant source of error was attributed to mispositioning of events due to pile-up, presenting in count-related axial and transaxial nonuniformities that were not corrected for with the normalization method used here. Within the range of singles counts observed during clinical trials residual error after applying all corrections was comparable to that of a commercial whole body PET/CT system. The results suggest that DbPET/CT is capable of producing quantitative images under the operating conditions expected during patient imaging.

Preliminary evaluation of a silicon strip detector for photon-counting spectral CT

An edge-on silicon strip detector designed for photon-counting spectral computed tomography (CT) is presented. Progress on the development of an application specific integrated circuit (ASIC) to process the pulses and sort them into energy bins is reported upon. The ASIC and detector are evaluated in terms of electronic noise, energy resolution, count rate linearity under high-frequency periodic pulses, threshold variation and gain. The high-frequency periodic pulses are injected both by means of an external pulse generator and a pulsed laser illuminating the silicon diode. The pulsed laser system has ∼100ps pulse width and thus generates near instantaneous pulses in the diode, thus mimicking real X-ray conversions.The evaluation shows a low thermal noise level of 0.77keV RMS, an energy resolution of 1.5keV RMS when electron-hole pairs are generated in the detector diode by the laser injection. The test results furthermore indicate a good energy-discriminating capability of the detector with the thresholds spread out, assigning the external pulses to higher and higher energy bins as the pulse intensity is increased.

Quantitative Evaluation of Scintillation Camera Imaging Characteristics of Isotopes Used in Liver Radioembolization

BackgroundScintillation camera imaging is used for treatment planning and post-treatment dosimetry in liver radioembolization (RE). In yttrium-90 (90Y) RE, scintigraphic images of technetium-99m (99mTc) are used for treatment planning, while 90Y Bremsstrahlung images are used for post-treatment dosimetry. In holmium-166 (166Ho) RE, scintigraphic images of 166Ho can be used for both treatment planning and post-treatment dosimetry. The aim of this study is to quantitatively evaluate and compare the imaging characteristics of these three isotopes, in order that imaging protocols can be optimized and RE studies with varying isotopes can be compared.Methodology/Principal FindingsPhantom experiments were performed in line with NEMA guidelines to assess the spatial resolution, sensitivity, count rate linearity, and contrast recovery of 99mTc, 90Y and 166Ho. In addition, Monte Carlo simulations were performed to obtain detailed information about the history of detected photons. The results showed that the use of a broad energy window and the high-energy collimator gave optimal combination of sensitivity, spatial resolution, and primary photon fraction for 90Y Bremsstrahlung imaging, although differences with the medium-energy collimator were small. For 166Ho, the high-energy collimator also slightly outperformed the medium-energy collimator. In comparison with 99mTc, the image quality of both 90Y and 166Ho is degraded by a lower spatial resolution, a lower sensitivity, and larger scatter and collimator penetration fractions.Conclusions/SignificanceThe quantitative evaluation of the scintillation camera characteristics presented in this study helps to optimize acquisition parameters and supports future analysis of clinical comparisons between RE studies.