Primary infertility is a major crisis, triggering negative impact on psychological aspects among couples in treatment. Globally, psychological counselling is advocated as a supportive model in alleviating psychological distress during Assisted Reproductive Technology Treatment (ART). The aim of this systematic review was to investigate the available evidence from India on the effects of psychological counselling intervention among couples taking ART treatment due to primary infertility. A total of sixtynine studies were identified from PubMed, Google scholar, Science Direct and electronic databases from the beginning of May 2022. Out of sixty-nine relevant articles, a total of five doctoral theses and one original article were systematically reviewed and included based on inclusion and exclusion criteria. Five doctoral research work and one original article involving 2082 samples of primary infertile women and men were included for the present systematic review. All the reviewed studies have shown that infertile women and men in the intervention group experienced improvement in infertility related stress, depression, anxiety, coping ability and marital understanding. Overall, our finding suggests that there is not much research conducted in India to find the effect of psychological counselling. Due to the lack of pertinent studies from India, more indigenous studies with sound methodology are necessary to draw definitive conclusion about the need for psychological counselling during ART treatment.