55 Background: Treatment decisions in oncology care have financial implications. A shift in reimbursement from traditional fee-for-service models toward episode-based care sets the framework for assessing the value of therapies. The objective of this study was to determine episode-based total cost (medical and pharmacy) and resource utilization by therapy for patients with metastatic renal cell carcinoma (mRCC) using the Oncology Care Model methodology. Methods: Retrospective analysis of commercial claims data incurred between Jan 1, 2013 and Jun 30, 2018. Patients included had ≥1 claim with a diagnosis code of renal cell carcinoma (RCC), ≥2 claims for metastasis on or after initial RCC diagnosis date, evidence of any mRCC systemic therapy on or after initial mRCC diagnosis date, and continuous enrollment from ≥6 months before until ≥6 months after the index date and were ≥18 years old on the index date. Patients were classified by 1 of 6 therapy classes: tyrosine kinase inhibitors (TKIs) monotherapy, mechanistic target of rapamycin (mTOR) monotherapy, immuno-oncology (IO) monotherapy, other (e.g., interferon) monotherapy, changed therapy class (e.g., from TKI to mTOR), or traditional chemotherapy. Results: 606 commercially insured patients with mRCC met the inclusion criteria. Most received monotherapy, and 53% had ≥2 episodes. Specifically, 59% of TKI, 17% of mTOR, 28% of IO, 59% of other, 85% of changed therapy class, and 38% of chemotherapy patients had ≥2 episodes. IO patients had the longest average inpatient length of stay per episode (7 days; p = 0.0002). There were differences in total episode costs among each selected therapeutic class: TKI (n = 161; $61,417), mTOR (n = 30; $67,637), IO (n = 75; $92,082), other (n = 34; $98,877), changed therapy (n = 130; $84,480), and chemotherapy (n = 34; $55,743) (p < 0.0001). Conclusions: Differences in total episode costs exist in each monotherapy class used to treat mRCC, even in an episode-based structure. As healthcare financing shifts to alternative payment models, it is important to investigate overall episode cost of care for various therapies, as the cost for the individual drug may not accurately reflect the total episode value.
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