Introduction: Intestinal transplantation has recently become an accepted therapy for selected patient with irreversible intestinal failure in Taiwan since 2012. Outcome of intestinal transplantation have continued to improve in recent years. Due to our center is the first qualified hospital to implement intestinal transplantation. Most transplantation recipient was referred from a distant location. After transplantation, they need travel long distances for medical clinical follow up. That will affect the outcome of intestinal transplantation outcome. To reduce unnecessary patient travel, and thereby reduce the travel cost and inconvenience of consultations without compromising the quality of patient follow up program. We set a tele-care program to provide an integrated delivery system for follow up intestinal transplant patient. Methods: Tele-care program including: tele-consultation, tele-monitoring and tele-education. Patient was instructed to add the connection list of Tele-care program and address data including current body weight, blood pressure ileostomy output and defecation frequency. Stool nature was report by photography. Tele-monitoring responsibility for transplant coordinator involved daily monitoring of data and initiation of contact with patient. Discuss the data to transplant team member and inform patient if any problem. Patient were encouraged to discuss any concerns related to self-care or acquire advice to tele-monitoring. Most patients common satisfied to tele-consultation by real-time communication which remains a face-to-face or picture consultation in their mobile phone. The LINE communication offer free massage and phone consultation held 24 hours by transplant coordinator nurse and that service was free cost for patient. Results: From 2011–2016, 15 intestinal transplantation were performed and every patient has used these services for home care. The utility rate of medical care consultation was higher than previous traditional care model because low communication cost and effectiveness. Conclusion: The use of LINE communication to provide Tele-Care program can offer the patient with intestinal transplantation an effectiveness and continued care after discharge. That helps reduce the medical and patient cost of post intestinal transplant follow up and enhance caregiver and patient confident. The new program provide patient assessment and education, and enhance positive patient outcomes, including patient compliance.