Consistent with cosmological constraints, there are scenarios with the large lepton asymmetry which can lead to the finite baryochemical potential at the cosmic QCD phase transition scale. In this paper, we investigate this possibility in the holographic models. Using the holographic renormalization method, we find the first order Hawking–Page phase transition, between the Reissner–Nordström AdS black hole and thermal charged AdS space, corresponding to the de/confinement phase transition. We obtain the gravitational wave spectra generated during the evolution of bubbles for a range of the bubble wall velocity and examine the reliability of the scenarios and consequent calculations by gravitational wave experiments.