Cosmetic Moisturizer Research Articles

Epidermal Growth Factor Inhibitor-induced Cutaneous Toxicity Improves with Moisturizers

Although epidermal growth factor receptor (EGFR) inhibitors are one of the most effective treatment options for lung cancer, they frequently cause cutaneous toxicity that can lead to treatment discontinuation. Dryness, which is a common form of cutaneous toxicity, is usually treated using medical moisturizing agents. We aimed to investigate the treatment of cutaneous toxicity caused by EGFR inhibitors by comparing patients who used a cosmetic moisturizer with those who used conventional medical moisturizers. This study included 12 patients with lung cancer, who were receiving EGFR inhibitors and using topical medical moisturizers. The participants were assigned to a group that continued using medical moisturizers or a group that began using NOV® skin cream D. The study’s findings showed that like conventional medical moisturizers, NOV®skin cream D improved the cutaneous dryness caused by EGFR inhibitors and that it might additionally improve patients’ quality of life. Also, we obtained novel findings that NOV® skin cream D normalized keratinization, which is a component of normal skin cell differentiation impeded by EGFR inhibitors. Hence, the cosmetic moisturizer may help to prevent the discontinuation of EGFR inhibitors, thereby ensuring their continuous therapeutic effects.

Epidermal Growth Factor Inhibitor-induced Cutaneous Toxicity Improves with Moisturizers

Although epidermal growth factor receptor (EGFR) inhibitors are one of the most effective treatment options for lung cancer, they frequently cause cutaneous toxicity that can lead to treatment discontinuation. Dryness, which is a common form of cutaneous toxicity, is usually treated using medical moisturizing agents. We aimed to investigate the treatment of cutaneous toxicity caused by EGFR inhibitors by comparing patients who used a cosmetic moisturizer with those who used conventional medical moisturizers. This study included 12 patients with lung cancer, who were receiving EGFR inhibitors and using topical medical moisturizers. The participants were assigned to a group that continued using medical moisturizers or a group that began using NOV® skin cream D. The study’s findings showed that like conventional medical moisturizers, NOV®skin cream D improved the cutaneous dryness caused by EGFR inhibitors and that it might additionally improve patients’ quality of life. Also, we obtained novel findings that NOV® skin cream D normalized keratinization, which is a component of normal skin cell differentiation impeded by EGFR inhibitors. Hence, the cosmetic moisturizer may help to prevent the discontinuation of EGFR inhibitors, thereby ensuring their continuous therapeutic effects.

Deciphering metabolic responses of biosurfactant lichenysin on biosynthesis of poly-γ-glutamic acid.

Poly-γ-glutamic acid (γ-PGA) is an extracellularly produced biodegradable polymer, which has been widely used as agricultural fertilizer, mineral fortifier, cosmetic moisturizer, and drug carrier. This study firstly discovered that lichenysin, as a biosurfactant, showed the capability to enhance γ-PGA production in Bacillus licheniformis. The exogenous addition of lichenysin improved the γ-PGA yield up to 17.9% and 21.9%, respectively, in the native strain B. licheniformis WX-02 and the lichenysin-deficient strain B. licheniformis WX02-ΔlchAC. The capability of intracellular biosynthesis of lichenysin was positively correlated with γ-PGA production. The yield of γ-PGA increased by 25.1% in the lichenysin-enhanced strain B. licheniformis WX02-Psrflch and decreased by 12.2% in the lichenysin-deficient strain WX02-ΔlchAC. Analysis of key enzyme activities and gene expression in the TCA cycle, precursor glutamate synthesis, and γ-PGA synthesis pathway revealed that the existence of lichenysin led to increased γ-PGA via shifting the carbon flux in the TCA cycle towards glutamate and γ-PGA biosynthetic pathways, minimizing by-product formation, and facilitating the uptake of extracellular substrates and the polymerization of glutamate to γ-PGA. Insight into the mechanisms of enhanced production of γ-PGA by lichenysin would define the essential parameters involved in γ-PGA biosynthesis and provide the basis for large-scale production of γ-PGA.

Skin acceptability of a cosmetic moisturizer formulation in female subjects with sensitive skin.

PurposeThis 3-week, open-label, noncomparative clinical study evaluated the skin acceptability of a cosmetic moisturizer in subjects with sensitive skin, by monitoring adverse events (AEs) and cutaneous discomfort related to normal usage.Materials and methodsFemale subjects aged between 18–60 years, with Fitzpatrick phototype classification I–IV and sensitive skin, verified by a positive reaction on the stinging test at screening, were included. Subjects applied the moisturizer to their face and body twice daily for 21±2 days at home and recorded study product usage and feelings of cutaneous discomfort (eg, dryness, prickling, stinging, and itching) in a diary; any AEs were reported to the clinic. At study end, skin acceptability of the moisturizer was investigator-assessed based on the nature of AEs and subjects’ self-reported feelings of discomfort, and by clinical evaluation of skin reactions in the area of moisturizer application (appearance of erythema, formation of edema, and skin desquamation; scored according to an adapted Draize and Kligman scale). Only subjects with a treatment compliance of ≥80% were included in the final analysis.ResultsIn total, 35 subjects initiated and completed the study; all were compliant to the minimum study product usage. Per investigator clinical dermatological assessment at study end, none of the 35 subjects had skin reactions in the area of moisturizer application and there were no reported AEs. One subject reported sensations of mild prickling and itching immediately after applying the moisturizer (not classified as AEs), which spontaneously remitted after complete absorption of the product and were noted only in exposed areas. These events were considered by the investigator as being possibly/probably related to the use of study product; however, no clinical signs of skin reaction were observed in the exposed areas.ConclusionThis cosmetic moisturizer appears generally well tolerated and suitable for topical use in subjects with sensitive skin.

Clinical Effects of the Cosmetic Moisturizer for Senile Xerotic Skin

Clinical Effects of the Cosmetic Moisturizer for Senile Xerotic Skin

Asiaticoside increases aquaporin-3 protein expression in the cytoplasm of normal human epidermal keratinocytes

<p>Introduction<br />Skin hydration decreases with aging. Aquaporin-3 (AQP3) is a major protein that plays a role in skin hydration, therefore it is a novel target for skin moisturizing treatment. Retinoic acid (RA) as a well-known active agent in antiaging treatment increases AQP3 expression, but frequently causes harmful side effects. Asiaticoside, a saponin compound isolated from Centella asiatica (CA) is also known as an antiaging cosmetic and plays a role in wound healing. The aim of this study was to evaluate and compare the effect of asiaticoside isolated from CA and the effect of RA on the AQP3 expression in normal human epidermal keratinocytes (NHEKs).</p><p>Methods <br />An experimental laboratory study was performed using primary NHEKs that were derived from the foreskin of a boy. AQP3 expression in NHEKs was examined in vitro after the cells were incubated for 24 hours with asiaticoside or with RA at several concentrations. The AQP3 expression was evaluated by immunocytochemistry and quantitatively analyzed by Image-J software. Independent t-test and one-way ANOVA were used to analyze the data, followed by post-hoc Tukey test.</p><p>Results<br />There was an increasing trend of AQP3 expression upon exposure to asiaticoside at all concentrations compared to the control group. However, RA exposure seemed to induce a higher level of AQP3 expression. Asiaticoside effected a lower increase in AQP3 expression in NHEKs than did RA (p=0.042). Optimal results were achieved at 1 mg/mL concentration of asiaticoside.</p><p>Conclusions<br />Asiaticoside isolated from CA can enhance the AQP3 expression in NHEKs. Therefore it can be used as an active ingredient in cosmetic moisturizer formulation for dry skin treatment.</p>

Combination of three laboratory data as predictor of severe dengue in adults : a retrospective cohort study

<p>Introduction<br />Skin hydration decreases with aging. Aquaporin-3 (AQP3) is a major protein that plays a role in skin hydration, therefore it is a novel target for skin moisturizing treatment. Retinoic acid (RA) as a well-known active agent in antiaging treatment increases AQP3 expression, but frequently causes harmful side effects. Asiaticoside, a saponin compound isolated from Centella asiatica (CA) is also known as an antiaging cosmetic and plays a role in wound healing. The aim of this study was to evaluate and compare the effect of asiaticoside isolated from CA and the effect of RA on the AQP3 expression in normal human epidermal keratinocytes (NHEKs).</p><p>Methods <br />An experimental laboratory study was performed using primary NHEKs that were derived from the foreskin of a boy. AQP3 expression in NHEKs was examined in vitro after the cells were incubated for 24 hours with asiaticoside or with RA at several concentrations. The AQP3 expression was evaluated by immunocytochemistry and quantitatively analyzed by Image-J software. Independent t-test and one-way ANOVA were used to analyze the data, followed by post-hoc Tukey test.</p><p>Results<br />There was an increasing trend of AQP3 expression upon exposure to asiaticoside at all concentrations compared to the control group. However, RA exposure seemed to induce a higher level of AQP3 expression. Asiaticoside effected a lower increase in AQP3 expression in NHEKs than did RA (p=0.042). Optimal results were achieved at 1 mg/ml concentration of asiaticoside.</p><p>Conclusions<br />Asiaticoside isolated from CA can enhance the AQP3 expression in NHEKs. Therefore it can be used as an active ingredient in cosmetic moisturizer formulation for dry skin treatment.</p>

Improved appearance of eye-area wrinkles with use of a cosmetic moisturizer containing retinyl propionate, peptides and niacinamide

Improved appearance of eye-area wrinkles with use of a cosmetic moisturizer containing retinyl propionate, peptides and niacinamide

Evaluation of water holding property for applying a cosmetic moisturizer from oil palm trunk CNF

ABSTRACT Cellulose nanofibrils (CNF) was made from oil palm trunk (OPT) with soda-anthraquinone pulping, chlorine dioxide bleaching, carboxymethylation, followed by mechanical grind-ing. Size of this CNF was 16-40 nm of width confirmed by TEM. To evaluate CNF from OPT as cosmetics raw materials for moisturizing component, water holding properties was compared with hyaluronic acid and collagen. CNF from OPT had better water holding property than collagen or hyaluronic acid whether phenoxyethanol was added as antiseptic or without additive. Keywords: Oil palm trunk, carboxymethylation, cellulose nanofibrils, water-holding property • 충북대학교 임산공학과 (Department of Forest Products and Engineering, Chungbuk National University, Chungbuk 28644, Korea) † 교신저자 (Corresponding Author): E-mail: soojshin@cbnu.ac.kr http://dx.doi.org/10.7584/ktappi.2016.48.2.091Journal of Korea TAPPIVol. 48. No. 2, 2016, 91-98pISSN (Print): 0253-3200Printed in Korea 1. 서 론 셀룰로오스는 포도당 분자가 베타-1,4-결합에 의하여 만들어진 선형 고분자 물질이며, 지구상에 가장 널리 존재하는 유기물로 일반적으로 식물의 엽록체에서 광합성에 의해서 생성된 포도당의 연결체 고분자이지만 일부 박테리아가 포도당을 원료로 합성을 하기도 하고, 멍게의 껍질을 구성하는 동물성 셀룰로오스도 존재한다.

Enzymatic hydrolysis of the β–β amide linkage in poly-β-aspartate

Polyaspartate is a biodegradable and water-soluble polymer, and an important material as an alternative to polyacrylate. Polyacrylate is widely used as a builder of detergents, pigment dispersant, cosmetic moisturizer, water treatment agents (scale preventive, metal corrosion preventive), water absorptive polymer of disposable diaper, and so on, and are likely accumulated in the environment. Replacement of the polymer by biodegradable polyaspartate should reduce the accumulation and therefore environmental pollution. Thermally synthesized polyaspartate contains both α- and β-amide linkages. Recently, three bacterial enzymes that degrade polyaspartate have been isolated and characterized. An enzyme from Pedobacter sp. KP-2 specifically catalyzes the hydrolysis of the β–β-amide linkage in the polymer. The enzyme is a monomeric periplasmic protein, and the mature form contains 265 amino acid residues with a molecular weight of about 30,000. To understand the mechanisms underlying the interactions with the polymer substrate and hydrolysis of the β–β amide linkage, we set out the crystallographic study of the enzyme. We succeeded in crystallization of the enzyme by vapor-diffusion using polyethylene glycol 4,000. Crystals belonged to orthorhombic space group C222. Addition of cobalt salt in the mother liquor altered the space group of crystals to P6422 and greatly improved the diffraction quality. Data sets for native and mutant enzymes were collected to a resolution of 1.9 Å at SPring-8, Japan. Phases were calculated by cobalt-SAD. The obtained structure represented an α/β hydrolase fold which is often observed for a large number of serine esterases such as lipase and PHB depolymerase. Residues Ser125, Asp193, and His248 were within hydrogen bonding interactions, forming a catalytic triad. Structures of subsites 1 and 2 for binding of monomer units of the polymer were determined for the mutant enzyme complexed with an oligomer substrate. The monomer unit bound to subsite 1 was in extensive hydrogen bond interactions with residues including arginine. Though overall structural similar between the enzyme and PHB depolymerase from Penicillium funiculosum, residues that may interact with polymer substrates were totally different.

Improved appearance of facial wrinkles in post menopausal women with use of a cosmetic moisturizer containing specifically prepared artichoke extract

Improved appearance of facial wrinkles in post menopausal women with use of a cosmetic moisturizer containing specifically prepared artichoke extract

Improved appearance of facial hyperpigmentation with use of a cosmetic moisturizer containing N-acetyl glucosamine and niacinamide

Improved appearance of facial hyperpigmentation with use of a cosmetic moisturizer containing N-acetyl glucosamine and niacinamide

Comparison of improvements in facial skin appearance among women in 2 different age groups after cosmetic moisturizer treatments

Comparison of improvements in facial skin appearance among women in 2 different age groups after cosmetic moisturizer treatments

Improved appearance of facial wrinkles with use of a cosmetic moisturizer containing olive derivative, dill seed extract, Pal-KTTKS, and niacinamide

Improved appearance of facial wrinkles with use of a cosmetic moisturizer containing olive derivative, dill seed extract, Pal-KTTKS, and niacinamide

Improved appearance of facial wrinkles with use of a cosmetic moisturizer containing retinyl propionate, peptides, and niacinamide

Improved appearance of facial wrinkles with use of a cosmetic moisturizer containing retinyl propionate, peptides, and niacinamide

Assessment of niacinamide in vivo skin penetration from a cosmetic moisturizer formula

Assessment of niacinamide in vivo skin penetration from a cosmetic moisturizer formula

A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0·02% tretinoin product regimen

BackgroundTretinoin is considered the benchmark prescription topical therapy for improving fine facial wrinkles, but skin tolerance issues can affect patient compliance. In contrast, cosmetic antiwrinkle products are well tolerated but are generally presumed to be less efficacious than tretinoin.ObjectivesTo compare the efficacy of a cosmetic moisturizer regimen vs. a prescription regimen with 0·02% tretinoin for improving the appearance of facial wrinkles.MethodsAn 8-week, randomized, parallel-group study was conducted in 196 women with moderate to moderately severe periorbital wrinkles. Following 2 weeks washout, subjects on the cosmetic regimen (n=99) used a sun protection factor (SPF) 30 moisturizing lotion containing 5% niacinamide, peptides and antioxidants, a moisturizing cream containing niacinamide and peptides, and a targeted wrinkle product containing niacinamide, peptides and 0·3% retinyl propionate. Subjects on the prescription regimen (n=97) used 0·02% tretinoin plus moisturizing SPF 30 sunscreen. Subject cohorts (n=25) continued treatment for an additional 16 weeks. Changes in facial wrinkling were assessed by both expert grading and image analysis of digital images of subjects’ faces and by self-assessment questionnaire. Product tolerance was assessed via clinical erythema and dryness grading, subject self-assessment, and determinations of skin barrier integrity (transepidermal water loss) and stratum corneum protein changes.ResultsThe cosmetic regimen significantly improved wrinkle appearance after 8 weeks relative to tretinoin, with comparable benefits after 24 weeks. The cosmetic regimen was significantly better tolerated than tretinoin through 8 weeks by all measures.ConclusionsAn appropriately designed cosmetic regimen can improve facial wrinkle appearance comparably with the benchmark prescription treatment, with improved tolerability.