Correlational Study Research Articles

The relationship between traumatic childbirth perception, desire to avoid pregnancy, and sexual quality of life in women.

To identify factors influencing women's perceptions of traumatic childbirth (TCP) and to determine the relationship between TCP, desire to avoid pregnancy, and sexual quality of life. A descriptive and correlational research study was designed. Data were collected from 225 women aged between 18 and 45 years old. A Demographic Information Form, the Desire to Avoid Pregnancy Scale (DAP), the Sexual Quality of Life Questionnaire-Female (SQLQ-F), and the Perception of Traumatic Childbirth Scale (PTCS) were used for data collection. Women who were not employed, had given birth previously, and did not plan their last pregnancy tended to have higher levels of TCP. Conversely, women who did not experience health problems in their last pregnancy and recalled their last childbirth as very comfortable and happy tended to have lower levels of TCP. A very weak, statistically significant, positive correlation was found between the mean DAP and PTCS scores (r = 0.168, P < 0.05). A very weak, statistically significant, negative correlation was found between the mean SQLQ-F and PTCS sores (r = -0.138, P < 0.05). A 1-unit increase in TCP was associated with a 0.005-unit increase in the desire to avoid pregnancy and a 0.094-unit decrease in sexual quality of life. TCP in women is associated with an increase in the desire to avoid pregnancy and a decrease in sexual quality of life. It is recommended to identify women with high levels of TCP, determine factors contributing to this perception, and plan appropriate nursing interventions accordingly.

Insights into inflammation and implications for the pathogenesis and long-term outcomes of endometrial cancer: genome-wide surveys and a clinical cohort study

BackgroundDespite evidence showing a connection between inflammation and endometrial cancer (EC) risk, the surveys on genetic correlation and cohort studies investigating the impact on long-term outcomes have yet to be refined. We aimed to address the impact of inflammation factors on the pathogenesis, progression and consequences of EC.MethodsFor the genetic correlation analyses, a two-sample of Mendelian randomization (MR) study was applied to investigate inflammation-related single-nucleotide polymorphisms involved with endometrial cancer from GWAS databases. The observational retrospective study included consecutive patients diagnosed with EC (stage I to IV) with surgeries between January 2010 and October 2020 at the Cancer Hospital of Shantou University Medical College.ResultsThe 2-sample MR surveys indicated no causal relationship between inflammatory cytokines and endometrial cancer. 780 cases (median age, 55.0 years ) diagnosed with EC were included in the cohort and followed up for an average of 6.8 years. Increased inflammatory parameters at baseline were associated with a higher FIGO stage and invasive EC risk (odds ratios [OR] 1.01 to 4.20). Multivariate-cox regression suggested that multiple inflammatory indicators were significantly associated with overall survival (OS) and progression-free survival (PFS) (P < 0.05). Nomogram models based on inflammatory risk and clinical factors were developed for OS and PFS with C-index of 0.811 and 0.789, respectively. LASSO regression for the validation supported the predictive efficacy of inflammatory and clinical factors on the long-term outcomes of EC.ConclusionsDespite the fact that the genetic surveys did not show a detrimental impact of inflammatory cytokines on the endometrial cancer risk, our cohort study suggested that inflammatory level was associated with the progression and long-term outcomes of EC. This evidence may contribute to new strategies targeted at decreasing inflammation levels during EC therapy.

Correlation Study of Multi-Element Composition and Oxidative Stability of Ziziphus Lotus Lam. Seed Oils Collected from Different Regions of Tunisia

Correlation Study of Multi-Element Composition and Oxidative Stability of Ziziphus Lotus Lam. Seed Oils Collected from Different Regions of Tunisia

Relationships of Psychosocial Factors to Diabetes Self-efficacy: A Cross-sectional, Correlational Study.

Self-care in people with diabetes is poor, which could be influenced by positive and negative psychosocial factors. Self-efficacy is an important factor affecting self-care, and depressive symptoms and diabetes distress may directly and indirectly affect self-efficacy. The aim of this study was to examine the relationships of depressive symptoms, diabetes distress, age, sex, self-compassion, resilience, self-esteem, and social support to diabetes self-efficacy and the mediating roles of diabetes distress and depressive symptoms in the relationships among people with diabetes. In this cross-sectional, correlational study, data on all the psychosocial and demographic factors were collected (N = 148; 57.6 years old) through Research Electronic Data Capture in 2023. The PROCESS macro for SPSS was used to address the purpose. The mean score of diabetes self-efficacy was 28.6 (range, 8-40). In 1 model, depressive symptoms were directly and indirectly associated with diabetes self-efficacy through diabetes distress (direct effect, -3.524; t = -3.020, P = .003; indirect effect, -2.089; 95% bootstrap confidence interval, -3.494 to -0.911). In another model, diabetes distress was directly and indirectly associated with diabetes self-efficacy through depressive symptoms (direct effect, -3.778; t = -3.638, P < .001; indirect effect, -0.785; 95% bootstrap confidence interval, -1.868 to -0.089). In addition, self-esteem was associated with both depressive symptoms and diabetes distress. Resilience was associated with diabetes self-efficacy in 1 model. Negative psychological factors were directly and indirectly associated with diabetes self-efficacy. Depressive symptoms, diabetes distress, self-esteem, and resilience can be important targets of interventions to improve diabetes self-efficacy.

Effect of Transient Waterlogging Stress on Growth, Physiology and Yield of Cowpea (Vigna unguiculata L.) in Semi-Arid Region

Cowpea cultivation during rainy season is highly affected by the waterlogging stress due to unpredicted high-intensity rains. The studies on assessment of waterlogging effect on different growth stages of cowpea are necessary for planning mitigation strategies. Hence study was conducted during kharif (June to September) 2022 under factorial randomized block design (FRCBD) set up. The first factor consisted of seven waterlogging durations (3 to 15 days), and second factor was three growth stages of cowpea (15 DAE; Days after emergence, 25 DAE and at 50% flowering). The results revealed that regardless of growth stages, growth and yield attributes were drastically decreased with increased duration of waterlogging. The highest plant height (25.07 cm), number of branches plant–1 (5.33) and leaf area (205.27 cm2 plant–1), and number of pods plant–1 (4.27), pod length (15.24 cm), number of seeds pod–1 (14.27), grain (6.27 g plant–1) and haulm yield (15.62 g plant–1) were recorded with 3 days of waterlogging, whereas lowest values were reported with 15 days of waterlogging. Regarding growth stages, highest growth, and yield attributes were recorded with waterlogging during 50% flowering, followed by 25 DAE and 15 DAE. Moreover, the correlation study indicated that physiological parameters such as leaf protein content (r = 0.95) and Normalized Difference Vegetation Index NDVI (r = 0.97) were positively related to grain yield. It was found that, cowpea is sensitive to high-intensity waterlogging (beyond 3–5 days) especially during the early growth stage (15 DAE).

Correlation Study between Returns and ESG Ratings

Correlation Study between Returns and ESG Ratings

Path Coefficient Analysis and Character Association of Yield and Yield Contributing Traits of Rice Landraces

An experiment was carried out during Kharif 2020 to estimate the direct and indirect effects of various independent characteristics on the dependent character and to assess the degree of relationship between yield and yield contributing traits of rice landraces. The experimental material consists of 188 landraces including two checks IR-64 and Jeerashankar and these genotypes were planted in Randomized Block Design with three replications. Based on correlation and path analysis studies, significant positive correlation and high direct positive effect on grain yield per plant were found for traits flag leaf length, number of tillers, number of effective tillers, panicle weight, harvesting index, panicle index, fertile spikelet per panicle and biological yield per plant. Itdepicted that during the formulation of criterion in the rice improvement program as well as for plant ideotype, these traits would be of significant relevance.

Differences in self-harm among adolescents and young adults with autism spectrum disorder: a gender-based approach

Self-harm in children and young people with autism spectrum disorder (ASD) poses risks to their physical well-being, negatively impacts their quality of life and that of their families, and presents challenges to their integration into school and social environments. This study aimed to investigate possible differences in terms of gender between adolescents and young adults with autism admitted to the neurodevelopmental unit of ITA Argentona due to non-suicidal self-harming behaviour. A sample of 50 patients with ASD, whose ages ranged from 14 to 27 years, who were treated in the ITA Argentona neurodevelopmental unit. The methodology adopted consisted of a non-causal correlational cross-sectional study, for which the Autism Diagnostic Observation Schedule, second edition, and the Autism Diagnostic Interview-Revised were administered, as well as the Inventory of Statements About Self-injury. The results obtained revealed significant and positive correlations between sex and certain types of self-harm (burning, pulling hair and carving) and the motivations or functions that the participants report for engaging in non-suicidal self-harm. Although the study concluded that there is no substantially greater likelihood of one sex in particular engaging non-suicidal self-harm, significant differences were identified in terms of the specific types of self-harm, and the motivations or functions associated with these non-suicidal self-harming behaviours.

Differential Impacts of Maternal and Paternal Attachments on Adolescent Delinquency: Implications for Counselling

Delinquency among adolescents is a growing concern in Iranian society. Research on the role of maternal and paternal attachments, particularly in the Iranian context, has received limited attention. This correlational study aims to concurrently investigate the predictive capacity of both maternal and paternal attachment on delinquent behaviours among Iranian adolescents. The sample included 528 students aged 15 and 17 from 10 government high schools in Tehran who were selected using multi-stage cluster sampling. Participants completed self-administered questionnaires using two established instruments. The findings highlighted a significant association between high parental attachment scores and low adolescent delinquent activity. Secure attachments to mothers and fathers were found to reduce engagement in delinquency. Adolescent age, fathers’ educational level, and maternal attachment emerged as significant predictors of delinquency. Adolescents with insecure maternal attachments and older adolescents with educated fathers showed greater susceptibility to delinquent behaviour. The study also emphasises the vast contribution of mothers to adolescent development, suggesting the need for further exploration of paternal influence on internal dynamics and delinquency in future research. In a broader sense, understanding the differential impacts of these attachments on adolescent delinquency may help counsellors to effectively address these issues and provide appropriate interventions.

Effects of major air pollutants on angina hospitalizations: a correlation study

BackgroundAngina is a crucial risk signal for cardiovascular disease. However, few studies have evaluated the effects of ambient air pollution exposure on angina.ObjectiveWe aimed to explore the short-term effects of air pollution on hospitalization for angina and its lag effects.MethodsWe collected data on air pollutant concentrations and angina hospitalizations from 2013 to 2020. Distributed lag nonlinear model (DLNM) was used to evaluate the short-term effects of air pollutants on angina hospitalization under different lag structures. Stratified analysis by sex, age and season was obtained.ResultsA total of 39,110 cases of angina hospitalization were included in the study. The results showed a significant positive correlation between PM2.5, SO2, NO2, and CO and angina hospitalization. Their maximum harmful effects were observed at lag0-7 (RR = 1.042; 95% CI: 1.017, 1.068), lag0-3 (RR = 1.067; 95% CI: 1.005, 1.133), lag0-6 (RR = 1.078; 95% CI: 1.041, 1.117), and lag0-6 (RR = 1.244; 95% CI: 1.109, 1.397), respectively. PM10 did not have an overall risk effect on angina hospitalization, but it did have a risk effect on women and the elderly. O3 was significantly negatively correlated with angina hospitalization, with the most pronounced effect observed at lag0-6 (RR = 0.960; 95% CI: 0.940, 0.982). Stratified analysis results showed that women and the elderly were more susceptible to pollutants, and the adverse effects of pollutants were stronger in the cold season.ConclusionShort-term exposure to PM2.5, SO2, NO2, and CO increases the risk of hospitalization for angina.

Undergraduate Student Nurses’ Satisfaction, Self-confidence, and Perception of High-fidelity Simulation-based Learning on Critically-ill Patients

Background and Objective. Replicating critical care practice settings in high-fidelity simulation (HFS) providesmore learning opportunities to develop competencies, improve self-confidence, and learner satisfaction in a safe environment. Simulation is increasingly adopted globally as an alternative teaching strategy. Yet, data on the HFS experience of Filipino undergraduate nursing students is limited. This study describes the satisfaction, self- confidence, and perception of undergraduate nursing students on the use of HFS-based learning on critically-ill adult and pediatric patients requiring advanced life support (ALS). Methods. A quantitative, descriptive, correlational study was conducted using purposive sampling on all fourth-year BS Nursing students enrolled in Critical Care Nursing course in a state university. Data were collected through an online survey on demographic data, and the students’ perceptions towards high-fidelity simulation-based learning (SBL) using three tools, namely: Simulation Design Scale, Educational Practices Questionnaire, and Student Satisfaction and Self-confidence in Learning. T-test and ANOVA were used to compare the means of the variables. Bivariate analysis (Pearson’s product-moment correlation) was performed to find the relationship between variables. Results. A total of 86 students participated in the survey. Overall, the students were highly satisfied with the simulation experience (4.46 out of 5.0, SD=0.47), and had high ratings of self-confidence in SBL (4.44 out of 5.0, SD=0.42). Overall satisfaction level was positively related to student’s perception on simulation design (r=0.61, p&lt;0.01) and educational practices (r=0.59, p&lt;0.01). Similarly, the students’ overall self-confidence with SBL was also positively correlated with their perceptions of the simulation design (r=0.32, p&lt;0.01), and educational practices (r=0.34, p&lt;0.01). Conclusion. Effective use of technology through HFS-based learning is useful in increasing satisfaction and self-confidence of Filipino undergraduate nursing students in caring for critically-ill patients needing ALS. Educators must highly consider all parameters of simulation design and educational practices in planning and implementing HFS- based learning to achieve meaningful learner experience.

Navigating the Dynamics of Brent Crude Oil Prices: Factors, Trends, and Insights

Accurate Brent Crude Oil price prediction is essential for informed decision-making and risk control in the global energy market. This paper examines the dynamics of Brent Crude Oil prices over the previous 35 years, utilizing predictive modelling techniques to project future prices and analyzing historical trends and relationships with the GDPs of major economies. The statistical methods used in this paper include the moving average and Pearson correlation coefficient. While correlation studies show significant positive links between Brent Crude Oil prices and the GDPs of major economies like China, Saudi Arabia, Europe, Russia, and the United States, historical data analysis reveals large price volatility. Highly accurate price forecasting using LSTM (Long Short-Term Memory) modelling approaches provides detailed risk management and decision-making information in the global energy market. The application of the Neural Network and the ARIMA model shows an increase in the price of Brent crude oil in the next year, 2024. Identifying the importance of the Brent crude oil price forecast and its effect on the international market is highly needed. This paper thus might help to increase economic growth. These results highlight the importance of advanced modelling techniques and economic indicators in managing oil price changes and help make informed decisions in the energy industry.

Spirituality, Religiosity, Caring Behavior, Spiritual Care, and Personalized Care Among Student Nurses: A Descriptive Correlational Study in the Philippines.

This study sought to determine the student nurses' spirituality, religiosity, caring behavior, spiritual care, and personalized care. Further, it sought to determine the relationship between spirituality, religiosity, and caring behavior in student nurses' spiritual care and personalized care. The study used a descriptive correlational design using convenience sampling to collect data from 1248 student nurses in the Philippines from December 2023 to February 2024. We collected data using the Spirituality and Spiritual Care Scale rating scale and the Caring Behaviors Inventory. The study revealed that the mean scores of the students in their "spirituality" and "religiosity" were 4.08 (SD = 0.98) and 2.99 (SD = 1.26), respectively. Student nurses had sufficient confidence and skills in spiritual care, caring behavior, and personalized care. The students' age had a weak and negative association with the students' spirituality and religiosity. Students from University A had higher levels of spirituality and religiosity than students from University B, University C, and University D. Students in the 4th year level were more religious than 3rd year students. Students who had their last clinical exposure in the Admission and emergency room reported poorer caring behaviors than those who had previous clinical exposure in the Medical-surgical ward, Obstetrics and gynecology, Intensive Care Units, and Community. There is no significant relationship between a student nurse's spiritual care and caring behavior. This trend is similar to caring behavior and personalized care. The students' age predicts their personalized care.

Exploring the role of CBLB in acute myocardial infarction: transcriptomic, microbiomic, and metabolomic analyses

BackgroundSpecific alterations in gut microbiota and metabolites have been linked to AMI, with CBLB potentially playing an essential role. However, the precise interactions remain understudied, creating a significant gap in our understanding. This study aims to address this by exploring these interactions in CBLB-intervened AMI mice using transcriptome sequencing, 16 S rDNA, and non-targeted metabolite analysis.MethodsTo probe the therapeutic potential and mechanistic underpinnings of CBLB overexpression in AMI, we utilized an integrative multi-omics strategy encompassing transcriptomics, metabolomics, and 16s rDNA sequencing. We selected these particular methods as they facilitate a holistic comprehension of the intricate interplay between the host and its microbiota, and the potential effects on the host’s metabolic and gene expression profiles. The uniqueness of our investigation stems from utilizing a multi-omics approach to illuminate the role of CBLB in AMI, an approach yet unreported to the best of our knowledge. Our experimental protocol encompassed transfection of CBLB lentivirus-packaged vectors into 293T cells, followed by subsequent intervention in AMI mice. Subsequently, we conducted pathological staining, fecal 16s rDNA sequencing, and serum non-targeted metabolome sequencing. We applied differential expression analysis to discern differentially expressed genes (DEGs), differential metabolites, and differential microbiota. We performed protein-protein interaction analysis to identify core genes, and conducted correlation studies to clarify the relationships amongst these core genes, paramount metabolites, and key microbiota.ResultsFollowing the intervention of CBLB in AMI, we observed a significant decrease in inflammatory cell infiltration and collagen fiber formation in the infarcted region of mice hearts. We identified key changes in microbiota, metabolites, and DEGs that were associated with this intervention. The findings revealed that CBLB has a significant correlation with DEGs, differential metabolites and microbiota, respectively. This suggests it could play a pivotal role in the regulation of AMI.ConclusionThis study confirmed the potential of differentially expressed genes, metabolites, and microbiota in AMI regulation post-CBLB intervention. Our findings lay groundwork for future exploration of CBLB’s role in AMI, suggesting potential therapeutic applications and novel research directions in AMI treatment strategies.

Molecular circadian clock disruption in the leukocytes of individuals with type 2 diabetes and overweight, and its relationship with leukocyte-endothelial interactions.

Alterations in circadian rhythms increase the likelihood of developing type 2 diabetes and CVD. Circadian rhythms are controlled by several core clock genes, which are expressed in nearly every cell, including immune cells. Immune cells are key players in the pathophysiology of type 2 diabetes, and participate in the atherosclerotic process that underlies cardiovascular risk in these patients. The role of the core clock in the leukocytes of people with type 2 diabetes and the inflammatory process associated with it are unknown. We aimed to evaluate whether the molecular clock system is impaired in the leukocytes of type 2 diabetes patients and to explore the mechanism by which this alteration leads to an increased cardiovascular risk in this population. This is an observational cross-sectional study performed in 25 participants with type 2 diabetes and 28 healthy control participants. Clinical and biochemical parameters were obtained. Peripheral blood leukocytes were isolated using magnetic bead technology. RNA and protein lysates were obtained to assess clock-related gene transcript and protein levels using real-time PCR and western blot, respectively. Luminex XMAP technology was used to assess levels of inflammatory markers. Leukocyte-endothelial interaction assays were performed by perfusing participants' leukocytes or THP-1 cells (with/without CLK8) over a HUVEC monolayer in a parallel flow chamber using a dynamic adhesion system. Participants with type 2 diabetes showed increased BMAL1 and NR1D1 mRNA levels and decreased protein levels of circadian locomotor output cycles kaput (CLOCK), cryptochrome 1 (CRY1), phosphorylated basic helix-loop-helix ARNT like 1 (p-BMAL1) and period circadian protein homologue 2 (PER2). Correlation studies revealed that these alterations in clock proteins were negatively associated with glucose, HbA1c, insulin and HOMA-IR levels and leukocyte cell counts. The leukocyte rolling velocity was reduced and rolling flux and adhesion were enhanced in individuals with type 2 diabetes compared with healthy participants. Interestingly, inhibition of CLOCK/BMAL1 activity in leukocytes using the CLOCK inhibitor CLK8 mimicked the effects of type 2 diabetes on leukocyte-endothelial interactions. Our study demonstrates alterations in the molecular clock system in leukocytes of individuals with type 2 diabetes, manifested in increased mRNA levels and decreased protein levels of the core clock machinery. These alterations correlated with the impaired metabolic and proinflammatory profile of the participants with type 2 diabetes. Our findings support a causal role for decreased CLOCK/BMAL1 activity in the increased level of leukocyte-endothelial interactions. Overall, our data suggest that alterations in core clock proteins accelerate the inflammatory process, which may ultimately precipitate the onset of CVD in patients with type 2 diabetes.

Femorotibial angle scan-rescan reproducibility: A high-precision calculation on a large cohort.

Femorotibial angle (FTA) is a convenient measure of coronal knee alignment that can be extracted from a short knee radiograph, avoiding the additional radiation exposure and specialist equipment required for full-leg radiographs. While intra- and inter-reader reproducibility from the same image has been reported, the full scan-rescan reproducibility across images, as calculated in this study, has not. In this study, 4589 FTA measurement pairs from 2586 subjects acquired a year apart were used to estimate FTA scan-rescan reproducibility using data from the Osteoarthritis Initiative. Subjects with radiographic progression of osteoarthritis or other conditions that may cause a change in coronal knee alignment were excluded. Measurement pairs were analysed using paired-samples tests to detect differences and compared to symptomatic changes in Western Ontario and McMaster Universities Arthritis Index scores for joint pain, stiffnessand physical function to detect correlations. The 95% limit of agreement and the paired-samplescorrelation were calculated with high precision to be [-1.76°, +1.78°] and 0.938, considerably worse than the corresponding figures for intra- and inter-reader reproducibility, without relation to symptomatic or radiographic changes in knee condition. This error will weakly attenuate and values from their true values in correlative studies involving FTA. The realistic maximum value for is 87%and for Pearson's is 93%. The scan-rescan reproducibility in FTAis almost double the intra- and inter-reader reliability from a single scan. At almost ±2° accuracy, FTA is inappropriate for surgical use, but it is sufficiently reproducible to produce good correlations in studies predicting disease incidence and progression. Level II, retrospective study.

Femorotibial angle scan-rescan reproducibility: A high-precision calculation on a large cohort.

Femorotibial angle (FTA) is a convenient measure of coronal knee alignment that can be extracted from a short knee radiograph, avoiding the additional radiation exposure and specialist equipment required for full-leg radiographs. While intra- and inter-reader reproducibility from the same image has been reported, the full scan-rescan reproducibility across images, as calculated in this study, has not. In this study, 4589 FTA measurement pairs from 2586 subjects acquired a year apart were used to estimate FTA scan-rescan reproducibility using data from the Osteoarthritis Initiative. Subjects with radiographic progression of osteoarthritis or other conditions that may cause a change in coronal knee alignment were excluded. Measurement pairs were analysed using paired-samples tests to detect differences and compared to symptomatic changes in Western Ontario and McMaster Universities Arthritis Index scores for joint pain, stiffnessand physical function to detect correlations. The 95% limit of agreement and the paired-samplescorrelation were calculated with high precision to be [-1.76°, +1.78°] and 0.938, considerably worse than the corresponding figures for intra- and inter-reader reproducibility, without relation to symptomatic or radiographic changes in knee condition. This error will weakly attenuate and values from their true values in correlative studies involving FTA. The realistic maximum value for is 87%and for Pearson's is 93%. The scan-rescan reproducibility in FTAis almost double the intra- and inter-reader reliability from a single scan. At almost ±2° accuracy, FTA is inappropriate for surgical use, but it is sufficiently reproducible to produce good correlations in studies predicting disease incidence and progression. Level II, retrospective study.

Functional and clinical roles of stromal PDGF receptors in tumor biology.

PDGF receptors play pivotal roles in both developmental and physiological processes through the regulation of mesenchymal cells involved in paracrine instructive interactions with epithelial or endothelial cells. Tumor biology studies, alongside analyses of patient tissue samples, provide strong indications that the PDGF signaling pathways are also critical in various types of human cancer. This review summarizes experimental findings and correlative studies, which have explored the biological mechanisms and clinical relevance of PDGFRs in mesenchymal cells of the tumor microenvironment. Collectively, these studies support the overall concept that the PDGF system is a critical regulator of tumor growth, metastasis, and drug efficacy, suggesting yet unexploited targeting opportunities. The inter-patient variability in stromal PDGFR expression, as being linked to prognosis and treatment responses, not only indicates the need for stratified approaches in upcoming therapeutic investigations but also implies the potential for the development of PDGFRs as biomarkers of clinical utility, interestingly also in settings outside PDGFR-directed treatments.

Association study of allelic variation identified at yield contributing loci in rice (Oryza sativa L.)

The knowledge of functionally characterized genes and linked markers that govern grain yield and its related traits were used to unravel the markers/genes that associate with diversity of yield traits in a panel 30 novel rice genotypes comprising of indica, japonica, aromatic, landraces, interspecific crosses (O.glaberrima/O.sativa) etc. The ANOVA showed significant differences (P=&lt;0.001) for all traits among the genotypes. Molecular analysis was done by employing 37 gene-specific markers targeting 24 yield governing genes in rice. Two markers viz., RM223(YLD) on chromosome 8 and GW004(GW2, LOC_Os02g14720) on chromosome 2 were identified as polymorphic. Average PIC (polymorphic information content) value for these primers was 0.37, suggesting the availability of accountable variability at these loci. Cluster analysis grouped the genotypes into three clusters. Marker-trait-association analysis revealed significant association of the marker GW004 with panicle length, plant height and filled grains in rice. Pearson correlation study also supported the molecular associations through significant phenotypic associations for trait pairs plant height and filled grains, panicle length and plant height. The phenotypic variance explained (R2%) by the marker across panicle length, plant height and filled grains was ≥15%, suggesting major role of the locus/gene in controlling respective traits. Thus, GW004 marker could be employed in breeding programs for simultaneous selection of three traits panicle length, plant height and filled grains. From the current study it can be concluded that allelic variation studies using novel genotypes can result in the identification of suitable donors along with trait associated markers for rice yield improvement.

A cellular senescence-related signature for predicting prognosis, immunotherapy response, and candidate drugs in patients treated with transarterial chemoembolization (TACE).

Cellular senescence is essentialtoTME development, progression, and remodeling. Few studies have examined cellular senescence in HCC after TACE. Investigating the relationship between cellular senescence, post-TACE prognosis, the TME, and immune treatment responses is crucial. We analyzed the GSE104580 dataset to identify DEGs. A cellular senescence-related signature was developed using LASSO Cox regression in the GSE14520 dataset and validated in the ICGC dataset. High- and low-risk subgroups were compared using GSVA and GSEA. Correlation studies were conducted to explore the relationship between the prognostic model, immune infiltration, immunotherapy response, and drug sensitivity. A cellular senescence-related signature comprising FOXM1, CDK1, CHEK1, and SERPINE1 was created and validated. High-risk patients showed significantly lower OS than low-risk patients. High-risk patients had carcinogenetic pathways activated, immunosuppressive cells infiltrated, and immunomodulatory genes overexpressed. They also showed higher sensitivity to EPZ004777_1237 and MK-2206_1053 and potential benefits from GSK-3 inhibitor IX, nortriptyline, lestaurtinib, and JNK-9L. This study constructed a cellular senescence-related signature that could be used to predict HCC patients' responses to and prognosis after TACE treatment, aiding in the development of personalized treatment plans.