Correct Drug Research Articles

Clinical Applications of Antisense Oligonucleotides in Cancer: A Focus on Glioblastoma

Antisense oligonucleotides (ASOs) are promising drugs capable of modulating the protein expression of virtually any target with high specificity and high affinity through complementary base pairing. However, this requires a deep understanding of the target sequence and significant effort in designing the correct complementary drug. In addition, ASOs have been demonstrated to be well tolerated during their clinical use. Indeed, they are already used in many diseases due to pathogenic RNAs of known sequences and in several neurodegenerative diseases and metabolic diseases, for which they were given marketing authorizations (MAs) in Europe and the United States. Their use in oncology is gaining momentum with several identified targets, promising preclinical and clinical results, and recent market authorizations in the US. However, many challenges remain for their clinical use in cancer. It seems necessary to take a step back and review our knowledge of ASOs and their therapeutic uses in oncology. The objectives of this review are (i) to summarize the current state of the art of ASOs; (ii) to discuss the therapeutic use of ASOs in cancer; and (iii) to focus on ASO usage in glioblastoma, the challenges, and the perspective ahead.

Evaluation of Drug Accuracy and Cardiac Drug Dose Accuracy in Heart Failure Patients Hospitalized in Samarinda Medika Citra Hospital

Background: Heart failure is a condition where the heart is unable to pump blood to the tissues to meet the body's metabolic needs. Heart failure has a variety of therapies and drug options available, so careful consideration is needed in selecting drugs for heart failure patients. Evaluation is carried out to identify problems with the accuracy of drug use and dosage accuracy. The many types of drugs available present its their problems in the use of drugs, especially in the selection and use of drugs that are effective, correct, and safe. Inappropriate and rational use of drugs can increase morbidity and mortality. Objectives: To determine the accuracy of drugs and heart drug dosages in patients with heart failure at the inpatient installation of Samarinda Medika Citra Hospital. Material and Methods: This research is a descriptive observational study with retrospective data collection in 2022. The sample consisted of all adult heart failure inpatients who met the inclusion criteria of 60 patients. Results: The results of the study showed that out of 60 patients, the accuracy of therapy included 93% of the correct drug and 88% of the correct dose. The heart failure drugs used were furosemide (39%), spironolactone (19%), digoxin (18%), candesartan (15%), captopril (4%), bisoprolol (3%), and lisinopril (2%). Conclusions: From the research results, it was found that 93% of the drug accuracy and 88% of the drug dose accuracy in heart failure patients.

EP480 - Auditing antiplatelet and statin prescription around admission on an inpatient vascular surgical unit

Abstract Aims Antiplatelet and Statin management is crucial in ensuring optimal outcomes for patients after peripheral arterial interventions (Vitturi et al, 2023; National Institute for Health and Care Excellence, 2020). The aim of this study was to interrogate if the patients were being discharged on the correct drugs and dosages following hospitalisation. Methods We investigated antiplatelet and statin prescription around admission and matched this with documented management plan on an inpatient vascular unit. Ward rounds were done by registrars along with Foundation Year 1 doctors (FY1s). Newly graduated FY1s with no prior vascular training rotated through the unit every four months. In October 2022, FY1s were educated on existing guidelines and they then handed over verbally to new FY1s in December, when a template was implemented documenting ward rounds and discharge planning. Two sets of data collection were done in October 2022 and then January 2023. Results Of 24 patients discharged in October 2022, 17(71%) received a statin, 7 did not. 15 (63%) patients received their planned antiplatelets, 1 received a different regimen; 8 (33%) had no clear plan outlined. Of 25 patients discharged in January, 15 (60%) received a statin; 10 were discharged without, but only 1 had a documented plan for this. 16 (64%) patients received antiplatelets as planned; 9 (36%) had no clearly documented plan. Conclusions Established guidelines recommend statin and antiplatelet treatment in Peripheral arterial disease. A clear plan should be outlined at discharge, with tools to ensure this particularly when working with juniors without prior experience. Of note, the documentation template developed was not used consistently.

Quality, supply chain, and use of Trypanocidal drugs among camel keepers in north-eastern Kenya: A cross-sectional study

The non-cyclic trypanosomiasis (surra), caused by Trypanosoma evansi, and mechanically transmitted by biting flies, hinders camel productivity in Kenya. Trypanocides are the most commonly used drugs to control surra. However, emergence of drug resistance by the parasites is a major limitation to control efforts. There is limited information on the quality of trypanocides, the supply chain and drug-use practices among camel keepers potentially contributing to development of drug resistance in Kenya. We sought to fill this gap by conducting a cross-sectional study among camel keepers in Isiolo and Marsabit counties, Kenya. We mapped the trypanocide drugs supply chain through quantitative and qualitative surveys. We administered a semi-structured questionnaire to camel keepers to generate data on trypanocides-use practices, including the types, sources, person who administers treatment, reconstitution, dosage, route and frequency of administration, among others. Additionally, we tested the quality of trypanocidal drugs retailed in the region. We mapped a total of 55 and 49 agro-veterinary outlets and general (ordinary) shops retailing veterinary drugs in the two counties, respectively. These comprised of 29 and 26 agro-veterinary outlets, as well as 24 and 25 general shops in Isiolo and Marsabit counties, respectively. Overall, the respondents experienced 283 surra cases in the three-month recall period, which were treated with trypanocides. The majority of these cases were diagnosed by camel owners (71.7%) and herders (24.1%). A significant proportion of the cases were treated by camel owners (54.8%), herders (35.3%), the owner's son (3.2%) and veterinary personnel (1.1%) (χ2 = 24.99, p = 0.000). Most of the households sourced the drugs from agro-veterinary outlets (59.0%), followed by general shops (19.8%), veterinary personnel (2.1%), and open-air markets (0.4%) (χ2 = 319.24, p = 0.000). Quinapyramine was the most (56.9%) predominantly used trypanocide in treatment of surra, followed by homidium (19.8%), isometamidium (15.9%), diminazene aceturate (6.7%), and ethidium (0.7%) (χ2 = 340.75, p < 0.000). Only a meager proportion of respondents (15.2%) used the drugs correctly as instructed by the manufacturers. We recorded an association between correct drug usage, with the person who administers the treatment (χ2 = 17.7, p = 0.003), and the type of trypanocide used (χ2 = 19.4, p < 0.001). All the drug samples tested had correct concentrations of active ingredient (100.0%), and therefore of good quality. We have demonstrated that whereas the trypanocides retailed in the region by authorized vendors are of good quality, there is widespread incorrect handling and use of the drugs by unqualified individuals, which may contribute to treatment failure and emergence of trypanocide resistance.

Artificial Trabecular Meshwork Structure Combining Melt Electrowriting and Solution Electrospinning.

The human trabecular meshwork (HTM) is responsible for regulating intraocular pressure (IOP) by means of gradient porosity. Changes in its physical properties, like increases in stiffness or alterations in the extracellular matrix (ECM), are associated with increases in the IOP, which is the primary cause of glaucoma. The complexity of its structure limits the engineered models to one-layered and simple approaches, which do not accurately replicate the biological and physiological cues related to glaucoma. Here, a combination of melt electrowriting (MEW) and solution electrospinning (SE) is explored as a biofabrication technique used to produce a gradient porous scaffold that mimics the multi-layered structure of the native HTM. Polycaprolactone (PCL) constructs with a height of 20-710 µm and fiber diameters of 0.7-37.5 µm were fabricated. After mechanical characterization, primary human trabecular meshwork cells (HTMCs) were seeded over the scaffolds within the subsequent 14-21 days. In order to validate the system's responsiveness, cells were treated with dexamethasone (Dex) and the rho inhibitor Netarsudil (Net). Scanning electron microscopy and immunochemistry staining were performed to evaluate the expected morphological changes caused by the drugs. Cells in the engineered membranes exhibited an HTMC-like morphology and a correct drug response. Although this work demonstrates the utility of combining MEW and SE in reconstructing complex morphological features like the HTM, new geometries and dimensions should be tested, and future works need to be directed towards perfusion studies.

Evaluasi Rasionalitas Insulin Pada Pasien Diabetes Mellitus Tipe 2 Rawat Jalan di RSUD Kota Madiun Periode 2022

Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia that occurs due to defects in insulin secretion, insulin action or both. Diabetes mellitus (DM) is currently a global health threat. Various epidemiological studies have shown an increase in the incidence and prevalence of DM in the world. Based on data from the profile of the East Java Health Office in 2021, it is estimated that DM patients in Madiun City rank fourth in the East Java region. . Objective: This research was conducted to determine the evaluation of the rationality of insulin in type 2 DM patients in the Outpatient Hospital of Madiun City Hospital for the period 2022. Methods: This research method is in the form of an observational research, retrospective data collection in the form of medical records of history of type 2 diabetes mellitus patients at Outpatient Hospital at RSUD Madison City. The total population in this study in the period January - December 2022 was 165 patients. Results: From the 62 type 2 DM patients who were outpatients at Madiun City Regional Hospital, it was found that 14.52% using single insulin and 12.90% used Detemir insulin. The use of the insulin combination was 85.48% and the Detemir – Aspart insulin combination was 58.06%. Conclusion: Evaluation of the rationality of insulin use showed that the correct drug was 100% and the correct dose was 93,55%.

Parents' experiences on handling paediatric anticancer drugs at home after an educational intervention.

The shift of treatment of paediatric cancer patients to include more care at home puts a lot of pressure on health care professionals (HCPs) to prepare and train parents on safe and correct drug handling at home. Parents must take in and understand the information presented to them while coping with their own fear related to their child's cancer diagnosis. In Sweden, parents are expected to handle and manipulate oral anticancer drugs (OADs) in the home setting. There is however a lack of a standardized method to inform and educate parents on how to handle OADs in a correct way at home. To describe parents' experiences of handling OADs at home after participating in an educational intervention. Educational intervention in the present study aimed to improve parents' knowledge in key concepts that is, handling OADs at home by using information presented in different forms. Fifteen parents to 12 children with cancer were recruited from a paediatric oncology ward in Sweden to participate in an interview. The interviews were transcribed verbatim and subjected to qualitative content analysis. Parents' experiences are presented in categories: Relieved stress, Awareness of own exposure, Facilitated my everyday life, Parents need continued support individually. The educational intervention resulted in both positive and negative feelings, increased awareness of drug exposure and correct drug handling at home. Practical training and information presented in different ways facilitated the process of drug handling. To handle the drug correctly at home parents requested to be trained and informed in the beginning of their child's oral drug treatment. In addition, parents requested to be individually approached by HCP to get answers to questions and concerns. This educational intervention study shows promising results for the method used by HCPs to inform and educate parents on complicated topics such as handling OADs at home.

Current Advances in Radioactive Iodine-Refractory Differentiated Thyroid Cancer.

Differentiated thyroid cancer (DTC) patients have an outstanding overall long-term survival rate, and certain subsets of DTC patients have a very high likelihood of disease recurrence. Radioactive iodine (RAI) therapy is a cornerstone in DTC management, but cancer cells can eventually develop resistance to RAI. Radioactive iodine-refractory DTC (RAIR-DTC) is a condition defined by ATA 2015 guidelines when DTC cannot concentrate RAI ab initio or loses RAI uptake ability after the initial therapy. The RAIR condition implies that RAI cannot reveal new met-astatic foci, so RAIR-DTC metabolic imaging needs new tracers. 18F-FDG PET/CT has been widely used and has demonstrated prognostic value, but 18F-FDG DTC avidity may remain low. Fibroblast activation protein inhibitors (FA-Pi)s, prostatic-specific membrane antigen (PSMA), and somatostatin receptor (SSTR) tracers have been proposed as theragnostic agents in experimental settings and Arg-Gly-Asp (RGD) peptides in the diagnostic trial field. Multi-targeted tyrosine kinase inhibitors are relatively new drugs approved in RAIR-DTC therapy. Despite the promising targeted setting, they relate to frequent adverse-event onset. Sorafenib and trametinib have been included in re-differentiation protocols aimed at re-inducing RAI accumulation in DTC cells. Results appear promising, but not excellent. RAIR-DTC remains a challenging nosological entity. There are still controversies on RAIR-DTC definition and post-RAI therapy evaluation, with post-therapy whole-body scan (PT-WBS) the only validated criterion of response. The recent introduction of multiple diagnostic and therapeutic agents obliges physicians to pursue a multidisciplinary approach aiming to correct drug introduction and timing choice.

A Cross Sectional Study on Prescription Pattern of Antiepileptic Medication among Children of Southern Rajasthan in a Tertiary Care Teaching Hospital

Background: Drug utilization studies are powerful exploratory tools for establishing the role of drugs in society and also effective methods for assessing the prescribing pattern of clinicians. Around 4-10% of children suffer at least one seizure episode at 16 years of age. Even after the availability of several Antiepileptic drugs (AEDs), choosing the correct drug with accurate dosing will produce seizure-free generation. Hence, this study aims to examine the prescription patterns of drugs in epileptic children. Methods: This study was a cross sectional observational study. Children &lt;16 years old visiting neurology department with a history of epileptic seizures and already on antiepileptic drug therapy were included in the study. The data comprised of demographic details, disease history, type of seizure, diagnosis, investigations done, along with prescribed medication noted in case record form. The total study duration was 13 months. Results: In this study, the maximum epilepsy encountering age in male and female children was below the 12-year age group, male predominance was higher than females (male 60.83% vs. female 39.16%). The majority of children were diagnosed with generalized tonic colonic seizures, 54.17%, followed by focal/or partial seizures, 39.17%. Sodium valproate 19.16%, carbamazepine 14.17%, oxcarbazepine 16.67%, and levetriacetam 13.33% were the most commonly prescribed single drug regimens for treating both types of seizures, followed by clobazam added as second and third adjuvant drug in resistant epilepsy to valproate 12.5%, oxcarbazepine 6.67%, and levetriacetam plus carbamazepine combination 5% respectively. Conclusion: Monotherapy was majorly followed in 70% of pediatric patients for maintaining better patient compliance. Both old and new AEDs regimens are prescribed for maintaining the quality of life in patients.

Оценка результатов сравнительного исследования эффективности и безопасности применения комплекса «Фосфалит®» у пациентов с фосфатной формой мочекаменной болезни.

Introduction. Urolithiasis is a widespread disease. The percentage of phosphate stones reaches up to 35% of all cases of all kidney stones. Patients with phosphate stones and with various urinary catheters in particular are a complex category of patients requiring the close attention of doctors. Phosphate urolithiasis clinical patterns create a constant search for various oral therapy options. The purpose of this study is to evaluate the effectiveness of the Phosphalit complex as an optional drug for metabolic disorder correction in phosphate kidney stones. Materials and methods. The prospective randomized control study included 135 patients, 131 people returned for a second visit. All the patients were divided in 4 groups: patients with phosphate urolithiasis who received Phosphalit® on a regular basis, 2 capsules 2 times a day; patients with phosphate urolithiasis who received general recommendations for lifestyle and diet changes; patients with phosphate urolithiasis against the back- ground of existing permanent urinary catheters, receiving the drug Phosphalit® on a regular basis, 2 capsules 2 times a day; patients with phosphate urolithiasis on the background of permanent urinary catheters, who received general recommendations for lifestyle and diet changes. The duration of observation and intervention was 90 days. Results. The total effectiveness of Phosphalit® in reducing the level of phosphates in the blood in both groups of patients (with and without catheters) was 90.1%, and in reducing the excretion of phosphates in urine – 93.3%. The dynamics of the degree of crystalluria and the stone size also showed positive dynamics in all the studied groups. Conclusions. Phosphalit® is an effective and safe remedy in the treatment of the phosphate urolithiasis, including patients with urinary catheters.

The Six Right Principles of Drug Administration to Patients with Diabetes Mellitus in Hospitals: A Case Study

Background: About one-third of adverse events are drug-related medication administration errors (MAE). One method to improve drug administration safety is the application of the six rights of drug administration which include right patient, right drug, correct dose, right time, right route, and proper documentation. Nurses must apply it generously and nursing professional students must be able to use it well too. Purpose: The purpose of this case study is to compare the application of the six right medicine principles between nursing and nursing professional students to Mrs. E with Diabetes Mellitus in Hospital. Methods: This case study uses a quantitative study approach with a comparative descriptive design. Data were obtained through observation for seven days with an observation measuring instrument for applying the six correct drug administration are consist of 33 statements. Respondents were obtained from purposive sampling consisting of 7 Nursing Profession students at the Faculty of Nursing, University of Jember, and seven nurses at the Hospital. Results: The difference in applying the six right principles of drug administration to Mrs. E for seven days (14 shifts) by 11 students and nurses (4.8%). Conclusion: An indicator that still really needs to be improved by students and nurses is the true indicator of patients who are still below 50%. Meanwhile, the other indicators have achieved a total implementation of &gt;70%.

Drug therapy for acute and elective stent angioplasty

Carotid artery stenoses are constrictions of the common carotid artery and the internal carotid artery. They cause around 15% of all cerebral ischemia, which is why their detection and correct treatment play an important role in clinical practice. Depending on the severity and clinical symptoms, carotid artery stenosis is treated conservatively, surgically or endovascularly by means of stent angioplasty. In the case of stent angioplasty in particular, correct drug therapy plays an important role in avoiding/reducing thromboembolic complications.

Immune-related adverse effects: Recognition and initiation of appropriate treatment in cancer patients on immunotherapy.

Delayed or improper identification of immune-related adverse events (IRAEs) during cancer treatment can impact time to receive proper treatment. This study describes rates of IRAE recognition and appropriate treatment in adult patients with cancer at a community teaching hospital. This single-center, retrospective, cohort study evaluated rates of proper IRAE treatment in conjunction with National Comprehensive Cancer Network (NCCN) guidelines. Secondary outcomes included time from presentation to IRAE diagnosis and hospital readmissions/repeat emergency department (ED) visits following initial admission for IRAE. Retrospective chart review assessed IRAE presentation including common terminology criteria for adverse event (CTCAE) grading and treatment choices. Fifteen subjects included in this study contributed to 21 encounters with noted IRAE. Over half (52.4%) of the encounters received proper IRAE treatment (e.g. correct drug, dose, route, frequency, or therapy duration). Nearly 22% of total actionable components were improper, occurring more often in patients with colitis, pneumonitis, and hepatitis. Median time to IRAE diagnosis was approximately 3.5 days, with the longest being 24 days. There were eight all-cause rehospitalizations one year after initial IRAE presentation, with four directly IRAE-related. Most (75%) IRAE-related rehospitalizations occurred with colitis. Seven ED return visits were also noted. Many IRAEs were misdiagnosed and/or received improper treatment resulting in increased rehospitalization/return ED visit rates. The importance of medical oncology involvement (e.g. medical oncology consult at time of admission and/or notification of primary oncologist) in IRAE management in the hospital or ED was also stressed. Organizations may benefit from systematic improvements and staff education to improve patient outcomes and prevent readmissions.

Treatment of Esophageal-Pleural Fistula After Diverticulectomy Using Transluminal Vacuum Therapy in a Patient with HIV Infection

Abstract A clinical observation of the successful treatment of an HIV-infected patient with esophageal-pleural fistula and pleural empyema after diverticulectomy is presented, where the key tactical decision was the use of transluminal vacuum therapy together with adequate drainage of the pleural cavity and correct drug therapy. When analyzing the available literature, no publications concerning the treatment of HIV-infected patients with the discussed esophageal pathology were found.Aim of study To discuss the Results of treatment of postoperative esophageal-pleural fistula using transluminal vacuum therapy in a patient with HIV infection.

Comparison of Acebrophylline vs Theophylline on Chronic Obstructive Pulmonary Disease

Over the past few decades, there has been a positive increase in the use of pharmaceutical treatment for chronic obstructive pulmonary disease (COPD). Methylamines are often used in COPD patients. Theophylline is a well-known bronchodilator and anti-inflammatory medication, and acebrophylline is a relatively recent addition to contemporary respiratory care. Both are used as adjunctive therapy for patients with stable COPD who are receiving long-acting muscarinic antagonists (LAMAs). One of the world's most pressing public health issues at the moment is chronic obstructive pulmonary disease (COPD). Oral medication therapy is utilised as a second- or third-line maintenance treatment for COPD, while inhaled treatments constitute the first-line maintenance treatment. In comparison to inhaled therapy, oral medications exhibit modest bronchodilator and anti-inflammatory properties, albeit at a lesser concentration. A number of benefits of oral medication therapy include its rapid availability, cloudiest pharmacologic methods of action, convenience of administration, lack of complications with correct inhalational drug deposition in lung airways, and cost-effectiveness.

A Systematic review of Inflammatory biomarkers, Clinical significance, Detection, and their therapeutic agents

Biomarkers in inflammation are measurable and valuable biological indicators that can be used to assess the severity, presence, progression of inflammatory processes within the body. Inflammation is a complex physiological response that occurs in response to various stimuli, such as tissue damage, infections, and autoimmune reactions. There are several types of biomarkers Cytokines, Eicosanoids, Calprotectin, E-selectin, P-selectin, Fibrinogen, C-reactive protein (CRP), Exosomes, Myeloperoxidase (MPO), Chemokines , Neurofilament light chain (NfL), MMPs, 8-isoPGF2α, TIMPs, cell NO2-, adhesion molecules, PTX3, autoantibodies, complements, sRAGE, NT-proBNP, acute-phase and immunology-related proteins, thrombogenicity markers, ghrelin, leptin and adipokines, Presepsin, p75ECD, phosphorylated neurofilament heavy (pNfH), IDO1 and TARC, SCCA2, CTACK, EDN, MDC, LDH, and commonly used in the context of inflammation. We analysed the literature through online databases such as PubMed ScienceDirect and Google Scholar were used to search for journals and studies published. In this review, we discuss about different types of biomarkers involved in inflammation and their levels of elevation in various disease conditions. Quantified inflammatory biomarkers are effective clinical strategy for correct and reasonable drug treatment. There may have been advancements in the development of new treatments or therapies since my last update. Therapeutic agents like colchicine can modulate the immune response to reduce inflammation.

A drug prescription recommendation system based on novel DIAKID ontology and extensive semantic rules

According to the World Health Organization (WHO) data from 2000 to 2019, the number of people living with Diabetes Mellitus and Chronic Kidney Disease (CKD) is increasing rapidly. It is observed that Diabetes Mellitus increased by 70% and ranked in the top 10 among all causes of death, while the rate of those who died from CKD increased by 63% and rose from the 13th place to the 10th place. In this work, we combined the drug dose prediction model, drug-drug interaction warnings and drugs that potassium raising (K-raising) warnings to create a novel and effective ontology-based assistive prescription recommendation system for patients having both Type-2 Diabetes Mellitus (T2DM) and CKD. Although there are several computational solutions that use ontology-based systems for treatment plans for these type of diseases, none of them combine information analysis and treatment plans prediction for T2DM and CKD. The proposed method is novel: (1) We develop a new drug-drug interaction model and drug dose ontology called DIAKID (for drugs of T2DM and CKD). (2) Using comprehensive Semantic Web Rule Language (SWRL) rules, we automatically extract the correct drug dose, K-raising drugs, and drug-drug interaction warnings based on the Glomerular Filtration Rate (GFR) value of T2DM and CKD patients. The proposed work achieves very competitive results, and this is the first time such a study conducted on both diseases. The proposed system will guide clinicians in preparing prescriptions by giving necessary warnings about drug-drug interactions and doses.

Do Nurses Follow The “Right Response”? Mixed Methods Research

Aim: Drug administration and management is an important procedure among clinical nursing practices and is one of the significant indicators affecting patient safety and quality of care. It was aimed to determine the nurses' monitoring of drug effects after drug treatment.&#x0D; Methods: In the study, sequential explanatory design from exploratory and mixed research methods was used. Quantitative data were collected using a data collection form and qualitative data were collected through in-depth and individual interviews using a semi-structured interview form. The interviews were recorded with a voice recorder.&#x0D; Results: It was determined that the average age, working years, weekly working hours, and daily number of patients cared for by the nurses were respectively 30.46±6.96, 7.1±6.31, 44.92±5.71, 15.42±11.89 years. It was found that 54.2% of the nurses checked the drug package insert before administering the medication, 74.5% of the nurses always considered the history of drug and food allergy to be of vital importance before drug administration, and 97.9% of the nurses reported unexpected side/toxic effects. As a result of in-depth interviews with the nurses participating in the study, three themes were identified: the approach of right drug administration principles, the approach of following the right response, and the follow-up status of nurses after drug administration.&#x0D; Conclusion: In the study, it was determined that nurses lacked knowledge about the right to correct medication, and could not implement the right to correct response due to high workload, low number of nurses and lack of time. It was observed that nurses gave the responsibility of correct response follow-up to the patient or the patient's relatives. By evaluating the reasons for not implementing the right to correct response, it is recommended that the number of nurses should be increased, the workload should be regulated, and nurses should receive training on correct drug administration and especially on the importance of correct response. It is also recommended that nurses receive training and counseling on their duties, authorities and responsibilities.

A review on micro beads: Formulation, technological aspects, and extraction

Any drug delivery system's purpose is to deliver a therapeutic amount of medicine to the appropriate place in the body while also achieving and maintaining the correct drug concentration. This could be accomplished by using numerous unit dosage forms such as microgranules/spheroids, pellets, microcapsules, and beads, which are divided into many separate units, referred to as subunits, each of which possesses certain desired features. The advantages of micro particle drug delivery systems over single unit dose form are well documented. One of the solutions that does not entail the use of harsh chemicals or elevated temperatures is the production of microbeads medication delivery systems. The traditional procedures require the use of ionotropic gelation methods, which include internal and external gelation methods, emulsion gelation methods, polyelectrolyte complexation methods, and so on. Because of the ease of preparation, the majority of work has been done on the preparation of microbeads using the ionotropic gelation process rather than alternative approaches.

An Overview of Pharmaceutical Reconciliation

During the move between healthcare settings and changes in the medical status of patients, it is very important to update the correct drug regimen according to the clinical conditions to avoid the possibility of medical errors. Nearly half of medication errors occur during initial admission, transfer between hospital departments, and before discharge. Among these errors, about 30% of cases have the potential of seriously harming the patient. Some risk factors, such as old age and the number of drugs used, are associated with an increased risk of medication discrepancies. The medication reconciliation process can significantly reduce the risk of potential errors. It includes obtaining, verifying, and documenting a list of the patient's current medications and comparing it to the patient's medication orders and condition to identify and resolve any discrepancies. Comparing what is being prescribed in one setting with what is being taken in another will prevent errors of drug-drug interactions, omission, and other discrepancies. Pharmaceutical reconciliation is an important element of patient safety and rational drug use, and it can significantly contribute to the health economy.