A static scene statistical nonuniformity correction ( S 3 NUC ) method was developed based on the higher-order moments of a linear statistical model of a photodetection process. S 3 NUC relieves the requirement for calibrated targets or a moving scene for NUC by utilizing two data sets of different intensities but requires low scene intensity levels. The first-, second-, and third-order moments of the two data sets are used to estimate the gain and bias values for the detectors in a focal-plane array (FPA). These gain and bias values may then be used to correct the nonuniformities between detectors or to initialize other continuous calibration methods. S 3 NUC was successfully applied to simulated data as well as measured data at visible wavelengths.