Drooping mouth corner may lead to a sad, tired or aging appearance, which could be corrected by injection of botulinum neurotoxin. In the article, we describe a novel "cross injection" technique for mouth corner lift with botulinum neurotoxin injection guided by ultrasound. Patients with drooping mouth corner were treated with botulinum neurotoxin injection using ultrasound-guided "cross injection" technique. The patient was told to contact the doctor immediately and return to the hospital as soon as the injection takes effect. The photographs of patients were taken during the follow-up appointment. After the injection, there were noticeable improvements on all patients. The mouth corners were elevated and desired effects were achieved. The ultrasound-guided "cross injection" technique is precise and controllable, which can achieve stable aesthetic improvement of the drooped mouth corners, while significantly reducing the rate of injection-related complications. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
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