Background: Streptococcus pneumoniae is often the cause of infections, including eye infections such as endophthalmitis, keratitis, and conjunctivitis. Endophthalmitis is a severe infection and can cause blindness. This case report aims to investigate and report the incidence of endophthalmitis caused by S. pneumoniae. Case presentation: We report the case of a 67-year-old man with blurred vision in his right eye accompanied by red, watery eyes, discharge, swollen eyelids. The patient was assessed as having exogenous endophthalmitis ocular dextra et causa bacterial infection with a post-secondary implant for three years. From the result of the culture and sensitivity test of the cornea and vitreous sample, S. pneumoniae was found to have a 97% probability using VITEK 2 Compact. We continued to examine the serotype using Polymerase Chain Reaction (PCR), and the result was S. pneumoniae serotype 3. The patient was treated with ceftriaxone as definitive therapy, and the condition improved. Conclusion: S. pneumoniae is the known organism that causes one eye infection with risk factors such as previous cataract surgery. Prompt diagnosis and treatment are needed for good outcomes.