Core Disturbance Research Articles

An Empirical-Phenomenological Exploration of Anderssein (Feeling Different) in Schizophrenia: Being in-between Particular and Universal

Introduction: In this paper, we wish to elucidate alterations of basic existential and intersubjective configurations in schizophrenia spectrum disorders (SSD) through the phenomenon of Anderssein (“feeling different”). Anderssein is an important yet neglected notion from German psychiatry, referring to a specific sense of feeling profoundly different from others occurring in SSD. Although phenomenological-psychopathological research mentions it as an aspect of the core disturbance of SSD (namely, “self-disorders”), the phenomenon has not yet been explored in empirical or theoretical detail. Method: We present material from a phenomenological-empirical study on the mode and onset of psychosis based on qualitative interviews with 25 patients with SSD. Results: Most of the participants in our study report having felt fundamentally and often ineffably different since childhood and articulate it as a sense of existing “outside” of the shared reality. Intersubjective reality appears progressively unreal or inauthentic, and simultaneously, the patient’s intimate, subjective sphere is permeated by an alien otherness. Importantly, this outside position should be understood carefully as it is often accompanied by the sense of being invaded by social rules, other people’s thoughts, or emotions. Incipient psychosis is described as a gradual extension of precedent alterations of the structures of (inter)subjectivity. Conclusion: We conceptualize the ontological feature of Anderssein as an altered “being in-between” – that is, some sort of halting of the dynamic movement between particularity and intersubjectivity. Finally, we discuss the critical implications of these results for research into the “onset” of schizophrenia.

High-precision U-Pb geochronology for the Miocene Climate Optimum and a novel approach for calibrating age models in deep-sea sediment cores

Abstract Scientific ocean drilling cores recovered years ago (legacy cores), especially as recovered by rotary drilling, commonly show incomplete recovery and core disturbance. We present a novel method to date such cores by presenting the first high-precision U-Pb zircon ages targeting the duration of the Miocene Climate Optimum (MCO; ca. 17–14 Ma) from volcanic ashes at Ocean Drilling Program Site 1000 (on the Nicaragua Rise in the Caribbean Sea). We place these ages within a newly developed framework to address incomplete core recovery and use them to calibrate a high-resolution bulk carbonate δ13C and δ18O record. Our Site 1000 ages show that volcanism of the Columbia River Basalt Group (CRBG) large igneous province was coincident with the interval of greatest sustained MCO warmth at this site. However, if the CRBG were the primary driver of the MCO, our chronology may allow for outgassing preceding volcanism as a major source of CO2. We thus document a promising new way to obtain highly resolved, accurate, and precise numerical age models for legacy deep-sea sediment cores that does not depend on correlation to other records.

Patterns and impacts of an unprecedented outbreak of bark beetles in Central Europe: A glimpse into the future?

Natural disturbances have significantly intensified across European forests, with bark beetle outbreaks being the most rapidly escalating disturbance type. Since 2018, the Czech Republic (Central Europe) has become a Europe's disturbance epicentre due to the unprecedented outbreak of spruce bark beetle Ips typographus in the forests dominated by Norway spruce Picea abies. Here we provide novel insights into the impacts and dynamics of this disturbance from 2016 to 2022. The investigation is based on annual forest change maps developed by the classification of optical and Synthetic Aperture Radar satellite imagery. We identified seven major outbreak foci across the country, where the outbreaks culminated between 2018 and 2021. Most of the outbreak waves exhibited a symmetric shape, characterized by a three-year build-up phase, a single culmination year, and the subsequent decline. The substantial proportion of spruce remaining in the outbreak areas after the culmination point implies that resource depletion is an improbable cause for the outbreak's retreat. In the year of retreat, the proportion of spruce in the forest ranged between 26% and 36% in most of the outbreak areas. The disturbance dynamics manifested a transition from the emergence of new tree mortality spots in the early outbreak phase to their short-range expansion, suggesting density-dependent changes in bark beetle dispersal during the studied period. The core disturbance zone, pinpointed in 2022, covered an area of 9,000 ​km2 and experienced a 38% loss in forest cover. Within this area, forest fragmentation increased significantly, leading to a greater forest patch complexity and reduced connectivity among the patches. The presented findings can serve as a glimpse into the future for other European regions, revealing the potential impacts of natural disturbances amplified by climate change.

Coring tools have an effect on lithification and physical properties of marine carbonate sediments

Abstract. The International Ocean Discovery Program (IODP) JOIDES Resolution Science Operator typically uses an advanced piston corer (APC) in soft ooze and sediments and an extended core barrel (XCB) in firm sediments. The coring tool exchange typically occurs around the same depth in adjacent holes of the same site. However, during IODP Expedition 356, the coring tool switch occurred at different depths: IODP Sites U1463 and U1464 are marked by a stratigraphic interval (> 25 m thick) that was XCB cored in one hole and APC cored in other holes. Shipboard scientists remarked that APC-cored sediments were unlithified or partially lithified, while XCB-cored sediments were fully lithified. This difference in sedimentological description of the same formation seems to be an effect of coring technique. To provide further insight, we assessed the physical properties (bulk density, porosity, and P-wave velocity), downhole wireline logging data, scanning electron microscope (SEM) images, and micro-computed tomography (µCT) scans of those intervals. We find systematic differences between the different coring techniques. XCB cores are characterized by systematically lower bulk density, higher porosity, and higher P-wave velocity than APC cores. Downhole logging data suggest that the original P-wave velocity of the formation is better preserved in XCB cores, despite the typical “biscuit-and-gravy” core disturbance (i.e. well-preserved core fragments surrounded by squelched core material). In conjunction with SEM and µCT images, we conclude that the APC tool destroyed early lithification by breaking cements between individual grains. Moreover, µCT images reveal denser packing and smaller pore volumes in the APC cores. These sedimentary changes likely occur when the APC pressure wave passes through the sediment. The destruction of grain-to-grain cements provides an explanation for the significantly lower P-wave velocities in APC cores. Interestingly, the gravy sections in XCB drilled cores mimic the destruction of early lithification and reduction of pore volume. We conclude that APC remains the tool of choice for recovering soft sediments, especially for paleoclimate purposes. However, for the study of lithification, XCB biscuits provide a more representative image of the formation. For the study of early diagenesis, further studies are required to ascertain the preservation of key sedimentary features using existing and new drilling tools.

An integrated, non-destructive method for evaluating core quality from R/V Legend’s giant piston coring system (LGD-GPC)

Despite technological advances, some core disturbances due to piston coring process still occur and can be extremely difficult to identify characteristics of sedimentary structures during qualitative visual core description and core lithologies. Few quantitative methods have offered plausible ways to define the exact magnitude of the distorted sedimentary structures in imperfect sedimentary records in the context of overly limited sedimentary records. In this study, an investigation was conducted on the Kaoping slope offshore southwestern Taiwan, a region known for its high sedimentation rate (> 0.9 g/cm2/year), using both the LGD-GPC (giant piston corer) and giant gravity corer techniques. To examine how GPC procedures have shaped the retrieval of sedimentary sequences and affected core quality, we apply well-developed, non-destructive analyses, including physical property measurements, visible color reflectance and digital core images with quantitative curvature index (CI), to recovered sediments. Cores at 22° 23′N, 120° 13′E were as the basis for non-destructive measurement comparison. Evidence from digital core imaging and the CI calculation further supports the mechanism of piston suction. We suggest that shear deformation of sediment against the core barrel would be the prominent factor that govern the observed core disturbances in LGD-GPC cores. Meanwhile, excessive pulling forcing from a modified TORI piston and a slowly lift speed during LGD-GPC coring process may further aggravate core disturbances at the revisited site. The sedimentary length of core LGD-T43-B-PC is overestimated by more than 200%. We further demonstrate that an integration of the CI and color reflectance is an effective way to evaluate the transformation and distorted sedimentary sequences.

Cutting Migration and Core Disturbance Caused by the Hydraulic Structure of Pressure- and Gas-Maintaining Coring Bits

Gas disaster prevention and control is essential to coal mine safety production, with accurate measurement of gas pressure and content being the challenging key aspect. Pressure- and gas-maintaining coring devices can characterize cores in situ to achieve this accurate measurement. As an important part of these devices, the hydraulic structure of the coring bit plays a decisive role in the migration, coring rate, and core disturbance of the bottom-hole cuttings, and studying this structure is thus of great significance. In this paper, the fluid simulation software FLUENT is used to carry out numerical simulation of the bottom-hole flow field to study the cutting movement and core disturbance caused by coring bits with different hydraulic structures. The results show that (1) the best nozzle azimuth angle of 75° is beneficial to bottom-hole cutting discharge and reduces the scouring effect of the drilling fluid on the core. (2) The larger the diameter of the nozzle of the coring bit is, the weaker the cutting removal ability of the drill bit and the smaller the cutting scouring effect of the drilling fluid. The optimal nozzle diameter is 12 mm. (3) Adding a sluice channel inside the water barrier ring can reduce the erosion of drilling fluid on the core. (4) Bits with a rectangular inner passage promote cutting migration. Field application results show that the designed coring bit performs well, and the research results can provide a reference for the structure optimization of coring bits for pressure and gas retention.

Metacognition in psychosis: a renewed path to understanding of core disturbances and recovery-oriented treatment.

Metacognition in psychosis: a renewed path to understanding of core disturbances and recovery-oriented treatment.

Schizophrenia, Temporality, and Affection

Temporal experience and its radical alteration in schizophrenia have been one of the central objects of investigation in phenomenological psychopathology. Various phenomenologically oriented researchers have argued that the change in the mode of temporal experience present in schizophrenia can foreground its psychotic symptoms of delusion. This paper aims to further the development of such a phenomenological investigation by highlighting a much-neglected aspect of schizophrenic temporal experience, i.e., its non-emotional affective characteristic. In this paper, it denotes the type of an experience wherein an afflicted individual experiences a pervasive pull or attraction coming from the past, present, and future. By employing Husserl’s account of affection, I argue that such an affectively prominent temporal experience is not yet another abnormality that happens to be present in schizophrenia. Instead, it is indicative of the core disturbance that underpins the schizophrenic temporal mode of experience. I identify such a disturbance as ‘affective modification dysfunction’ and employ it as a core concept with which I synthesize and organise heterogeneous components of schizophrenic temporal experience in their conceptual unity. For the sake of clear description, I organise those components into the following categories: 1.) Time Stop 2.) Ante-festum 3.) Déjà vu/vécu and 4.) Time Fragmentation. I conclude by demonstrating how approaching schizophrenic temporal experience from its affective dimension can further help us better understand its pre-psychotic phase known to precipitate schizophrenic primary delusion, i.e., delusional mood.

Quaternary environments and monsoonal climate off northwest Australia: Palynological evidence from Ocean Drilling Program Site 765

The bathyal Ocean Drilling Program Site 765 at 5725 m water depth, offshore northwest Australia at 16°S is directly under the influence of the Australian monsoon during the Austral summer and is the recipient of continental dust during the Austral winter. It is downstream of the Indonesian Throughflow, which is a major arm of the global thermohaline circulation. As such it is ideally situated to record the climate and oceanic consequences of Quaternary climate variability. Despite being over 400 km from northwest Australia, palynomorphs (pollen and spores) are relatively common in this section, sourced via aeolian (during the dry winter) and benthic transportation processes and sediment plumes (during the summer monsoon). Detailed palynological analyses of this flora in the upper part of this core reveals intermittent snap shots of environmental and climate change over the last 300 kyrs. Interglacial stages are interpreted to be characterised by palynomorph-rich turbidite and calcareous ooze deposition whereas palynomorph-poor slowly accumulating siliceous oozes (deposited below the Calcium Carbonate Compensation Depth) are present during glacials. The dominance of Poaceae sourced from the Australian mainland in interglacial periods suggests that vegetation during these periods was similar to today. Interglacial palynofloral assemblages suggest a more intense wet season (Australian monsoon) with higher rainfall that allowed more active erosion and deposition onto the shelf. The presence of Indonesian sourced pollen and fern spore taxa, as well as warm water dinoflagellate species suggest enhanced Leeuwin Current and monsoonal intensity during interglacials times. The youngest part of the core is dominated by siliceous ooze, likely deposited during the Last Glacial Maximum and the early Holocene. The lack of calcareous ooze near the top of the core is likely caused by Holocene to Recent erosive processes or core disturbance. The presence of common charcoal in all samples over the last 300 kyrs shows that fire was a constant feature of the landscape in northwest Australia prior to human occupation of the region 65,000 years ago.

Thought Disorder on Object Sorting Test Is Associated with Executive Dysfunction in Schizophrenia.

Background:Thought disorder is considered to be central to the core disturbances in schizophrenia and was described by Goldstein as aberrant “concept formation.” Executive dysfunction is another core deficit in schizophrenia. With a greater emphasis on psychopathology in nosological systems, the classical thought disorder receives less prominence. The present study aimed to understand the association between classical thought disorder (aberrant concept formation and concrete abstraction) and executive dysfunction.Methods:Thirty patients with schizophrenia and thirty healthy subjects, matched on age, gender, education, and socioeconomic status, were screened using MINI 5.0, following which they were assessed on object sorting test (OST) and selected tests for executive functions (EFs).Results:Individuals with schizophrenia were found to have significantly decreased performance on all domains of EFs and OST. Total peculiar scores on OST were significantly associated with mental speed, focused attention, and divided attention. Total impoverished scores on OST was significantly associated with focused attention, sustained attention, planning, set shifting, perseveration, and concept formation.Conclusion:Several correlations, among performance on OST and neuropsychological tests, suggest that patterns of responses on OST can point to underlying executive dysfunction. Both thought disorder and executive dysfunction mirror similar constructs. This similarity represents a conceptual bridge between the classical and contemporary descriptions of the core deficits in schizophrenia.

Detecting disturbed forest tracts in the Sariska Tiger Reserve, India, using forest canopy density and fragmentation models

The paper explored the level of forest disturbance in the Sariska Tiger Reserve (STR) of Indian tropical forest. We acquired single scene image of Landsat-5 (1989) and Landsat-8 (2015) for the analysis. Disturbance map was produced using fragmentation and canopy density models. The map was categorized into high, moderate, low, and undisturbed forest tracts. Spatiotemporal analysis of forest disturbance (1989–2015) revealed that highly disturbed tracts experienced a decrease of 43%, while medium and low disturbed tracts showed an increase of 57% and 30%, respectively. Undisturbed forest tracts witnessed decrease mainly due to a decrease in very high canopy density and increase in forest fragmentation. Within cores I, II and III of STR, undisturbed forest tracts in core I have significantly declined due to increased anthropogenic activities. Thus, the study calls for immediate attention to check forest disturbance in core I of STR. Though the government has initiated relocation program of the villages and restoration of the STR, the execution process has still a long way to achieve the goal. The methodology adopted in this study can effectively be utilized for assessing the forest disturbance tracts at spatial scales.

Long-Period Gratings and Multimode Interference in Helical Single-Mode Fiber

Many interesting phenomena in twisted fiber have been reported. In this letter, the twisted single-mode fiber (TSMF) was proposed and studied. It was fabricated by CO2 splicer. Experiments and robust cladding modes resonant theoretical model demonstrated it has transmission dips of long-period gratings. Besides, the light in core will scatter into cladding due to disturbance in core. It will cause multimode interference. A tangential direction theoretical model was put forward to test the experiment characteristic, and was in good agreement with experiment results. In addition, some performance of physical parameters, such as temperature and bending loss response of TSMF are also analyzed. The results indicate that TSMF is a good candidate in sensing and the telecommunication fields.

Self and world experience in non-affective first episode of psychosis

A disturbance of “minimal self,” — of the immediate sense of mine-ness inherent in experience—is hypothesized to be the core disturbance in schizophrenia. Research with the Examination of Anomalous Self Experience (EASE) has demonstrated the selective aggregation of anomalous self-experiences in the schizophrenia spectrum. Conceptual research suggests that anomalous world experiences, including changes in the experience of space, time, and other persons, occur alongside anomalous self-experiences and are an important aspect of subjectivity in schizophrenia. The Examination of Anomalous World Experience (EAWE) is a recently published interview format designed to explore changes in world experience in schizophrenia. In the current study, 24 hospital outpatients with non-affective first-episode psychosis and 24 healthy-control participants were assessed with the EAWE and the EASE. First episode psychosis patients had total EAWE and EASE scores that were both, on average, significantly higher than the healthy-control group. EAWE and EASE scores were highly correlated, even after removing overlapping items. The distribution of EAWE items and subtypes in the first-episode psychosis sample was heterogeneous. We conclude that anomalous world experiences represent a relevant aspect of first-episode psychosis, and that they may be related to the self-disturbances thought to underlie schizophrenia spectrum disorders.

Impact of sampling techniques on the concentration of ammonia and sulfide in pore water of marine sediments

AbstractThree ex situ pore water sampling procedures (I – rhizon samplers, II – centrifugation of sediment subsamples collected from different sediment depths without core sectioning, III – core sectioning and centrifugation of sediment sections) were compared to indicate factors that may affect concentrations of pore water constituents (ammonia and sulfides). The methods were selected and modified in such a way as to determine how the concentrations are affected by different factors related to sampling procedures, e.g. contact with atmospheric air, filtration and sediment core disturbance. They were tested on nine sediment cores collected at one site in the southern Baltic Sea. The concentration of ammonia in pore water from centrifuged sediment sections was significantly higher compared to pore water extracted by rhizons – probably due to the impact of changing pH. The factor with the greatest impact on the H2S/HS–concentration in the analyzed pore water was the contact with atmospheric air and/or the extrusion of sediments from a core liner. Rhizons proved to be the best option for sampling pore waters analyzed for H2S/HS–and NH4+/NH3. In the case of H2S/HS–we noticed the smallest loss of the analyzed constituents. For ammonia, the centrifugation of the whole sediment sections was likely to cause interferences in the indophenol blue method.

India National Gas Hydrate Program Expedition 02 summary of scientific results: Evaluation of natural gas-hydrate-bearing pressure cores

Abstract India's National Gas Hydrate Program (NGHP) Expedition-02 was conducted in 2015 with the goal of investigating numerous locations that had been determined to be prospective for gas hydrate at high saturation in sand-rich reservoirs. Initial logging while drilling data revealed extensive sand-rich gas hydrate occurrences at multiple drill sites in two broad areas. These sites were further investigated through the acquisition and analyses of pressure cores designed to document 1) gas hydrate occurrence within the reservoirs; 2) the petrophysical nature of the reservoir and associated seals, in their native state as well as during and after the dissociation of gas hydrate; 3) the geomechanical nature of the reservoir and seals; and 4) the geochemical nature of reservoir fluids. The cores were initially evaluated at sea, and select subsamples were transferred for more extensive analyses at specialized laboratories both in Japan and in the United States. The samples encompassed a wide range of gas hydrate saturation (from 0 to 100%) within reservoir sediments ranging from sandy silts to gravels, providing opportunities to extend and refine insights into the nature of gas hydrate reservoirs gained in previous programs. Select findings and implications of this coordinated pressure-core evaluation program are reported in numerous papers within the NGHP-02 Special Thematic Volume and are summarized here with respect to the following issues: the evaluation and mitigation of core disturbance, the assessment of gas hydrate occurrence and saturation, the geomechanics and petrophysics of both reservoirs and “seals” in situ, and the potential dynamic geomechanical and petrophysical behavior of reservoir and seals during production.

Exploring the nature of the 2016 γ-ray emission in the blazar 1749+096

Recent Fermi-Large Area Telescope (LAT) light curves indicate an active $\gamma$-ray state spanning about five months from 2016 June to 2016 October in the BL Lac object 1749+096 (OT 081). During this period, we find two notable $\gamma$-ray events: an exceptionally strong outburst followed by a significant enhancement (local peak). In this study, we analyze multi-waveband light curves (radio, optical, X-ray, and $\gamma$-ray) plus very-long baseline interferometry (VLBI) data to investigate the nature of the $\gamma$-ray events. The $\gamma$-ray outburst coincides with flux maxima at longer wavelengths. We find a spectral hardening of the $\gamma$-ray photon index during the $\gamma$-ray outburst. The photon index shows a transition from a softer-when-brighter to a harder-when-brighter trend at around 1.8 $\times$ $10^{-7}$ ph cm$^{-2}$ s$^{-1}$. We see indication that both the $\gamma$-ray outburst and the subsequent enhancement precede the propagation of a polarized knot in a region near the VLBI core. The highest polarized intensity, 230\,mJy, and an electric vector position angle rotation, by $\sim$32$^{\circ}$, are detected about 12 days after the $\gamma$-ray outburst. We conclude that both $\gamma$-ray events are caused by the propagation of a disturbance in the mm-wave core.

Compact Object Mergers Driven by Gas Fallback

Recently, several gravitational wave detections have shown evidence for compact object mergers. However, the astrophysical origin of merging binaries is not well understood. Stellar binaries are typically at much larger separations than what is needed for the binaries to merge due to gravitational wave emission, which leads to the so-called final AU problem. In this Letter we propose a new channel for mergers of compact object binaries which solves the final AU problem. We examine the binary evolution following gas expansion due to a weak failed supernova explosion, neutrino mass loss, core disturbance, or envelope instability. In such situations the binary is possibly hardened by ambient gas. We investigate the evolution of the binary system after a shock has propagated by performing smoothed particle hydrodynamics simulations. We find that significant binary hardening occurs when the gas mass bound to the binary exceeds that of the compact objects. This mechanism represents a new possibility for the pathway to mergers for gravitational wave events.

Evidence of disturbances of deep levels of semantic cohesion within personal narratives in schizophrenia

Since initial conceptualizations, schizophrenia has been thought to involve core disturbances in the ability to form complex, integrated ideas. Although this has been studied in terms of formal thought disorder, the level of involvement of altered latent semantic structure is less clear. To explore this question, we compared the personal narratives of adults with schizophrenia (n=200) to those produced by an HIV+ sample (n=55) using selected indices from Coh-Metrix. Coh-Metrix is a software system designed to compute various language usage statistics from transcribed written and spoken language documents. It differs from many other frequency-based systems in that Coh-Metrix measures a wide range of language processes, ranging from basic descriptors (e.g., total words) to indices assessing more sophisticated processes within sentences, between sentences, and across paragraphs (e.g., deep cohesion). Consistent with predictions, the narratives in schizophrenia exhibited less cohesion even after controlling for age and education. Specifically, the schizophrenia group spoke fewer words, demonstrated less connection between ideas and clauses, provided fewer causal/intentional markers, and displayed lower levels of deep cohesion. A classification model using only Coh-Metrix indices found language markers correctly classified participants in nearly three-fourths of cases. These findings suggest a particular pattern of difficulties cohesively connecting thoughts about oneself and the world results in a perceived lack of coherence in schizophrenia. These results are consistent with Bleuler's model of schizophrenia and offer a novel way to understand and measure alterations in thought and speech over time.

Psychopathological Functioning Levels (PFLs) and their possible relevance in psychiatric treatments: a qualitative research project.

BackgroundSymptoms description is often not enough to provide clinicians with guidelines for treatments and patients’ clinical history does not represent an exhaustive source of data. Psychopathological dysfunctions are known to relate to the core disturbances that underlie different forms of psychopathology so the identification of such dysfunctions could be helpful for treatments. Some tools are available although highly complex and lengthy. This study aimed to provide clinicians with an easy-to-administer instrument able to capture different levels of impairment in psychopathological functioning, namely the Psychopathological Functioning Levels – Rating Scale (PFL-RS).MethodsThe Psychopathological Functioning Level - Research and Training Committee (PFL-RTC) has been established in Turin since 2002 including psychiatrists and clinical psychologists with extensive clinical and research experience. Our research was grounded on the Qualitative Research Criteria (QRC) 1-7 and conducted with subsequent steps in order to identify those core psychopathological dysfunctions to be rated by this tool.ResultsFrom 2002 until 2014, 316 outpatients were administered the clinical interview on at least two different occasions. Diagnoses were mixed and included: Schizophrenic and Psychotic Disorders, Depressive Disorders, Anxiety Disorders, Obsessive-Compulsive Disorder, Post- Traumatic Stress Disorder, Somatic Symptoms Disorders, Eating Disorders and Personality Disorders. Focus groups were conducted to identify those psychopathological dysfunctions which needed to be rated, according to two Phenomenological Selection Criteria (PhSC) and four Etiopathogenetic Selection Criteria (EtSC). As a result, five dysfunctional areas emerged: Identity (ID); Comprehension (CO); Negative Emotions (NE); Action-Regulation (AR); Social Skills (SS). After checking such dimensions for consistency with the existing instruments, 7 levels of severity were identified for each area. Finally, a provisional Italian schedule of Psychopathological Functioning Levels – Rating Scale (PFL-RS) was obtained and checked for semantic comprehension and then administered gathering preliminary data.ConclusionsPsychopathological dysfunctions underlying mental disorders have been recognized in the present study with the PFL-RS. This instrument seems promising to inform in a specific way treatments strategies and goals, specifically concerning psychotherapy. Notwithstanding, further research is needed in order to confirm validity, sensitivity and reliability of this instrument.

Alterations in Prefrontal Cortical Circuitry and Cognitive Dysfunction in Schizophrenia.

Deficits in working memory, a core disturbance of schizophrenia, appear to emerge from an impaired capacity to generate gamma oscillations in the neural networks of the prefrontal cortex. Cortical gamma oscillations arise principally in layer 3 where strong inhibitory inputs from the parvalbumin (PV) basket cell class of GABA neurons synchronize the activity of local groups of pyramidal neurons which in turn send excitatory inputs to PV basket cells. Schizophrenia is associated with deficits in markers of excitatory activity of layer 3 pyramidal cells and multiple pre- and postsynaptic abnormalities consistent with weaker inhibitory inputs to pyramidal cells from PV basket cells. These findings suggest that prefrontal cortical dysfunction in schizophrenia results from an “upstream” deficit in pyramidal cell excitation and that inhibition from PV basket cells is downregulated to compensate for this low network activity. This compensation is thought to rebalance cortical excitation and inhibition, but at a level insufficient to generate the gamma oscillation power in prefrontal neural networks required for optimal working memory performance.