ABSTRACT In this research, a new sensor was designed that exhibits high biological and thermal sensitivities. It is suitable for use as a biosensor, a thermal sensor, or both simultaneously. This nanostructure sensor is based on two non-identical copper rings, which are dependent on two dielectric environments, and has been optimised to enhance sensitivity. To control and increase the sensitivity of the designed metamaterial, the E7 liquid crystal was used, which has a temperature-dependent refractive index. The optimised data indicate that the highest sensitivity for the structural parameters; R, dr and d are 70, 43 and 30 nm, respectively. This nanostructure demonstrates a refractive index sensitivity of 500 nm/RIU and a very high temperature sensitivity of 11 nm/K in the wavelength range of 500–1000 nanometres and a temperature range of 290–330 Kelvin. The second peak has the highest sensitivity to the refractive index and the third peak has the highest sensitivity to temperature. The high temperature sensitivity reported is at a 90-degree orientation angle of the liquid crystal director. Therefore, the simulation and optimisation of this ultra-thin film indicates that it can be suitable for use as a high-quality bio-thermal sensor with a high figure of merit.