Background Although previous studies have highlighted the detrimental impact of sexism on other substance use and use-related outcomes among women, limited empirical attention has tested whether sexism is related to worse cannabis-related outcomes. It may be that women use cannabis to cope with negative affect related to experiencing sexism, and thus continue to use despite cannabis-related problems. However, no known studies have tested this hypothesis. Objectives We tested whether experiencing sexism was related to more cannabis use-related problems via the serial effects of negative affect (anxiety, depression) and coping-motivated cannabis use among 304 women who endorsed current (past three-month) cannabis use. Results Sexism was significantly positively related to coping-motivated-cannabis use and use-related problems. Sexism was indirectly related to cannabis problems via the serial effects of anxiety and coping motives and via the serial effects of depression and coping motives, but not via the indirect effects of anxiety, depression, or coping motives alone. Conclusions Findings suggest that women may use cannabis to cope with sexism-related negative affect, and thus continue to use despite experiencing greater cannabis problems. These results may have important clinical implications and emphasize the need for greater gender-responsive approaches in prevention and intervention efforts for women who use cannabis.
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