Coordination Capacity Research Articles

Devolved education policymaking in the UK: a four jurisdictions perspective

This short paper addresses the pace, ebb and flow of policy moves in education in the context of the continuing process of political and administrative devolution in the UK. The concept of policy making is explicitly approached as a process. Given the potentially broad policy arena, the focus is necessarily selective and restricted to policy for schools. The paper identifies areas of policy mobility and immobility drawing on the concepts of ‘policy mortality’ ‘drift’, ‘paralysis’ and ‘reversal’ (Gunter and Courtney, 2023; Béland et al., 2016; Gallagher, 2021). This brief review aims to show how policy possibilities in the four closely-linked jurisdictions are influenced by varying degrees of coordinative capacity, ministerial influence, policy styles and advisory systems, and the power and influence of potential veto players. Critical attention is afforded to the enactment of the principle of subsidiarity in relation to education change. Rather than progressive linear advance, the paper notes three alternate moves: continuing tension between central control and local autonomy in education governance in Wales and Scotland, paralysing policy drift from political division in Northern Ireland, and rapid acceleration of market-oriented change in England.

Epidemic preparedness and response capacity against infectious disease outbreaks in 186 countries, 2018–2022

ObjectivesDisruptive public health risks and events, including infectious disease outbreaks, are inevitable, but their effects can be mitigated by investing in prevention and preparedness. We assessed the epidemic preparedness and response capacities of health systems in 186 countries from 2018 to 2022.MethodsWe utilized data from the International Health Regulations (IHR) State Party Self-Assessment Annual Reporting (SPAR) submissions to assess health systems’ IHR capacities to (1) prevent, (2) detect, (3) respond, (4) enable resources and coordinate, and (5) ensure operational readiness from 2018 to 2022. We categorized the IHR capacities into five levels, with level 1 denoting the lowest level of national capacity and level 5 the highest. We calculated each index’s capacity level as the arithmetic mean of its related indicators and analyzed changes over time using the Mann–Kendall nonparametric trend test.ResultsSPAR reporting marginally improved from 92.9% (182 of 196 countries) in 2018 to 94.9% (186 of 196 countries) in 2022, with considerable improvement in all five capacity domains over this period: prevention (58.4 in 2018 to 66.5 in 2022), detection (74.7 to 78.3), response (56.5 to 67.8), enabling resources and coordination (63.0 to 68.3), and ensuring operational readiness (62.8 to 69.9). From the 2022 submissions, 116 (62%) countries reported functional (Level 4 or 5) prevention capacity, 162 (87%) had functional detection capacity, 118 (63%) had functional response capacity, 121 (65%) had functional enabling resources and coordination capacity, and 133 (72%) had functional operational readiness against public health events. Across all the indexes, the WHO African Region reported the fewest countries with functional capacity in these domains.ConclusionsThere was an overall increase in functional capacity across all five domains at both global and regional levels; and a high percentage of countries achieved functional capacity across all domains in 2022. However, a significant number of countries, particularly in the Global South, have yet to achieve functional competence in these capacities, leaving the world vulnerable to the persistent risk of epidemics and infectious biohazards. Strengthening IHR competencies through local, national, and global engagements must be urgently prioritized to achieve global health security against infectious diseases.

An Intramolecular Bis(Amido)Phosphine‐Stabilised Phosphinidene: Synthesis and CuCl Coordination

Extending the available intramolecularly‐stabilised phosphinidene ligands, we report a novel naphthalene supported system derived from readily available starting materials. Specifically, 1,8‐bis(diaminophosphino)naphthalene, naphth‐1,8‐{P(NEt2)2}2 (1), reacts with ethereal HCl to form the mixed diphosphine naphth‐1‐(PCl2)‐8‐{P(NEt2)2} 2 as a phosphoranide Zwitterion, which is readily reduced with elemental Mg in forming the target intramolecularly‐stabilised phosphinidene 3. The electronic nature of this species is explored through computational DFT, NBO, and TD‐DFT analyses, indicating a high electron density at the PI, which delocalizes across the naphthalene ring lending this deep red‐purple compound its colour. The coordination capacity of 3 is demonstrated through its reaction with excess CuCl, which surprisingly leads to exclusive formation of the 2:1 complex of 3 to Cu, giving the initial insights into the coordination chemistry of this novel ligand.

THE STUDY OF THE SPATIO-TEMPORAL ORIENTATION ABILITY OF STUDENTS PRACTICING SPORTS DANCE AT THE UNIVERSITY OF BUCHAREST

Background. Sports dance is characterized by a complex coordination, its most important components being, in our opinion: the segmental, general and multisegmental coordination; the capacity of kinesthetic differentiation; the static and dynamic coordination, the ability of spatio-temporal orientation; the ability to perceive and reproduce musical rhythm and tempo. Sports dance lessons are held in the University of Bucharest with students who opt for this discipline without having a prior selection. In sports dance, all the motor capacities are involved in different weights, but we proposed for this study to analyze from the perspective of the coordinative capacities, the spatio-temporal orientation. Objectives. The subjects in this study are students in the 1st and 2nd years, belonging to different faculties of the university and they were divided into the control and the experimental groups. Both groups worked to test a salsa choreography during the lessons. In the experimental group, the choreography was practiced facing points 1,3,5,7, and in the control group, the choreography was practiced facing point 1. The test was realized with reference to point 5. Methods. The working methods used are observation, testing method, statistical-mathematical and graphical interpretation method. Results. The results were significantly better in the experimental group compared to the control group. The subjects in the experimental group were able to orient themselves better in space and time in a percentage of 85% and in the control group the percentage was about 30% Conclusion. We believe that the orientation in space and time can be improved by simple means, prepared by the teacher in the sports discipline, the methodological work being implemented according to the groups.

Analysis of Regulatory Quality, Interagency Coordination, and Institutional Capacity on the Effectiveness of Public Services in Jakarta

This study examines the impact of regulatory quality, interagency coordination, and institutional capacity on the effectiveness of public services in Jakarta. Using a quantitative approach, data were collected from 100 respondents working in Jakarta’s public service sector. A Likert scale (1-5) questionnaire was employed to measure perceptions of the governance factors and service effectiveness, and the data were analyzed using Structural Equation Modeling-Partial Least Squares (SEM-PLS 3). The results reveal that all three governance factors—regulatory quality, interagency coordination, and institutional capacity—significantly and positively affect public service effectiveness, with institutional capacity having the strongest influence. The findings highlight the importance of governance reforms aimed at improving regulatory frameworks, enhancing interagency collaboration, and strengthening institutional capacity to ensure efficient public service delivery in Jakarta. This research provides key insights for policymakers to optimize governance systems for better public sector performance.

The potential benefits of regionally differentiated Covid-19 policies

Abstract While many countries introduced regionally differentiated policy measures for Covid-19, such as social distancing, lockdowns and working from home, the Netherlands opted for national binding policies already in the early stages of the pandemic. Using detailed data on the impacts of the first lockdown on consumers’ and producers’ behaviour, as well as scenarios varying on intensities of measures, we show that regional differentiated policies could have mitigated a significant part of the losses in production resulting from the Covid-19 measures. The self-organizing capacities of the regional economic system fuel this mitigation, with regional variation in policies being a sufficient precondition. Coordinated and explicitly planned policies aimed at supporting specific region-industry clusters may further mitigate impacts but are difficult to achieve due to the number (wickedness) of possible policy options. It would also assume full information and coordination capacities in governance that are not present. The results of our analysis hold important implications for future mitigation strategies for pandemics or other regional shocks.

Coordination Tuning of FeNi-HMT Frameworks Derived Effective Hybrid Catalysts for Water Oxidation.

FeNi-based hybrid materials are promising oxygen evolution reaction (OER) catalysts for water electrolysis in hydrogen generation. In this work, the coordination tuning of FeNi-HMT frameworks was achieved by simply changing the Fe/Ni ratios using hexamethylenetetramine (HMT) as an organic ligand, and the derived hybrid FeNi catalysts with varied compositions were probed for OER. Incorporating varying amounts of Fe3+ by adjusting the Ni/Fe ratio results in different metal-organic framework (MOF) structures, and higher Fe feed leads to the formation of amorphous structures due to the coordination structure destruction from the weaker coordination capacity of Fe3+ compared to Ni2+ combining with the tertiary amine ligand. Among them, the FeNi-HMT (with the Fe/Ni molar ratio of 1/1) derived catalyst, consisting of Fe0.36Ni0.64 alloy/Ni0.4Fe2.6O4 spinel oxide heterostructures supported by graphitized carbon matrix, exhibits the highest OER performance. The unique structure facilitates significant electron transfer at the alloy/spinel interface due to the large work function difference between each phase. This strong electronic effect downshifts the d-band center of the catalyst and optimizes the binding energies to the crucial oxygenated intermediates, thereby promoting the OER kinetics. This work highlights the importance of the coordination tuning of FeNi-HMT frameworks for highly efficient catalyst development.

Venezuelan migration in South America: coordinating regional responses to a transboundary reception crisis

ABSTRACT Migration is a policy field that is prone to transboundary reception crises due to the weakness of inter-state cooperation and global governance institutions’ incomplete architecture. Research suggests that the regional level is a more realistic policy arena where cooperation to coordinate responses may emerge. Our paper aims to explore and analyse the conditions under which coordinated responses to transboundary reception crises are present in (or absent from) regional migration governance. Below we develop an analytical model based on crisis management scholarship to examine coordination capacities at the regional level. Empirically, we comparatively assess the ability of old regional institutions (i.e. MERCOSUR, the South American Conference of Migration) and new ones (i.e. the Quito Process) to orchestrate responses to receive Venezuelan migrants across the region. Our findings reveal that coordination capacities remain scarce as regional institutions navigate from non-crisis to crisis times. This is largely because there was a shift in policy framing regarding immigrant reception, to self-interested national, regional and extra-regional actors promoting new regional mechanisms, and to the increasing complexity of regional migration governance as (new) competing actors emerge. Our conceptual and empirical contributions provide insights into how governance processes in South America have changed, particularly during crises.

Research on Carbon Unlocking Pathway in Sichuan Province under the Background of “Dual Carbon”

In the progress of realizing green development and transformation, many difficulties exist in Sichuan Province, such as low level of ‘carbon unlocking’, unbalanced development of ‘carbon unlocking’ among regions, and insufficient systematic coordination and governance capacity. So, this paper from technology, system and industry and other aspects, based on the ‘double carbon’ goal of Sichuan Province, to construct the ‘carbon unlocking’ mechanism with the characteristics of Sichuan Province, to create a ‘multi-body-multi-path’ synergistic mechanism. This will help to promote green technology innovation and help to achieve the ‘dual-carbon’ goal on schedule.

The chromatin remodeler SMARCA5 binds to d-block metal supports: Characterization of affinities by IMAC chromatography and QM analysis.

The ISWI family protein SMARCA5 contains the ATP-binding pocket that coordinates the catalytic Mg2+ ion and water molecules for ATP hydrolysis. In this study, we demonstrate that SMARCA5 can also possess an alternative metal-binding ability. First, we isolated SMARCA5 on the cobalt column (IMAC) to near homogeneity. Examination of the interactions of SMARCA5 with metal-chelating supports showed that, apart from Co2+, it binds to Cu2+, Zn2+ and Ni2+. The efficiency of the binding to the last-listed metal was influenced by the chelating ligand, resulting in a strong preference for Ni-NTA over the Ni-CM-Asp equivalent. To gain insight in the preferential affinity for the Ni-NTA ligand, QM calculations were performed on model systems and metal-ligand complexes with a limited protein fragment of SMARCA5 containing the double-histidine (dHis) motif. The calculations correlated the observed affinity with the relative stability of the d-block metals to tetradentate ligand coordination over tridentate, as well as their overall octahedral coordination capacity. Likewise, binding free energies derived from model imidazole complexes mirrored the observed Ni-NTA/Ni-CM-Asp preferential affinity. Finally, similar calculations on complexes with a SMARCA5 peptide fragment derived from the AlphaFold structural prediction, captured almost accurately the expected relative stability of the TM complexes, and produced a large energetic separation (~10 kcal∙mol-1) between Ni-NTA and Ni-CM-Asp in favour of the former.

Molecular Design Engineering Regulates the Ground-State Passivation Ability of Benzophenone Derivatives in Perovskite Solar Cells.

Intramolecular hydrogen bonding (H-bonding) involved in the excited-state proton transfer (ESPT) process results in benzophenone derivatives (BPDs) with an excellent ability to passivate defects. However, the BPDs are in a continuing dynamic transition process between the ground state and the excited state under light radiation conditions. The ground-state BPDs may lose their ability to passivate defects, resulting in an increased defect density of the perovskite. Therefore, enhancing the passivation ability of the ground-state BPDs can help to achieve the full passivation ability of their ground state to excited state. Herein, we have researched the various BPDs by density functional theory and found that intramolecular H-bonding can weaken the passivation ability of ground-state BPDs, but intramolecular H-bonding is indispensable in the ESPT process. To address the issue, we investigated the influence of electron-donor properties and dipole moments of hydroxyl (-OH), methoxy (-OCH3), and n-octyloxy (-OC8H17) groups in BPD molecules on their coordination capacity through molecular design engineering. Ultimately, 2-hydroxy-4-n-octyloxy-benzophenone (UV5) with strong electron-donor n-octyloxy (-OC8H17) and elongated carbon-chain structure was selected as an additive, which enhances the passivate defect capability in both the ground and excited states. As a result, the UV5-based champion device achieved a power conversion efficiency (PCE) of 24.46% and remained at 75% of the initial PCE with exposure to UV light. This work focuses on the defect passivation capability of ground-state BPDs for the first time and opens a new concept for applying BPDs in PSCs.

Deformation behavior of PST-TiAl bicrystals at 800 °C

PST (polysynthetic twinned) TiAl crystal exhibits excellent mechanical properties, and thus, it has been regarded as a critical candidate for turbine blades in the aero-engine industry. For the first time, the deformation behavior of PST-TiAl bicrystals with two different α2/γ lamellar orientations was studied in this work. Ti-46Al-6Nb bicrystals were cut from directionally solidified ingots, and three bicrystals of B1 (10°–14°), B2 (10°–19°), B3 (6°–75°) together with a single crystal of S1 (3°) were stretched at 800 °C. Then, the deformation behaviors, including fracture morphology, crack propagation, and deformation mechanism, were analyzed. Interestingly, these bicrystals show good high-temperature tensile performance, and their deformation behaviors seem to be very anisotropic. The findings indicate that the misorientation disparity in bicrystals primarily determines their deformation coordination capacity and corresponding mechanical performance. Subsequently, the difference in deformation orientation between the two lamellae significantly controls fracture behavior and deformation compatibility. High slip potential and abundant variant choices in γ phases are supposed to be beneficial for deformation capacity improvement. Meanwhile, the deformation potential of ordinary dislocation and superlattice dislocation slip systems in the α2 phase was also examined. Results show that the disparity in dislocation motion ability between γ variants gradually amplifies the advantages of the easy-mode phase in deformation through strain coordination, while mitigating the disadvantages associated with the difficult-mode phase. During further deformation, the relatively low bicrystal misorientation and small deformation capacity differences between the two lamellae determine high deformation coordination and improved performance. Overall, our work reveals that bicrystal deformation initiates at the relatively softer lamellae and proceeds to the harder lamellae, and its final comprehensive performance is determined by the deformation coordination capacity between the two lamellae.

Transforming contaminant ligands at water–solid interfaces via trivalent metal coordination

In environmental matrices, the migration and distribution of contaminants at water–solid interfaces play a crucial role in their capture or dissemination. Scientists working in environmental remediation and wastewater treatment are increasingly aware of metal–contaminant coordination; however, interfacial behaviors remain underexplored. Here, we show that trivalent metal ions (e.g. Al3+ and Fe3+) mediate the migration of pollutant ligands (e.g. tetracycline (TC) and ofloxacin) to the organic solid interface. In the absence of Al3+, humic acid (HA) colloids (50 mg/L) capture 26.1 % of the TC in water (initial concentration: 10 mg/L) via weak intermolecular interactions (binding energy: −5.71 kcal/mol). Adding Al3+ (2.5 mg/L) significantly enhances the binding of TC to an impressive 94.2 % via Al3+ mediated coordination (binding energy: −84.89 kcal/mol). The significant increase in binding energy results in superior interfacial immobilization. However, excess free Al3+ competes for TC binding via direct binary coordination, as confirmed based on the unique fluorescence of Al3+–TC complexes. Density functional theory calculations reveal the intricate process of HA–Al3+ binding via carboxyl and phenolic hydroxyl sites. The HA–Al3+ flocs then leverage the remaining coordination capacity of Al3+ to chelate with TC. As well as providing insights into the pivotal role of metal ion on the self-purification of natural water bodies, our findings on the interfacial behavior of metal–contaminant coordination will propel coagulation technology to the capture of microscale pollutants.

Benefits of Table Tennis for Children and Adolescents: A Narrative Review.

This study aims to review the scientific evidence regarding the effects of table tennis practice on children and adolescents. Studies were searched in three electronic databases (PubMed, Scopus, and SportDiscus) from their inception up to May 2024. The methodological quality of the included studies was assessed using the 10-point Physiotherapy Evidence Database (PEDro) and Methodological Index for Non-Randomized Studies (MINORS). A total of twelve studies were examined, with interventions involving children with intellectual disabilities, ADHD, DCD, ASD, and typically developing children. A variety of training programs were assessed over durations ranging from 6 weeks to 1 year in the studies included. Table tennis was shown to positively impact various domains, including executive function, motor skills, visual perception, graphomotor function, gross motor skills, coordination capacity, behavioral inhibition, and social behavior. Nonetheless, it is imperative to expand the number of studies on children and adolescents with diverse conditions to more comprehensively evaluate the benefits of table tennis for each specific condition.

Highly active carbon dots based nanozyme for enhanced cholesterol detection and antibacterial activity

Recently, nanozyme have emerged as promising direction for chemical sensing, biomedicine, environmental monitoring. However, the novel nanozyme with better catalytic activity and specificity is urgently required realized great application performance. Herein, Fe doped carbon dots (Cit-Fe-CDs) with peroxidase (POD) like activity are synthesized by hydrothermal treatment of ferric ammonium citrate. Due to the strong coordination capacity between Fe(Ⅲ) and citric acid, the Cit-Fe-CDs exhibited excellent POD activity. Namely the catalytic constant (Kcat) and catalytic efficiency (Kcat /Km) are determined, which are much higher than previous work. Highly effective colorimetric detection of cholesterol in human serum have been realized by the POD activity of Cit-Fe-CDs. Under optimal conditions, the linear range is determined to be 10 and 100 μM with a detection limit (LOD) of 0.061 μM. The LOD is two orders of magnitude lower than most of the existing analysis method. Since substantial amounts of free radicals are involved in the catalytic cycle of POD activity, excellent antibacterial activity against Methicillin-Resistant Staphylococcus aureus (MRSA) should be realized by Cit-Fe-CDs. Notably, about 99.999 % inactivation rate towards MRSA can be realized by 125 μg/mL Cit-Fe-CDs, which showcases promising prospects in addressing bacterial resistance concerns. And we have confirmed that the antibacterials mechanism is related to the generation of hydroxyl radicals by the excellent POD activity of Cit-Fe-CDs.

Using Networks to Engage Community Health Workers in Participatory Action Research in High-Poverty Rural Communities

Previous research shows that health and social service networks can improve service and system coordination and increase capacity to respond to critical social determinants and health needs. This article describes strategies, methods and tools used to engage community health workers (CHWs) in the development and implementation of initiatives associated with the COVID-19 Response Network, a collaborative between academicians, regional clinical and social service administrators, practitioners, and regional community and faith-based organizations. Network initiatives included community-based participatory action (CBPT) research approaches to respond to social determinants and health needs in rural Missouri during the COVID-19 pandemic. Mixed methods were used to ascertain the impact of these approaches, including surveys and key informant interviews with Network members. Survey responses showed the network to be a venue where decision-making was democratic, CHW voices were valued, and network members trusted each other. Analysis revealed two themes: How the Network improved CHWs’ capacity to respond to the COVID-19 pandemic (“Getting a seat at the table”) and how trust is built through relational exchange processes (“They need to believe in you”). The results clarify practical approaches to participatory action research for bringing together and maximizing the contributions of a combination of CHWs, clinicians, and administrators in clinical and social services stakeholders in the community in leadership positions to improve health outcomes. Implications for academic researchers and academic institutions are discussed.

Nucleobase-modulated copper nanomaterials with laccase-like activity for high-performance degradation and detection of phenolic pollutants

Laccases are the most commonly used agents for the treatment of phenolic pollutants. To address the instability and high cost of natural laccases, we investigated nucleobase-modulated copper nanomaterial with laccase-like activity. Various nucleobases, including adenine, guanine, cytosine, and thymine, were investigated as templates for Cu2+ reduction and copper nanomaterials formation due to their coordination capacity. By comparing structure and catalytic activity, the cytosine-mediated copper nanomaterial (C–Cu) had the best laccase-like activity and other nucleobase-templated copper nanomaterials exhibited low catalytic activity under the same conditions. The mechanism of nucleobase regulation of the catalytic activity of copper nanomaterials was further analyzed using X-ray photoelectron spectroscopy and density functional theory. The possible catalytic mechanisms of C–Cu, including substrate adsorption, substrate oxidation, oxygen binding, and oxygen reduction, were proposed. Remarkably, nucleobase-modulated copper nanozymes showed high stability and catalytic oxidation performance at various pH values, temperatures, long-term storage, and high salinity. In combination with electrochemical techniques, a portable electrochemical sensor for measuring phenolic pollutants was developed. This novel sensor exhibited a good linear response to catechol (10–1000 μM) with a limit of detection of 1.8 μM and excellent selectivity and anti-interference ability. This study provides not only a new strategy for the regulation of the laccase-like activity of copper nanomaterials but also a novel tool for the effective removal and low-cost detection of phenolic pollutants.

Leaf Trait Variations and Ecological Adaptation Mechanisms of Populus euphratica at Different Developmental Stages and Canopy Heights

The ability of plants to alter specific combinations of leaf traits during development and in response to abiotic stress is crucial for their success and survival. While there are numerous studies on the variation of leaf traits within the canopies of Populus species, the application of network analysis to understand the variation and combinations of these traits across different growth stages is rare. The leaves of Populus euphratica, a dominant species in arid regions, exhibit notable morphological variations at different developmental stages and canopy heights in response to water scarcity and climate change. In this study, 34 leaf traits (morphological, chemical, photosynthetic, and hydraulic) and their roles in drought adaptation were investigated in 60 Populus euphratica plants at five developmental stages and five canopy heights using leaf trait network (LTN) analysis. The aim was to analyze adaptive strategies to arid environments at different developmental stages and canopy heights through the interdependence of leaf traits. The results showed that the internal coordination capacity of leaf trait networks decreased and then increased with each developmental stage, while the functional modules of leaf trait networks were loosely connected and aggregated with the increase in tree diameter at breast height. With increasing canopy height, the coordination linkage’s ability between leaf traits showed an increasing then decreasing trend, and the traits of the leaves in the canopy at 6 m were more closely connected, less modular, and simpler in topology compared with those in the other layers. Leaves form functional modules by coordinating specific traits that promote growth and resist drought. Leaf photosynthesis, water transport, and nutrient traits were central to different developmental stages, whereas leaf morphology, nutrient metabolism, and drought-resistance-related traits were central to the canopy height. Leaf morphology and osmoregulatory traits play key roles in leaf trait network regulation, including leaf length and width, leaf shape index, soluble sugars, and soluble proteins, which are important “intermediary traits” in the Populus euphratica leaf network. Further analysis revealed that structural traits were important at different developmental stages and canopy heights. When resources are limited, the leaf preferentially maintains a stable connection between structural traits to enhance photosynthesis, and these traits and their combinations might confer drought resistance. During the rapid development stage, the connection between chemical traits becomes important, and the leaf grows by rapidly accumulating nutrients. In summary, this study provides new perspectives and insights into the drought adaptation strategies of P. euphratica at different developmental stages and canopy heights by analyzing leaf trait networks.

Current Status and Optimization Strategies of Physical Fitness Training for the Elderly in the Digital Age

With the advent of digital technology and the improvement of people's living standards, the decline of physical fitness among the elderly has become an urgent problem to be addressed. Physical fitness typically includes abilities such as strength, flexibility, agility, speed, coordination, and other capacities, which not only play an important role in athletic performance but are also crucial for the daily lives of the elderly. This study investigates the current state of physical fitness training for the elderly in the digital age and aims to explore the optimization of scientific approaches and the role of digital products in improving training strategies. Through literature research and logical analysis, this paper collects and analyzes related data to further explore the status of the elderly's physical fitness training and their training strategies under the empowerment of science and technology. The investigation of related materials reveals that currently, the elderly have a low awareness of scientific training, especially regarding the concept of scientific training. Moreover, the main activities engaged in by the elderly for physical fitness training are fitness Qigong, square dancing, and other similar projects, which indicates that the elderly tend to engage in aerobic exercises and meet their psychological needs through group activities. By integrating current large-scale digital technologies and scientific products, the paper proposes optimization strategies for the elderly's training. These include utilizing robot learning and smart devices to collect information through smart devices, analyzing the collected data using large models to develop individualized training programs to improve efficiency. Additionally, wearable devices like smart bracelets, Firstbeat heart rate monitoring systems, and Gymaware monitoring systems can collect data on the body, reflecting physical conditions and further reducing the risk of injury. VR virtual interactive technology can be used to train cognitive responses, and VBT technology can make exercises more efficient, reducing the risk of injury. As technology continues to advance and awareness increases, achieving a healthy China is within reach.

Glutathione-Scavenging Celastrol-Cu Nanoparticles Induce Self-Amplified Cuproptosis for Augmented Cancer Immunotherapy.

Cuproptosis is a novel copper-dependent programmed cell death. The efficacy of cuproptosis is highly dependent on intracellular copper accumulation and counteracted by a high level of glutathione (GSH) in tumor cells. Here, this work develops a self-amplified cuproptosis nanoparticles (Cel-Cu NP) using celastrol (Cel), a natural product isolated from medical plant. In Cel-Cu NP, Cel serves as a versatile copper ionophore, exhibiting an ideal coordination capacity toward copper ions without compromising the cuproptosis induction. Notably, Cel can simultaneously scavenge GSH content to amplify cuproptosis. Moreover, this self-amplified cuproptosis further activates immunogenic cell death (ICD) to elicit robust immune response. Combining with immune checkpoint blockade, Cel-Cu NP effectively eradicates metastatic tumors in a mouse lung metastasis model. This study provides an efficient nanomedicine by inducing self-amplified cuproptosis for robust immunotherapy.