Coordination Action Research Articles

Research and Innovation Supporting the Farm to Fork Strategy of the European Commission

The EU Think Tank(as part of theFIT4FOOD2030 Coordination and Support Action) strongly supports the development of the Farm to Fork Strategy as a key component of the European Green Deal, recognising the need to transform the food system as a whole. This policy brief calls for innovative approaches tothe Farm to Fork Strategy to provide practical answersto two central questions: i) how can a shift towards healthier and more sustainable diets be facilitated?;and ii) how can all actors in the food system be empoweredto adopt more sustainable practices? Answers tothese questions raise the need fornew transdisciplinary, multi-actor and participatory Research and Innovation (R&I)approachesthat enable citizens,farmers, fishers, food processors, distributors, retailers and consumers to contribute to more coherent, cross policy-sector food initiatives that leverage on European food systems to deliver a balance of public goods (including food security and environmental integrity).

The coordinate actions of calcineurin and Hog1 mediate the stress response through multiple nodes of the cell cycle network.

Upon exposure to environmental stressors, cells transiently arrest the cell cycle while they adapt and restore homeostasis. A challenge for all cells is to distinguish between stress signals and coordinate the appropriate adaptive response with cell cycle arrest. Here we investigate the role of the phosphatase calcineurin (CN) in the stress response and demonstrate that CN activates the Hog1/p38 pathway in both yeast and human cells. In yeast, the MAPK Hog1 is transiently activated in response to several well-studied osmostressors. We show that when a stressor simultaneously activates CN and Hog1, CN disrupts Hog1-stimulated negative feedback to prolong Hog1 activation and the period of cell cycle arrest. Regulation of Hog1 by CN also contributes to inactivation of multiple cell cycle-regulatory transcription factors (TFs) and the decreased expression of cell cycle-regulated genes. CN-dependent downregulation of G1/S genes is dependent upon Hog1 activation, whereas CN inactivates G2/M TFs through a combination of Hog1-dependent and -independent mechanisms. These findings demonstrate that CN and Hog1 act in a coordinated manner to inhibit multiple nodes of the cell cycle-regulatory network. Our results suggest that crosstalk between CN and stress-activated MAPKs helps cells tailor their adaptive responses to specific stressors.

Positive and Negative Sequence Voltage Compensation Using Statcom at Wind Farm

The study of shunt connected FACTS devices is a connected field with the problem of positive and negative voltage compensation and better mitigation of instability problems in today’s world. In this project, the shunt operation of FACTS controller is studied, the STATCOM, and how it helps in the better utilization of a network operating under normal conditions. First literature review of many papers related to FACTS and STATCOM is carried out, along with positive and negative voltage compensation. The study of STATCOM and its principles of operation and control, including phase angle control and PWM techniques, are carried out. The study of shunt connected devices is a shunt connected field positive and negative sequence voltage compensation and better mitigation of transmission related world. Statcom is a FACTS device whose capacitive or inductive current can be controlled independent of system ac voltage. Whenever an asymmetrical fault occurs in a system, power loss and voltage instability can occur in that system. So to increase the life time of generator drives and to reduce that voltage instability, Statcom can be used. Statcom can compensate positive sequence voltage for improving voltage stability and for reducing torque ripples negative sequence voltage has to be compensated. Statcom can perform co-ordinated action regarding positive and negative voltage compensation. In this thesis, review of positive and negative voltage compensation and results for positive sequence voltage compensation and negative voltage compensation using MATLAB simulation is shown.

Plakophilin 3 phosphorylation by ribosomal S6 kinases supports desmosome assembly.

Desmosome remodeling is crucial for epidermal regeneration, differentiation and wound healing. It is mediated by adapting the composition, and by post-translational modifications, of constituent proteins. We have previously demonstrated in mouse suprabasal keratinocytes that plakophilin (PKP) 1 mediates strong adhesion, which is negatively regulated by insulin-like growth factor 1 (IGF1) signaling. The importance of PKP3 for epidermal adhesion is incompletely understood. Here, we identify a major role of epidermal growth factor (EGF), but not IGF1, signaling in PKP3 recruitment to the plasma membrane to facilitate desmosome assembly. We find that ribosomal S6 kinases (RSKs) associate with and phosphorylate PKP3, which promotes PKP3 association with desmosomes downstream of the EGF receptor. Knockdown of RSKs as well as mutation of an RSK phosphorylation site in PKP3 interfered with desmosome formation, maturation and adhesion. Our findings implicate a coordinate action of distinct growth factors in the control of adhesive properties of desmosomes through modulation of PKPs in a context-dependent manner.

Valuing intra-day coordination of electric power and natural gas system operations

Increasing renewable energy penetrations and low natural gas prices have increased the reliance of U.S. power systems on natural gas-fired generation. Increased reliance has sparked concerns over and resulted in natural gas deliverability constraints. To mitigate these constraints, research and regulatory reform have tried to improve coordination between power and gas systems. The U.S. Federal Energy Regulatory Commission (FERC) issued Order 809 in 2015 to improve day-ahead and intra-day coordination of power and gas systems. Given little research on intra-day coordination and FERC's recent action, we quantify the value of improved intra-day coordination between gas and electric power systems. To do so, we co-simulate coordinated day-ahead, intra-day, and real-time operations of an interconnected power and natural gas test system using a dynamic natural gas simulation model and a power system optimization model. We find intra-day coordination reduces total power system production costs and natural gas deliverability constraints, yielding cost and reliability benefits. Sensitivity analysis indicates improved intra-day renewable energy forecasts and higher renewable energy capacities increase intra-day coordination benefits for gas network congestion. Our results indicate FERC Order 809 and other policies aimed at enhancing intra-day coordination between power and gas systems will likely yield cost and reliability benefits.

Corporate Disclosure as a Tacit Coordination Mechanism: Evidence from Cartel Enforcement Regulations

ABSTRACTWe empirically study how collusion in product markets affects firms' financial disclosure strategies. We find that after a rise in cartel enforcement, U.S. firms start sharing more detailed information in their financial disclosure about their customers, contracts, and products. This new information potentially benefits peers by helping to tacitly coordinate actions in product markets. Indeed, changes in disclosure are associated with higher future profitability. Our results highlight the potential conflict between securities and antitrust regulations.

Show Them or Involve Them? Two Organizations of Embodied Instruction

ABSTRACTWhen instructors train people in physical actions, they often demonstrate what they want the learner to do. When basketball coaches use reenactments in training sessions, we find that they organize them in two ways: (a) as a performance treating the players as passive learners (what we call “demonstration as performance”); and (b) as active co-ordinated action among the players as involved coparticipants (what we call “demonstration as enactment”). It is through this ordering of cooperative organizations that, we argue, an enactment is achieved that is maximally coherent and followable as instructions for the observing audience of learners. Data are in Australian English.

The CBL-CIPK Calcium Signaling Network: Unified Paradigm from 20 Years of Discoveries.

Calcium (Ca2+) serves as an essential nutrient as well as a signaling agent in all eukaryotes. In plants, calcineurin B-like proteins (CBLs) are a unique group of Ca2+ sensors that decode Ca2+ signals by activating a family of plant-specific protein kinases known as CBL-interacting protein kinases (CIPKs). Interactions between CBLs and CIPKs constitute a signaling network that enables information integration and physiological coordination in response to a variety of extracellular cues such as nutrient deprivation and abiotic stresses. Studies in the past two decades have established a unified paradigm that illustrates the functions of CBL-CIPK complexes in controlling membrane transport through targeting transporters and channels in the plasma membrane and tonoplast.

Blockchains and Constitutional Catallaxy

The proposition that constitutional rules serve as permanent, fixed points of interaction are challenged by observations of contestable rule amendment and the emergence of de facto authority. This observation not only applies to conventional political constitutions, but to the fundamental rules which govern interactions by numerous people using new forms of technology. Blockchain technology aims to coordinate action in a world of incomplete information and opportunism, but the governance arrangements in blockchain protocols remain far from settled. Drawing upon recent theoretical developments regarding constitutional change, we interpret changes to the fundamental working rules of blockchain protocols as central to the adaptive, emergent nature of activity within this technological space. We apply this concept of “constitutional catallaxy” to selected blockchain platform case studies, illustrating the dynamism inherent in establishing protocols within the blockchain. Blockchain coordination changes and adapts not only to the technological limitations of the available protocols, but to mutual expectations and influence of interacting stakeholders.

Integrative data modeling from lung and lymphatic cancer predicts functional roles for miR-34a and miR-16 in cell fate regulation

MiR-34a and miR-16 coordinately control cell cycle checkpoint in non-small cell lung cancer (NSCLC) cells. In cutaneous T-cell lymphoma (CTCL) cells miR-16 regulates a switch between apoptosis and senescence, however the role of miR-34a in this process is unclear. Both miRNAs share many common targets and experimental evidences suggest that they synergistically control the cell-fate regulation of NSCLC. In this work we investigate whether the coordinate action between miR-34a and miR-16 can explain experimental results in multiple cell lines of NSCLC and CTCL. For that we propose a Boolean model of the G1/S checkpoint regulation contemplating the regulatory influences of both miRNAs. Model validation was performed by comparisons with experimental information from the following cell lines: A549, H460, H1299, MyLa and MJ presenting excellent agreement. The model integrates in a single logical framework the mechanisms responsible for cell fate decision in NSCLC and CTCL cells. From the model analysis we suggest that miR-34a is the main controller of miR-16 activity in these cells. The model also allows to investigate perturbations of single or more molecules with the purpose to intervene in cell fate mechanisms of NSCLC and CTCL cells.

Organizar la lucha de masas en tiempos del ’tercer período’: la Revista Comunista del Secretariado Sudamericano de la Comintern (1930-1932)

Creado en 1925, el Secretariado Sudamericano fue una de las escasas estructuras regionales que integraron la maquinaria organizativa impulsada por la Internacional Comunista para coordinar acciones del comunismo internacional. En septiembre de 1930 el Secretariado comenzó a editar su órgano teórico: Revista Comunista. En sus páginas se plasmaron diagnósticos referidos a cada uno de los partidos comunistas de Sudamérica y a las diversas situaciones nacionales en las que debían operar. En este sentido, una reposición de aquellas líneas interpretativas de la realidad coyuntural resulta relevante para profundizar y problematizar la comprensión del desarrollo del comunismo sudamericano durante el llamado “tercer período”.

Myths, instrumental reality, or cultural change? Modern service-oriented government reforms in China

This article provides a greater understanding of the service-oriented government (SOG) reforms that China carried out at the central level in 2008, 2013, and 2018. These reforms involved two common post-NPM structural measures – namely, super-ministries and cross-ministerial networks or leading groups. Using a mythical, an instrumental, and a cultural perspective, this article examines how SOG reforms were carried out and enquires into the relevance of “Chinese characteristics.” Our analysis shows that China’s SOG reforms represent quite a complex and hybrid pattern with a dual orientation of service value and coordination action. The CPC’s leadership of government reform and major work in all areas are fundamental characteristics of China’s socialist administrative system.

Electric hybrid control method of assembly line robot based on PLC

With the development of modern industry, manipulators have become a kind of mechanical equipment widely used in assembly lines, which not only can improve production efficiency and product quality, but also improve working conditions. Taking the polar co-ordinate manipulator in the automated assembly line as the research object, the programmable logic contoller (PLC) based assembly line manipulator electrical hybrid control method is analyzed. The assembly line robot includes the base, the stepping motor to drive the rotation of the waist, the cylinder controlled arm and the gripper, based on the polar co-ordinate manipulator action requirements, FX2N series programmable logic contoller is selected to analyze programmable logic contoller based stepper motor, pneumatic servo positioning device, pitch cylinder and gripper control method in detail. The components of the assembly line manipulator are organically combined by programmable logic contoller to realize the electrical mixing control of the assembly line manipulator. The experimental results show that the assembly success rate and breakage rate of the assembly line robot controlled by the proposed method are 99.25% and 0.85%, respectively. The transmission performance and anti-noise performance are better than the comparison method, compared with the traditional method, this method has significant performance advantages in control accuracy, cost, practicability and so on and it has a good application prospect.

Euratom success stories in facilitating pan-European education and training collaborative efforts

The European Atomic Energy Community (Euratom) Research and Training framework programmes are benefitting from a consistent success in pursuing excellence in research and facilitating Pan European collaborative efforts across a broad range of nuclear science and technologies, nuclear fission and radiation protection. To fulfil Euratom R&D programmes key objectives of maintaining high levels of nuclear knowledge and building a more dynamic and competitive European industry, promotion of Pan-European mobility of researchers are implemented by co-financing transnational access to research infrastructures and joint research activities through Research and Innovation and Coordination and Support Actions' funding schemes. Establishment by the research community of European technology platforms are being capitalised. Mapping of research infrastructures and E&T capabilities is allowing a closer cooperation within the European Union and beyond, benefiting from multilateral international agreements and from closer cooperation between Euratom, OECD/NEA, IAEA and international fora. ‘Euratom success stories' in facilitating Pan-European E&T collaborative efforts through Research and Training framework programmes show the benefits of research efforts in key fields, of building an effective ‘critical mass’ and implementing European MSc curricula, of promoting the creation of ‘Centre of Excellence’ with an increased support for ‘Open access to key research infrastructures’, exploitation of research results, management of knowledge, dissemination and sharing of learning outcomes.

Standards4Quantum: Making Quantum Technology Ready for Industry. Putting Science into Standards

The European Commission organized in Brussels on 28-29 March 2019 the Putting-Science-Into-Standards (PSIS) workshop on Quantum Technologies. PSIS workshops is an initiative that brings together researchers, industry and standardizers with the purpose of facilitating the identification and screening of emerging science and technology areas that can be introduced early into the process of standardization to enable innovation. The participants identified aspects that would benefit from standardization activities in three main areas: (i) Quantum Key Distribution and quantum-safe security, (ii) Quantum metrology, sensing and imaging, (iii) and Quantum computing and internet. Several existing standardization activities focusing on quantum enabled security techniques, quantum computing and communication were also mapped. With the direct involvement of the participants, the workshop prepared the ground towards a roadmap of additional pressing technology fields where standardization could add value to the deployment of Quantum Technologies in industrial applications, including security, sensing, imaging and measurement. Next steps would be to start an interaction with the Quantum Flagship and in particular with the recently launched Coordination and Support Action of the Quantum Flagship. As concrete actions for standardization, the workshop suggested to focus on the standardization of a quantum technology terminology and on the development of an EU standardization roadmap for Quantum Technologies.

ДОСЛІДЖЕННЯ МЕТОДИК ТАЙМ-МЕНЕДЖМЕНТУ ТА ЇХ ВИКОРИСТАННЯ В ДІЯЛЬНОСТІ ДЕРЖАВНИХ СЛУЖБОВЦІВ

Our country pursues a strategic direction of joining the European community, this fact createsmore and more requirements on the government and civil servants. High-quality and timely fulfillmentof the undertaken obligations, effective performance of the official duties assume ability to organizeeffectively both working and personal time, to plan and coordinate actions for performance of thetasks. The lack of time problem is the main one faced by the mass of employees, and the correctuse of time is the key to successful performance of professional duties, achievement of goals inany field of activity including public administration. Every civil servant, as a subject of management, strives to perform his professional duties well, but the organization of the management process isconditioned by the emergence of a large number of situations that need immediate resolution (withinits competence): consideration of applications, complaints, urgent meetings, etc. In many cases,inefficient use of working time is due to insufficient ability of civil servants to set priorities, plan theiractivities, manage time and human resources. One of the tools that has been successfully testedin the commercial sphere is time management. Time management combines a set of techniques,methods and technologies that allow the distribution of working and personal time in order toincrease the effectiveness of use. Using time management techniques (namely time managementtools) civil servants will be able to plan their working day in the most rational way, set priorities ineveryday affairs, and focus on the most important aspects of work. The article is dedicated to theessence of time management and the need to use for to improve the effectiveness of working hoursin the activities of civil servants. Features of working time planning are revealed. The existing timemanagement methods with the purpose of use during formation of own management working hourssystem of civil servants are considered. The advantages of using time management in the activitiesof civil servants are presented.The subject of further scientific research should be the study of methods and technologiesof self-control and self-motivation, as well as adaptation of these methods to the activities of civilservants, which will increase the effectiveness of their activities.

СТРУКТУРАТАМЕТОДИКАВИКОРИСТАННЯТРЕНАЖЕРУ «ПРАКТИКАНТ» У ПРОЦЕСІ ВИРОБНИЧОГО НАВЧАННЯ

The article describes the structure of the electronic simulator " Trainee " for students of specialty 015.21 "Professional education (Food technology). Stu-dents of this specialty, according to the scientific plan, undergo industrial training at the workplaces of food industry enterprises. The relevance and expediency of using such a resource which allows you to realize a close relationship between trainees and managers from the production and educational institution in order to coordi-nate actions in accordance with the educational and professional training program for specialists in the food industry are disclosed. Such communication is carried out by means of the “Coordinator of Actions”, where all the actions of partici-pants in industrial training are clearly described. In addition, the technique of using the "Trainee" simu-lator in production conditions is provided. The essence of the sections of the electronic simulator, which is used there is disclosed. The examples of students practicing individual sections of the simulator show the formation of skills that can be acquired by trainees of food industry, which, in turn, helps to shape their read-iness for future professional activities. Thus, the use of an electronic simulator “Trainee” in training in the process of training engineers-educators of food industry provides for subject differentiation and promotes an individual approach to training, taking into account the possibilities of personality. In addition, the introduction of such a simulator into training forms among students: personal statement of the purposes, that means the ability of a person to define the purposes of his activity; learning situation of training, which is based on creation by the teacher of industrial situations (their purpose is a challenge of motivation of the future specialists and a direction of their activities in the knowledge of industrial objects and the decision of problems connected with them) training productivity, consists in creating new previously unknown training products, based on theoretical knowledge disciplines of food industry and the latest achievements of science and technology.

Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2.

Antibiotic-induced dysbiosis is a key predisposing factor for Clostridium difficile infections (CDIs), which cause intestinal disease ranging from mild diarrhea to pseudomembranous colitis. Here, we examined the impact of a microbiota-derived metabolite, short-chain fatty acid acetate, on an acute mouse model of CDI. We found that administration of acetate is remarkably beneficial in ameliorating disease. Mechanistically, we show that acetate enhances innate immune responses by acting on both neutrophils and ILC3s through its cognate receptor free fatty acid receptor 2 (FFAR2). In neutrophils, acetate-FFAR2 signaling accelerates their recruitment to the inflammatory sites, facilitates inflammasome activation, and promotes the release of IL-1β; in ILC3s, acetate-FFAR2 augments expression of the IL-1 receptor, which boosts IL-22 secretion in response to IL-1β. We conclude that microbiota-derived acetate promotes host innate responses to C. difficile through coordinate action on neutrophils and ILC3s.

Precariousness, access to care and home support, a coordination support system

In their daily practice, professionals are called upon to meet older people who are more in distress than others. In order to best meet their needs, it is necessary first to define these difficulties and then to consider the mechanisms that can provide assistance adapted to the requirements and needs of the people. Access to hospital health care services and coordination support mechanisms, as defined by the law of 26 July 2019, can contribute to this assistance, without criteria limiting access to care. Examples of prevention and coordination actions carried out by the Access to Health Care, Rights and Education Network.

Социальные сети как канал коммуникации с властью (на примере протестных движений Ярославской области)

Статья посвящена анализу возможностей влияния общественных кампаний в социальных сетях на процесс принятия решений органами власти. Авторами рассматриваются основные преимущества Интернета, информационно-коммуникативных технологий и социальных сетей. Указывается, что они предоставляют возможности получить доступ к альтернативным источникам информации, создать условия для открытых дискуссий, вовлечь молодежь в общественно-политическую активность, обеспечить обратную связь с деятельностью органов власти, координировать коллективные действия, выстраивать неиерархическую организационную структуру. Отмечается, что социальные сети позволяют формировать альтернативное информационное пространство, позволяющее преодолевать цензуру. В статье рассматривается пример влияния кампании в социальных сетях на решения и действия органов власти в Ярославской области: против складирования московского мусора на территории региона. В ходе анализа была выявлена интенсивность освещения проблемы в социальных сетях, использованные инструменты. Авторами делается вывод о том, что Интернет становится неотъемлемой частью жизни общества, увеличивая возможности влияния граждан на процесс принятия решений органами власти