Coordinated Research Program Research Articles

Climate Anxiety: Current Evidence and Future Directions.

Challenging cognitive, somatic, and behavioral responses to climate change are often conceptualized as climate anxiety (CA). Due to the increased recognition of the impacts of climate change on mental health, a growing body of scientific literature is developing. The purpose of this manuscript is to review the current evidence base for CA and propose future research needs for this emerging construct. Early evidence supports underlying psychological mechanisms in the development and maintenance of CA, which are similar to other anxiety-related conditions. However, the study of CA poses unique challenges to researchers. The psychological impacts that occur in the context of climate change may be adaptive depending on the imminent threat of natural disasters, forced migration, or other climate-related challenges. Due to the potentially adaptive nature of CA and limited current evidence, a coordinated research program of climate-related distress is necessary. A review of the extant literature identified current gaps in understanding the epidemiology and individual differences that promote CA. Current evidence supports the prominent role of neuroticism, intolerance of uncertainty, and rumination. The development of evidence-based models of climate-related distress may provide a more valid and comprehensive depiction of the impacts of climate change on mental health. Transdiagnostic treatment methods are likely the most appropriate intervention for climate-related distress. As models, measures, and treatments of climate-related distress are developed, it is crucial to incorporate studies of populations most at risk for climate change-related mental health effects.

Developing a coordinated response to chemsex across health, justice and social care settings: expert consensus statement.

Chemsex occurs primarily among gay, bisexual and other men who have sex with men (GBMSM), and there is evidence of a subgroup of users who carry out chemsex-related criminal offences and experience harm. Challenges with chemsex can present to various settings; there are concerns that harm is increasing, including at interfaces between health, social care and criminal justice systems. The UK response to date has lacked a coordinated approach. An expert reference group was convened to share chemsex knowledge, articulate priorities for research and pathway development, and foster collaborative working between agencies. It made three key recommendations: develop and increase training and awareness across all services; implement a coordinated research programme with the development of a common data-set and assessment tool to fully characterise population-level needs; develop a professional network to share information, provide professional support and act as a knowledge hub. There was support for a unified multi-agency strategy incorporating the priorities identified as overarching principles.

Linking Public Health Monitoring to Dialogue-based Decision-making During the COVID-19 Pandemic: Experiences from a Participatory Pilot in the Netherlands

Introduction:In the Netherlands, a nationally coordinated research program has been initiated to monitor the immediate and long-term public health impact of the COVID-19 pandemic. This contribution describes the design and early results of a continuous dialectic process to involve national and local public health authorities and professionals in monitor-driven decision-making to anticipate the health impact of viral infections and mitigation measures.Method:An ongoing series of dialogue sessions was organized upon the release of quarterly and annual results of the monitoring program. Apart from supporting public health decision-making, the stepwise dialectic process aimed to ensure multi-sectoral learning and co-creation and nurture a sense of ownership among stakeholders from policy, practice and science. National and regional public health authorities served as hub coordinators and participated in determining and approaching relevant stakeholders. Whenever considered relevant, new stakeholders were invited to participate.Results:In the first year, three dialogue sessions were organized, with an emphasis on youth and young adults. Representatives from ministries, municipalities, health organizations, experiential experts and knowledge institutes attended the sessions. Based on the exchange, policy recommendations were formulated and shared among participants. The themes prioritized included mental health issues, overburdened healthcare services, involvement of vulnerable groups in policy development and understanding the complex myriad of risk factors. Moreover, several factors were identified that might facilitate or hinder the implementation and uptake of monitoring findings.Conclusion:The dissemination and discussion of monitoring data proved to be of added value in developing evidence-informed solutions and areas of attention for future monitoring, including the need to track progress of local and national implementation of recommendations. More broadly, the methodology piloted during the program requires further testing as a community engagement strategy and might be meaningful in other crises or problem contexts as well.

Introduction to food, feed, and health wealth in African yam bean, a locked-in African indigenous tuberous legume

The African yam bean, Sphenostylis stenocarpa Hochst Ex. A. Richmond, Harms, is an indigenous tuberous legume of the humid tropics of Africa. Its edible pulse and tuber host significant promises for food, nutrition, and health security. It was identified as a counterpart of cowpea in the 1970s and rated to be highly nutritious, but notable constraints have denied it research and funding attention. “Cowpea revolution” further deprived focus on the African yam bean. However, some research updated and promoted its significant food, feed, and nutritional-pharmaceutical values between 1973 and 2000. The global trend for food diversification has further improved awareness and research on the African yam bean this past decade, but research focus on the tuber is incomparably small. The abundant minerals, vitamins, and bioactive compounds in the two economic products unveiled in the present review assure food, health, and nutritional security. The analytical comparison of nutritional values of the African yam beans and other grain legumes demonstrated the significant place of the crop among its counterparts. Furthermore, investigative research identified the grain as a good substitute for soybean for livestock feed formulations. Although no clinical study has been reported, some in vivo, in vitro, and ex vivo biological activities and human studies of the two economic products revealed their efficacy in the management of anti-natal lactation induction, anemia, diabetes, arthritis, etc. However, African yam bean still suffer displacement in rank, utilization, and popularity compared to the “favored” legumes. While the present review adds to its advocacy, awareness, and utilization, a coordinated research program that will boost its value chain is most necessary for progress.

The integrated GOR-COVID-19 health monitor: research-informed policy-making through dialogue

Abstract Introduction Like in many other countries, the COVID-19 pandemic and the government restrictions introduced to contain the spread of the virus had major consequences for the health and wellbeing of the population in the Netherlands. To monitor the short and long-term public health impact, a nationally coordinated research program was initiated with the intention to guide decision-making by local and national public health authorities. This contribution presents the process to establish a continuous dialogue with end-users of information to add focus to the monitor, make sense of the findings and formulate policy recommendation and practical guidance, both at the national and regional level. Methods To facilitate the translation and dissemination of research results among policy makers, practitioners and scientists, an ongoing series of dialogue sessions is organized during the monitoring program. Apart from the objective of evidence-informed public health decision-making, the dialectic process seeks to ensure multi-sectoral learning and co-creation and contribute to a broad sense of ownership among stakeholders. National and regional health participants serve as hub coordinators. New stakeholders are invited and will be actively approached wherever considered relevant. Results At the EUPHA conference experiences with organizing the dialogue in app. the first two years of the program will be presented together with preliminary results and a reflection on factors that helped or hindered the implementation and uptake of findings. Discussion Monitoring data collected using robust methods and analyzed in such a way that vulnerability factors are carefully considered, is invaluable for decision-making. However, in order to effectively serve as guidance to public health policy, whether in the context of the COVID-19 pandemic or in non-crisis situations, a constructive, ongoing exchange between end-users of the information needs to be facilitated.

A Summary of United States Research and Monitoring in Support of the Ross Sea Region Marine Protected Area

Due to the remarkable ecological value of the Ross Sea, the Commission for the Conservation of Antarctic Marine Living Resources (CCAMLR) adopted a large-scale Ross Sea region marine protected area (RSRMPA) in 2016. Since then, many CCAMLR Members have conducted research and monitoring in the region. In 2021, the U.S. Ross Sea science community convened a workshop to collate, synthesize, and coordinate U.S. research and monitoring in the RSRMPA. Here we present workshop results, including an extensive synthesis of the peer-reviewed literature related to the region during the period 2010–early 2021. From the synthesis, several things stand out. First, the quantity and breadth of U.S. Ross Sea research compares to a National Science Foundation Long Term Ecological Research project, especially involving McMurdo Sound. These studies are foundational in assessing effectiveness of the RSRMPA. Second, climate change and fishing remain the two factors most critical to changing ecosystem structure and function in the region. Third, studies that integrate ecological processes with physical oceanographic change continue to be needed, especially in a directed and coordinated research program, in order to effectively separate climate from fishing to explain trends among designated indicator species.

Propagation of VHTRC manufacturing uncertainties with RAVEN/PHISICS

The International Atomic Energy Agency recently concluded a Coordinated Research Program (CRP) to evaluate the effect of propagation of uncertainties on design and safety parameters in High Temperature Gas-cooled Reactors (HTGRs). This CRP catalyzed the development of novel software and methods relevant to HTGR uncertainty analysis. In the framework of this CRP, the statistical analysis code RAVEN was coupled to the neutron transport code PHISICS, using 6-group cross section libraries generated with the modules TRITON/NEWT from SCALE 6.2.1. This article describes the mechanics of the RAVEN/PHISICS sequence, and reports the effects of manufacturing uncertainties on integral parameter uncertainties found in the Very High Temperature Reactor Critical (VHTRC) core.The VHTRC experimental results included propagation of manufacturing uncertainties to obtain eigenvalue (keff) and temperature coefficient (αT) uncertainties. RAVEN/PHISICS was used to reproduce this analysis and to compare the predicted output uncertainties to the experimental measurements on the three VHTRC cores (HC-I, HP, HC-II). Results from the sequence agree with the experimental values (σ[keff] ~ 0.00300).The analysis also focuses on the interpretation of input uncertainties. The simulations conducted with RAVEN/PHISICS demonstrated the input uncertainties can induce a threefold increase in the resulting output uncertainties, depending on the mathematical modeling of the raw input uncertainties. In particular, the use of a unique uncertainty value repeated over lattice elements constitutes the major contribution to the keff and αT uncertainties, while modeling these uncertainties with random independent values leads to negligible keff and αT uncertainties, due to cancellation of errors. The propagation of the manufacturing uncertainties was also repeated using 56 energy groups in the neutron transport calculations, and showed a moderate impact on the output (keff, αT) uncertainties (~10 % difference) compared to the base-case 6-group simulations.

Approaches and research needs for advancing the protection and recovery of imperilled freshwater fishes and mussels in Canada1

Effective conservation requires that species recovery measures are informed by rigorous scientific research. For imperilled freshwater fishes and mussels in Canada, numerous research gaps exist, in part owing to the need for specialized research methods. The Canadian Freshwater Species at Risk Research Network (SARNET) was formed and identified or implemented approaches to address current research gaps, including (1) captive experimental research populations, (2) nonlethal methods for estimating abundance and distribution, (3) nonlethal field methods to measure life-history parameters, (4) species distribution models informed by co-occurring species, (5) conservation physiology to inform habitat and threat science, (6) evidence syntheses to evaluate threats and recovery measures, (7) disease-transmission models to understand mussel–host relationships, (8) experimental mesocosms and manipulative experiments to evaluate key habitat stressors, (9) threat and hazard models for predictive applications, and (10) rigorous evaluation of surrogate species. Over a dozen threat- and recovery-focused SARNET research applications are summarized, demonstrating the value of a coordinated research program between academics and government to advance scientific research on, and to support the recovery of, imperilled freshwater species.

Failure to respond to a coral disease epizootic in Florida: causes and consequences

Stony coral tissue loss disease (SCTLD) was first observed in September 2014 near Virginia Key, Florida. In roughly six years, the disease spread throughout Florida and into the greater Caribbean basin. The high prevalence of SCTLD and high resulting mortality in coral populations, and the large number of susceptible species affected, suggest that this outbreak is one of the most lethal ever recorded. The initial recognition and management response to this catastrophic disease in Florida was slow, which delayed the start of monitoring programs and prevented coordinated research programs by at least two years. The slow management response was a result of several factors that operated concurrently. First, the Port Miami dredging project was ongoing during the coral disease epidemic and dredging rather than SCTLD was blamed by some managers and local environmental groups for the extreme coral losses reported in the project’s compliance monitoring program. Second, this blame was amplified in the media because dredging projects are intuitively assumed to be bad for coral reefs. Third, during this same time State of Florida policy prohibited government employees to acknowledge global warming in their work. This was problematic because ocean warming is a proximal cause of many coral diseases. As a result, the well-known links between warming and coral disease were ignored. A consequence of this policy was that the dredging project provided an easy target to blame for the coral mortality noted in the monitoring program, despite convincing data that suggested otherwise. Specifically, results from the intensive compliance monitoring program, conducted by trained scientific divers, were clear. SCTLD that was killing massive numbers of corals throughout Florida was also killing corals at the dredge site – and in the same proportions and among the same suite of species. While eradication of the disease was never a possibility, early control measures may have slowed its spread or allowed for the rescue of significant numbers of large colonies of iconic species. This coral disease outbreak has similarities to the COVID-19 pandemic in the United States and there are lessons learned from both that will improve disease response outcomes in the future, to the benefit of coral reefs and human populations.

Development of Microbiome Biobanks – Challenges and Opportunities

The microbiome research field is rapidly evolving, but the required biobanking infrastructure is currently fragmented and not prepared for the biobanking of microbiomes. The rapid advancement of technologies requires an urgent assessment of how biobanks can underpin research by preserving microbiome samples and their functional potential.

On the necessity of domestic research on nuclear materials science

Globally, systematic research is going on to better understand the operation induced degradation effects of reactor structural materials and to enhance the effectiveness of their in-service monitoring. In Hungary, there are four reactor units in operation and two new ones are soon to be built. Some of the construction features of the new units differ from that of the operating ones. In order to be prepared in time for efficiently managing materials science related questions, it is necessary to establish a coordinated research program utilizing the capabilities of domestic research institutions. This paper describes the major elements of this potential program. Implementation of the program can assist ageing management activities of the operating units.

SOLATINA: A Latin-American Society for Bee Research to Foster the Interactions Between Scientists and Coordinate Large-Scale Research Programs

Bees (members of the super family Apoidea) are the main pollinators in modern agro-ecosystems, where they have a critical positive effect on yield improvement for about 75% of world's crops (Klein ...

Trends in beekeeping and honey bee colony losses in Latin America

Over the past decade, several countries have carried out monitoring programs of managed honey bee colonies, which suggest beekeeping difficulties, with high colony loss rates all over the world. Although Latin America plays a major role in the global honey supply, information about trends in beekeeping activities and honey bee colony losses are lacking. Using the Food and Agriculture Organization of the United Nations (FAO) dataset and a synthesis of unpublished data of colony losses survey carried out over the last 7 years, we reveal a worrying situation of the beekeeping in this region. The Latin American trends in honey production and beehive numbers are drifting from the global pattern, and several high colony loss rates were registered in this region. These results reveal the presence of beekeeping difficulties in Latin America. However, the variability in methods of colony loss survey across initiatives prevent proper conclusion on loss rates. Efforts are needed to adapt, centralize and standardize methods to monitor honey bee health and colony losses across countries in Latin America, the main objective of the “colony losses” working group at the Latin-American Society for Bee Research, SOLATINA, a large-scale platform created in 2017 to coordinate bee research programs in Latin America.

Personal values influencing career path in academic medicine: Perspectives of selected Canadian trainees

To pursue research, education, and health policy in one’s career, broadly defined as academic medicine, is one of the most important decisions of a trainee doctor’s career. Despite this, there is scant literature on which factors influence trainees’ choices towards clinical work or academic research. As the MD/PhD is a relatively young training path compared to the traditional PhD (Doctor of Philosophy) and MD (Doctor of Medicine) programs, it prompts the question: at the crossroads of a career, what sways the individual to select an MD, PhD, or MD/PhD program? This is a valuable question to be answered for trainees who are considering multiple career paths, for educators who want to guide undifferentiated students, and for policy makers who develop and coordinate research programs. “Intellectual stimulation” is the most consistently identified personal value which draws trainees to academic medicine. Mentorship is linked strongly to success in the field. Conversely, long training periods, a lack of autonomy, and financial considerations are deterrents from a career in academic medicine. Insight into the decision-making process is provided by recent Canadian trainees in these respective fields, in a series of short interviews.

Trends in Global Agricultural Land Use: Implications for Environmental Health and Food Security

The eighteenth-century Malthusian prediction of population growth outstripping food production has not yet come to bear. Unprecedented agricultural land expansions since 1700, and technological innovations that began in the 1930s, have enabled more calorie production per capita than was ever available before in history. This remarkable success, however, has come at a great cost. Agriculture is a major cause of global environmental degradation. Malnutrition persists among large sections of the population, and a new epidemic of obesity is on the rise. We review both the successes and failures of the global food system, addressing ongoing debates on pathways to environmental health and food security. To deal with these challenges, a new coordinated research program blending modern breeding with agro-ecological methods is needed. We call on plant biologists to lead this effort and help steer humanity toward a safe operating space for agriculture.

Development of a charcoal rot rating index for multilocation trials of sorghum

Comparing the performance of sorghum genotypes for charcoal rot resistance in a multilocation trial becomes difficult due to non-uniform disease reactions over locations obtained by applying mean number of nodes cross (MNC) scale. This study analyzed the relationship between disease incidence and severity and developed a disease rating index for use in the multilocation trial. The incidence-severity relationship for the disease was studied based on multilocation and multiyear data sets obtained from the all India coordinated research programme on sorghum. The incidence, severity and relationship between them varied depending on the crop growing environments (year, locations) suggesting that it would be inappropriate to consider incidence in place of severity and vice versa for the measurement of the disease. The reasons for the inconsistent I-S relationship were attributed to the environmental and pathogenic variations across the locations and years. Five charcoal rot rating indices (CRI 1 to CRI 5) were developed combining incidence and severity in different proportions to average out these effects. Suitability of the indices for comparing the performance of sorghum genotypes in the multilocation trials was tested using genotype + genotype-environment (GGE) biplot analysis. CRI 2 that combined incidence and severity in the 40:60 proportions was found to be the most stable index in terms of performance across the locations. CRI 2 rated the charcoal rot reactions of the sorghum genotypes with greater accuracy and reliability (R2 = 0.341, p = 0.001) compared to the existing MNC scale (R2 = 0.001, p = 0.965) in replicated field trials. The index (CRI 2) will help identify disease reactions among sorghum genotypes with greater consistency in multilocation trials.

The IAEA CRP on HTGR uncertainties: Sensitivity study of PHISICS/RELAP5-3D MHTGR-350 core calculations using various SCALE/NEWT cross-section sets for Ex. II-1a

Uncertainty and sensitivity analysis is an indispensable element of any substantial attempt in reactor simulation validation. A Coordinated Research Program (CRP) supervised by the International Atomic Energy Agency was started to investigate the various uncertainty quantification methodologies for High Temperature Gas-cooled Reactors. The first phase of the CRP is dedicated to the estimation of cell and lattice model uncertainties due to the neutron cross sections. Phase II is oriented towards the investigation of propagated uncertainties from the lattice to the coupled neutronics/thermal hydraulics core calculations. Best-estimate results for the prismatic single block (Ex. I-2a) and super cell models (Ex. I-2c) were obtained using the SCALE 6.2.0 two-dimensional lattice code NEWT. A reference spectrum was obtained with Serpent 2.1.27 for the single block, super cell and core models. The flux spectrum in the system of interest plays a primary role in the quantification of uncertainties caused by cross sections. In this work, the TRITON/NEWT-flux-weighted cross sections obtained for Ex. I-2a and various models of Ex.I-2c are utilized to perform a sensitivity analysis of the MHTGR-350 core power densities and eigenvalues. The core solutions are obtained with the Idaho National Laboratory (INL) coupled code PHISICS/RELAP5-3D. It is observed that axial shape of the core power density does not vary significantly with the various lattice cell libraries utilized. The use of cross section libraries originating from super cells induces changes of the core power density by 1–10% radially as compared to the Ex.I-2a cross sections. The magnitude of these variations increases as the moderator-to-fuel ratio increases in the super cell lattice models. A lattice flux spectrum resembling the core spectrum is hence necessary for correct predictions in nodal core calculations.

The Origin and Limitations of Modern Mathematical Economics: A Historical Approach

We have first demonstrated that Debreu’s view regarding the publication of The Theory of Games and Economic Behavior by von Neumann and Morgenstern in 1944 as the birth of modern mathematical economics is not convincing. In this paper, we have proposed the hypothesis that the coordinated research programs in the 1930’s, initiated by the Econometric Society and the Cowles Commission for Research in Economics with the objective of unifying economic theory, mathematics and statistics, can be regarded as the beginning of modern mathematical economics as well as econometrics. We have argued that this unification has failed to satisfactorily bridge the gap between mathematical economics and the real world economic issues. However, contrary to Marshall's view that mathematics is not an engine of inquiry in economics but is only a shorthand language, we have established in this paper that the application of mathematics in modern mathematical economics can, under certain conditions, produce economic results of value.

Challenges associated with the behaviour of radioactive particles in the environment

A series of different nuclear sources associated with the nuclear weapon and fuel cycles have contributed to the release of radioactive particles to the environment. Following nuclear weapon tests, safety tests, conventional destruction of weapons, reactor explosions and fires, a major fraction of released refractory radionuclides such as uranium (U) and plutonium (Pu) were present as entities ranging from sub microns to fragments. Furthermore, radioactive particles and colloids have been released from reprocessing facilities and civil reactors, from radioactive waste dumped at sea, and from NORM sites. Thus, whenever refractory radionuclides are released to the environment following nuclear events, radioactive particles should be expected.Results from many years of research have shown that particle characteristics such as elemental composition depend on the source, while characteristics such as particle size distribution, structure, and oxidation state influencing ecosystem transfer depend also on the release scenarios. When radioactive particles are deposited in the environment, weathering processes occur and associated radionuclides are subsequently mobilized, changing the apparent Kd. Thus, particles retained in soils or sediments are unevenly distributed, and dissolution of radionuclides from particles may be partial. For areas affected by particle contamination, the inventories can therefore be underestimated, and impact and risk assessments may suffer from unacceptable large uncertainties if radioactive particles are ignored. To integrate radioactive particles into environmental impact assessments, key challenges include the linking of particle characteristics to specific sources, to ecosystem transfer, and to uptake and retention in biological systems. To elucidate these issues, the EC-funded COMET and RATE projects and the IAEA Coordinated Research Program on particles have revisited selected contaminated sites and archive samples. This COMET position paper summarizes new knowledge on key sources that have contributed to particle releases, including particle characteristics based on advanced techniques, with emphasis on particle weathering processes as well as on heterogeneities in biological samples to evaluate potential uptake and retention of radioactive particles.

A cross-sectional examination of the profile of chiropractors recruited to the Australian Chiropractic Research Network (ACORN): a sustainable resource for future chiropractic research

ObjectivesThe Australian Chiropractic Research Network (ACORN) practice-based research network (PBRN) cohort was established to provide sustainable infrastructure necessary to address lack of rigorous investigation and to bridge the research–practice gap...