Developments in computer communications and networks have led to exciting new areas of research and application, including the internet of things, vehicular networks, collaborative big data analysis, to name just a few. Moreover, the design and implementation of energy efficient future generation communication and networking technologies have fostered the development of new mobile, pervasive, and large-scale computing technologies. The International Conference on Computing and Communications Networks serves as a forum for exchanging the latest findings and experiences ranging from theoretical research to practical system development in all aspects of computing and networking. In its 2021 edition (ICCCN2021), many of those contributions had a significant artificial intelligence component, which is the focus of this Special Issue, which brings together selected papers from ICCCN2021. Of around 25 submitted articles, only 10 papers were selected based on their reviews. Each paper was reviewed by at least two reviewers and went through at least two rounds of reviews. The contributions of these papers are summarized briefly below. Ibrahim et al., 2022 propose a developed system to create a reliable COVID-19 prediction network using various layers starting with the segmentation of the lung CT scan image and ending with disease prediction. The initial step of the system starts with a proposed technique for lung segmentation that relies on a no-threshold histogram-based image segmentation method. Afterward, the GrabCut method was used as a post-segmentation method to enhance segmentation outcomes and avoid over- and under-segmentation problems. Then, three pre-trained models of standard DL methods, including Visual Geometry Group Network, convolutional deep belief network, and high-resolution network, were utilized to extract the most affective features from the segmented images that can help to identify COVID-19. Gupta et al., 2022 present a new AI technique based on optimal deep convolutional neural network (AI-ODCNN) for retinal fundus image classification. Primarily, the proposed model uses the Gaussian Blur based noise removal and contrast enhancement technique (CLAHE) based contrast enhancement technique to pre-process the retinal fundus image. In addition, morphology and contour-based image segmentation is performed. Moreover, the deep CNN with RMSProp Optimizer is employed for retinal fundus image classification. A wide range of simulations was performed on the automated retinal image analysis and structured analysis of the retina and the outcomes are examined with respect to various measures. The simulation outcomes ensured the better performance of the proposed approach related to other recent algorithms with maximum accuracy of 96.47%. Zhang et al., 2022 present a genetic algorithm-based on-orbit self-repair implementation for SRAM FPGAs to address the disadvantages of the genetic algorithm-based fault repair method in the aerospace industry. The proposed method has been verified by various applications in XC7VX330T, which demonstrates its engineering practicability. Mishra & Kohli, 2022 present the Anas platyrhynchos optimizer with deep learning-enabled block-based motion estimation (APODL-BBME) model. The proposed model estimates motion using block-based concepts and DL approaches. To accomplish this, the training and testing frames are separated into non-overlapping block categories, and the blocks are filtered via the bilateral filtering (BF) approach. In addition, a histogram of gradients (HOG) and densely connected network (DenseNet) model are employed to extract features, which are then fed into the bidirectional long short-term memory (BiLSTM) model to classify the input features. Finally, the APO algorithm is applied to optimally tune the hyperparameters of the BiLSTM model, which helps to improve the overall motion estimation efficacy, showing the novelty of the work. To demonstrate the enhanced performance of the APODL-BBME model, a comprehensive analysis is carried out, and when we compare the results, the APODL-BBME model outperforms recent motion estimation approaches. Bedi et al., 2022 propose an unsupervised approach for extractive summarization, based on semantic similarity and keyword-phrase extraction. Merging Concept Map and the RAKE method, a generic summary is computed based on threshold values. Both single-document and multi-document summarization can be accomplished with the approach. To evaluate the proposed unsupervised approach, various biomedical transcripts of neuro-science, general medicine, gastroenterology, orthopaedic and radiology domain are used. MT Sample Dataset is used to collect 1040 different transcripts. Using the proposed approach, an average ROUGE score of 0.77 for single-document summarization; however, for generic summary, an average ROUGE is 0.72. The proposed technique is validated for the previous corpus of BioMed articles, and results are better with state-of-the-art techniques. Marzouk et al., 2022 introduce a Quasi-Oppositional Wild Horse Optimization-based Multi-Agent Path Finding (QOWHO-MAPF) scheme for real-time IoT systems. The aim of the proposed QOWHO-MAPF scheme is to determine the optimal set of paths to reach the destination in real-time IoT networks. QOWHO algorithm is created by integrating the concepts of Quasi-Oppositional Based Learning (QOBL) and conventional WHO algorithm. In addition, the proposed QOWHO-MAPF model derives a fitness function that involves two input parameters such as residual energy and distance-to-destination. The proposed QOWHO-MAPF model was experimentally analysed and the results were inspected under several aspects. The simulation results established that QOWHO-MAPF model is a superior model compared with other state-of-the-art models. Vinoth & Prabhavathy, 2022 propose an automated sarcasm detection and classification tool using hyperparameter tuned deep learning (ASDC-HPTDL) model for social media. The proposed ASDC-HPTDL technique primarily involves pre-processing stage to transform the data into useful format. In the next stage of pre-processing, the pre-processed data are converted into the feature vector by Glove Embedding's technique. Then attention bidirectional gated recurrent unit (ABiGRU) technique is utilized to detect and classify sarcasm. In order to boost the detection outcomes of the ABiGRU technique, a hyperparameter tuning process using improved artificial flora algorithm (IAFO) is employed, showing the novelty of the work. The proposed model is validated using the benchmark dataset and the results are examined in terms of precision, recall, accuracy, and F1-score. Nyangaresi et al., 2022 deploy an ANN for target cell selection in a 5G network, and authentication of communicating entities takes place before being admitted in the new cell. It has a low packet loss ratio and latency variations. This scheme is resilient against conventional 5G attack vectors at relatively low costs. Finding drug-target interactions (DTI) is crucial in making new drugs. As new drugs are discovered, there is a significant focus on repurposing existing drugs and incorporating approved drugs. Most computer models for predicting drug-target interactions emphasize binary classification, but the goal is to determine if two drug targets interact. Sharma & Deswal, 2022 compare drug and protein-encoding techniques to predict DT binding affinities. The validation results on the standard dataset show that the proposed model can help with drug discovery by predicting how well DT binds. Finally, Maray et al., 2022; Marzouk et al., 2022 introduce Intelligent Metaheuristics-based Feature Selection model with Optimal ML approach for Malware Detection (IMFSOML-MD) on IoT-enabled MTS. Primarily, IMFSOML-MD technique involves the design of Quantum Invasive Weed Optimization Algorithm-based Feature Selection technique to optimally choose a subset of features. Moreover, an Optimal Wavelet Neural Network (OWNN) model is employed to perform the classification process. The initial parameters of the WNN model are optimally tuned with the help of Colliding Bodies Optimization algorithm, thereby improving the detection performance. The proposed IMFSOML-MD technique was experimentally validated using publicly available CICMalDroid2020 dataset. The results from extensive comparative analysis demonstrated the superiority of the proposed IMFSOML-MD technique over other compared methods in terms of detection performance with maximum accuracy of 98.96%. We want to express our sincere thanks to the editor-in-chief for allowing us to organize this particular issue. The editorial office staffs are excellent, and we thank them for their support. We are also thankful to all the authors who made this special issue possible, and to the reviewers for their thoughtful contributions. Deepak Gupta received a B. Tech. Degree in 2006 from the Guru Gobind Singh Indraprastha University, Delhi, India. He received an M.E. degree in 2010 from Delhi Technological University, India, and PhD degree in 2017 from Dr. APJ Abdul Kalam Technical University (AKTU), Lucknow, India. He completed his Post-Doc from the National Institute of Telecommunications (Inatel), Brazil, in 2018. He has co-authored more than 207 journal articles, including 168 SCI papers and 45 conference articles. He has authored/edited 60 books, published by IEEE-Wiley, Elsevier, Springer, Wiley, CRC Press, DeGruyter, and Katsons. He has filled four Indian patents. He is the convener of the ICICC, ICDAM, ICCCN, ICIIP & DoSCI Springer conferences series. He is Associate Editor of Computer & Electrical Engineering, Expert Systems, Alexandria Engineering Journal, Intelligent Decision Technologies. He is the recipient of the 2021 IEEE System Council Best Paper Award. He has been featured in the list of top 2% scientist/researcher databases worldwide. In India, Rank 1 as a researcher in the field of healthcare applications (as per Google Scholar citation) and Ranked #78 in India among Top Scientists 2022 by Research.com. He is also working towards promoting Startups and also serving as a Startup Consultant. He is also a series editor of “Elsevier Biomedical Engineering” at Academic Press, Elsevier, “Intelligent Biomedical Data Analysis” at De Gruyter, Germany, and “Explainable AI (XAI) for Engineering Applications” at CRC Press. He is appointed as Consulting Editor at Elsevier. Accomplished productive collaborative research with grants of approximately $144000 from various international funding agencies, and he is Co-PI in an International Indo-Russian Joint project of Rs. 1.31 CR from the Department of Science and Technology.