Convex Side Of Curvature Research Articles

Surgical treatment of juvenile progressive scoliosis (staged message)

At the Department of Child and Adolescent Vertebrology of Novosibirsk SRI TO a multi-step technique was used for the surgical treatment of 21 patients with progressive juvenile scoliosis. That technique included epiphysiospondylodesis on the convex side of curvature, step by step distraction with endocorrector from the Cotrel-Dubousset instrumentation set and completely posterior spondylodesis at the age of sexual maturation. Six out of 21 patients completed treatment; the deformity was decreased from 74.6 to 41.5 and the achieved correction has been almost completely preserved. That surgical technique did not disturb the growth of patients trunk (mean growth rate was 6 cm per year). Torsion component of the deformity did not increase confirming the efficacy of epiphysiospondylodesis. Mean follow up made up 27 months. In spite of the significant number of complications the obtained results testified the prospectiveness of that direction.

Methylation of estrogen receptor 2 (ESR2) in deep paravertebral muscles and its association with idiopathic scoliosis

Idiopathic scoliosis (IS) is one of the most common spinal disorders in adolescents. Despite many studies, the etiopathogenesis of IS is still poorly understood. In recent years, the role of epigenetic factors in the etiopathogenesis of IS has been increasingly investigated. It has also been postulated that the development and progression of the disease is related to gender and puberty, and could be associated with estrogen action. Estrogen hormones act via estrogen receptor 1 (ESR1) and estrogen receptor 2 (ESR2). It has been suggested that ESR2 expression is dependent on methylation within its gene promoter. So far, no studies have evaluated local, tissue-specific DNA methylation in patients with IS. Thus, our study aimed to analyze the methylation and expression level of ESR2 in the paraspinal muscles of the convex and concave side of the IS curvature. The methylation level within ESR2 promoter 0N, but not exon 0N, was significantly higher on the concave side of the curvature compared to the convex side. There was no significant correlation between ESR2 expression and methylation level in the promoter 0N on the convexity of thoracic scoliosis, whereas, on the concave side of the curvature, we observed a moderate negative correlation. There was no difference in the methylation levels of the ESR2 promoter and exon 0N between groups of patients with Cobb angle ≤ 70° and > 70° on the concave and convex side of the curvature. We also found no statistically significant correlation between the Cobb angle value and the mean methylation level in either the ESR2 promoter or exon 0N on the convex or concave side of the curvature. Our findings demonstrate that DNA methylation at the ESR2 promoter in deep paravertebral muscle tissue is associated with the occurrence but not with the severity of idiopathic scoliosis.

Lateral Electrical Surface Stimulation (LESS) for Treatment of Idiopathic Scoliosis

We presented short-term results of electrical surface stimulation in 11 cases of idiopathic scoliosis. The stimulation was made by low frequency wave through silver spike point electrodes (SSP electrotherapy), that were placed on the skin of the thoracic cage in the convex side of curvature around the apex. The stimulation was applied during sleeping at night for six months to one year.Arrest of curve progression or curve correction was observed in ten of them except one. Skin irritation and burns that are likely to happen in electrotherapy were seen in none.