Conversion Of Thebaine Research Articles

Synthesis of nalbuphine and investigation of several mixtures of nalbuphine with other drugs for BALB/c mice anesthesia

AbstractIn this research, the conversion of thebaine into oxycodone was achieved using oxidizing reagents, with a yield of 80%. Subsequently, oxycodone was converted into oxymorphone in the presence of an acidic environment, resulting in a yield of 55%. The synthesized oxymorphone was then de‐methylated using ethyl chloroformate to obtain the intermediate noroxymorphone. The latter was further transformed into nalbuphone using cyclobutyl methyl bromide reagent, with a yield of 82%. Finally, nalbuphone was converted into nalbuphine using a reducing reagent, with a yield of 75%. The identification of all intermediates was ensured through the use of NMR, FT‐IR, Mass, and HPLC spectroscopy. The chemical transformations were primarily associated with the formation of noroxymorphone, which served as a crucial intermediate in the synthesis of nalbuphin. Additionally, the effects of three drugs, namely azaperone, medetomidine, and nalbuphine, were investigated on BALB/c mice. The results showed that the best formulation for short‐term anesthesia of mice was a combination of the three drugs, each at a concentration of 1 mg/kg of body weight.

Transformations in the morphine series. IV. Conversion of thebaine into l-methyl-3alpha-(3'-hydroxy-6'-methylphenyl)-4,2'-oxidooctahydroindole by two different routes. A rearrangement via an Aziridinium intermediate.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransformations in the morphine series. IV. Conversion of thebaine into 3,11-dimethyl-8-hydroxy-3,3a.alpha.,4,5,6,6a.beta.-hexahydrobenzofuro[3,2-d]indole by two different routes. A rearrangement via an aziridinium intermediateMichael MokotoffCite this: J. Org. Chem. 1968, 33, 9, 3556–3559Publication Date (Print):September 1, 1968Publication History Published online1 May 2002Published inissue 1 September 1968https://doi.org/10.1021/jo01273a044RIGHTS & PERMISSIONSArticle Views47Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (544 KB) Get e-Alerts Get e-Alerts

Transformations in the morphine series. 3. Conversion of thebaine into methanobenzofuro[3,2-d]azocines.

Transformations in the morphine series. 3. Conversion of thebaine into methanobenzofuro[3,2-d]azocines.

Codeinone as the intermediate in the biosynthetic conversion of thebaine to codeine.

Codeinone as the intermediate in the biosynthetic conversion of thebaine to codeine.