To enhance the path tracking capability and driving stability of intelligent vehicles, a controller is designed that synergizes active front wheel steering (AFS) and direct yaw moment (DYC), specifically tailored for distributed-drive electric vehicles. To address the challenge of determining the weight matrix in the linear quadratic regulator (LQR) algorithm during the path tracking design for intelligent vehicles on conventional roads, a genetic algorithm (GA)-optimized LQR path tracking controller is introduced. The 2-degree-of-freedom vehicle dynamics error model and the desired path information are established. The genetic algorithm optimization strategy, utilizing the vehicle’s lateral error, heading error, and output front wheel steering angle as the objective functions, is employed to optimally determine the weight matrices Q and R. Subsequently, the optimal front wheel steering angle control (AFS) output of the vehicle is calculated. Under extreme operating conditions, to enhance vehicle dynamics stability, while ensuring effective path tracking, the active yaw moment is crafted using the sliding mode control with a hyperbolic tangent convergence law function. The control weights of the sliding mode surface related to the center-of-mass lateral declination are adjusted based on the theory of the center-of-mass lateral declination phase diagram, and the vehicle’s target yaw moment is calculated. Validation is conducted through Matlab/Simulink and Carsim co-simulation. The results demonstrate that the genetic algorithm-optimized LQR path tracking controller enhances vehicle tracking accuracy and exhibits improved robustness under conventional road conditions. In extreme working conditions, the designed path tracking and stability cooperative controller (AFS+DYC) is implemented to enhance the vehicle’s path tracking effect, while ensuring its driving stability.