Conventional Machine Learning Classifiers Research Articles

Comprehensive Review of Feature Extraction Techniques for sEMG Signal Classification: From Handcrafted Features to Deep Learning Approaches

Surface Electromyography (sEMG) has become an essential tool in various fields, including prosthetic control and clinical evaluation of the neuromusculoskeletal system. In recent years, the application of machine learning and deep learning techniques to sEMG signal classification has gained significant interest. This survey provides a detailed exploration of feature extraction methods for sEMG classification, from traditional handcrafted features to learned features. ObjectivesThis review aims to provide a comprehensive overview of feature extraction techniques for sEMG signal classification, focusing on both handcrafted and learned features. It seeks to advance research by offering a deeper understanding of fundamental concepts in sEMG signal analysis, along with comparisons and summaries of state-of-the-art approaches. Materials and MethodsThe survey covers various feature extraction techniques used for sEMG classification, including signal acquisition, preprocessing, and the application of conventional machine learning and deep learning classifiers. It offers taxonomies, definitions, and performance comparisons, equipping researchers with a broad understanding of current methodologies. ResultsHandcrafted features combined with traditional machine learning classifiers have demonstrated strong performance, especially with smaller datasets. However, deep learning techniques have shown superior results in many applications, despite challenges related to data availability and model interpretability. The survey highlights key findings regarding the performance of both approaches. ConclusionThis study bridges the gap between traditional and learned feature extraction techniques for sEMG signal classification. It provides a valuable resource for researchers and practitioners, offering insights that can guide future advancements. Key areas for future research include addressing data scarcity in deep learning and improving model interpretability for clinical applications.

MetaCGRP is a high-precision meta-model for large-scale identification of CGRP inhibitors using multi-view information

Migraine is considered one of the debilitating primary headache conditions with an estimated worldwide occurrence of approximately 14–15%, contributing highly to factors responsible for global disability. Calcitonin gene-related peptide (CGRP) is a neuropeptide that plays a crucial role in the pathophysiology of migraines and thus, its inhibition can help relieve migraine symptoms. However, conventional process of CGRP drug development has been laborious and time-consuming with incurred costs exceeding one billion dollars. On the other hand, machine learning (ML)-based approaches that are capable of accurately identifying CGRP inhibitors could greatly facilitate in expediting the discovery of novel CGRP drugs. Therefore, this study proposes a novel and high-accuracy meta-model, namely MetaCGRP, that can precisely identify CGRP inhibitors. To the best of our knowledge, MetaCGRP is the first SMILES-based approach that has been developed to identify CGRP inhibitors without the use of 3D structural information. In brief, we initially employed different molecular representation methods coupled with popular ML algorithms to construct a pool of baseline models. Then, all baseline models were optimized and used to generate multi-view features. Finally, we employed the feature selection method to optimize the multi-view features and determine the best feature subset to enable the construction of the meta-model. Both cross-validation and independent tests indicated that MetaCGRP clearly outperforms several conventional ML classifiers, with accuracies of 0.898 and 0.799 on the training and independent test datasets, respectively. In addition, MetaCGRP in conjunction with molecular docking was utilized to identify five potential natural product candidates from Thai herbal pharmacopoeia and analyze their binding affinity and interactions to CGRP. To facilitate community-wide efforts in expediting the discovery of novel CGRP inhibitors, a user-friendly web server for MetaCGRP is freely available at https://pmlabqsar.pythonanywhere.com/MetaCGRP.

Social Media Authentication and Combating Deepfakes using Semi-fragile Invisible Image Watermarking

With the significant advances in deep generative models for image and video synthesis, Deepfakes and manipulated media have raised severe societal concerns. Conventional machine learning classifiers for deepfake detection often fail to cope with evolving deepfake generation technology and are susceptible to adversarial attacks. Alternatively, invisible image watermarking is being researched as a proactive defense technique that allows media authentication by verifying an invisible secret message embedded in the image pixels. A handful of invisible image watermarking techniques introduced for media authentication have proven vulnerable to basic image processing operations and watermark removal attacks. In response, we have proposed a semi-fragile image watermarking technique that embeds an invisible secret message into real images for media authentication. Our proposed watermarking framework is designed to be fragile to facial manipulations or tampering while being robust to benign image-processing operations and watermark removal attacks. This is facilitated through a unique architecture of our proposed technique consisting of critic and adversarial networks that enforce high image quality and resiliency to watermark removal efforts, respectively, along with the backbone encoder-decoder and the discriminator networks. This allows images shared over the Internet to retain the verifiable watermark as long as facial manipulations or any other Deepfake modification technique is not applied. Thorough experimental investigations on SOTA facial Deepfake datasets demonstrate that our proposed model can embed a \(64\) -bit secret as an imperceptible image watermark that can be recovered with a high-bit recovery accuracy when benign image processing operations are applied while being non-recoverable when unseen Deepfake manipulations are applied. In addition, our proposed watermarking technique demonstrates high resilience to several white-box and black-box watermark removal attacks. Thus, obtaining state-of-the-art performance.

A Lightweight Multi-Mental Disorders Detection Method Using Entropy-Based Matrix from Single-Channel EEG Signals.

Background: Mental health issues are increasingly prominent worldwide, posing significant threats to patients and deeply affecting their families and social relationships. Traditional diagnostic methods are subjective and delayed, indicating the need for an objective and effective early diagnosis method. Methods: To this end, this paper proposes a lightweight detection method for multi-mental disorders with fewer data sources, aiming to improve diagnostic procedures and enable early patient detection. First, the proposed method takes Electroencephalography (EEG) signals as sources, acquires brain rhythms through Discrete Wavelet Decomposition (DWT), and extracts their approximate entropy, fuzzy entropy, permutation entropy, and sample entropy to establish the entropy-based matrix. Then, six kinds of conventional machine learning classifiers, including Support Vector Machine (SVM), k-Nearest Neighbors (kNN), Naive Bayes (NB), Generalized Additive Model (GAM), Linear Discriminant Analysis (LDA), and Decision Tree (DT), are adopted for the entropy-based matrix to achieve the detection task. Their performances are assessed by accuracy, sensitivity, specificity, and F1-score. Concerning these experiments, three public datasets of schizophrenia, epilepsy, and depression are utilized for method validation. Results: The analysis of the results from these datasets identifies the representative single-channel signals (schizophrenia: O1, epilepsy: F3, depression: O2), satisfying classification accuracies (88.10%, 75.47%, and 89.92%, respectively) with minimal input. Conclusions: Such performances are impressive when considering fewer data sources as a concern, which also improves the interpretability of the entropy features in EEG, providing a reliable detection approach for multi-mental disorders and advancing insights into their underlying mechanisms and pathological states.

Deep neural networks and conventional machine learning classifiers to analyze thoracic survival data

Lung cancer is a prevalent global health concern and most prevalent malignancy in Indonesian hospitals. Following thoracic surgery, patients were categorized into two classes: individuals who experienced mortality within a year and those who achieved survival. Despite being about socks, the dataset for the deceased category consisted of 70 data samples, while the dataset for the final group comprised 400 samples. Data calculation involves the utilization of both deep neural networks and standard machine learning algorithms. The study use the Python programming language to evaluate the algorithms, and it measures their performance using metrics such as accuracy, F1-Score, precision, recall, receiver operating characteristic (ROC), and area under curve (AUC). The test results indicate that the deep neural network method achieves an accuracy of 95,56%, an F1 score of 79,24%, a precision of 91,96%, a recall of 85,52%, and an AUC of 85,52%. This study suggests that utilizing deep neural network data mining techniques, specifically with a cross-validation fold of 10, variations of six hidden layer encoder-decoder, relu, sigmoid activation function, optimizer Adam, and learning rate of 0,01, dropout rate of 0,2. Employing the Synthetic Minority Over-sampling Technique data preprocessing method, can effectively analyze thoracic patient survival data sets.

Arabic dialect identification in social media: A hybrid model with transformer models and BiLSTM

Arabic Dialect Identification (ADI) is a challenging task in natural language processing applications due to its diversity and regional variations. Despite previous efforts, this task is still difficult. Therefore, this study aims to use transformers to address the issue of ADI on social media. A combination of two hybrid models is proposed in this study: one that combines Bidirectional Long Short-Term Memory (BiLSTM) with CAMeLBERT, and the second model that combines the BiLSTM model with AlBERT. In addition, a novel dataset comprising 121,289 user-generated comments from various social media network platforms and four major Arabic dialects (Egyptian, Jordanian, Gulf and Yemeni) was introduced. Several experiments have been conducted using conventional Machine Learning Classifiers (MLCs) and Deep Learning Models (DLMs) as baselines to measure the performance and effectiveness of the proposed models. In addition, binary classification is performed between two dialects to determine which are closest to each other. The performance of the model is measured using common metrics such as precision, recall, F-score and F-measure. Experiment results demonstrate the superior efficiency of the proposed hybrid models in ADI, CAMeLBERT with BiLSTM and ALBERT with BiLSTM, which both recorded an accuracy of 87.67 % and 86.51 %, respectively.

NaII-Pred: An ensemble-learning framework for the identification and interpretation of sodium ion inhibitors by fusing multiple feature representation

High-affinity ligand peptides for ion channels are essential for controlling the flow of ions across the plasma membrane. These peptides are now being investigated as possible therapeutic possibilities for a variety of illnesses, including cancer and cardiovascular disease. So, the identification and interpretation of ligand peptide inhibitors to control ion flow across cells become pivotal for exploration. In this work, we developed an ensemble-based model, NaII-Pred, for the identification of sodium ion inhibitors. The ensemble model was trained, tested, and evaluated on three different datasets. The NaII-Pred method employs six different descriptors and a hybrid feature set in conjunction with five conventional machine learning classifiers to create 35 baseline models. Through an ensemble approach, the top five baseline models trained on the hybrid feature set were integrated to yield the final predictive model, NaII-Pred. Our proposed model, NaII-Pred, outperforms the baseline models and the current predictors on both datasets. We believe NaII-Pred will play a critical role in screening and identifying potential sodium ion inhibitors and will be an invaluable tool.

Independent Video Steganalysis Framework Perspective of Secure Video Processing

We have designed an algorithm of cross-domain feature set extraction for cross-domain video steganalysis of video steganography in multiple domains. For video steganography, we implemented the recently proposed steganography methods such as PMs, MVs, and IPMs. The outcomes of these techniques have fed as input to the proposed Steganalysis approach. We have designed a cross-domain technique for Steganalysis in which the global feature set is extracted according to common statistical properties. After the extraction of global features, the domain-specific features have been extracted in the local features set. Both global and local features are set to form the cross-domain steganalysis technique. The classification has been performed by using the conventional machine learning classifiers such as Support Vector Machine (SVM) and Artificial Neural Network (ANN).

Using Ensemble Learning for Anomaly Detection in Cyber–Physical Systems

The swift embrace of Industry 4.0 paradigms has led to the growing convergence of Information Technology (IT) networks and Operational Technology (OT) networks. Traditionally isolated on air-gapped and fully trusted networks, OT networks are now becoming more interconnected with IT networks due to the advancement and applications of IoT. This expanded attack surface has led to vulnerabilities in Cyber–Physical Systems (CPSs), resulting in increasingly frequent compromises with substantial economic and life safety repercussions. The existing methods for the anomaly detection of security threats typically use simple threshold-based strategies or apply Machine Learning (ML) algorithms to historical data for the prediction of future anomalies. However, due to the high levels of heterogeneity across different CPS environments, minimizing the opportunities for transfer learning, and the scarcity of real-world data for training, the existing ML-based anomaly detection techniques suffer from a poor predictive performance. This paper introduces a hybrid anomaly detection approach designed to identify threats to CPSs by combining the signature-based anomaly detection typically utilized in IT networks, the threshold-based anomaly detection typically utilized in OT networks, and behavioural-based anomaly detection using Ensemble Learning (EL), which leverages the strengths of multiple ML algorithms against the same dataset to increase the accuracy. Multiple public research datasets were used to validate the proposed approach, with the hybrid methodology employing a divide-and-conquer strategy to offload the detection of certain cyber threats to computationally inexpensive signature-based and threshold-based methods using domain knowledge to minimize the size of the behavioural-based data needed for ML model training, thus achieving a higher accuracy over a reduced timeframe. The experimental results showed accuracy improvements of 4–7% over those of the conventional ML classifiers in performing anomaly detection across multiple datasets, which is particularly important to the operators of CPS environments due to the high financial and life safety costs associated with interruptions to system availability.

Real-time classification of tumour and non-tumour tissue in colorectal cancer using diffuse reflectance spectroscopy and neural networks to aid margin assessment.

Colorectal cancer is the third most commonly diagnosed malignancy and the second leading cause of mortality worldwide. A positive resection margin following surgery for colorectal cancer is linked with higher rates of local recurrence and poorer survival. We investigated diffuse reflectance spectroscopy (DRS) to distinguish tumour and non-tumour tissue in ex vivo colorectal specimens, to aid margin assessment and provide augmented visual maps to the surgeon in real-time. Patients undergoing elective colorectal cancer resection surgery at a London-based hospital were prospectively recruited. A hand-held DRS probe was used on the surface of freshly resected ex vivo colorectal tissue. Spectral data was acquired for tumour and non-tumour tissue. Binary classification was achieved using conventional machine learning classifiers and a convolutional neural network (CNN), which were evaluated in terms of sensitivity, specificity, accuracy and the area under the curve. A total of 7692 mean spectra were obtained for tumour and non-tumour colorectal tissue. The CNN-based classifier was the best performing machine learning algorithm, when compared to contrastive approaches, for differentiating tumour and non-tumour colorectal tissue, with an overall diagnostic accuracy of 90.8% and area under the curve of 96.8%. Live on-screen classification of tissue type was achieved using a graduated colourmap. A high diagnostic accuracy for a DRS probe and tracking system to differentiate ex vivo tumour and non-tumour colorectal tissue in real-time with on-screen visual feedback was highlighted by this study. Further in vivo studies are needed to ensure integration into a surgical workflow.

An integrative machine learning model for the identification of tumor T-cell antigens

The escalating global incidence of cancer poses significant health challenges, underscoring the need for innovative and more efficacious treatments. Cancer immunotherapy, a promising approach leveraging the body’s immune system against cancer, emerges as a compelling solution. Consequently, the identification and characterization of tumor T-cell antigens (TTCAs) have become pivotal for exploration. In this manuscript, we introduce TTCA-IF, an integrative machine learning-based framework designed for TTCAs identification. TTCA-IF employs ten feature encoding types in conjunction with five conventional machine learning classifiers. To establish a robust foundation, these classifiers are trained, resulting in the creation of 150 baseline models. The outputs from these baseline models are then fed back into the five classifiers, generating their respective meta-models. Through an ensemble approach, the five meta-models are seamlessly integrated to yield the final predictive model, the TTCA-IF model. Our proposed model, TTCA-IF, surpasses both baseline models and existing predictors in performance. In a comparative analysis involving nine novel peptide sequences, TTCA-IF demonstrated exceptional accuracy by correctly identifying 8 out of 9 peptides as TTCAs. As a tool for screening and pinpointing potential TTCAs, we anticipate TTCA-IF to be invaluable in advancing cancer immunotherapy.

Deep-WET: a deep learning-based approach for predicting DNA-binding proteins using word embedding techniques with weighted features

DNA-binding proteins (DBPs) play a significant role in all phases of genetic processes, including DNA recombination, repair, and modification. They are often utilized in drug discovery as fundamental elements of steroids, antibiotics, and anticancer drugs. Predicting them poses the most challenging task in proteomics research. Conventional experimental methods for DBP identification are costly and sometimes biased toward prediction. Therefore, developing powerful computational methods that can accurately and rapidly identify DBPs from sequence information is an urgent need. In this study, we propose a novel deep learning-based method called Deep-WET to accurately identify DBPs from primary sequence information. In Deep-WET, we employed three powerful feature encoding schemes containing Global Vectors, Word2Vec, and fastText to encode the protein sequence. Subsequently, these three features were sequentially combined and weighted using the weights obtained from the elements learned through the differential evolution (DE) algorithm. To enhance the predictive performance of Deep-WET, we applied the SHapley Additive exPlanations approach to remove irrelevant features. Finally, the optimal feature subset was input into convolutional neural networks to construct the Deep-WET predictor. Both cross-validation and independent tests indicated that Deep-WET achieved superior predictive performance compared to conventional machine learning classifiers. In addition, in extensive independent test, Deep-WET was effective and outperformed than several state-of-the-art methods for DBP prediction, with accuracy of 78.08%, MCC of 0.559, and AUC of 0.805. This superior performance shows that Deep-WET has a tremendous predictive capacity to predict DBPs. The web server of Deep-WET and curated datasets in this study are available at https://deepwet-dna.monarcatechnical.com/. The proposed Deep-WET is anticipated to serve the community-wide effort for large-scale identification of potential DBPs.

AttentiveSkin: To Predict Skin Corrosion/Irritation Potentials of Chemicals via Explainable Machine Learning Methods.

Skin Corrosion/Irritation (Corr./Irrit.) has long been a health hazard in the Globally Harmonized System (GHS). Several in silico models have been built to predict Skin Corr./Irrit. as an alternative to the increasingly restricted animal testing. However, current studies are limited by data amount/quality and model availability. To address these issues, we compiled a traceable consensus GHS data set comprising 731 Corr., 1283 Irrit., and 1205 negative (Neg.) samples from 6 governmental databases and 2 external data sets. Then, a series of binary classifiers were developed with five machine learning (ML) algorithms and six molecular representations. For 10-fold cross-validation, the best Corr. vs Neg. classifier achieved an Area Under the Receiver Operating Characteristic Curve (AUC) of 97.1%, while the best Irrit. vs Neg. classifier achieved an AUC of 84.7%. Compared with existing in silico tools on external validation, our Attentive FP classifiers showed the highest metrics on Corr. vs Neg. and the second highest accuracy on Irrit. vs Neg. The SHapley Additive exPlanation approach was further applied to figure out important molecular features, and the attention weights were visualized to perform interpretable prediction. Structural alerts associated with Skin Corr./Irrit. were also identified. The interpretable Attentive FP classifiers were integrated into the software AttentiveSkin at https://github.com/BeeBeeWong/AttentiveSkin. The conventional ML classifiers are also provided on our platform admetSAR at http://lmmd.ecust.edu.cn/admetsar2/. Considering the data deficiency and the limited model availability of Skin Corr./Irrit., we believe that our data set and models could facilitate chemical safety assessment and relevant studies.

A DEEP LEARNING-BASED APPROACH FOR DETECTING AND CLASSIFYING INAPPROPRIATE CONTENT IN YOUTUBE VIDEOS

There are now billions of videos on YouTube, with most of the viewers being young people. The growth in the quantity of videos has been exponential. To add insult to injury, some unscrupulous users post unsettling animated cartoon films and other material that parents should not allow their children to see. Therefore, social media sites should have a way to filter videos automatically in real time. In order to identify and categorize objectionable video material, this research proposes a new architecture based on deep learning. To do this, the suggested system employs a convolutional neural network (CNN) model named EfficientNet-B7 that has been pre-trained on ImageNet to extract video descriptors. A bidirectional long short-term memory (BiLSTM) network is trained to classify videos into many categories using these characteristics. In order to distribute attention probabilities throughout the network, an attention mechanism is also included after BiLSTM. We test these models using a dataset that has 111,156 cartoon clips tagged by humans from YouTube videos. The experimental findings showed that EfficientNet-BiLSTM achieved a higher accuracy (D=95.30%) than the EfficientNet-BiLSTM framework that was based on the attention mechanism. To continue, when compared to more conventional machine learning classifiers, deep learning ones outperform the pack. With an overall f1 score of D 0.9267, the combination of EfficientNet and BiLSTM, which includes 128 hidden units, achieved state-of-the-art performance. Furthermore, when stacked on top of CNN, BiLSTM outperforms state-of-the-art methods in detecting and classifying children-unsuitable video content because it better grasps the contextual information of video descriptors in network architecture.

StackER: a novel SMILES-based stacked approach for the accelerated and efficient discovery of ERα and ERβ antagonists

The role of estrogen receptors (ERs) in breast cancer is of great importance in both clinical practice and scientific exploration. However, around 15–30% of those affected do not see benefits from the usual treatments owing to the innate resistance mechanisms, while 30–40% will gain resistance through treatments. In order to address this problem and facilitate community-wide efforts, machine learning (ML)-based approaches are considered one of the most cost-effective and large-scale identification methods. Herein, we propose a new SMILES-based stacked approach, termed StackER, for the accelerated and efficient identification of ERα and ERβ inhibitors. In StackER, we first established an up-to-date dataset consisting of 1,996 and 1,207 compounds for ERα and ERβ, respectively. Using the up-to-date dataset, StackER explored a wide range of different SMILES-based feature descriptors and ML algorithms in order to generate probabilistic features (PFs). Finally, the selected PFs derived from the two-step feature selection strategy were used for the development of an efficient stacked model. Both cross-validation and independent tests showed that StackER surpassed several conventional ML classifiers and the existing method in precisely predicting ERα and ERβ inhibitors. Remarkably, StackER achieved MCC values of 0.829–0.847 and 0.712–0.786 in terms of the cross-validation and independent tests, respectively, which were 5.92–8.29 and 1.59–3.45% higher than the existing method. In addition, StackER was applied to determine useful features for being ERα and ERβ inhibitors and identify FDA-approved drugs as potential ERα inhibitors in efforts to facilitate drug repurposing. This innovative stacked method is anticipated to facilitate community-wide efforts in efficiently narrowing down ER inhibitor screening.

Strength of ensemble learning in automatic sleep stages classification using single-channel EEG and ECG signals.

Healthy sleep plays an essential role in human daily life. Classification of sleep stages is a crucial tool for assisting physicians in diagnosing and treating sleep disorders. In this study, a strong ensemble learning model is proposed to enhance the ability of classification models in accurate sleep staging, particularly in multi-class classification. We asserted that high-accuracy sleep classification is achievable using only single-channel electroencephalogram (EEG) and electrocardiogram (ECG) by combining their best-extractable features in the time and frequency domains we recommended. More importantly, the superiority of the recommended method, which is the simultaneous use of stacking and bagging, over conventional machine learning classifiers in sleep staging was demonstrated, using the MIT-BIH Polysomnographic and Sleep-EDF expanded databases. Finally, K-fold cross-validation was used to fairly estimate these models. The best mean test accuracy rates for distinguishing between two classes of "sleep vs. wake," "rapid vs. non-rapid eye movement," and "deep vs. light sleep," were obtained 99.93%, 99.64%, and 99.69%, respectively. Furthermore, our proposed method achieved accuracies of 97.14%, 95.18%, 92.7%, and 85.64% for separating three, four, five, and six sleep classes, respectively. Compared to recent studies, our method outperforms other sleep stage classification schemes, especially in multi-class staging.

A Deep Survey on Human Activity Recognition Using Mobile and Wearable Sensors

Activity-based wellness management is thought to be a powerful application for mobile health. It is possible to provide context-aware wellness services and track human activity thanks to accessing for multiple devices as well as gadgets that we use every day. Generally in smart gadgets like phones, watches, rings etc., the embedded sensors having a wealth data that can be incorporated to person task tracking identification. In a real-world setting, all researchers shown effective boosting algorithms can extract information in person task identification. Identifying basic person tasks such as talk, walk, sit along sleep. Our findings demonstrate that boosting classifiers perform better than conventional machine learning classifiers. Moreover, the feature engineering for differentiating an activity detection capability for smart phones and smart watches. For the purpose of improving the classification of fundamental human activities, upcoming mechanisms give the guidelines for identification for various sensors and wearable devices.

IF-AIP: A machine learning method for the identification of anti-inflammatory peptides using multi-feature fusion strategy

Background:The most commonly used therapy currently for inflammatory and autoimmune diseases is nonspecific anti-inflammatory drugs, which have various hazardous side effects. Recently, some anti-inflammatory peptides (AIPs) have been found to be a substitute therapy for inflammatory diseases like rheumatoid arthritis and Alzheimer’s. Therefore, the identification of these AIPs is an emerging topic that is equally important. Methods:In this work, we have proposed an identification model for AIPs using a voting classifier. We used eight different feature descriptors and five conventional machine-learning classifiers. The eight feature encodings were concatenated to get a hybrid feature set. The five baseline models trained on the hybrid feature set were integrated via a voting classifier. Finally, a feature selection algorithm was used to select the optimal feature set for the construction of our final model, named IF-AIP. Results:We tested the proposed model on two independent datasets. On independent data 1, the IF-AIP model shows an improvement of 3%–5.6% in terms of accuracies and 6.7%–10.8% in terms of MCC compared to the existing methods. On the independent dataset 2, our model IF-AIP shows an overall improvement of 2.9%–5.7% in terms of accuracy and 8.3%–8.6% in terms of MCC score compared to the existing methods. A comparative performance analysis was conducted between the proposed model and existing methods using a set of 24 novel peptide sequences. Notably, the IF-AIP method exhibited exceptional accuracy, correctly identifying all 24 peptides as AIPs. The source code, pre-trained models, and all datasets are made available at https://github.com/Mir-Saima/IF-AIP.

Deep learning-based meta-learner strategy for electricity theft detection

Electricity theft damages power grid infrastructure and is also responsible for huge revenue losses for electric utilities. Integrating smart meters in traditional power grids enables real-time monitoring and collection of consumers’ electricity consumption (EC) data. Based on the collected data, it is possible to identify the normal and malicious behavior of consumers by analyzing the data using machine learning (ML) and deep learning methods. This paper proposes a deep learning-based meta-learner model to distinguish between normal and malicious patterns in EC data. The proposed model consists of two stages. In Fold-0, the ML classifiers extract diverse knowledge and learns based on EC data. In Fold-1, a multilayer perceptron is used as a meta-learner, which takes the prediction results of Fold-0 classifiers as input, automatically learns non-linear relationships among them, and extracts hidden complicated features to classify normal and malicious behaviors. Therefore, the proposed model controls the overfitting problem and achieves high accuracy. Moreover, extensive experiments are conducted to compare its performance with boosting, bagging, standalone conventional ML classifiers, and baseline models published in top-tier outlets. The proposed model is evaluated using a real EC dataset, which is provided by the Energy Informatics Group in Pakistan. The model achieves 0.910 ROC-AUC and 0.988 PR-AUC values on the test dataset, which are higher than those of the compared models.

TROLLOPE: A novel sequence-based stacked approach for the accelerated discovery of linear T-cell epitopes of hepatitis C virus.

Hepatitis C virus (HCV) infection is a concerning health issue that causes chronic liver diseases. Despite many successful therapeutic outcomes, no effective HCV vaccines are currently available. Focusing on T cell activity, the primary effector for HCV clearance, T cell epitopes of HCV (TCE-HCV) are considered promising elements to accelerate HCV vaccine efficacy. Thus, accurate and rapid identification of TCE-HCVs is recommended to obtain more efficient therapy for chronic HCV infection. In this study, a novel sequence-based stacked approach, termed TROLLOPE, is proposed to accurately identify TCE-HCVs from sequence information. Specifically, we employed 12 different sequence-based feature descriptors from heterogeneous perspectives, such as physicochemical properties, composition-transition-distribution information and composition information. These descriptors were used in cooperation with 12 popular machine learning (ML) algorithms to create 144 base-classifiers. To maximize the utility of these base-classifiers, we used a feature selection strategy to determine a collection of potential base-classifiers and integrated them to develop the meta-classifier. Comprehensive experiments based on both cross-validation and independent tests demonstrated the superior predictive performance of TROLLOPE compared with conventional ML classifiers, with cross-validation and independent test accuracies of 0.745 and 0.747, respectively. Finally, a user-friendly online web server of TROLLOPE (http://pmlabqsar.pythonanywhere.com/TROLLOPE) has been developed to serve research efforts in the large-scale identification of potential TCE-HCVs for follow-up experimental verification.