Liquid desiccant and desiccant wheel systems are feasible approaches for the dehumidification process in modern buildings. Some specialized buildings and industrial fields have the demand for deep dehumidification process to produce supply air with low dew point temperature below 0 °C. In this study, the numerical investigation has been conducted to evaluate the energy and exergy performance of multiple cascading deep dehumidification systems assisted with liquid desiccant and desiccant wheel under a great dehumidification gradient. To process the air from 21 g/kg to 1 g/kg, the results indicate that the cascading liquid desiccant and desiccant wheel deep dehumidification system (LD-DW system) driven by two stages of heat pump exhibits the lowest demand of power consumption compared with the conventional dehumidification systems. It also shows less exergy loss and significantly higher exergy efficiency than other systems. The effects of influencing parameters on the dehumidification performance are also evaluated. The LD-DW system can effectively match the air state with the proper treatment dehumidification process, thus achieving a superior coefficient of system performance (COPsys) of 3.70, and it is an energy and exergy efficient method for advancing the deep dehumidification process.
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