Controlled Vocabulary Research Articles

Forms and Functions of Author Keywords in Theses and Dissertations at the UNESP Institutional Repository (Brazil)

This research aimed to prepare guidelines for authors by investigating forms and functions of keywords assigned by authors in theses and dissertations defended in 2023 in the Graduate Program in Information Science at Unesp. The exploratory and descriptive study utilized a sample collected in the Unesp Institutional Repository. A corpus of 31 theses and 14 dissertations submitted to the Unesp Institutional Repository comprised a total of 183 keywords in Portuguese without duplicates and an average of 4.7 keywords, considering 213 keywords with duplicates. The analysis results initially identified that the Repository has a tutorial on using the Unesp Thesaurus to control vocabulary and that the authors use natural language to assign keywords. The findings reveal that, out of the 183 keywords, 89 (48\%) are exclusive, singular and specific to the area of Information Science, candidates for descriptors in the Unesp Thesaurus. The other 94 keywords (51.3\%) have 40 (21.3\%) exact descriptors, and the other 54 (29.5\%) present forms and functions that serve as examples for inclusion in the tutorial instructions. Based on the results obtained, it is concluded that the percentage of 21\% overlap between keywords and descriptors reveals that the Unesp Thesaurus was consulted by the authors when filling out keyword metadata and that the low number of exact descriptors and exclusive keywords indicate that they need to be included as new terms. It is recommended, therefore, to define an Indexing Policy that considers the need for hybrid coexistence between natural language and vocabulary control.

Freedom Versus Standard in Article Keyword Generation: An Empirical Study

This study compares the overlap among author-furnished keywords, Library of Congress Subject Headings and a consolidated controlled vocabulary for articles published in Annals of Library & Information Studies, published by NISCAIR from 2018 to 2023, India. The study focuses on the effectiveness of controlled vocabulary for keyword generation. The work is intended to contribute to the literature on author keywords versus keyword standardization in measuring information retrieval efficacy in real-time. The aggregated controlled vocabulary constructed for this study provided a positive result, showing the usefulness and requirements of such a robust controlled vocabulary. The study reflects the extended views of thesauri for a standard author keyword suggester or recommender system.

The use of prescription medications and non-prescription medications during lactation in a prospective Canadian cohort study

BackgroundA lack of safety data on postpartum medication use presents a potential barrier to breastfeeding and may result in infant exposure to medications in breastmilk. The type and extent of medication use by lactating women requires investigation.MethodsData were collected from the CHILD Cohort Study which enrolled pregnant women across Canada between 2008 and 2012. Participants completed questionnaires regarding medications and non-prescription medications used and breastfeeding status at 3, 6 and 12 months postpartum. Medications, along with self-reported reasons for medication use, were categorized by ontologies [hierarchical controlled vocabulary] as part of a large-scale curation effort to enable more robust investigations of reasons for medication use.ResultsA total of 3542 mother-infant dyads were recruited to the CHILD study. Breastfeeding rates were 87.4%, 75.3%, 45.5% at 3, 6 and 12 months respectively. About 40% of women who were breastfeeding at 3 months used at least one prescription medication during the first three months postpartum; this proportion decreased over time to 29.5% % at 6 months and 32.8% at 12 months. The most commonly used prescription medication by breastfeeding women was domperidone at 3 months (9.0%, n = 229/2540) and 6 months (5.6%, n = 109/1948), and norethisterone at 12 months (4.1%, n = 48/1180). The vast majority of domperidone use by breastfeeding women (97.3%) was for lactation purposes which is off-label (signifying unapproved use of an approved medication). Non-prescription medications were more often used among breastfeeding than non-breastfeeding women (67.6% versus 48.9% at 3 months, p < 0.0001), The most commonly used non-prescription medications were multivitamins and Vitamin D at 3, 6 and 12 months postpartum.ConclusionsIn Canada, medication use is common postpartum; 40% of breastfeeding women use prescription medications in the first 3 months postpartum. A diverse range of medications were used, with many women taking more than one prescription and non-prescription medicines. The most commonly used prescription medication by breastfeeding women were domperidone for off-label lactation support, signalling a need for more data on the efficacy of domperidone for this indication. This data should inform research priorities and communication strategies developed to optimize care during lactation.

Treatments and interventions addressing chronic somatic pain in torture survivors: A systematic review.

Torture survivors experience chronic, somatic pain that may be exacerbated by environmental, social, and structural factors that extend beyond immediate traumatic events and diagnoses. We conducted a systematic review of research describing the types and efficacy of treatments for chronic somatic pain in a global population of torture survivors. In this systematic review, we searched Ovid MEDLINE, Ovid EMBASE (1974 to present), and PubMed. We used all appropriate controlled vocabulary and keywords for interventions and treatments for chronic somatic pain in torture survivors. The population included survivors of torture of any age and in any country. Outcomes included pain relief, pain intensity, distress level, and quality of life. Four authors participated in screening, full-text review, and quality assessment, with each title and abstract being independently reviewed by two authors. This study is reported according to the PRISMA guidelines and registered in PROSPERO. We included six pre-post intervention studies and four pilot or modified randomized controlled trials (RCTs), for a total of ten studies included in the analysis. Different combinations of interventions targeted pain reduction in refugees, the majority of whom were torture survivors as the primary (n = 1) or secondary (n = 9) outcome. Sample sizes varied from eight to 470 participants. We identified three main types of interventions: multimodal combined, manual therapy, and specific types of talk therapy. Five studies demonstrated positive outcomes on pain and its intensity, three reported no effect, and two had mixed outcomes. Pain in torture survivors is often considered a symptom secondary to mental health illness and not targeted directly. Instead, combined interventions are mainly directed at posttraumatic stress disorder (PTSD), depression, and anxiety. Most studies noted promising preliminary results and plans to conduct RCTs to increase the reproducibility and quality of their pilot data.

Grammar intervention using graduated input type variation (GITV) for pre-primary children: A single-case experimental design study

Purpose This study examined the early efficacy of a new theory-driven principle of grammar intervention, graduated input type variation (GITV). Method Three Cantonese-speaking children, aged between 4;01 and 5;10, with oral language difficulties participated in this single baseline within-participant single case experimental study. The children received a total of 300 teaching episodes of the target serial verb construction via focused stimulation and recast over 10 30- to 45-minute sessions. The 30 exemplars of the target included low type variation of the verbs in each of the first five sessions, followed by high type variation in the remaining sessions. Result Visual analysis revealed that all children improved their performance in the target construction but not the control vocabulary in the probes, suggesting a treatment effect. Maintenance of treatment effects was also observed in all children. Positive results in across-behaviour generalisation to the untrained construction were observed in all children. Generalisation to other less structured linguistic contexts and to the narrative retell discourse context was minimal and observed in one child only. Conclusion Preliminary evidence suggested early efficacy of GITV as a principle for grammar intervention. Modifications in the research methodology are recommended for future studies involving children with developmental language disorder.

Standardizing Extracted Data Using Automated Application of Controlled Vocabularies.

Extraction of toxicological end points from primary sources is a central component of systematic reviews and human health risk assessments. To ensure optimal use of these data, consistent language should be used for end point descriptions. However, primary source language describing treatment-related end points can vary greatly, resulting in large labor efforts to manually standardize extractions before data are fit for use. To minimize these labor efforts, we applied an augmented intelligence approach and developed automated tools to support standardization of extracted information via application of preexisting controlled vocabularies. We created and applied a harmonized controlled vocabulary crosswalk, consisting of Unified Medical Language System (UMLS) codes, German Federal Institute for Risk Assessment (BfR) DevTox harmonized terms, and The Organization for Economic Co-operation and Development (OECD) end point vocabularies, to roughly 34,000 extractions from prenatal developmental toxicology studies conducted by the National Toxicology Program (NTP) and 6,400 extractions from European Chemicals Agency (ECHA) prenatal developmental toxicology studies, all recorded based on the original study report language. We automatically applied standardized controlled vocabulary terms to 75% of the NTP extracted end points and 57% of the ECHA extracted end points. Of all the standardized extracted end points, about half (51%) required manual review for potential extraneous matches or inaccuracies. Extracted end points that were not mapped to standardized terms tended to be too general or required human logic to find a good match. We estimate that this augmented intelligence approach saved hours of manual effort and yielded valuable resources including a controlled vocabulary crosswalk, organized related terms lists, code for implementing an automated mapping workflow, and a computationally accessible dataset. Augmenting manual efforts with automation tools increased the efficiency of producing a findable, accessible, interoperable, and reusable (FAIR) dataset of regulatory guideline studies. This open-source approach can be readily applied to other legacy developmental toxicology datasets, and the code design is customizable for other study types. https://doi.org/10.1289/EHP13215.

ToxRefDB v2.1: update to curated in vivo study data in the Toxicity Reference Database.

The Toxicity Reference Database (ToxRefDB) contains in vivo study data from over 5,900 guideline or guideline-like studies for over 1,100 chemicals. The database includes information regarding study design, chemical treatment, dosing, treatment group parameters, treatment-related (significantly different from control) and critical (adverse) effects, guided by a controlled effect vocabulary, as well as endpoint testing status according to health effects guideline requirements. ToxRefDB v2.1 is an update to address a compilation error found in ToxRefDB v2.0 that resulted in some effects being inadvertently omitted from the database. Though effect data has been recovered, no new studies were added. The recovered data improves the utility of ToxRefDB as a resource for curated legacy in vivo information, which enhances scientific confidence in vitro high-throughput screening of chemicals and supports retrospective and predictive toxicology applications for which outcomes in traditional regulatory toxicology studies serve as reference information.

SBOannotator: a Python Tool for the Automated Assignment of Systems Biology Ontology Terms.

The number and size of computational models in biology have drastically increased over the past years and continue to grow. Modeled networks are becoming more complex, and reconstructing them from the beginning in an exchangeable and reproducible manner is challenging. Using precisely defined ontologies enables the encoding of field-specific knowledge and the association of disparate data types. In computational modeling, the medium for representing domain knowledge is the set of orthogonal structured controlled vocabularies named Systems Biology Ontology (SBO). The SBO terms enable modelers to explicitly define and describe model entities, including their roles and characteristics. Here, we present the first standalone tool that automatically assigns SBO terms to multiple entities of a given SBML model, named the SBOannotator. The main focus lies on the reactions, as the correct assignment of precise SBO annotations requires their extensive classification. Our implementation does not consider only top-level terms but examines the functionality of the underlying enzymes to allocate precise and highly specific ontology terms to biochemical reactions. Transport reactions are examined separately and are classified based on the mechanism of molecule transport. Pseudo-reactions that serve modeling purposes are given reasonable terms to distinguish between biomass production and the import or export of metabolites. Finally, other model entities, such as metabolites and genes, are annotated with appropriate terms. Including SBO annotations in the models will enhance the reproducibility, usability, and analysis of biochemical networks. SBOannotator is freely available from https://github.com/draeger-lab/SBOannotator/. Supplementary data are available at Bioinformatics online.

Characterizing terminology applied by authors and database producers to informatics literature on consumer engagement with wearable devices.

Identifying consumer health informatics (CHI) literature is challenging. To recommend strategies to improve discoverability, we aimed to characterize controlled vocabulary and author terminology applied to a subset of CHI literature on wearable technologies. To retrieve articles from PubMed that addressed patient/consumer engagement with wearables, we developed a search strategy of textwords and Medical Subject Headings (MeSH). To refine our methodology, we used a random sample of 200 articles from 2016 to 2018. A descriptive analysis of articles (N = 2522) from 2019 identified 308 (12.2%) CHI-related articles, for which we characterized their assigned terminology. We visualized the 100 most frequent terms assigned to the articles from MeSH, author keywords, CINAHL, and Engineering Databases (Compendex and Inspec together). We assessed the overlap of CHI terms among sources and evaluated terms related to consumer engagement. The 308 articles were published in 181 journals, more in health journals (82%) than informatics (11%). Only 44% were indexed with the MeSH term "wearable electronic devices." Author keywords were common (91%) but rarely represented consumer engagement with device data, eg, self-monitoring (n = 12, 0.7%) or self-management (n = 9, 0.5%). Only 10 articles (3%) had terminology from all sources (authors, PubMed, CINAHL, Compendex, and Inspec). Our main finding was that consumer engagement was not well represented in health and engineering database thesauri. Authors of CHI studies should indicate consumer/patient engagement and the specific technology investigated in titles, abstracts, and author keywords to facilitate discovery by readers and expand vocabularies and indexing.

The coverage of information science and knowledge organization in the Library of Congress Subject Headings

PurposeThis article examines the Library of Congress Subject Headings (LCSH), which is the most used subject heading system in the world and an instance of a controlled vocabulary (CV).Design/methodology/approachThe method used to examine the system is based on both authors’ subject knowledge in the field of information science (IS) and the subfield of knowledge organization (KO). Core concepts in this domain were examined (1) by checking if they are present or not in the system; (2) if not, by determining whether LCSH contains alternative terms useful for searching documents about the missing concept, by examining books indexed by the Library of Congress; (3) by identifying the semantic relations between subject headings.FindingsThe results demonstrate fundamental problems in the logical consistency of the representation of IS and KO in LCSH.Practical implicationsThe implications for CVs in general are discussed.Originality/valueNo previous study has used our method to examine LCSH’s coverage of IS.

Errors to avoid when searching for studies for systematic reviews: A guide for nurse researchers

Systematic reviews aim to provide reliable answers to research questions by identifying and synthesising the available evidence using rigorous methods. This makes systematic reviews a cornerstone of evidence-based practice in healthcare settings. However, despite the avowed aim and importance of systematic reviews, studies have shown that they often include serious flaws, including in the search for studies. In this article, some commonly seen errors in systematic review search strategies are described with the intention of alerting nurse researchers who are planning a systematic review to what should be avoided. These include errors relating to bibliographic databases and supplementary searches, including database selection, free-text searching, controlled vocabulary and structural errors. The paper is framed within the context of older people nursing but has relevance to nurse researchers more widely.

Multilingual translation for zero-shot biomedical classification using BioTranslator

Existing annotation paradigms rely on controlled vocabularies, where each data instance is classified into one term from a predefined set of controlled vocabularies. This paradigm restricts the analysis to concepts that are known and well-characterized. Here, we present the novel multilingual translation method BioTranslator to address this problem. BioTranslator takes a user-written textual description of a new concept and then translates this description to a non-text biological data instance. The key idea of BioTranslator is to develop a multilingual translation framework, where multiple modalities of biological data are all translated to text. We demonstrate how BioTranslator enables the identification of novel cell types using only a textual description and how BioTranslator can be further generalized to protein function prediction and drug target identification. Our tool frees scientists from limiting their analyses within predefined controlled vocabularies, enabling them to interact with biological data using free text.

P867 Cost-effectiveness and cost-only studies for Inflammatory Bowel Disease surgery: a scoping review

Abstract Background Studies examining the relative cost-effectiveness of surgical procedures and surgery-related interventions for patients with inflammatory bowel disease (IBD) remain limited. This dearth of studies hampers decision-makers’ assessment of surgery-related interventions for IBD patients. The purpose of this study was to conduct a scoping review of available literature for cost-effectiveness analyses of IBD-related surgery. Methods We performed a comprehensive search of English-language articles in MEDLINE, EMBASE, Cochrane Reviews, and Scopus from each database's inception to May 1, 2022. Preplanned controlled vocabulary related to IBD and its subtypes, surgery, and measures of costs were used. We defined study selection criteria to include all IBD-related surgical interventions (including preoperative, intraoperative, and postoperative) in all age groups that also reported a measure of costs of care. Studies comparing medical versus surgical interventions for refractory IBD were excluded. All search findings were screened by two reviewers using titles, abstracts, and ultimately full-length manuscripts. Full screened studies were then extracted for study characteristics and findings to facilitate a qualitative synthesis of results. Results We identified 1,804 citations for screening and ultimately found 10 formal cost-effectiveness studies and 56 cost-only studies. Cost-effectiveness studies assessed intraoperative (50%) and postoperative interventions (50%) mostly in patients with Crohn's disease (60%). Topics included comparisons of surgical approach (50%), venous thromboembolism prophylaxis (30%), and surveillance for postoperative recurrence (2%). Of the cost-only studies, the majority focused on intraoperative interventions (89%), particularly in ulcerative colitis patients (60%). Areas of interest included costs associated with healthcare resource utilization during a surgery-related admission (89%), venous thromboembolism prophylaxis (4%), and others (7%). Pre-defined areas of interest with no reported interventions included IBD-specific roles of Enhanced Recovery After Surgery interventions such as alvimopan, robotic surgery, timing to surgery, surgical therapies for perianal disease, pediatric Crohn's Disease, and genetic testing. Conclusion A scoping review found minimal literature using cost-effectiveness techniques to inform IBD-related surgical care. There are many more cost-only than cost-effectiveness studies related to these clinical topics. This asymmetry highlights immediately available opportunities for broadening the use of cost-effectiveness analysis of IBD-related surgical interventions.

The indexing policy in the practices of Brazilian institutional repositories: A diagnostic study from the perception of managers and indexers

Institutional repositories aim to gather, treat and disseminate information resources produced in a given institution. The adoption of an indexing policy aims to improve information retrieval by the user community of the institutional repository, by proposing elements that standardize the practices of librarians who work in subject cataloging. The objective of the research is to analyze the perception of managers and indexers of Brazilian institutional repositories about the indexing policy for information organization and representation, with the specific objectives of performing a compared evaluation of elements and variables (characteristics, processes, and instruments) of the indexing policy regarding indexing and retrieval, discussion of vocabulary control procedures, and obtaining an overview focusing on the perception of the need for an indexing policy in Brazilian institutional repositories. Semi-structured interviews were applied to nine participants from eight institutional repositories to investigate the requirements, elements and variables of the indexing policy in the practice of managers and librarians of institutional repositories. The results reveal the need for improvements in the practices of the analyzed institutional repositories regarding the activities of subject cataloging, standardization of subject metadata, and vocabulary control, queries, and in carrying out tests or trials for continuous evaluation of indexing and information retrieval with users. The study also revealed that this scenario can be more positive if institutional repositories adopt an indexing policy for the practices they perform in repositories to be understood by managers and librarians as a tool to improve information retrieval. La política de indización en las prácticas de los repositorios institucionales brasileños: un estudio de diagnóstico desde la percepción de gestores e indexadores

Proteomics Standards Initiative at Twenty Years: Current Activities and Future Work.

The Human Proteome Organization (HUPO) Proteomics Standards Initiative (PSI) has been successfully developing guidelines, data formats, and controlled vocabularies (CVs) for the proteomics community and other fields supported by mass spectrometry since its inception 20 years ago. Here we describe the general operation of the PSI, including its leadership, working groups, yearly workshops, and the document process by which proposals are thoroughly and publicly reviewed in order to be ratified as PSI standards. We briefly describe the current state of the many existing PSI standards, some of which remain the same as when originally developed, some of which have undergone subsequent revisions, and some of which have become obsolete. Then the set of proposals currently being developed are described, with an open call to the community for participation in the forging of the next generation of standards. Finally, we describe some synergies and collaborations with other organizations and look to the future in how the PSI will continue to promote the open sharing of data and thus accelerate the progress of the field of proteomics.

Evaluation of Indexation Consistency in Publisher Subject Metadata

This work aims at evaluating the indexing of subject metadata published on the MercadoEditorial.org platform. The goal: to verify if the indexing is consistent. First, analysis was done of the tools available on the platform for assigning keywords, and, afterwards, publishers on the platform were documented and verified by running intrinsic evaluation for interconsistency. This was all done to compare the indexing of one work by four authors. The authors were Ciranda Cultural, IBEP, Excelsior Editora, and Via Leitura. The chosen book was “The Alienist” by Machado de Assis, a classic in Brazilian literature. The result of the indexing analysis was that publishers gave keywords such as title, author’s name, characters’ names, names of other books, and excessively used and repeated words. The last category was further broken down being with or without accentuation, being in the singular or plural form. Other terms were assigned that were related to university entrance exams. Thus, it can be concluded that an absence of vocabulary control can make retrieval of a work difficult, simply by assigning terms that inadequately define the subject of the book, and by lacking semantic, syntactic, and morphological standardization among the terms.

Abstract 12898: Mobile Health Interventions and Remote Blood Pressure Monitoring in Underserved Populations: A Systematic Review and Meta-Analysis

Introduction: Disparities in blood pressure (BP) control persist in underserved communities. Although mobile health (mHealth) technologies have increased access to routine care for HTN, few studies have analyzed the effectiveness of mHealth interventions in populations experiencing HTN disparities. Methods: We conducted a systematic review of studies in seven databases published up to November 2021. The search used controlled vocabulary and keywords for HTN, mHealth interventions, and social determinants of health. We included papers that focused on mHealth interventions to manage HTN in underserved populations based on racial, ethnic, and socioeconomic factors. The primary outcome was change in systolic BP (SBP) and diastolic BP (DBP), and we assessed variations in the primary outcome by each study’s relative sociodemographic representation. Results: Among 2,644 unique studies identified, 24 studies (evaluating 7,960 participants in total) met our inclusion criteria. Demographic characteristics were similar between intervention and control groups (intervention: mean age 57.7 [SD 6.2] years; 59.8% women; 40.4% Black; 22.2% Hispanic). Among 18 studies that reported 6-month BP changes, reductions in SBP and DBP values in the intervention group were -7.03 mmHg (control: -2.71 mmHg) and -3.65 mmHg (control: -1.63 mmHg), respectively. Subgroup analysis showed that studies with a higher representation of Hispanic, low-income, and low-education level participants had less pronounced BP improvements than studies with a lower representation of these subgroups. Conclusion: This review provides evidence for the effectiveness of mHealth interventions for HTN management. Future studies and community-based initiatives are needed to further increase individuals’ access to these interventions and to ensure their effectiveness across all populations disproportionately impacted by HTN.

User Interface Features and Knowledge Organisation Systems in Institutional Repositories A Case Study of Centrally Funded Technical Institutions in India

Institutional Repositories (IRs) are effective systems for managing and disseminating institutions’ in scholarly communication. More specifically, an IR enhances the visibility and discoverability of the content and validates the repository’s importance. Knowledge Organisation System (KOS) strengthens the digital content organisation, connects users with collections, and improves information retrieval functionalities. This paper investigates the present status of user interface features and incorporates KOS in the institutional repository of technical institutions, restricted to Centrally Funded Technical Institutions in India. A group of twenty-four web-accessible institutional repositories was identified, and their KOS and user interface features were evaluated. It was found that user interfaces of all IRs under study comply with essential search and navigation functionalities, such as simple and advanced search, browsing, faceted or filtering approaches, and integration with multiple KOS. Only a few of them include complex KOS, such as control vocabulary. All repositories show their search results in both normal-text and metadata views. Some have specific display features, such as highlighting the query or displaying a thumbnail. Google is one of the most popular search engines that indexes IR content for visibility and discoverability, and approximately 90 per cent of repositories are linked with NDLI. Global visibility and impact participation are moderate, and they require attention.

Using the Audubon Core Controlled Vocabularies for subjectPart and subjectOrientation

When the Audubon Core Multimedia Resources Metadata Schema*1 was ratified, it included two terms for describing what was being viewed in an image of an organism: ac:subjectPart, to indicate the morphological component of the organism included in the view, and ac:subjectOrientation, to describe the direction or viewing angle of the subject part relative to the image aquisition device. Although it was recommended that values for those terms come from controlled vocabularies, no such vocabularies had been created by TDWG. In 2019, the Views Controlled Vocabularies Task Group*2 was chartered to develop controlled vocabularies for these two terms. The result was two Simple Knowledge Organization System*3 (SKOS) concept schemes*4, 5, and a mechanism for determining which subjectOrientation values are appropriate for a given subjectPart and which subjectParts are appropriate for various organism groups. In this presentation, we briefly review the vocabulary development process, key features of the vocabularies, and give an overview of how the vocabularies can be used in several example cases.

Drug repurposing: a systematic review on root causes, barriers and facilitators

BackgroundRepurposing is a drug development strategy receiving heightened attention after the Food and Drug Administration granted emergency use authorization of several repurposed drugs to treat Covid-19. There remain knowledge gaps on the root causes, facilitators and barriers for repurposing.MethodThis systematic review used controlled vocabulary and free text terms to search ABI/Informa, Academic Search Premier, Business Source Complete, Cochrane Library, EconLit, Google Scholar, Ovid Embase, Ovid Medline, Pubmed, Scopus, and Web of Science Core Collection databases for the characteristics, reasons and example of companies deprioritizing development of promising drugs and barriers, facilitators and examples of successful re-purposing.ResultsWe identified 11,814 articles, screened 5,976 for relevance, found 437 eligible for full text review, 115 of which were included in full analysis. Most articles (66%, 76/115) discussed why promising drugs are abandoned, with lack of efficacy or superiority to other therapies (n = 59), strategic business reasons (n = 35), safety problems (n = 28), research design decisions (n = 12), the complex nature of a studied disease or drug (n = 7) and regulatory bodies requiring more information (n = 2) among top reasons. Key barriers to repurposing include inadequate resources (n = 42), trial data access and transparency around abandoned compounds (n = 20) and expertise (n = 11). Additional barriers include uncertainty about the value of repurposing (n = 13), liability risks (n = 5) and intellectual property (IP) challenges (n = 26). Facilitators include the ability to form multi-partner collaborations (n = 38), access to compound databases and database screening tools (n = 32), regulatory modifications (n = 5) and tax incentives (n = 2).ConclusionPromising drugs are commonly shelved due to insufficient efficacy or superiority to alternate therapies, poor market prospects, and industry consolidation. Inadequate resources and data access and challenges negotiating IP are key barriers to repurposing reaching its full potential as a core approach in drug development. Multi-partner collaborations and the availability and use of compound databases and tax incentives are key facilitators for repurposing. More research is needed on the current value of repurposing in drug development and how to better facilitate resources to support it, where valuable, especially financial, staffing for out-licensing shelved products, and legal expertise to negotiate IP agreements in multi-partner collaborations.Trial registrationThe protocol was registered on Open Science Framework (https://osf.io/f634k/) as it was not eligible for registration on PROSPERO as the review did not focus on a health-related outcome.