Using the case study of rinderpest (a viral cattle disease), this book analyzes how “biological interconnectedness” was one of the “internationalisms” that shaped twentieth-century global political relations (p. 10). Rinderpest was declared eradicated in 2011 by the Food and Agriculture Organization (Fao) and the Office International des Épizooties (Oie). The author argues that the key to this success was “international cooperation” driven by a widely articulated desire to use technologies to advance human “dominion” over nature to improve human welfare (p. 161). This study contributes to scholars' recent work on the “new internationalism(s)” (by Sunil Amrith and Akira Iriye) and on integrating nonhuman actors into transnational histories (in work by J. R. McNeill and Timothy Mitchell, among others). The book's argument begins by relating how rinderpest aided European colonialism during the nineteenth century by killing off indigenous bovines (domesticated and wild), causing widespread starvation and drastic impoverishment over much of the continent of Africa and parts of south and east Asia. To protect colonizers' economic interests, “inter-imperial cooperation” began under rinderpest control in the 1860s with a series of politically inflected scientific conferences that continued through the 1930s (p. 38). Next, the author details a seventy-year history of antirinderpest vaccines, which were tailored to the available infrastructure to develop and deploy them and the different biological reactions of cattle breeds around the world. The book's middle chapters analyze how vaccines enabled “biological development” that bound nations together in post–World War II recovery and restoration (led by the Fao, Oie, and others) (p. 107). Developing the cooperative “machinery” of the Fao's antirinderpest campaigns eventually overcame even Cold War barriers and national security concerns (including rinderpest's development as a biological weapon) (p. 121). The final chapter focuses on the Fao- and Oie-led effort to control the natural disease and declare it eradicated.