Littleseed canarygrass (∼canarygrass) evolved populations that are resistant to isoproturon during the early 1990s in north‐western India. Clodinafop‐propargyl (∼clodinafop) was recommended for controlling these populations. It has been used extensively in wheat for the last several years. Recently, poor or no control of canarygrass by clodinafop has been observed in large areas, which could be related to cross‐resistance or multiple resistance. This study was designed to test whether resistance has evolved in canarygrass populations against clodinafop and to explore control of the resistant populations with sulfosulfuron and pinoxaden. Among the 311 canarygrass populations that were tested, 86, 55 and 34 showed variable phytotoxicity (0–99%) due to 0.030, 0.060 and 0.120 kg ha−1 clodinafop, respectively. Based on the resistance index, 11 populations were “highly resistant”, 60 were “resistant” and the rest (240) were “susceptible” to clodinafop. Five and six clodinafop‐resistant populations showed slight resistance to 0.0125 kg ha−1 sulfosulfuron and 0.025 kg ha−1 pinoxaden, respectively. But, sulfosulfuron at 0.025 and 0.050 kg ha−1 and pinoxaden at 0.050 and 0.100 kg ha−1 controlled all the canarygrass populations. Clodinafop used for 4 years increased the chance of resistance evolving, whereas its rotation with sulfosulfuron reduced the chance of resistance evolving. This study showed that considerable canarygrass populations have evolved a low‐to‐high degree of resistance against clodinafop. The further use of clodinafop would lead to the spread of resistance in larger areas through the dispersal of resistant seeds. Clodinafop should be replaced with 0.025 kg ha−1 sulfosulfuron or 0.050 kg ha−1 pinoxaden. Besides, where canarygrass has not evolved resistance, the yearly rotation of sulfosulfuron with clodanafop or pinoxaden might delay the evolution of resistance.
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