In this article, aiming at the longitudinal dynamics model of air-breathing hypersonic vehicles, a fuzzy-approximation-based prescribed performance control scheme with input constraints is proposed. First, this article presents a novel prescribed performance function, which does not depend on the sign of initial tracking error. And combining prescribed performance control method with backstepping control, the control scheme can ensure that system can converge at a prescribed rate of convergence, overshoot, and steady-state error. In order to solve the problem that backstepping control method needs to be differentiated multiple times, fuzzy approximators are used to estimate the unknown functions, and norm estimation approach is used to simplify the computation of fuzzy approximator. Aiming at the problem of input saturation of actuator in subsystem of air-breathing hypersonic vehicle, the new auxiliary system is designed to ensure the stability and robustness of air-breathing hypersonic vehicle system under input constraints. Finally, the effectiveness of the proposed control strategy is verified by simulation analysis.