This paper proposes a neural sliding mode control method for the tracking problem of the longitudinal dynamics of air-breathing hypersonic vehicles (ABHV). Considering the input/output feedback linearization, a high-order sliding mode law of the elevator deflection and the fuel equivalence ratio is designed. Moreover, the effect of uncertain model and control input disturbances is approximated with a Radial Basis Function Neural Network (RBFNN). The stability of the closed-loop system is analysed based on Lyapunov theorem. Simulation results shows the good tracking performance of the proposed controller and robustness with parameter uncertainties. All the signals are globally bounded and converged in short time.