Contralateral Anterior Cruciate Ligament Reconstruction Research Articles

Primary All-Soft Tissue Quadriceps Tendon Autograft Anterior Cruciate Ligament Reconstruction With Suture Tape Augmentation Resulted in Satisfactory Patient Outcomes and a Low Graft Failure Rate in High School and Collegiate Athletes

To evaluate ≥2-year patient outcomes after primary all-soft tissue quadriceps tendon autograft (ASTQ) anterior cruciate ligament reconstruction (ACLR) with suture tape augmentation (STA) in skeletally mature high school and collegiate athletes. All high school and collegiate athletes who underwent primary ASTQ ACLR with STA with a minimum of 2-year follow-up were analyzed retrospectively. Patients were administered validated patient-reported outcome measures (PROMs) pre- and postoperatively. The minimal clinically important difference was calculated for each PROM based on this study population and applied to the individual patient. Return to sport, subsequent surgical intervention including contralateral ACLR, and KT-1000 arthrometer measurements for knee laxity were collected. Complications were assessed by physical examination, radiologic studies, or obtained via telephone. In total, 60 patients were included in the final data analysis, with a mean age of 16.8 years (95% confidence interval 13-23) and mean final follow-up of 37.1 months (95% confidence interval 33.1-41.1). Twelve patients (20%) required subsequent surgery on the ipsilateral knee, which included 7 patients having a subsequent meniscal procedure and 3 patients who underwent arthrolysis. None sustained a graft failure, and 6 patients sustained a contralateral ACL injury necessitating surgery. All PROMs improved at the final follow-up (P < .001). In addition, KT-1000 arthrometer measurements significantly improved postoperatively at 1-year clinical follow-up (P < .001). Most patients obtained the minimal clinically important difference thresholds for each PROM at the final follow-up. There were 48 patients (80%) who participated in pivoting sports. The return-to-sport rate at same level was 54 patients (90%), with 6 patients (10%) not returning to the same level because of graduation. ASTQ ACLR with STA in a young athletic patient population may result in a low graft failure rate while maintaining satisfactory patient outcomes at short-term follow-up, including a return to sport at the same level of 90%. Level IV, retrospective case series.

Association of Quadriceps Tendon Harvest for ACL Reconstruction With Development of Osteochondritis Dissecans of the Patella in Pediatric Patients.

There are various reported complications after primary anterior cruciate ligament reconstruction (ACLR) necessitating additional surgery in skeletally immature patients, regardless of technique and autograft type. To analyze the rate and type of complications encountered with soft tissue quadriceps tendon autograft (QTA) for ACLR in patients ≤18 years as well as the overall rate of second surgery, unrelated to the use of the QTA. Case series; Level of evidence, 4. A total of 141 patients ≤18 years who underwent ACLR with a QTA and had minimum 6-month follow-up were included. All patients underwent ACLR by utilizing a full-thickness soft tissue QTA. Complications associated with the QTA harvest site and use of QTA were reported. The mean age of the included cohort (84 men, 57 women) was 14.8 ± 1.6 years. The average follow-up was of 2.0 ± 1.2 years. A total of 30 (21%) patients had a subsequent complication that required surgical intervention; in 11 (8%) patients, the complication was specifically associated with the use of a QTA, whereas in 19 (13%) patients, the complication was related to the ACLR. In addition, 13 (9%) patients underwent a contralateral ACLR procedure. Of the QTA-related complications, 2 patients developed osteochondritis dissecans (OCD)-like lesions in the superior aspect of the patella, 2 patients had injured their quadriceps extensor mechanism and required surgical repair, and 8 patients had a subsequent procedure to remove nonabsorbable sutures used for donor site quadriceps tendon closure. One of the patients who underwent the removal of nonabsorbable sutures also had an arthroscopic debridement of patellar chondral damage. We reported complications encountered with soft tissue QTA for ACLR. The complication rate for QTA harvest was 8%. However, given that the removal of nonabsorbable sutures from the donor site was caused by the surgical technique used, the revised nonsuture-related complication rate for QTA graft harvest was 2%. Although the use of a QTA has recently gained popularity due to its high return-to-sport and low graft-failure rates, surgeons should be aware of the complications associated with using this graft type.

Psychological Readiness to Return to Sport and Return to Sport Rates Are Similar in Patients After Either Bilateral or Unilateral Anterior Cruciate Ligament Reconstruction

To compare psychological readiness to return to sport (RTS), RTS rate, level of return, and time to return between patients who underwent bilateral anterior cruciate ligament reconstruction (ACLR) and those who underwent unilateral ACLR. The electronic medical record at a single academic medical center was queried for patients who underwent ACLR from January 2012 to May 2020. The inclusion criteria were skeletally mature patients who underwent either single or sequential bilateral ACLR and who had undergone either the primary ACLR or second contralateral ACLR at least 2 years earlier. Bilateral ACLRs were matched 1:3 to unilateral reconstructions based on age, sex, and body mass index. Psychological readiness to RTS was assessed using the validated ACL Return to Sport After Injury (ACL-RSI) scale. This, along with time to return and level of RTS, was compared between the 2 cohorts. In total, 170 patients were included, of whom 44 underwent bilateral ACLR and 132 underwent unilateral ACLR. At the time of the first surgical procedure, patients in the unilateral cohort were aged 28.8 ± 9.4 years and those in the bilateral cohort were aged 25.7 ± 9.8 years (P= .06). The average time difference between the first and second surgical procedures was 28.4 ± 22.3 months. There was no difference in psychological readiness to RTS (50.5 in bilateral cohort vs 48.1 in unilateral cohort, P= .66), RTS rate (78.0% in unilateral cohort vs 65.9% in bilateral cohort, P= .16), percentage of return to preinjury sport level (61.2% in unilateral cohort vs 69.0% in bilateral cohort, P= .21), or time to return (41.2± 29.3 weeks in unilateral cohort vs 35.2 ± 23.7 weeks in bilateral cohort, P= .31) between the 2 cohorts. Compared with patients who undergo unilateral ACLR, patients who undergo bilateral ACLR are equally as psychologically ready to RTS, showing equal rates of RTS, time to return, and level of return. Level III, retrospective cohort study.

Ten-year outcomes of anterior cruciate ligament reconstruction with hamstring tendon autograft and femoral fixation with a cortico-cancellous screw suspension device

PurposeTo evaluate the clinical and radiographic outcomes of anterior cruciate (ACL) reconstruction at minimum 10-year follow-up.MethodsNinety-three patients who underwent primary unilateral ACL reconstruction with hamstring tendon autograft, transtibial technique and femoral cortico-cancellous screw suspension device (Athrax, Leader Medica s.r.l) between 2010 and 2012 were retrospectively reviewed. Mean follow-up was 136 months. Evaluation was performed using the International Knee Documentation Committee score (IKDC), Knee injury and Osteoarthritis Outcome Score (KOOS), Lysholm Knee Score and Tegner Activity Level Scale. Incidence of OA was determined by comparing standard anteroposterior and lateral weightbearing radiographs of the ACL-reconstructed and contralateral knee. Osteoarthritis severity was graded according to the Kellgren–Lawrence (KL) score.ResultsMedian Tegner activity level was 6 (5–7). Lysholm and IKDC scores were 100 (95–100) and 90 (86–95), respectively, KOOS was 98 (95–100). Of ACL-reconstructed knees, 41 (50%) had radiographic OA, of which 6 (7.3%) had severe OA (KL III). Of the contralateral healthy knees, 28 (34.1%) had radiographic evidence of OA. Of these 22 (26.8%) and 6 (7.3%) patients had, respectively, KL-I and KL-II. 11 patients (11.8%) underwent subsequent knee surgery: 5 (5.4%) revisions, 3 (3.2%) meniscal surgeries, 2 (2.2%) other surgeries, 1 (1.1%) contralateral ACL reconstruction.ConclusionsThe study demonstrates that ACL reconstruction with HT autograft and cortico-cancellous screw suspension device determines satisfying clinical results after 10 years of follow-up. From our cohort, a low rate of graft failure has been reported, even though almost 50% of patients present a knee OA greater or equal to grade II KL.

Poster 314: Hamstring Autograft Diameter Effect on Surgical Outcome in a Prospective ACL Reconstruction Patient Cohort

Objectives: The purpose was to investigate the effect of hamstring autograft diameter on risk of graft failure and subsequent either knee surgery following ACLR in a prospective cohort. Background: Optimization of graft selection and incorporation in anterior cruciate ligament (ACL) reconstruction (ACLR) is an evolving science. Recent studies suggest hamstring tendon autograft diameter may influence outcomes in primary ACLR, with a larger diameter acting as a protective factor against ACL graft rupture. Further evidence using a prospective patient database is valuable in corroborating the association between ACL autograft diameter and patient outcomes. Methods: Prospective data was collected for a cohort of patients undergoing primary ACLR from February 2015 to February 2018. Exclusion criteria included non-hamstring graft selection, allograft augmentation, skeletally immature patients, revision ACLR, prior contralateral ACLR, and multiligament injuries. Cases from 10 fellowship-trained surgeons within a single institution were included. Recorded tunnel size was utilized as a surrogate for autograft diameter. The contribution of age, sex, BMI and operating surgeon on autograft diameter was studied via mixed effect modeling. The effect of hamstring tendon autograft diameter on risk of subsequent surgery was measured using multivariable linear regression modeling that controlled for patient and surgery characteristics including age, sex, BMI, Marx activity score, and graft diameter. Two-year outcomes were collected for incidence of subsequent surgery to either knee, including ipsilateral revision ACLR and contralateral primary ACLR. Results: Of the patients undergoing ACLR with hamstring autograft who met inclusion criteria, there was 90.5% follow up for subsequent surgery outcomes at minimum of 2 years, resulting in 381 patients. Female sex and lower BMI was associated with smaller autograft diameter and operating surgeon had a significant effect on autograft diameter. 59 patients (15.5%) had subsequent ipsilateral surgery and 27 patients (7.09%) had revision ACLR within 2 years. 29 patients (7.61%) had contralateral subsequent knee surgery and 20 patients (5.25%) had primary contralateral ACLR within 2 years. After controlling for age, sex, BMI, and baseline Marx activity score, hamstring autograft diameter was not associated with risk of all ipsilateral subsequent knee surgery (odds ratio (OR) 0.87, 95% confidence interval (CI) 0.56 - 1.36, p = 0.536). Baseline Marx score greater than or equal to 12 was associated with risk of all ipsilateral subsequent knee surgery with OR 2.55 (CI 1.41 – 4.59, p = 0.002). After controlling for age, sex and BMI, hamstring autograft diameter was not associated with risk of revision ACLR (OR 0.71, CI 0.38 - 1.33, p = 0.286). Age was associated with risk of ipsilateral revision ACLR with OR 0.16 (CI 0.05 – 0.51, p = 0.002). After controlling for age, sex and BMI, hamstring autograft diameter was not associated with risk of all contralateral subsequent knee surgery (OR 0.89, CI 0.50 - 1.59, p = 0.703) including contralateral ACLR (OR 0.78, CI 0.39 - 1.59, p = 0.501). Age was found to be a significant prognostic variable of contralateral ACLR with OR 0.30 (CI 0.10 – 0.93, p = 0.037). No variables within the model were associated with risk of all contralateral subsequent surgery events. Conclusions: Hamstring autograft diameter greater than 8mm was not associated with risk of revision ACLR or other subsequent surgery in the ipsilateral or contralateral knee in a multivariable logistic regression analysis of a prospective patient cohort. Lower age was associated with risk of ipsilateral revision ACLR and contralateral ACLR. Baseline Marx activity score greater than or equal to 12 was associated with risk of all subsequent ipsilateral knee surgery. [Table: see text][Table: see text][Table: see text][Table: see text]

Poster 331: ACL Graft Tear or Contralateral ACL Tear: Which is Worse???

Objectives: Anterior cruciate ligament (ACL) graft tears and contralateral ACL tears are both relatively common following primary ACL reconstruction (ACLR). While some prior studies have combined these injuries as an outcome variable (“subsequent cruciate injury”), there is little prior work comparing the outcomes of these injuries. We hypothesize that patient reported outcome measures (PROMs) and activity level are lower following revision ACLR than following contralateral ACLR. Methods: From a prospective cohort study of 2333 patients who underwent primary, unilateral ACLR, 298 patients were identified who underwent revision ACLR or contralateral ACLR within 5 years of primary ACLR. Following exclusion of 11 patients who had both injuries, 256 patients were eligible for study inclusion, including 124 patients who underwent revision ACLR and 132 patients who underwent contralateral ACLR. Patients were contacted for follow-up at 6 years after the primary ACL reconstruction and PROMs were collected including subjective International Knee Documentation Committee (IKDC) score, Knee Osteoarthritis pain (KOOS-Pain) and knee-related quality of life (KOOS- QOL) subscales, and Marx activity level. Patient demographic and initial injury factors, surgical factors, and PROMs were compared between groups. Multiple regression models were used to determine whether side of subsequent surgery (revision versus contralateral ACLR) was a significant predictor of outcome. Results: Two hundred trenty-three of 256 patients (87%) were contacted and completed PROMs at 6 years following primary ACLR. The median time from primary ACLR to second ACL surgery was lower in the revision group (1.3 years) than the contralateral group (2.0 years, p &lt; 0.001). The revision group also demonstrated a lower incidence of partial lateral meniscectomy and was more likely to have received an allograft for the primary ACLR. There were no significant differences in age, sex, smoking status, pre- operative knee laxity, articular cartilage status at primary ACLR, medial meniscus status at primary ACLR, sport, or pre-operative PROMs between the two groups. At follow-up, the revision ACLR group demonstrated lower Marx activity level and PROMs than the contralateral injury group (Table 1). When controlling for the above factors, the revision ACL group demonstrated a 7.8 point lower IKDC (p&lt;0.001), a 3.2 point lower KOOS-pain (p=0.012), a 10.4 point lower KOOS-QOL (p&lt;0.001), and 2.0 point lower Marx score (p=0.002) than the contralateral ACLR group. Conclusions: Patients who undergo revision ACL R demonstrate with poorer PROMs and lower activity level than those who undergo subsequent revision ACLR. [Table: see text]

Poster 273: Vascularity Assessment of Quadriceps Tendon Donor Site After Anterior Cruciate Ligament Reconstruction Using Ultrasound with Superb Microvascular Imaging (SMI)

Objectives: Quadriceps tendon (QT) is an increasingly popular graft choice for anterior cruciate ligament reconstruction (ACL-R) 1. Evaluation of vascularity using ultrasound has been performed to assess the healing response of tendons 2. Ultrasound with Superb Microvascular Imaging (SMI) is a novel microvascular imaging technology capable of visualizing a slower and smaller blood flow relative to conventional doppler modalities and has been applied to evaluate the vascularity of tendons. Therefore, vascularity assessment using ultrasound with SMI would be helpful to understand the healing response of QT donor site after ACL-R. The objectives of this study were 1) to compare the vascularity of the QT donor site with the contralateral, nonoperative site, 2) to assess whether different areas of the QT donor site healed relatively faster than others, and 3) to assess changes in vascularity of the QT donor site following ACL-R at various pre- and postoperative timepoints. Methods: Patients who were pre- and post ACL-R using QT autograft were included in this study. Those who had contralateral ACL-R using QT autograft and had additional surgery for meniscal pathology or manipulation under anesthesia following primary ACL-R, were excluded. Ultrasound examination was performed before ACL-R, and 2, 4, 6, 9, and 12 months after ACL-R using a 18-5 MHz linear ultrasound transducer (Aplio i800, Canon medical systems, Japan) by a single sports medicine expert with 11 years’ experience. Participants were positioned supine with the knee at 20˚ of knee flexion. The transducer was placed on the anterior aspect of the knee perpendicular to the longitudinal axis of the QT to obtain the short axis of QT. Short axis images were acquired at 0, 15, 30, and 45 mm proximal to the superior pole of the patella. QT vascularity was assessed using ultrasound with SMI (Figure 1). A three-second video at each location was used to capture the moment of greatest vascularity. To quantify the amount of the vascularity signal within the QT, the area ratio of the vascular signal was evaluated with respect to the total area of QT using Image J software 3. QT vascularity ratio between donor and contralateral sites was compared using Wilcoxon signed-rank test. Vascularity ratio among each timepoint or each assessment location was compared using a Friedman test followed by Bonferroni correction for post-hoc analysis. Statistical significance was set at p &lt; 0.05. Results: All tendons showed healing and no defects were observed at any timepoints. In total, 62 pre- and postoperative timepoints of 40 individuals (22 male, 18 female, 18 right, 22 left) with a mean age of 25.2 ±7.8 years were included for analysis. With regard to the contralateral site, there was no vascularity signal in greater than 85% of cases at any timepoints. No significant difference between donor and contralateral sides was seen preoperatively. After ACL-R, significantly greater vascularity within the donor site was observed compared to contralateral, nonoperative QT at 2 months (all assessment locations), 4 months (all assessment locations), 6 months (0, 15, and 30 mm proximal to the superior pole of the patella), 9 months (0 mm), and 12 months (0 and 15 mm) following ACL-R (Table 1). Vascularity ratio 6 to 12 months after ACL-R was greater at 0 or 15 mm than at 30 and/or 45 mm proximal to the superior pole of the patella (Figure 2). In addition, vascularity ratios 4 months after ACL- R were significantly greater than other timepoints (Figure 3). Conclusions: The most important finding of this study was demonstration of increased vascularity 4 months after ACL-R. According to literature on patellar tendon donor site, vascularity 2 months after ACL-R was greater than other timepoints by Doppler ultrasound 2. QT donor site healing speed was similar to that of patellar tendon donor site. In this study, vascularity was seen at all observed postoperative timepoints. Surgeons may consider careful closure of the donor site defect especially near the proximal pole of the patellar where healing was observed even until 12 months as demonstrated by high vascularity. Based on this study, QT is an excellent graft choice for patients with ACL tears. Further studies are warranted to investigate the timing of distal QT harvest site healing. [Table: see text]

Poster 338: Analysis of Patient Reported Outcomes and Subsequent Surgery Rate following Quadriceps Tendon Anterior Cruciate Ligament Reconstruction and Lateral Extra-articular Tenodesis in Skeletally Immature Patients: Two Year Follow-Up

Objectives: The incidence of anterior cruciate ligament reconstruction (ACLR) in pediatric and adolescent patients is increasing significantly and many patients possess risk factors that predispose to ACL re-tear. Lateral extra-articular tenodesis (LET) may be performed in conjunction with ACLR to reduce the risk of ACL re-tear. The purpose of this study is to evaluate the 2-year clinical outcomes of ACLR with soft tissue quadriceps tendon (QUAD) autograft and a lateral extra-articular tenodesis (LET) using a modified Lemaire technique in skeletally immature patients. Methods: A consecutive series of patients who underwent QUAD tendon autograft ACLR and LET with a minimum of 2-year follow-up data was analyzed retrospectively. ACLR techniques included all- epiphyseal (AE) and complete transphyseal (CT) and were indicated based on skeletal age. Outcome measures included participants’ return to sports (RTS), concomitant or subsequent surgical procedures and multiple patient-reported outcome measures, including Single Assessment Numeric Evaluation (SANE), Pediatric International Knee Documentation Committee (Pedi-IKDC) and HSS Functional Activity Brief Scale (HSS Pedi-FABS) scores. Results: The final cohort included 50 consecutive adolescent patients aged 11 to 16 years (mean 14.2 ± 1 years) with a minimum follow-up of 2 years. Two patients were lost to follow-up. Of the patients included in the study (n=48), 98% participated in high-risk competitive sports (Table 1). Two patients (4%) were revision ACLR. Ten (21%) patients underwent AE and 38 (79%) underwent CT ACLR. Sixteen patients (33%) had subsequent surgical procedures, including 5 contralateral ACLR, 4 meniscus surgeries, 4 QUAD autograft scar revision, 4 irrigation and debridement (2 patients, 2 each) and 3 hardware removal procedures (2 for hemi-epiphysiodesis and 1 tibial socket button removal). The rate of graft failure was 0%. At two-year follow-up, mean SANE score was 93, mean Pedi-IKDC score was 90, and mean HSS-Pedi-FABS score was 23. RTS rate was 100%. Conclusions: A LET when performing an ACLR is safe and should be considered as a concomitant procedure for adolescent patients that are at high risk of re-tear. [Table: see text]

Incidence and risk factors for revision and contralateral anterior cruciate ligament reconstruction: A population-based retrospective cohort study.

There is a limited data on epidemiology of primary and recurrent anterior cruciate ligament reconstruction (ACLR) in Canada. The objectives of this study were to examine the incidence and factors associated with recurrent ACLR (revision and contralateral ACLR) in a western Canadian province of Alberta. We conducted a retrospective cohort study with an average follow up of 5.7 years. Albertans aged 10 to 60 years with a history of primary ACLR between 2010/11 to 2015/16 were included in the study. Participants were followed up until March 2019 to observe outcomes: Ipsilateral revision ACLR and contralateral ACLR. Kaplan Meir approach was used to estimate event free survival and Cox proportional hazard regression analysis was conducted to identify associated factors. Of the total participants with a history of primary ACLR on a single knee (n = 9292), n = 359, 3.9% (95% confidence interval: 3.5-4.3) underwent a revision ACLR. A similar proportion among those having primary ACLR on either knee (n = 9676), n = 344, 3.6% (95% confidence interval: 3.2-3.9) underwent a contralateral primary ACLR. Young age (<30 years) was associated with increased risk of contralateral ACLR. Similarly, young age (<30 years), having initial primary ACLR in winter and having allograft were associated with a risk of revision ACLR. Clinicians can use these findings in their clinical practice and designing rehabilitation plans as well as to educate patients about their risk for recurrent anterior cruciate ligament tear and graft failure.

A Modified Lemaire Lateral Extra-articular Tenodesis in High-Risk Adolescents Undergoing Anterior Cruciate Ligament Reconstruction With Quadriceps Tendon Autograft: 2-Year Clinical Outcomes

Background: The incidence of anterior cruciate ligament (ACL) reconstruction (ACLR) in children and adolescents has increased significantly, and many such patients are at increased risk for ACL retear. Lateral extra-articular tenodesis (LET) may be performed in conjunction with ACLR to reduce the risk of ACL retear. Purpose: To evaluate the 2-year clinical outcomes of ACLR with soft tissue quadriceps tendon (QUAD) autograft performed with a concomitant LET using a modified Lemaire technique in skeletally immature patients. Study Design: Case series; Level of evidence, 4. Methods: A consecutive series of adolescent patients who underwent QUAD autograft ACLR and LET with a minimum of 2 years of follow-up data were analyzed retrospectively. ACLR techniques, including all-epiphyseal and complete transphyseal, were indicated based on skeletal age. Outcome measures included return to sports, concomitant or subsequent surgical procedures, and multiple patient-reported outcome measures, including Single Assessment Numeric Evaluation (SANE), Pediatric International Knee Documentation Committee (Pedi-IKDC), and Hospital for Special Surgery Pediatric Functional Activity Brief Scale (HSS Pedi-FABS) scores. Results: The final cohort included 49 consecutive adolescent patients aged 11 to 16 years (mean, 14.2 ± 1 years) with a minimum follow-up of 2 years. One patient was lost to follow-up. Of the patients included in the study (N = 48; 27 male, 21 female), 98% participated in high-risk competitive sports. Two (4%) patients were undergoing revision ACLR. Thirty-eight (79%) patients underwent complete transphyseal, and 10 (21%) patients underwent all-epiphyseal ACLR. Sixteen (33%) patients had subsequent surgical procedures, including 5 contralateral ACLR, 4 meniscal surgery, 4 QUAD autograft scar revision, 4 irrigation and debridement (2 patients, 2 each), and 3 hardware removal (2 for hemi-epiphysiodesis and 1 tibial socket button removal) procedures. The rate of graft rupture was 0%. At a mean follow-up of 3.4 ± 1.2 years (range, 2-7 range), the mean SANE score was 93, the mean Pedi-IKDC score was 89, and the mean HSS Pedi-FABS score was 23. The return-to-sports rate was 100%. Conclusion: An LET performed concomitantly with an ACLR is safe and should be considered as a concomitant procedure for adolescent patients with nonmodifiable risk factors who are at high risk of retear.

Paper 13: Risk of Revision and Re-operation after ACL Reconstruction. Comparison of Quadriceps Tendon, BPTB, and Hamstring Autografts in a US-based Cohort Study of 19,960 Patients

Objectives: The purpose of this study was to evaluate risk for subsequent surgical outcomes, including revision and re-operation, for a cohort of primary anterior cruciate ligament reconstruction (ACLR) patients according to autograft selection. Methods: Data from a US healthcare system’s ACLR registry was used to conduct a cohort study. Primary isolated autograft ACLR patients were identified (2012-2020); those with prior procedures in the same knee were excluded. The exposure of interest autograft type: Quadriceps tendon (QT), bone-patellar tendon-bone (BPTB), and hamstring tendons. Multivariable Cox proportional hazard regression models were used to evaluate the risk for revision and risk for re-operation within 3-years follow-up according to autograft selection. Age, body mass index, gender, race/ethnicity, American Society of Anesthesiologist’s classification, activity at the time of injury, prior contralateral ACLR, lateral meniscus injury, medial meniscus injury, femoral fixation method, femoral tunnel drilling technique, average annual surgeon volume, operative time, and operative year were considered as covariates in regression analysis; models also included a cluster term for operating surgeon to account for correlation of ACLR performed by the same surgeon. Hazard ratios (HR) and 95% confidence intervals are reported. Two-sided tests were calculated with p&lt;0.05 the threshold for statistical significance. Results: The study sample comprised 19,960 ACLR performed by 280 surgeons at 51 hospitals. QT, BPTB, and hamstring autograft were used in 733 (3.7%), 8578 (43.0%), and 10,649 (53.3%) ACLR, respectively. The Figure presents the cumulative incidence of revision (left panel) and reoperation (right panel) during follow-up by graft type; number of patients still at risk for each year of follow-up is presented along the x-axis. In adjusted models, no significant differences were observed in revision risk (HR=1.52, 95% CI=0.83-2.80, p=0.177) or re-operation risk (HR=1.00, 95% CI=0.63-1.59, p=0.742) within 3-years follow-up when comparing QT ACLR to BPTB ACLR. Additionally, no differences in 3-year revision (HR=0.89, 95% CI=0.46-1.74, p=0.742) or re-operation (HR=1.21, 95% CI=0.74-1.99, p=0.442) risks were observed when comparing QT ACLR to hamstring ACLR. BPTB were noted to have a significantly lower risk of revision (HR=0.68, 95% CI=0.52-0.89, p=0.006) compared to hamstring tendons but no difference in risk of re-operation (HR=1.24, 95% CI=0.95-1.65, p=0.113). Conclusions: The results of this large multi-center study using data from an ACLR registry found no difference in the risk of revision or re-operation when quadriceps tendon was compared to BPTB or hamstring autograft with the numbers available but did find a 1.5 times higher risk of revision when hamstring tendon autograft was compared with BPTB autograft. Surgeons may use this information when choosing the appropriate graft for ACLR in their patients.

Poster 230: A Modified Lemaire Lateral Extra-Articular Tenodesis in High-Risk Adolescents Undergoing Anterior Cruciate Ligament Reconstruction: Two-Year Clinical Outcomes

Objectives:This study aimed to evaluate the safety and efficacy of performing a lateral extra-articular tenodesis (LET) with a modified Lemaire technique (MLT) in conjunction with anterior cruciate ligament reconstruction (ACLR) in children and adolescents at increased risk for failed ACLR.Methods:A consecutive series of patients ≤19 years who underwent simultaneous ACLR and LET with minimum two-year follow-up data were reviewed. Patients were indicated for LET when one or more of the following risk factors were present: participant in high-risk competitive sport such as football, lacrosse, soccer or basketball, grade 3 pivot shift, hyperlaxity (Beighton score > 6), recurvatum, revision ACLR, contralateral ACLR, or chronic ACL insufficiency. ACLR was performed using either full-thickness quadriceps tendon (QUAD) for skeletally immature patients or bone-patellar tendon-bone (BTB) autograft for skeletally mature patients. All-epiphyseal (AE) or complete transphyseal (CT) techniques were used depending on patients’ skeletal maturity. At a minimum two-year follow-up, patient-reported outcome measures included Single Assessment Numeric Evaluation (SANE), Pediatric International Knee Documentation Committee (Pedi-IKDC), and the HSS Functional Activity Brief Scale (HSS Pedi-FABS) scores. Return-to-sport (RTS) data and second surgeries were also obtained.Results:Sixty-one consecutive patients (mean age 15.17 ±1.73 years, range 11-19 years, 62% female) were analyzed (Table 1). 59 patients (97%) participated in organized sports including soccer, basketball, football and lacrosse, with soccer being the most popular one. The average grade at the time of surgery was 9th grade. Ten patients (16%) were revision ACLR procedures. Seven (11%) patients underwent AE and 54 (89%) underwent CT ACLR. Forty-two (69%) cases employed a QUAD autograft, while 19 (31%) utilized a BTB autograft. All patients underwent a LET with a MLT and 2 patients underwent simultaneous implant mediated guided growth with a plate for structural genu valgum. At two-year follow-up, mean SANE score was 95, median Pedi-IKDC score was 91, and median HSS-Pedi Fabs score was 27. RTS rate was 91.8%. Ten patients had subsequent surgical procedures, including two hardware removal procedures for hemiepiphysiodesis, three contralateral ACLR, three meniscus surgeries, one lysis of adhesions, and one revision ACLR for BTB graft re-rupture. Two patients were lost to follow-up and excluded from the study.Conclusions:The findings suggest that concomitant LET and ACLR in adolescent patients with risk factors for failed ACLR is associated with favorable patient-reported outcomes, high return to sports participation, and low ACL re-rupture rate at two years follow-up.Table 1.Patient Demographics and Surgical Characteristics.

Paper 28: Early Versus Standard Return to Sport Following ACL Reconstruction. Impact on Volume of Play and Career Logevity in 180 Professional European Soccer Players

Objectives:To retrospectively evaluate the impact of early(<6 months) vs standard(>6months) return to play(RTP) on the rate of failure, volume of play, and career longevity following ACL reconstruction in a cohort of professional European soccer players. It was hypothesized that athletes returning to professional competition earlier than 6 month after ACL reconstruction would not have an increased risk of failure, volume of play, and a shorter professional career.Methods:Professional soccer players treated for anterior cruciate ligament tear by a single surgeon were included in this retrospective study. The study was approved by the institutional review board. The inclusion criteria were that the patient was a (1) male, (2) professional soccer player with an (3) injury of the anterior cruciate ligament. Exclusion criteria were revision ACL, extra-articular ligamentous reconstruction, and previous contralateral ACL reconstruction. A total of 178 players who were all in the first or second division of their league met criteria for the study over a ten year period. Time from intervention to return to the first official game was recorded in days. Information if the patient was able to return to the same season was recorded, as well as the number of games and total and average minutes played in the return season. Number of seasons played after injury and if the player was active at the time of data collection (September 2019) was also recorded. If the player was still active, the player’s current club was recorded.Results:90-early RTP and 88 standard RTP players were identified. Players in the early RTP group returned to professional level soccer at a mean of 4.76 months, which was significantly sooner than players in the standard RTP group who returned at a mean of 9.21 months (p < 0.01) following ACLR. A significantly greater number of players in the early RTP group returned during the same season of intervention (n = 56/92, 60.9%) than in the standard RTP group (n = 18/88, 20.5%) (p < 0.01). Players in the early RTP group competed in an average of 11.5 games during their return season while those in the standard RTP group competed in an average of 12.9 games (p > 0.05). The early RTP group played, on average, a total of 759.2 minutes and 56.5 minutes/game in their return season, while the standard RTP group played an average of 812.8 total minutes and 50.0 minutes/game in their return season (p > 0.05). Players in the early RTP group had significantly longer careers following ACLR, averaging 5.62 seasons, compared to those in the standard RTP group who competed in an average of 4.75 seasons after surgical intervention (p < 0.01). The early RTP group had 4 failures while the late RTP group had 1 failure failure.Conclusions:Professional European soccer players who return to play earlier than 6 months after ACL reconstruction returned more frequently during the same season, played the same number of games and minutes during their return season, had longer careers, but had more ACL graft failures when compared with those who returned greater than 6 months after surgery. Professional European soccer players who returned early after ACL reconstruction (<6 months) did not appear to have poorer outcomes, however caution should be taken before extrapolating this to the general population as these athletes have exceptional resources, fitness, and athletic capacity. Decision on return to play ultimately lies with the patient/athlete as prolonged RTP has significant financial and career consequences.

Paper 02: A Modified Lemaire Lateral Extra-Articular Tenodesis in High Risk Adolescents Undergoing Anterior Cruciate Ligament Reconstruction: Two-Year Clinical Outcomes

Objectives:This study aimed to evaluate the safety and efficacy of performing a lateral extra-articular tenodesis (LET) with a modified Lemaire technique (MLT) in conjunction with anterior cruciate ligament reconstruction (ACLR) in children and adolescents at increased risk for failed ACLR.Methods:A consecutive series of patients ≤19 years who underwent simultaneous ACLR and LET with minimum two-year follow-up data were reviewed. Patients were indicated for LET when one or more of the following risk factors were present: participant in high-risk competitive sport such as football, lacrosse, soccer or basketball, grade 3 pivot shift, hyperlaxity (Beighton score > 6), recurvatum, revision ACLR, contralateral ACLR, or chronic ACL insufficiency. ACLR was performed using either full-thickness quadriceps tendon (QUAD) for skeletally immature patients or bone-patellar tendon-bone (BTB) autograft for skeletally mature patients. All-epiphyseal (AE) or complete transphyseal (CT)techniques were used depending on patients’ skeletal maturity. At a minimum two-year follow-up, patient-reported outcome measures included Single Assessment Numeric Evaluation (SANE), Pediatric International Knee Documentation Committee (Pedi-IKDC), and the HSS Functional Activity Brief Scale (HSS Pedi-FABS) scores. Return-to-sport (RTS)data and second surgeries were also obtained.Results:Sixty-one consecutive patients (mean age 15.17 ±1.73 years, range 11-19 years, 62% female) were analyzed (Table 1). 59 patients (97%) participated in organized sports including soccer, basketball, football and lacrosse, with soccer being the most popular one. The average grade at the time of surgery was 9th grade. Ten patients (16%) were revision ACLR procedures. Seven (11%) patients underwent AE and 54 (89%) underwent CT ACLR. Forty-two (69%) cases employed a QUAD autograft, while 19 (31%) utilized a BTB autograft. All patients underwent a LET with a MLT and 2 patients underwent simultaneous implant mediated guided growth with a plate for structural genu valgum. At two-year follow-up, mean SANE score was 95, median Pedi-IKDC score was 91, and median HSS-Pedi Fabs score was 27. RTS rate was 91.8%. Ten patients had subsequent surgical procedures, including two hardware removal procedures for hemiepiphysiodesis, three contralateral ACLR, three meniscus surgeries, one lysis of adhesions, and one revision ACLR for BTB graft re-rupture. Two patients were lost to follow-up and excluded from the study.Conclusions:The findings suggest that concomitant LET and ACLR in adolescent patients with risk factors for failed ACLR is associated with favorable patient-reported outcomes, high return to sports participation, and low ACL re-rupture rate at two years follow-up.

A Modified Lemaire Lateral Extra-Articular Tenodesis in High Risk Adolescents Undergoing Anterior Cruciate Ligament Reconstruction: Two-Year Clinical Outcomes

Background:The incidence of anterior cruciate ligament reconstruction (ACLR) in patients aged 19 years or younger is increasing significantly and many patients possess risk factors that predispose to ACL re-tear. Lateral extra-articular tenodesis (LET) may be performed in conjunction with ACLR to reduce the risk of ACL re-tear.Purpose:To evaluate the safety and efficacy of performing a lateral extra-articular tenodesis (LET) with a modified Lemaire technique (MLT) in conjunction with anterior cruciate ligament reconstruction (ACLR) in children and adolescents at increased risk for failed ACLR.Methods:A consecutive series of patients who underwent ACLR and LET with a minimum of 2-year follow-up data was analyzed retrospectively. ACLR techniques included all-epiphyseal (AE) and complete transphyseal (CT) and were indicated based on skeletal age. Skeletally immature patients underwent a QUAD ACLR. Patients with closed or closing growth plates underwent a BTB ALCR. Outcome measures included participants’ return to sports, concomitant or subsequent surgical procedures and multiple patient-reported outcome measures, including Single Assessment Numeric Evaluation (SANE), Pediatric International Knee Documentation Committee (Pedi-IKDC) and HSS Functional Activity Brief Scale (HSS Pedi-FABS) scores.Results:Sixty-seven consecutive patients (mean age 15.16 ±1.74 years, range 11-19 years, 64% female) were analyzed (Table 1). Sixty-five patients (97%) participated in organized sports including soccer, basketball, football and lacrosse, with soccer being the most popular one. The median grade at the time of surgery was 9th grade. Eleven patients (16%) were revision ACLR procedures. Eight (12%) patients underwent AE and 59 (88%) underwent CT ACLR. Forty-six (69%) cases employed a QUAD autograft, while 21 (31%) utilized a BTB autograft. All patients underwent a LET with a MLT and 2 patients underwent simultaneous implant mediated guided growth with a plate for structural genu valgum. At two-year follow-up, median SANE score was 97, median Pedi-IKDC score was 91, and median HSS-Pedi Fabs score was 25. RTS rate was 93%. Fifteen patients had subsequent surgical procedures, including 3 hardware removal procedures for hemiepiphysiodesis, 4 contralateral ACLR, 5 meniscus surgeries, 1 lysis of adhesions, 1 hammertoe correction and 1 revision ACLR for BTB graft re-rupture. Two patients were lost to follow-up and excluded from the study.Conclusion:The findings suggest that concomitant LET and ACLR in adolescent patients with risk factors for failed ACLR is associated with favorable patient-reported outcomes, high return to sports participation, and low ACL re-rupture rate at two years follow-up.Table 1Patient Demographics and Surgical Characteristics

Outcomes of Quadriceps Tendon Anterior Cruciate Ligament Reconstruction in Skeletally Immature Patients:2-Year Follow-Up

Background:The quadriceps tendon (QUAD) autograft has recently become an alternative to the hamstring tendon autograft that demonstrates superior preliminary outcomes in pediatric anterior cruciate ligament reconstruction (ACLR).Purpose:To evaluate 2-year clinical and patient-reported functional outcomes of primary ACLR with soft tissue QUAD autograft in skeletally immature patients.Methods:Consecutive skeletally immature patients who underwent ACLR with QUAD autograft were included. All cases utilized full thickness soft tissue QUAD autograft without a bone plug and were performed on patients with open growth plates. Preoperative demographic and surgical data were collected (Table 1). The ACLR technique was selected predicated upon skeletal age and included all-epiphyseal (AE) and complete transphyseal (CT). Patients were followed for a minimum of 24 months with successive clinical visits or contacted via telephone. Information regarding the return to sports and concomitant or subsequent surgical procedures was collected. KT-1000 was performed post-operatively, and Pediatric International Knee Documentation Committee (Pedi-IKDC) and HSS Functional Activity Brief Scale (HSS Pedi-FABS) scores were collected for each subject at their 2-year follow-up appointment.Results:The final cohort included of 60 consecutive adolescent patients aged 11.1 to 17.1 (13.9 ±1.2) with a minimum follow-up of 2 years. One patient was lost to follow-up. Prior to surgery, 86% of patients reported playing team sports including soccer, basketball, football and lacrosse, with soccer being the most popular one. 21 (35%) patients underwent AE and 39 (65%) underwent CT ACLR. Additionally, 35 (58%) underwent an a lateral extra-articular tenodesis procedure using the iliotibial band (ITB) with a modified Lemaire technique, and 5 (8%) patients underwent simultaneous implant mediated guided growth with a plate for structural genu valgum, both procedures were performed for non-modifiable risk factors as previously published for hamstring autograft ACLR. The rate of graft failure was 0%, and 10 patients had additional surgical procedures, of which 4 were concomitant removal of hardware for hemi-epiphysiodesis, 3 were contralateral ACLR, 3 were meniscal injuries that required surgical intervention and 2 were lysis of adhesions. The mean KT-1000 at 2-year follow-up was -0.36 ±0.75. The median Pedi-IKDC score was 87, and the median HSS-Pedi FABS score was 25. At 2 years after surgery, 90% patients reported returning to sports.Conclusion:This study reveals that QUAD autograft ACLR had a low failure rate when compared to previously reported studies of ACLR with hamstring autograft. Based on these results, we recommend this technique for skeletally immature patients undergoing ACLR.Table 1.Demographic and Surgical data of included knees.

Epidemiology and Revision Rates of Pediatric ACL Reconstruction in New York State

Background: There are limited epidemiologic data examining the incidence of pediatric anterior cruciate ligament reconstruction (ACLR) over the past decade. Purpose: To examine statewide population trends in the incidence of ACLR in a pediatric population. Study Design: Descriptive epidemiology study. Methods: Inpatient and outpatient claims for pediatric patients who underwent ACLR between 2009 and 2017 were identified in the New York Statewide Planning and Research Cooperative System database via International Classification of Diseases (ICD), Revision 9, Clinical Modification; ICD, Revision 10, Clinical Modification and Procedural Classification System; or Current Procedural Terminology codes. New York population data for each year between 2009 and 2017 were used from the New York State Department of Health to calculate the rates of ACLR per 100,000 people aged 3 to 19 years and determine the 95% confidence limits. The rates were then stratified by age, sex, and insurance. Two-year rates of revision and contralateral ACLR were also analyzed by sex. Results: Between 2009 and 2017, 20,170 pediatric ACLRs were identified. The rates of pediatric ACLR increased steadily from 49.3 per 100,000 in 2009 (95% CI, 47.2-51.4) to a peak of 61.0 (95% CI, 58.6-63.4) in 2014 and decreased to 51.8 (95% CI, 49.6-54.1) by 2017. The age group 15 to 17 years had the highest rates of ACLR of all age groups, peaking at 198.5 (95% CI, 188.3-208.7) per 100,000. Analysis by sex showed that ACLR rates between males and females were not different. Males had a 2-year ipsilateral revision rate of 4.3%, while females had a rate of 3.3% (P = .0001). Females had a contralateral ACLR rate of 4.0%, while males had a rate of 2.6% (P = .0002). Conclusion: Pediatric ACLR rates continued to rise until 2014, but there was a demonstrable decrease in rates after 2014. This decline in pediatric ACLR may point to the efficacy of injury prevention programs or changes in practice management. The high revision rate in males and high contralateral surgery rate in females can help guide patient counseling for return to play and complication risk. Clinical Relevance: This study showed that ACLR in pediatric patients may be decreasing in recent years. There were differences in revision and contralateral ACLR by sex.

Over-the-top Anterior Cruciate Ligament (ACL) reconstruction plus lateral plasty with hamstrings in high-school athletes: Results at 10 years

BackgroundAnterior Cruciate Ligament (ACL) injuries have grown in adolescent population in the last decades, and if surgical reconstruction resulted safe in the short term, its impact in the long term is still unclear. The purpose of this study was to assess the long-term risk of failure, the rate of contralateral injury and the clinical reported outcomes in a cohort of high-school athletes after ACL reconstruction. Methods54 consecutive patients (mean age 16.3 ± 1.4 years) underwent ACL reconstruction with a single-bundle plus lateral plasty hamstring technique between May 2006 and July 2009. The number of subsequent ipsilateral reoperations and contralateral ACL reconstruction, Lhysolm, KOOS, VAS for pain and Tegner Activity Level was determined at a minimum follow-up of 10 years. ResultsIpsilateral ACL revision was performed in 8 (3.4%) patients, contralateral ACL reconstruction in 11 (21.1%). The average Lysholm score was 95.1 ± 9.2. The average KOOS was 96.5 ± 6.3 for the Pain subscale, 92.2 ± 9.0 for the Symptom subscale, 99.2 ± 1.8 for the ADL subscale, 94.1 ± 10.1 for the Sport subscale and 91.8 ± 14.5 for the Quality-of-life subscale. The average VAS for pain during activity was 1.7 ± 2.3. 90% returned to sport, 15% decreased the activity level, 61% of patients were still involved in sport, 35% at the same pre-injury level. ConclusionAt long-term, single-bundle hamstring ACL-R plus lateral-plasty in a cohort of high school athletes resulted to have a comparable graft failure rate and contralateral ACL injury with other surgical techniques.

Muscle strength after the anterior cruciate ligament reconstruction via contralateral bone-tendon-bone autograft

PurposeThe anterior cruciate ligament (ACL) reconstruction via a contralateral bone-tendon-bone (C-BTB) autograft was introduced to encourage early return to sports. The purpose of this study is to evaluate whether primary contralateral BTB ACL reconstruction can be adapted for early return-to-sports modification by investigating the chronological changes of muscle strength after surgery.MethodsFifteen patients who had underwent C-BTB ACL reconstruction were compared with a matched group of 15 patients of ipsilateral BTB (I-BTB) ACL reconstruction. The clinical outcomes of the time of return-to-sports, Tegner activity scale and the rate of second ACL injuries, the tibial anterior translation measurement, and knee extension and flexion muscle strength were assessed.ResultsWithin 12 months after surgery, 14 of 15 patients from both groups returned to preinjury sports. The median time to return to sports after surgery was 6.5 months in the C-BTB group and 8.0 months in the I-BTB group (p = 0.021). No significant difference was noted with regard to the Tegner activity scale, reinjury rate or mean instrumental anterior tibial translation. The quadriceps muscle strength in the ACL-reconstructed knee compared with the opposite knee in both groups at 5 months after surgery was 120.6% in the C-BTB group and 70.0% in the I-BTB group (p < 0.001). However, the quadriceps muscle strength of the non-reconstructed limb, which instructed the graft harvested knee in the C-BTB and the intact knee in the I-BTB group, compared with that of the preoperative uninjured limb, was 74.5% in the C-BTB group and 118.7% in the I-BTB group (p = 0.0021) 5 months after surgery. Moreover, the quadriceps muscle strength of the reconstructed knee compared with the preoperative normal limb was 88.8% and 81.5% in the C-BTB and I-BTB groups, respectively (p = 0.38).ConclusionsACL reconstruction via the C-BTB autograft indicated better quadriceps muscle strength from early stage after surgery compared with I-BTB ACL reconstruction. However, the ostensible rapid symmetrical muscle strength recovery was attributed to strength deficits compared to the preoperative condition at the donor site limb and ACL-reconstructed limb.Level of evidenceLevel: Level: 4.

Long-term evaluation of pediatric ACL reconstruction: high risk of further surgery but a restrictive postoperative management was related to a lower revision rate

IntroductionThe guidelines regarding rehabilitation after pediatric anterior cruciate ligament reconstruction (ACLR) are sparse. The aim of the study was to retrospectively describe the long-term outcome regarding further surgery and with special emphasis on the revision rate after two different postoperative rehabilitation programs following pediatric ACLR.Material and methods193 consecutive patients < 15 years of age who had undergone ACLR at two centers, A (n = 116) and B (n = 77), in 2006–2010 were identified. Postoperative rehabilitation protocol at A: a brace locked in 30° of flexion with partial weight bearing for 3 weeks followed by another 3 weeks in the brace with limited range of motion 10°–90° and full weight bearing; return to sports after a minimum of 9 months. B: immediate free range of motion and weight bearing as tolerated; return to sports after a minimum of 6 months.The mean follow-up time was 6.9 (range 5–9) years. The mean age at ACLR was 13.2 years (range 7–14) years.The primary outcome measurement in the statistical analysis was the occurrence of revision. Multivariable logistic regression analysis was performed to investigate five potential risk factors: surgical center, sex, age at ACLR, time from injury to ACLR and graft diameter.ResultsThirty-three percent had further surgery in the operated knee including a revision rate of 12%. Twelve percent underwent ACLR in the contralateral knee. The only significant variable in the statistical analysis according to the multivariable logistic regression analysis was surgical center (p = 0.019). Eight percent of the patients at center A and 19% of the patients at B underwent ACL revision.ConclusionsFurther surgery in the operated knee could be expected in one third of the cases including a revision rate of 12%. The study also disclosed a similar rate of contralateral ACLR at 12%. The revision rate following pediatric ACLR was lower in a center which applied a more restrictive rehabilitation protocol.Level of evidenceCase-control study, Level III.