Extreme events (EEs) are rare and unpredictable, as have been observed in nature. Up to now, manipulating EEs has remained a challenge. Here, we experimentally observe the enhancement of EEs in a three cascade-coupled semiconductor laser system. Specifically, a continuous-wave optical injection semiconductor laser acts as the chaotic source with rare EEs, which is subsequently injected into a second laser for increasing the number of EEs. Interestingly, we find that the number and region size of EEs can be further enhanced by sequentially injecting into a third laser, i.e., a cascade-injection structure. Our experimental observations are in good agreement with the numerical results, which indicate that EEs can be significantly enhanced in wide injection parameter space due to the cascade-injection effect. Furthermore, our simulations show that the evoluation of the regions with enhanced EEs may be associated with the noise considered.