In this paper, the quadratic stability of continuous-time uncertain large-scale networked systems is considered. The systems are composed of many subsystems distributed in different locations in space and interconnected according to a certain network topology. A computationally efficient sufficient condition for the quadratic stability of large-scale networked systems is established, utilising effectively the block diagonal structure of the system parameter matrix and the sparseness of the subsystem connection matrix (SCM). Furthermore, a stability condition is presented, which is entirely contingent on the parameters of each subsystem. The simulation results show that the obtained conditions have obvious advantages in analysing the quadratic stability of large-scale networked systems.