Continuous Thermodilution Method Research Articles

Effects of age on microvascular function in patients with normal coronary arteries.

It has been suggested that coronary microvascular function decreases with age, irrespective of the presence of epicardial atherosclerosis. Our aim is to quantitatively investigate the effects of age on microvascular function in patients with normal coronary arteries. In 314 patients with angina with no obstructive coronary artery disease (ANOCA), microcirculatory function was tested using the continuous thermodilution method. In 305 patients, the association between age and both resting and hyperaemic myocardial blood flow (Q), microvascular resistance (Rμ), absolute coronary flow reserve (CFR) and microvascular resistance reserve (MRR) was assessed. In addition, patients were divided into 3 groups to test for differences based on age quartiles (≤52 years [24.9%], 53-64 years [49.2%], ≥65 years [25.9%]). The mean age was 59±9 years with a range from 22 to 79 years. The mean resting Q (Qrest) was not different in the 3 age groups (88±34 mL/min, 82±29 mL/min, and 86±38 mL/min, R2=0.001; p=0.62). A trend towards a decreasing mean hyperaemic Q (Qmax) was observed with increasing age (223±79 mL/min, 209±84 mL/min, 200±80 mL/min, R2=0.010; p=0.083). The mean resting Rμ (Rμ,rest) were 1,204±460 Wood units (WU), 1,260±411 WU, and 1,289±455 WU (p=0.23). The mean hyperaemic Rμ (Rμ,hyp) increased significantly with advancing age (429±149 WU, 464±164 WU, 503±162 WU, R2=0.026; p=0.005). Consequently, MRR decreased with age (3.2±1.2, 3.1±1.0, 2.9±0.9; p=0.038). This trend was present in both the patients with (n=121) and without (n=184) coronary microvascular dysfunction (CMD). There is an age-dependent physiological increase in minimal microvascular resistance and decrease in microvascular function, which is represented by a decreased MRR and is independent of atherosclerosis. The age-dependent decrease in MRR was present in both patients with and without CMD and was most evident in patients with smooth coronary arteries.

Coronary Flow Reserve Assessed by Continuous Thermodilution Method

Coronary Flow Reserve Assessed by Continuous Thermodilution Method

Coronary Vascular (DYS) Function and Invasive Physiology Assessment: Insights into Bolus and Continuous Thermodilution Methods.

A considerable number of patients with angina or myocardial ischemia have no significant coronary artery disease on invasive angiography. In recent years, several steps towards a better comprehension of the pathophysiology of these conditions, angina or ischemia with non-obstructive coronary arteries (ANOCA/INOCA), have been made. Nevertheless, several gaps in knowledge still remain. This review is intended to provide a comprehensive overview of ANOCA and INOCA, with a particular focus on pathophysiology, recent diagnostic innovations, gaps in knowledge and treatment modalities.

CRT-100.21 Coronary Flow Reserve Assessed by Continuous Thermodilution Method

CRT-100.21 Coronary Flow Reserve Assessed by Continuous Thermodilution Method

Agreement between cardiac output estimation by multi-beat analysis of arterial blood pressure waveforms and continuous thermodilution in post cardiac surgery intensive care unit patients

We sought to assess agreement of cardiac output estimation between continuous pulmonary artery catheter (PAC) guided thermodilution (CO-CTD) and a novel pulse wave analysis (PWA) method that performs an analysis of multiple beats of the arterial blood pressure waveform (CO-MBA) in post-operative cardiac surgery patients. PAC obtained CO-CTD measurements were compared with CO-MBA measurements from the Argos monitor (Retia Medical; Valhalla, NY, USA), in prospectively enrolled adult cardiac surgical intensive care unit patients. Agreement was assessed via Bland-Altman analysis. Subgroup analysis was performed on data segments identified as arrhythmia, or with low CO (less than 5 L/min). 927 hours of monitoring data from 79 patients was analyzed, of which 26 had arrhythmia. Mean CO-CTD was 5.29 ± 1.14 L/min (bias ± precision), whereas mean CO-MBA was 5.36 ± 1.33 L/min, (4.95 ± 0.80 L/min and 5.04 ± 1.07 L/min in the arrhythmia subgroup). Mean of differences was 0.04 ± 1.04 L/min with an error of 38.2%. In the arrhythmia subgroup, mean of differences was 0.14 ± 0.90 L/min with an error of 35.4%. In the low CO subgroup, mean of differences was 0.26 ± 0.89 L/min with an error of 40.4%. In adult patients after cardiac surgery, including those with low cardiac output and arrhythmia CO-MBA is not interchangeable with the continuous thermodilution method via a PAC, when using a 30% error threshold.

Quantification of Absolute Myocardial Flow and Resistance by Continuous Thermodilution in Patients with Ischemia and Nonobstructive Coronary Artery Disease (INOCA).

In approximately half of the patients undergoing coronary angiography for angina pectoris or for signs or symptoms suggestive of ischemic heart disease, no obstructive coronary artery disease is angiographically visible. The majority of these patients with angina or ischemia and no obstructive coronary artery disease (INOCA) have an underlying coronary vasomotor dysfunction, and current consensus documents recommend diagnostic invasive coronary vasomotor function testing (CFT). During CFT, a variety of vasomotor dysfunction endotypes can be assessed, including vasospastic coronary dysfunction (epicardial or microvascular vasospasm), and/or microvascular vasodilatory dysfunction, including impaired vasodilatory capacity and increased microvascular resistance. The quantification of the continuous thermodilution derived absolute coronary blood flow and resistance might be a better measure compared to the currently used standard physiologic measures. This article provides an overview of this continuous thermodilution method.

Continuous Thermodilution Method to Assess Coronary Flow Reserve

Coronary flow reserve (CFR) is a well-validated flow-based physiological parameter that has shown value in clinical risk stratification. CFR can be invasively assessed, classically by Doppler and, more recently, by thermodilution with saline boluses (CFRthermo-bolus). Alternatively, continuous thermodilution is a novel operator-independent, highly-reproducible technique to invasively quantify maximum absolute coronary flow (AF). This study aimed to assess the feasibility of this method to quantify resting AF and to determine CFR (CFRThermo-infusion) as compared with CFRthermo-bolus. Sixty-two consecutive patients with suspicion of coronary disease and absence of significant epicardial lesions were prospectively investigated. AF at maximal hyperemia (20 mL/min) and at lower infusion rates (6-8-10-12 mL/min) were systematically measured using a dedicated catheter and a temperature/pressure guidewire. The absence of baseline Pd/Pa decrease at 6 (0.15 ± 0.2%), 8 (0.17 ± 0.18%) and 10 mL/min (0.2 ± 0.12%) demonstrated absence of hyperemia at ≤10 mL/min (all p = NS). However, at 12 mL/min hyperemia was confirmed by a significant decrease in Pd/Pa (1.3 ± 1.5%, p <0.01) and increase in AF from 10 mL/min to 12 mL/min (31.4 ± 28.1 mL, p <0.05). All curve tracings at 10 mL/min (129/129, 100%) were adequate versus only (7/15, 53%) and (15/18, 17%) at 6 mL/min, and 8 mL/min, respectively, and this infusion-rate was considered to determine resting-AF. CFRThermo-infusion was determined as the ratio of hyperemic-AF (20 mL/min) by resting-AF (10 mL/min). Mean CFRThermo-infusion was 2.56 ± 0.9 and CFRthermo-bolus 2.49 ± 1. Both parameters showed a good correlation (r = 0.76; p <0.001) and intraclass agreement (ICC = 0.76; p <0.001).The continuous thermodilution method enables to quantify resting-AF providing a novel clinical tool to determine CRF. CFRThermo-infusion shows a good correlation with CFRthermo-bolus..

Reliability of Cardiac Output Measurements Using LiDCOrapid and Calibration by Transesophageal Echocardiography With the Continuous Pulmonary Artery Thermodilution Method in Patients Undergoing Aortic Valve Replacement for Aortic Stenosis

This study investigated the accuracy of arterial waveform analysis estimations of cardiac output (COAW) and the efficacy of calibrations involving transesophageal echocardiography with continuous cardiac output values obtained using a pulmonary artery catheter. Prospective cohort study. University hospital operating room. Twelve patients undergoing aortic valve replacement for aortic stenosis. A pulmonary artery catheter was placed in each patient, and continuous cardiac output was determined using thermodilution principles. LiDCOrapid and transesophageal echocardiography were used to measure COAW and to perform the calibration, respectively. Simultaneous recording of continuous cardiac output and COAW values were performed every 20 minutes, after inducing anesthesia. COAW was calibrated using transesophageal echocardiography (COAW-cal) before and after initiating cardiopulmonary bypass (CPB); the COAW and COAW-cal were recorded concurrently using a LiDCOrapid monitor. For the pre-CPB dataset (34 data pairs), the mean bias and percentage error were, respectively, 0.10 L/min and 34% for COAW versus continuous cardiac output and -0.098 L/min and 27% for COAW-cal versus continuous cardiac output. Similarly, for the post-CPB (45 data pairs), the mean bias and percentage error were, respectively, 0.75 L/min and 34% for COAW and 0.059 L/min and 26% for COAW-cal. A 4-quadrant plot demonstrated an acceptable pre-CPB concordance rate of 93.3% for COAW and 93.8% for COAW-cal. COAW measurements, using LiDCOrapid, have acceptable trending ability pre-CPB. The determination of cardiac output variations, using transesophageal echocardiography, is useful for managing patients undergoing aortic valve replacement for aortic stenosis.

Accuracy, Precision, and Trending Ability of Electrical Cardiometry Cardiac Index versus Continuous Pulmonary Artery Thermodilution Method: A Prospective, Observational Study.

Introduction Evaluation of accuracy, precision, and trending ability of cardiac index (CI) measurements using the Aesculon™ bioimpedance electrical cardiometry (Aesc) compared to the continuous pulmonary artery thermodilution catheter (PAC) technique before, during, and after cardiac surgery. Methods A prospective observational study with fifty patients with ASA 3-4. At six time points (T), measurements of CI simultaneously by continuous cardiac output pulmonary thermodilution and thoracic bioimpedance and standard hemodynamics were performed. Analysis was performed using Bland-Altman, four-quadrant plot, and polar plot methodology. Results CI obtained with pulmonary artery thermodilution and thoracic bioimpedance ranged from 1.00 to 6.75 L min−1 and 0.93 to 7.25 L min−1, respectively. Bland-Altman analysis showed a bias between CIBIO and CIPAC of 0.52 liters min−1 m−2, with LOA of [−2.2; 1.1] liters min−1 m−2. Percentage error between the two techniques was above 30% at every time point. Polar plot methodology and 4-quadrant analysis showed poor trending ability. Skin incision had no effect on the results. Conclusion CI obtained by continuous PAC and CI obtained by Aesculon bioimpedance are not interchangeable in cardiac surgical patients. No effects of skin incision were found. International clinical trial registration number is ISRCTN26732484.

Cardiac Output Assessed by the Fourth-Generation Arterial Waveform Analysis System Is Unreliable in Liver Transplant Recipients

BackgroundLiver transplant recipients often have violent hemodynamic fluctuation during surgery that may be related to perioperative and postoperative morbidity. Because there are some considerations for the risk of the pulmonary arterial catheter (PAC), the conventional invasive device for cardiac output (CO) measurement, a reliable and minimally invasive alternative is required. We validated the reliability of CO measurements with the use of a minimally invasive FloTrac system with the latest fourth-generation algorithm in liver transplant recipients. MethodsForty liver transplant recipients without atrial fibrillation, valvular pathology, or intracardiac shunt were recruited in this prospective, observational study. CO values measured by use of PAC with continuous thermodilution method (COTh) and FloTrac devices (COFT) were collected simultaneously throughout the operation for reliability validation. ResultsFour hundred pairs of CO data points were collected in total. The linear regression analysis showed a high correlation coefficient (73%, P < .001). However, the percent error between COTh and COFT was 42.2%, which is worse than the established interchangeability criterion of 30%. The concordance rates were calculated at 89% and 59% by 4-quadrant plot and polar plot analysis, respectively. Neither met the preset validation criteria (>92% for the 4-quadrant plot and >90% for polar plot analyses). ConclusionsOur study demonstrates that the CO measurements in liver transplant recipients by the latest FloTrac system and the PAC do not meet the recognized interchangeability criterion. Although the result showed improvement in linear regression analysis, it failed to display a qualified trending ability.

Transesophageal Echocardiographic Measurement of Cardiac Index by the Prosthetic Mitral Valve Method Is Not Similar to the Continuous Thermodilution Method Via a Pulmonary Artery Catheter.

To compare the agreement of cardiac index measurements between transesophageal echocardiography across the prosthetic mitral valve and the continuous thermodilution method through a pulmonary artery catheter (PAC-TD) in patients undergoing double-valve replacement. Observational prospective study. University hospital. Twenty-five patients undergoing double-valve replacement (12 men and 13 women, age 25-78 years, ASA III-IV, NYHA II-III, LVEF≥45%). Patients were grouped according to their prosthesis (mechanical prosthesis v bioprosthesis). All patients underwent cardiac index assessment during double-valve replacement. Cardiac index across the prosthetic mitral valve was measured simultaneously using transesophageal echocardiography (CI(MV)) and PAC-TD (CI(PAC)) at 15, 30, 45, and 60 minutes after weaning from cardiopulmonary bypass, and at 0, 15, and 30 minutes after incision closure. A correlation was present between CI(MV) and CI(PAC) in both groups (mechanical prosthesis: r = 0.47, p<0.01; bioprosthesis: r = 0.60, p<0.01). In the mechanical prosthesis group, the bias between techniques (CI(PAC) v CI(MV)) was-0.5 L/min/m(2) (95% CI:-1.97 to 0.97), and error was 55%. In the bioprosthesis group, the bias between both techniques was-1.3 L/min/m(2) (95% CI:-3.1 to 0.5), and error was 56%. A relatively weak correlation and lack of agreement between values of CI(PAC) and CI(MV) were observed in patients undergoing double-valve replacement. Therefore, transesophageal echocardiography might not be interchangeable with PAC-TD for measuring cardiac output or cardiac index. A regression equation is needed to correct the probable value of CI(PAC). CI(MV) might be useful as a quantitative or semi-quantitative cardiac output measurement.

The Accuracy of Continuous Thermodilution Method in Comparison with Bolus Cardiac Output Measurement Using Room Temperature Versus Cold Injectates in Cardiac Surgical Patients

The Accuracy of Continuous Thermodilution Method in Comparison with Bolus Cardiac Output Measurement Using Room Temperature Versus Cold Injectates in Cardiac Surgical Patients

A combination of thermal methods to assess coronary pressure and flow dynamics with a pressure-sensing guide wire

Measurement of coronary pressure and absolute flow dynamics have shown great potential in discerning different types of coronary circulatory disease. In the present study, the feasibility of assessing pressure and flow dynamics with a combination of two thermal methods, developed in combination with a pressure-sensor-tipped guide wire, was evaluated in an in vitro coronary model. A continuous infusion thermodilution method was employed to determine the average flow, whereas a thermal anemometric method was utilized to assess the pressure and flow dynamics, simultaneously. In the latter method, the electrical power supplied to an element, kept at constant temperature above ambient temperature, was used as a measure for the shear rate.It was found that, using a single calibration function, the method was able to assess coronary pressure and flow dynamics for different flow amplitudes, heart rates, and different pressure wires. However, due to the fact that the thermal anemometric method cannot detect local shear rate reversal, the method was unable to reliably measure flow dynamics close to zero. Nevertheless, the combined methodology was able to reliably assess diastolic hemodynamics. The diastolic peak flow and average diastolic resistance could be determined with a small relative error of (8±7)% and (7±5)%, respectively.

Assessing fluid responses after coronary surgery: role of mathematical coupling of global end-diastolic volume to cardiac output measured by transpulmonary thermodilution

Mathematical coupling may explain in part why cardiac filling volumes obtained by transpulmonary thermodilution may better predict and monitor responses of cardiac output to fluid loading than pressures obtained by pulmonary artery catheters (PACs). Eleven consecutive patients with hypovolaemia after coronary surgery and a PAC, allowing central venous pressure (CVP) and continuous cardiac index (CCIp) measurements, received a femoral artery catheter for transpulmonary thermodilution measurements of global end-diastolic blood volume index (GEDVI) and cardiac index (CItp). One to five colloid fluid-loading steps of 250 ml were done in each patient (n = 48 total). Fluid responses were predicted and monitored similarly by CItp and CCIp, whereas CItp and CCIp correlated at r = 0.70 (P < 0.001) with a bias of 0.40 l min(-1) m(-2). Changes in volumes (and not in CVP) related to changes in CItp and not in CCIp. Changes in CVP and GEDVI similarly related to changes in CItp, after exclusion of two patients with greatest CItp outliers (as compared to CCIp). Changes in GEDVI correlated better to changes in CItp when derived from the same thermodilution curve than to changes in CItp of unrelated curves and changes in CCIp. After coronary surgery, fluid responses can be similarly assessed by intermittent transpulmonary and continuous pulmonary thermodilution methods, in spite of overestimation of CCIp by CItp. Filling pressures are poor monitors of fluid responses and superiority of GEDVI can be caused, at least in part, by mathematical coupling when cardiac volume and output are derived from the same thermodilution curve.

Uncalibrated Arterial Pulse Contour Analysis Versus Continuous Thermodilution Technique: Effects of Alterations in Arterial Waveform

To compare an arterial pressure-derived cardiac output (APCO) (Vigileo software version 1.07; Edwards Lifesciences, Irvine, CA) and a thermodilution cardiac output (CCO) as methods for measuring cardiac output under different pathologic and experimental conditions that induce changes in arterial waveform morphology. A prospective study. A university hospital, single institutional. Fifty-two patients undergoing elective cardiac surgery. Simultaneous APCO and CCO were compared in low-risk patients undergoing elective coronary artery surgery (without valvular disease) (control, n = 20), patients with aortic stenosis (AS, n = 10), aortic insufficiency (AI, n = 10), and intra-aortic balloon pump (IABP, n = 12). In the control group, additional data were registered before and after median sternotomy and phenylephrine administration. In the control group, Bland-Altman showed a bias of -3% (95% limits of agreement: -59% to +53%) before cardiopulmonary bypass (CPB) and of -1% (95% limits of agreement: -51% to +50%) after CPB. In the AS group, the bias was -5% (95% limits of agreement: -34% to +24%) before CPB and 1% (95% limits of agreement: -28 to +30%) after CPB. In the AI group bias was +32% (95% limits of agreement: -4% to +68%) before CPB and -2% (95% limits of agreement: -35% to +32%) after CPB. Median sternotomy decreased CCO by 10% +/- 10%, whereas it increased APCO by 56% +/- 28%. Phenylephrine administration decreased CCO by 11% +/- 16%, whereas it increased APCO by 55% +/- 34%. Cardiac output measurement based on uncalibrated pulse contour analysis is able to reflect cardiac output measured with the continuous thermodilution method in patients undergoing uncomplicated coronary artery surgery. However, in situations in which the arterial pressure waveform is changed, agreement between techniques may be altered and data obtained with uncalibrated pulse contour analysis may become less reliable.

Cardiac output measurement after coronary artery bypass grafting using bolus thermodilution, continuous thermodilution, and whole-body impedance cardiography

Objective: To test the feasibility of continuous cardiac output (CO) monitoring with whole-body impedance cardiography after coronary artery bypass grafting and to compare the values obtained with those measured using the bolus and continuous thermodilution methods. Design: A prospective study. Setting: Intensive care unit in a university hospital. Patients: Twenty patients after coronary artery bypass grafting. Interventions: CO was measured intermittently using the bolus thermodilution method, and continuously using the continuous thermodilution method, and whole-body impedance cardiography immediately after transfer to the intensive care unit. Measurements and Main Results: Bolus thermodilution CO was measured in triplicate at up to 14 time points overnight. Continuous thermodilution CO and whole-body impedance cardiography CO values were recorded simultaneously. During the study period, the bias in CO values between bolus thermodilution and whole-body impedance cardiography ranged from 0.07 to 1.05 L/min and the precision (standard deviation of differences) ranged from 0.82 to 1.31 L/min. The bias between the bolus and continuous thermodilution methods ranged from 0.06 to 0.58 L/min and the precision from 0.43 to 1.02 L/min. Pulmonary artery temperature and CO level were the major determinants of the bias and precision in both comparisons. Conclusions: Agreement between whole-body impedance cardiography and bolus thermodilution is slightly inferior to that between the bolus and continuous thermodilution methods but not to the extent that it hampers the use of whole-body impedance cardiography for the continuous monitoring of CO after coronary artery bypass surgery. © 2003 Elsevier Inc. All rights reserved.

Comparaison de deux techniques de monitorage du débit cardiaque : méthode du contour de pouls et thermodilution artérielle pulmonaire continue

Two devices for continuous cardiac output (CO) monitoring at patient bedside were evaluated. Vigilance™ monitor (Baxter Lab.) provides CO measurements by intermittent bolus (TDCO Vig) and continuous thermodilution (CCO Vig) methods, curves are both collected using a pulmonary artery catheter ; PICCO™ monitor (Pulsion Lab.) also provides continuous CO by pulse contour analysis (CCO Pic) and intermittent trans-thoracic thermodilution CO measurements (TDCO Pic), which is used to calculate a calibration factor for further beat-to-beat estimations of CCO Pic. Both systemic arterial pressure and thermodilution curves are collected using a femoral arterial catheter. The objectives of the study were : 1) to compare both methods, 2) to identify the situations possibly responsible for a poor reliability of the pulse contour method. CO measurements ( n=301) were recorded simultaneously with both devices in 10 ICU patients : 44 conflicting data pairs, measured after vaso-active drugs initiation or following a calibration procedure performed during cardiac arythmia, were excluded. 257 data pairs for continuous CO measurements were compared using linear regressions and Bland-Altman plots method. Mean values for CCO Vig and CCO Pic were 7,3±2,63 and 7,8±3,04 l. min −1 respectively, and the correlation was significant ( r=0,94, p<10 −4). The average difference (bias) was 0,5± 1,06 l. min −1, i.e 7 % overestimation of CO by CCO Pic, and the 95 % confidence interval was large. For 9 among 10 patients the correlation between CCO Vig and CCO Pic was good (Spearman test). For CO values less than 8 l.min −1, the bias and 95 % confidence interval were smaller (0,2±0,66 l. min −1, n=180). Moreover, 108 data pairs for intermittent CO measurements were collected. The correlation between TDCO Vig (7,4±2,7 l. min −1) and TDCO Pic (8,1±1,06 l. min −1) was significant ( r=0,97, p<10 −4). The bias was 0,76±0,86 l. min −1 and could be related to a thermal loss between pulmonary and femoral arterial collection. On the whole, the agrement between both continuous CO measurments is acceptable. Since TDCO Pic is used for CCO Pic calibration, the difference between the two CO continuous methods could be partly explained by an overestimation of TDCO Pic. Consequently, the software calibration process should be refined. Moreover, we identified two situations that are responsible for erroneous values of CCO Pic and require a new calibration : cardiac arythmia during PICCO™ calibration, vaso-active drugs initiation.

Continuous and intermittent cardiac output measurement: pulmonary artery catheter versus aortic transpulmonary technique

Cardiac output (CO) can be measured intermittently by bolus thermodilution methods in the pulmonary artery (COpa) or in the aorta (COart). A continuous thermodilution method (CCO) and a method for continuous estimation using the arterial pulse wave (PCCO) are also available. We compared two methods of intermittent CO measurements in patients during liver transplantation: COpa, regarded as the current clinical standard, and an aortic transpulmonary thermodilution technique (COart) performed with the PiCCO system. We also compared CCO and PCCO. Measurements were made in 62 patients at three stages: after the induction of anaesthesia, after caval clamping phase, and at the end of surgery. We used Bland-Altman and correlation analysis. We found close agreement between the techniques. Mean bias between COart and COpa and PCCO and CCO was 0.15 (2SD of differences between methods=1.74) litre min(-1) and -0.03 (1.75) litre min(-1), respectively. Mean bias between CCO and COpa and PCCO and COpa was 0.02 (1.48) litre min(-1) and 0.04 (1.69) litre min(-1), respectively. Measurement with the aortic transpulmonary thermodilution technique gives continuous and intermittent values that agree with the pulmonary thermodilution method.

An assessment of attitudes to pulmonary artery flotation catheters in the United Kingdom and Ireland

There is concern over the safety of the use of pulmonary artery flotation catheters (PAFC) in the United Kingdom.1 We were unable to find any data directly applicable to practice in the United Kingdom and Ireland. The aim of our study was to assess the practice in this country by the use of a telephone questionnaire. A standardised questionnaire was used and answered by senior medical personnel. We phoned 48 intensive care units who had more than 8 beds and we stipulated that the answers reflected practice in the unit. We found that a trainee routinely passes the pulmonary artery flotation catheter however the decision to pass a PAFC was only made by a consultant in 30% of cases. In more than 80% of intensive care units less than 40% of patients had a PAFCin situ. The incidence of indications for placing a PAFC are sited in Table 27. In the intensive care units in our survey the main forms of measurement of cardiac output were cold injectate (77%), continuous thermodilution (48%), echocardiography and Doppler methods (4%), and thoracic bioimpedance (2%). In over 90% of cases the measurements routinely taken with the PAFC were pulmonary artery pressure, pulmonary capillary wedge pressure, cardiac output, central venous pressure and systemic vascular resistance. Oxygen delivery (48%), oxygen consumption (40%), mixed venous saturation (50%) and right and left stroke work index ( Our data suggest that in only 20% of the units we studied was a pulmonary artery flotation catheter routinely used. In addition it appears that not all clinicians in the United Kingdom and Ireland feel that a PAFC is indicated in a number of well documented clinical situations.

Effect of ambient temperature and cardiac stability on two methods of cardiac output measurement.

The dependence of cardiac output measurement precision on ambient temperature and cardiac output stability was assessed by concurrent continuous and bolus thermodilution methods in postoperative cardiac surgery patients. The degree of agreement between the two methods was depended on room temperature (0.1 L/min for each degree below 25 degrees C). The agreement was also closer in trials where cardiac output was stable (< 10% variation). The continuous thermodilution method shows sufficient agreement with the bolus method for use in critical care; however, improved precision of cardiac output thermodilution measurements can be achieved by use of correction factors for cardiac instability and for ambient temperature.