The Study aimed to identify the impact of Requirements Applying of Six Sigma Methodology with its dimensions (Top Management commitment and support, Continuous Improvement, Human Resources, technology and information systems) on Reducing Productive Wastage, the level of Requirements applying it and the Reducing Productive Wastage at Yemeni Pharmaceutical Manufacturing Companies. To achieve the study objectives, the descriptive analytical method was used and the study population consisted of the workers in Yemeni Pharmaceutical Manufacturing Companies with a total number of (476) employees. The study questionnaire was distributed on stratified random sample with a total number of (195) employees. By analyzing the data using descriptive analysis methods and multiple regression analysis using the SPSS program, the findings revealed positive impact of Requirements Applying of Six Sigma methodology on the reduction of productive waste in Yemeni Pharmaceutical Manufacturing Companies, and also that there is a positive impact of the three Applying of Six Sigma Methodology dimensions: Continuous Improvement, information and technology systems and Human Resources on Reducing Productive Wastage, while there was no impact of the top Management commitment and support on Reducing Productive Wastage in Yemeni Pharmaceutical Manufacturing Companies, due to the variation in the workers awareness level of Requirements Applying of Six Sigma Methodology. The findings also showed that the level of Requirements applying of the six-sigma methodology at Yemeni Pharmaceutical Manufacturing Companies was high, and the level of Reducing Productive Wastage was high as well in Yemeni Pharmaceutical Manufacturing Companies.