Suitable material design is the bottleneck for synergistic adsorption-photocatalysis reaction system for chlortetracycline (CTC) remediation. Herein, a S-scheme In-MOG/carbon doped ZnO (In-MOG/C-ZnO) was prepared to effectively enhance the adsorption-photocatalysis achieving the CTC removal of 94.01 % in 40 min and displaying excellent immunity to interference. Furthermore, the integrative effect with mutual amplification of adsorption and photocatalysis, the possible CTC degradation pathways, and the potential toxicity evaluation of CTC intermediates were elaborated. Importantly, the shapeable MZ@CBC was synthesized by immobilizing In-MOG/C350-ZnO with chitosan/bacterial cellulose (CBC) as the carrier matrix to effectively improve powder material recyclability, which was further evaluated for the prospect of large-scale application through the continuous removal of contaminants in a CAP reactor. The current study may serve as a reference perspective for engineering design of materials for bifunctional adsorption-photocatalysis system as well as large-scale continuous-flow wastewater remediation.