Pennsylvania’s Towanda Creek drainage basin geomorphic history is determined by using a recently proposed geology and glacial history paradigm (which predicts massive and prolonged southwest oriented continental ice sheet meltwater floods flowed across Pennsylvania) when interpreting previously unexplained topographic map drainage system and erosional landform evidence. The new paradigm explains most of the region’s erosional landforms including barbed tributaries, drainage divides, through valleys (valleys crossing drainage divides), water and wind gaps, valley orientations, entrenched meanders, through valley and gap floor elevations, regional ridge crest elevations, upland area elevations, and intervening lowland elevations. The new paradigm suggests the present-day northeast-oriented Towanda Creek drainage basin formed as immense and prolonged southwest-oriented floods first lowered a low relief surface (now preserved if preserved at all by the region’s highest elevations) in the area between the present-day northeast-trending Blossburg and Barclay synclinal uplands and also to the south of the Barclay synclinal upland. Those floodwaters after flowing across the present-day northeast-oriented Towanda Creek drainage basin flowed in a southwest direction through the now southwest-oriented Lycoming and Loyalsock Creek drainage basins and then to and along a now northeast oriented West Branch Susquehanna River valley segment before continuing in a southwest direction along what is now the Allegheny Front. Headward erosion of today’s southeast-oriented North Branch Susquehanna River valley segment between Pittston and Athens, Pennsylvania captured and reversed the beheaded southwest-oriented floodwaters to create the northeast-oriented Towanda Creek drainage system seen today.