Event Abstract Back to Event Integration of Reward-Based and Context-Based Decision Making in Human Prefrontal Cortex S. Duverne1* and E. Koechlin1 1 INSERM, Ecole normale superieure , Canada The lateral prefrontal cortex (PFC) implements task selection based on contextual information, whereas medial PFC is involved in selection based on reward information. Little is known, however, on how reward-based and context-based selection processes are integrated together. Using functional magnetic resonance imaging, we recorded brain activity in twenty-three participants responding to letter stimuli by choosing between two tasks based on either contextual cues or variable reward history associated with each task. We found that the lateral PFC regions were involved in both reward-based and context-based task selection. Reward-based trials, however, involved additional medial PFC regions, while lateral PFC activations increased in reward-compared to context-based trials. The results suggest that medial PFC regions contribute to decision-making by biasing selection processes in the lateral PFC according to rewarding values of task-sets, while lateral PFC integrates contextual and motivational signals to achieve task-set selection underlying executive control of behavior. Conference: The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010. Presentation Type: Poster Presentation Topic: Cognitive Neuroscience Citation: Duverne S and Koechlin E (2010). Integration of Reward-Based and Context-Based Decision Making in Human Prefrontal Cortex. Conference Abstract: The 20th Annual Rotman Research Institute Conference, The frontal lobes. doi: 10.3389/conf.fnins.2010.14.00103 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 29 Jun 2010; Published Online: 29 Jun 2010. * Correspondence: S. Duverne, INSERM, Ecole normale superieure, Paris, Canada, sandrine.duverne@ens.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers S. Duverne E. Koechlin Google S. Duverne E. Koechlin Google Scholar S. Duverne E. Koechlin PubMed S. Duverne E. Koechlin Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.