Knowledge is widely acknowledged as a pivotal asset, and various perspectives underscore the significance of effectively marshaling, deploying, and sharing knowledge within an organization for achieving organizational success. The National Museum of Kenya (NMK) was established with the primary goal of enriching knowledge and facilitating sustainable utilization of research information resources by stakeholders. However, the increasing diversification of knowledge sources has rendered content creation and knowledge management processes complex and laborious. Consequently, this complexity has resulted in inefficiencies throughout the knowledge management process, leading to inadequacies and disorganization. Despite the adoption of knowledge management systems, the integration of mobile phone technology in research activities at the museum has been neglected. This study aimed to scrutinize knowledge management practices at the NMK through the use of mobile apps, examine the associated challenges, and propose viable solutions. The study’s objectives were to investigate the challenges faced by researchers in generating knowledge and recommend feasible mobile technological solutions to address these challenges. The study was guided by the Knowledge Management Process Model, and employed a qualitative case study approach. The target population comprised researchers, knowledge managers, and ICT staff at the museum. Since this study was purely qualitative, data collection was achieved through interviews, and analyzed using narrative methods. The findings indicated that the NMK has implemented web-based systems supporting knowledge management activities. However, mobile phone technology has not been incorporated into any aspect of the museum’s knowledge management support tools. The study highlighted challenges such as; delayed data acquisition, misplacement of specimens, time consuming processes, data inaccuracies, and inefficiencies in knowledge management processes. Further, it was established that relying solely on web-based systems limits the flexibility of researchers in adapting to dynamic field conditions. Thus, this study recommends integrating mobile technologies into the knowledge management process at the National Museum of Kenya as a solution to the highlighted challenges. Mobile apps, known for their effectiveness and reliability, particularly in remote areas, offer a practical solution. This integration empowers researchers with more accessible and versatile tools, fostering improved content creation and knowledge management while ensuring inclusivity and efficiency, even in resource-constrained environments.