In Partial Shading Conditions (PSCs), Photo Voltaic (PV) systems often experience notable output power and efficiency reductions due to weather variations. This study is dedicated to determining the most effective PV array configuration under partial shading. Various configurations, including Series Parallel (SP), Total Cross Tied (TCT), Bridge Linked (BL), Honey Comb (HC), Double Tied (DT), and hybrid connections, are simulated and evaluated under PSCs. Nine shading patterns, such as vertical, horizontal, centre-wise, upper triangular, cross-wise, expansive, arbitrary, L-shaped, and diagonal, are examined using a 6 × 6 array of PV Configuration. Performance analysis is based on parameters such as open circuit voltage (Voc), short circuit current (Isc), Global Maximum Power Point (GMPP), maximum voltage (Vm), maximum current (Im), Fill Factor (FF), Mismatch Loss (ML)/Power Loss (PL), and efficiency (η). Additionally, hybrid configurations like Alternate- Total Cross Tied -Bridge Linked (ALT-TCT-BL), Alternate -Total Cross Tied -Double Tied (ALT-TCT-DT), and Alternate -Total Cross Tied -Triple Tied (ALT-TCT-TT) are investigated and compared with existing configurations. Hybrid configurations with fewer cross-ties are recommended to simplify circuit complexity. MATLAB/Simulink software is employed for simulation, using a Sunpower SPR-E18-295-COM panel. Comparative analysis confirms that hybrid configurations exhibit higher efficiency for various shading patterns than existing configurations, equal or at par with the TCT connection. For eight connections and nine shading scenarios along with zero (no) shading conditions, eighty distinct combinations have been analysed, and on comparative analysis with contemporary work, the optimal output is obtained from the connections considered under PSCs. For all the shading patterns considered, the proposed work fetches maximum efficiency compared to the contemporary work, and it ranges between 13.61 % and 17.84 % for different shading patterns. The maximum value of efficiencies for horizontal, vertical, diagonal, centre-wise, expansive, arbitrary, upper triangular and L-shaped shading patterns is 13.77 %, 17.24 %, 17.84 %, 15.66 %, 13.61 %, 17.21 %,17.35 % and 15.11 % respectively. The hybrid configuration achieves higher efficiency than current methods for all shading patterns and configurations, with improvements in efficiency ranging from 2.1 % to 42.22 % across all cases.