Consumption Of Other Drugs Research Articles

Psychiatric and obstetric characteristics of pregnant crack users admitted to a referral center in Southern Brazil

Background Psychoactive substance use among pregnant women has reached alarmingly high rates. Our aim was to characterize the psychiatric and clinical profiles of pregnant crack users in Brazil. Methods This was a cross-sectional study of 24 pregnant crack users admitted to a referral hospital for psychiatric disorders in pregnant women, in Porto Alegre, Brazil, over three years. The following instruments were applied: a clinical-obstetric questionnaire; the condensed version of the Addiction Severity Index; a diagnostic interview for psychoactive substance use based on DSM-5; the Mini International Neuropsychiatric Interview for DSM-IV; and the Semi-Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II). Results Most patients had severe crack dependence and used other substances, such as tobacco, cannabis, and alcohol. The median duration of crack use was three years, ranging between three and 12 years. Most women subsisted from illegal or informal activities; a fifth had previously been arrested and often had relationship problems. Twenty percent had HIV (n = 5), and 37.5% (n = 9) had syphilis. Borderline personality disorder was the most prevalent mental condition (62.5%), followed by suicidal tendencies (45.8%), hypomanic episodes due to substance use (37.5%), and past major depressive episodes (33.3%). Conclusions An alarmingly high prevalence of consumption of other drugs, psychiatric disorders, and difficult-to-treat personality disorders was observed in our study. Investigating the psychiatric profile of women who use substances is essential to minimize the impacts on the mother and child, optimize therapeutic approaches to comorbidities, and enable more effective relapse prevention.

A history of ethanol intake accelerates the development of morphine analgesic tolerance: A protective potential for omega-3 fatty acids.

Adolescence is a critical life period during which significant neurodevelopmental changes occur within the central nervous system. Consistently, substance abuse in this stage has been found to induce persistent changes in brain responsiveness to future drug challenges. Nowadays, heavy episodic alcohol consumption during adolescence, also known as binge-drinking behavior, is a growing concern in modern societies. On the other hand, alcohol is well known to act as a gateway drug, that is, it promotes the individual's craving for consumption of other drugs of abuse. With this in mind, we aimed to assess whether adolescent ethanol exposure could alter the development of tolerance and dependence to morphine, as an available common opioid drug. Tail flick test was used to measure thermal nociceptive changes in adult male Wistar rats undergone ethanol/vehicle exposure during adolescence. Furthermore, morphine withdrawal syndrome was induced by naloxone injection, and behavioral signs were recorded for 20 min. It was found that adolescent ethanol intake facilitates morphine analgesic tolerance and decreases baseline latency; however, the severity of dependence is not significantly altered. Moreover, we found that 15 days of treatment with omega-3 fatty acids (O3) prevents the mentioned ethanol-induced changes suggesting a therapeutic potential for this compound. O3 supplementation, as an inexpensive and noninvasive method, may assist the clinicians to reverse the adverse effect of alcohol binge drinking on adolescents' brains and to reduce the vulnerability to drug exposure in adulthood. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Cannabis recent use in sudden unexpected deaths

The aim of this study was to review all sudden unexpected death received in our laboratory over a four years’ period (2018–2021) in order to ascertain the prevalence of recent cannabis consumption. The main cause of death in industrialized countries is ischemic heart disease, and risk factors include smoking, obesity, age, hypercholesterolemia, arterial hypertension, diabetes mellitus and alcohol. The scientific literature now also links cannabis use to cardiovascular accidents. Cannabinoids exert their effects through the activation of two specific membrane receptors, CB1 and CB2 and, at the cardiovascular level, the activation of these receptors is related to increased cardiac output and sinus tachycardia. In total, 7150 cases of sudden unexpected death had been received in our laboratory for toxicological analysis from January 2018 to December 2021, 262 were related to cannabis use and we selected those in which recent cannabis use was demonstrate due to the presence of THC in blood, after having discarded those cases that presented a concomitant consumption of other drugs of abuse, as well as, other psychoactive substances at toxic concentrations. Blood samples were screened for cannabis by CEDIA and Δ9-tetrahydrocannabinol (THC), 11-hydroxy-Δ9-tetrahydrocannabinol (11-OH-THC) and 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) were confirmed and quantified using solid-phase extraction (SPE) followed by gas chromatography tandem mass spectrometry (GC-MS/MS). The cut-offs applied were 1 ng/mL for THC and 11-OH-THC and 5 ng/mL for THC-COOH. Forty-eight sudden unexpected deaths following recent cannabis use were recorded. THC blood levels have been increasing over the period studied. The mean in 2018 was 1.84 ng/mL, increasing to 8.08 ng/mL in 2021. In terms of sex, 87.5% of cases were male, the age range ranged from 16 to 74 years, with the median being 50 years and the mode 47 years. In 77% of the cases the cause of death was cardiogenic, 6.2% of the cases corresponded to subarachnoid hemorrhage and the rest to other causes. The highest incidence is presented by the population aged between 40–60 years (58.3%), with alcohol and/or tobacco consumption habits in 50% of the cases. In addition, in this group there are cases with different pathological antecedents like arterial hypertension, obesity, epilepsy and congenital heart disease. The lower incidence of sudden unexpected death is in the age group from 16 to 30 years (10.4%). The distribution of the number of deaths was not homogeneous throughout the four years studied. Both, an increase in the number of deaths and in THC blood levels can be seen. This may be directly related to the increase in THC concentrations in the different forms of cannabis presentations in street samples. Despite cannabis being the most consumed drug among young people, the incidence of sudden unexpected death in this age group is lower, which highlights the importance of the existence of previous pathologies. In people with certain pathologies and/or alcohol and tobacco consumption habits cannabis use is a risk factor that can contribute to sudden unexpected death.

Validity and Reliability of the Portuguese Version of the Healthy Lifestyle Questionnaire-EVS III.

The main objective of this study was to validate the Healthy Lifestyle Questionnaire—EVS III, using confirmatory factor analysis of the measurement model. A total of 822 Portuguese individuals of both genders, aged between 18 and 66 years old (M = 28.43 SD = 12.07), participated in this study, of which 382 were male (46.5%) and 440 were female (53.5%). The main results obtained revealed that the psychometric qualities prove the adequacy of the factor structure of the Healthy Lifestyles Questionnaire—EVS III (7 factors/32 items) and that it has acceptable validity indices: χ2 = 644.6828, p = 0.000, df = 168, χ2/df = 3.84, NFI = 0.901, TLI = 0.902, CFI = 0.921, IFI = 0.922, MFI = 0.900, GFI = 0.909, AGFI = 0.901, RMR = 0.073, SRMR = 0.059 and RMSEA = 0.059, enabling the assessment of factors related to a balanced diet, respect for mealtimes, tobacco consumption, alcohol consumption, consumption of other drugs, resting habits and physical activity habits. The Portuguese version of the Healthy Lifestyles Questionnaire—EVS III can be used with reasonable confidence for the assessment of healthy lifestyles.

Les schémas précoces inadaptés et la rechute au cours de traitement de maintien par la méthadone chez les toxicomanes (une approche cognitive)

Introduction/objectiveDysfunction of cognitive schemas and addictive behaviors are often coexisting which can cause relapse during drug treatment. The objective of this study is to assess early maladaptive schemas (EMS) among heroin users and their relationship with relapse during methadone maintenance treatment. Subject and methodsThis is a cross-sectional study carried out on 166 heroin users treated with methadone at the medico-psychological center in northern Morocco during 2017. The subjects completed both the Young short version schema questionnaire (YQS) and the ASI questionnaire (Addiction Severity Index) to measure the severity of drug addiction. ResultsThe results showed that the most activated schemas in the totality of the subjects were fear of losing control, Emotional deficiency and failure. They were also significantly more activated in women than in men for five schemas indicating rejection and separation, and a lack of autonomy. Regarding the relapse during treatment consumption there was a positive and significant correlation with ten out of thirteen SPI, which means the more the intensity of SPI decrease the greater the tendency to relapse (r=0.509, P<0.0001). However, there was also a weak correlation between the consumption of other drugs and SPI. ConclusionThe cognitive approach has highlighted the essential role of cognitive disorders in addictive behaviors that EMS may be predictors of relapse during substitution treatment, and that a concurrent therapy of schema may reduce the likelihood of relapse.

The Relationship between Drug Consumption and Dating App Use: Results from an Italian Survey

To date, the literature regarding the relationship between drug consumption and dating app use is still very scant and inconclusive. The present study was thus aimed at investigating the association between drug consumption and dating app use in the general population. A total of 1278 Italian respondents completed an online ad hoc questionnaire assessing drug consumption (cannabis versus other illicit drugs), dating app use, the primary motive for installing dating apps, and demographics. Multiple logistic regression analyses were run to investigate the role of demographics and dating app use on drug consumption. Being single predicted cannabis use. Using dating apps accounted for higher odds of cannabis use; however, people who intensely used the apps were less likely to consume marijuana. Conversely, dating app use was not associated with the consumption of other drugs. This study suggests the presence of common underlying factors between dating app use and cannabis use, and it highlights the mediating role of the intensity of app use. Conversely, the study suggests that dating app use and the use of other drugs are quite independent behaviors.

CASE SERIES: AMLODIPINE INTOXICATION

BACKGROUND: Drug poisoning is an important cause of morbidity and mortality in pediatric patients. However, amlodipine poisoning, a widely used dihydropyridine calcium chanel blocker, is not fully documented in Ecuador. Treatment consists of classic measures for shock management and specific measures for this type of intoxication. CASE REPORTS: We present two case reports, both of teenage patients admitted into the pediatric intensive care unit for suicide attempt by taking amlodipine and some other drugs. EVOLUTION: During hospital stay, they presented a different evolutionary course. In both cases vasoactive drugs were needed, dosage was modified according to clinical course. Also in both patients, calcium gluconate was administered along with other support measures described in this paper. Finally, both patients presented a good outcome and were discharged after psychological and psychiatric assessment and follow up. CONCLUSION: The low frequency of amlodipine poisoning and the lack of evidence-based knowledge, constitute it as a diagnostic and therapeutic challenge. Based on our experience, we highlight the importance of early suspicion and prioritizing the use of vasopressors over fluid resuscitation. Additionally, we recommend documenting the exact dose of intake and inquiring about consumption of other drugs to properly classify the severity of the poisoning and stablish the treatment plan. Finally, constant clinical monitoring and support of laboratory tests will guide the conduct.

Cost-Utility Analysis of Saxagliptin/Dapagliflozin Versus Gliclazide and Insulin Glargine: Economic Implications of the Outcomes of the CVD-Real Studies I and II.

Diabetes treatment cost represents an ever-growing problem. The adoption of new drugs in therapy, although they can guarantee an improvement in patient’s quality of life, can meet obstacles when it involves an increase in costs. We decided to compare the costs and benefits of the new saxagliptin and dapagliflozin combination versus traditional therapies. Bodyweight loss and the sharp reduction in hypoglycemic episodes were the 2 main clinical outcomes that emerged from registered studies of saxagliptin and dapagliflozin compared with the sulfonylureas. These results, combined with the good cardiovascular risk profile, led to develop a cost-utility analysis. We aimed to show the economic value of this new association therapy. We carried out a cost-utility analysis from the Italian National Healthcare System (NHS) perspective, focused on direct costs related to the treatment and management of main diabetes complications. Utility scores adopted have been measured based on the patient’s perception of weight changes. In light of the better durability profile of saxagliptin/dapagliflozin compared with gliclazide, we also considered a simulation scenario to assess the impact on costs of switching to basal insulin, starting from gliclazide and the fixed combination, respectively, and based on the related probabilities to switch. To assess the robustness of the results, a 1-way sensitivity analysis was performed by changing the main parameters by ±20%. Furthermore, the sensitivity of the results was tested considering the addition of a percent discount, because the purchase costs of drugs are usually subject to hidden discounts. We calculated the total direct annual cost per patient of saxagliptin/dapagliflozin versus gliclazide and insulin glargine for patients with type 2 diabetes mellitus not achieving glycemic control on metformin plus saxagliptin alone, dapagliflozin alone, or gliclazide at a lower dosage. Total treatment costs have been obtained adding the direct cost of the drug, needles, glycemic self-monitoring, hypoglycemic events, cardiovascular complications, and effect on consumption of other drugs. The total direct cost of saxagliptin/dapagliflozin fixed dose combination was €414.62 higher than gliclazide (€1.067.72 vs €653.10), and greater than basal insulin, with a difference of €166.99 (€1067.72 vs €900.72). Despite the higher annual direct total cost, the additional cost per quality-adjusted life year (QALY) gained, compared with gliclazide, has been €11 517, and €4639, when compared with insulin glargine in the base-case scenario, and the robustness of the results has been shown in the sensitivity analysis. The results of our cost-utility analysis, expressed as incremental cost-effectiveness ratios, were fully compliant with the threshold adopted for Italy. Then, saxagliptin/dapagliflozin can be considered a cost-effective oral hypoglycemic agent. The positive effect of this drug on the quality of life, induced by the bodyweight loss, has allowed this outcome, despite the higher annual cost per patient, mainly determined by the drug purchase cost.

Progresión y escalonamiento en el consumo de drogas: evidencia para Argentina

El objetivo de este trabajo es estudiar, para Argentina, la progresión en el consumo de drogas que se inicia con el consumo de drogas legales y avanza hacia el consumo de marihuana, cocaína y otras drogas ilícitas. Utilizando la ENPreCoSP del 2011, se analiza la relación entre el consumo de alcohol y tabaco y su edad de inicio con el consumo de marihuana incluyendo variables de propensión y acceso. A su vez, se estudia la relación entre el consumo de marihuana y su edad de inicio con el consumo de otras drogas. Los resultados obtenidos van en línea con la teoría de escalonamiento, el consumo de drogas legales y su inicio más temprano tienen una relación positiva con la probabilidad de consumir marihuana, y el consumo de esta última también se relaciona directamente con la probabilidad de consumir otras drogas ilícitas.

Follow-up Study of Drug Use, Depression, and Anxiety Reduction and Quality of Life in Addicts on Methadone Maintenance Therapy

Background: This study aimed to evaluate reduced drug consumption, risky behaviors, depression, and anxiety and improved quality of life in addicts on methadone maintenance therapy (MMT) at baseline and six months after therapy. Methods: In this descriptive cross-sectional study, 275 addicts were selected by a random sampling method in 2017. The data collection tools consisted of four questionnaires including a demographic information questionnaire, the Beck depression inventory questionnaire, WHOQOL-26, and Spielberger Anxiety Inventory. Data analysis was done by SPSS20 software at a confidence level of 95%. Results: Based on the obtained results, after six months, MMT efficiency was 50.5% and no cases of intravenous injection were reported. The consumption of other drugs was significantly reduced (P < 0.05). The highest prevalence of depression was observed in cannabis and opium users. Depression decreased from 85.81% to 63.27%. The mean scores of quality of life and anxiety after MMT increased to 89.6 and 20.41, respectively. The most improvement was in the physical health domain (mean score of 64.11). Conclusions: The results showed improvements in all the four domains of physical health, psychological health, social relationship, and environment and reductions in depression and anxiety.

FACTORS THAT INFLUENCE THE INCIDENCE OF DRUG INDUCED LIVER INJURY IN PULMONARY TUBERCULOSIS PATIENT

Background: The use of anti-tuberculosis drugs (ATD) is not uncommon to find side effects that complicate treatment. One of the side effects caused by ATD treatment is Drug Induced Liver Injury (DILI). Risk factors that trigger the incidence of DILI during tuberculosis (TB) treatment involving variety of factors. This study was conducted to determine the risk factors of DILI in pulmonary tuberculosis patient. Method: Conducted retrospective case-control study. Study subjects were all patients who underwent first category ATD treatment at Dr. Wahidin Sudirohusodo hospital of Makassar, Indonesia. Risk factors examined were age, gender, nutritional status, alcohol consumption, smoking, history of liver disease, consumption of other drug, ATD preparation of Fixed Dose Combination (FDC) and abnormality of SGPT/ total bilirubin control value at minimum of 2 weeks after starting treatment. Result: from total 47 samples who took part in the study, 10 samples (21.3%) suffered DILI. Samples characteristics who suffered from DILI, were an average age of 52.7 years old (P < 0.05), and consumption of other drug 29.4% (P < 0.05). There was no significant relationship between gender, nutritional status, alcohol consumption, smoking, and history of liver disease in the incidence of DILI. Conclusion: Old age and history of consumption of other drug has significant relationship as a risk factors for the incidence of DILI in TB patients who consume ATD, while no significant relationship found between gender, malnutrition, alcohol consumption, smoking, and history of liver disease.

Cost-minimization analysis of degludec/liraglutide versus glargine/aspart: economic implications of the DUAL VII study outcomes.

BackgroundDiabetes represents a relevant public health problem worldwide due to its increasing prevalence and socioeconomic burden. There is no doubt that tight glycemic control reduces the development of diabetic complications such as the long-term costs related to the disease. The aim of our model was to calculate total direct costs associated with the two treatments considered in DUAL VII study, and hence evaluate the potential economic benefits for the National Health System (NHS) deriving from the use of insulin degludec plus liraglutide (IDegLira) in a once-daily fixed combination.Materials and methodsWe applied the cost-minimization technique adopting the NHS point of view to the DUAL VII trial outcomes. In the model, developed in Microsoft Excel®, we calculated and compared annual costs per patient of the two therapeutic options for type 2 diabetes (T2D) patients not achieving glycemic control on basal insulin and metformin described in the trial, including costs of therapy management and side effects, both negative and positive. Annual treatment costs were calculated based on IDegLira and basal bolus end-of-trial doses resulting in a 1:2 ratio (40.4 U vs 84.1 U). Therefore, maintaining the IDegLira/basal bolus at 1:2 dose ratio, we calculated the correlation between the dose reduction and costs compared to DUAL VII doses base case scenario.ResultsTotal treatment costs were obtained by adding annual cost of drug, needles, glycemic self-monitoring, hypoglycemic events, and effect on consumption of other drugs. Total annual costs of IDegLira combination resulted in €434 higher than basal bolus in DUAL VII base case (40.4 U); the two treatments reported equal costs at 34% dose reduction (26.7 U), while below this value IDegLira treatment became less expensive, with about €215 gain at 50% dose reduction (20.2 U). It is also important to notice that above the break-even point, until an IDegLira dose of 30 U, the cost difference is negligible in view of the clinical benefit provided by the fixed combination highlighted in DUAL VII trial.ConclusionAdding the significant clinical findings derived from DUAL VII trial to our economic evaluation, IDegLira seems to offer an important alternative to basal-bolus therapy.

Crime and the legalization of recreational marijuana

First-pass evidence is provided that the legalization of the cannabis market across US states is inducing a crime drop. We exploit the staggered legalization of recreational marijuana enacted by the adjacent states of Washington (end of 2012) and Oregon (end of 2014). Combining county-level difference-in-differences and spatial regression discontinuity designs, we find that the policy caused a significant reduction in rapes and property crimes on the Washington side of the border in 2013–2014 relative to the Oregon side and relative to the pre-legalization years 2010–2012. The legalization also increased consumption of marijuana and reduced consumption of other drugs and both ordinary and binge alcohol. Four possible mechanisms are discussed: the direct psychotropic effects of cannabis; substitution away from violence-inducing substances; reallocation of police effort; reduced role of criminals in the marijuana business.

Does Previous Marijuana Use Increase the Use of Other Drugs: An Almost Ideal Demand System Approach

Abstract From a policy standpoint, the legalization of marijuana may affect other drug markets. The Almost Ideal Demand Model is used to estimate drug substitution between the most common illegal street drugs in the US including cocaine, heroin, marijuana, and methamphetamines. We control for past marijuana consumption. Results indicate that past marijuana consumption does not contribute to increased current consumption of other drugs. Further, marijuana is a weak complement to methamphetamines but marijuana price changes do not affect heroin or cocaine consumption.

The relationship between consumption of alcohol and other drugs and problematic Internet use among adolescents.

Alcohol and drug use among adolescents has been causing great concern for decades in Spain and in the European Union as a whole. In addition, the technology boom experienced over the last two decades has contributed to the emergence of a new public healthcare issue: problematic Internet use. The increasing importance that both problems have been gaining in recent years has led some authors to analyze the relationship between alcohol and the consumption of other drugs alongside problematic Internet use, and to provide relevant empirical evidence. Based on a sample of 3,882 Spanish adolescents aged between 12 and 18, the results obtained confirm that there is a relationship between the consumption of alcohol (measured by the AUDIT) and other drugs (measured by the CRAFFT and the CAST), and problematic Internet use (measured by the EUPI-a). Problematic Internet users among them not only have more significant levels of substance use, but also a three-times greater chance of developing hazardous drug use (39.4% vs 13.3%). This highlights the need to develop transversal prevention capable of acting on the common variables to both issues, beyond developing programs focused on specific behaviors. In this sense, values-based education and life skills training should be given priority in prevention.

Crime and the Legalization of Recreational Marijuana

We provide first-pass evidence that the legalization of the cannabis market across US states may be inducing a crime drop. Exploiting the recent staggered legalization enacted by the adjacent states of Washington (end of 2012) and Oregon (end of 2014) we find, combining county-level difference-in-differences and spatial regression discontinuity designs, that the legalization of recreational marijuana caused a significant reduction of rapes and thefts on the Washington side of the border in 2013-2014 relative to the Oregon side and relative to the pre-legalization years 2010-2012. We also find evidence that the legalization increased consumption of marijuana and reduced consumption of other drugs and both ordinary and binge alcohol.

An Examination of the Ethnicity-Specific Prevalence of and Factors Associated with Substance Use and Misuse: Cross-Sectional Analysis of Croatian and Bosniak Adolescents in Bosnia and Herzegovina.

Substance use and misuse (SUM) in adolescence is a significant public health problem and the extent to which adolescents exhibit SUM behaviors differs across ethnicity. This study aimed to explore the ethnicity-specific and gender-specific associations among sports factors, familial factors, and personal satisfaction with physical appearance (i.e., covariates) and SUM in a sample of adolescents from Federation of Bosnia and Herzegovina. In this cross-sectional study the participants were 1742 adolescents (17–18 years of age) from Bosnia and Herzegovina who were in their last year of high school education (high school seniors). The sample comprised 772 Croatian (558 females) and 970 Bosniak (485 females) adolescents. Variables were collected using a previously developed and validated questionnaire that included questions on SUM (alcohol drinking, cigarette smoking, and consumption of other drugs), sport factors, parental education, socioeconomic status, and satisfaction with physical appearance and body weight. The consumption of cigarettes remains high (37% of adolescents smoke cigarettes), with a higher prevalence among Croatians. Harmful drinking is also alarming (evidenced in 28.4% of adolescents). The consumption of illicit drugs remains low with 5.7% of adolescents who consume drugs, with a higher prevalence among Bosniaks. A higher likelihood of engaging in SUM is found among children who quit sports (for smoking and drinking), boys who perceive themselves to be good looking (for smoking), and girls who are not satisfied with their body weight (for smoking). Higher maternal education is systematically found to be associated with greater SUM in Bosniak girls. Information on the associations presented herein could be discretely disseminated as a part of regular school administrative functions. The results warrant future prospective studies that more precisely identify the causality among certain variables.

The problematic use of Information and Communication Technologies (ICT) in adolescents by the cross sectional JOITIC study

BackgroundThe emerging field of Information and Communications Technology (ICT) has brought about new interaction styles. Its excessive use may lead to addictive behaviours.The objective is to determine the prevalence of the problematic use of ICT such as Internet, mobile phones and video games, among adolescents enrolled in mandatory Secondary Education (ESO in Spanish) and to examine associated factors.MethodsCross sectional, multi-centric descriptive study. Population: 5538 students enrolled in years one to four of ESO at 28 schools in the Vallès Occidental region (Barcelona, Spain). Data collection: self-administered socio-demographic and ICT access questionnaire, and validated questionnaires on experiences related to the use of the Internet, mobile phones and video games (CERI, CERM, CERV).ResultsQuestionnaires were collected from 5,538 adolescents between the ages of 12 and 20 (77.3 % of the total response), 48.6 % were females. Problematic use of the Internet was observed in 13.6 % of the surveyed individuals; problematic use of mobile phones in 2.4 % and problematic use in video games in 6.2 %.Problematic Internet use was associated with female students, tobacco consumption, a background of binge drinking, the use of cannabis or other drugs, poor academic performance, poor family relationships and an intensive use of the computer.Factors associated with the problematic use of mobile phones were the consumption of other drugs and an intensive use of these devices.Frequent problems with video game use have been associated with male students, the consumption of other drugs, poor academic performance, poor family relationships and an intensive use of these games.ConclusionsThis study offers information on the prevalence of addictive behaviours of the Internet, mobile phones and video game use.The problematic use of these ICT devices has been related to the consumption of drugs, poor academic performance and poor family relationships.This intensive use may constitute a risk marker for ICT addiction.

Misuse of Substitution Drugs in the Substitution-Based Therapy

Background: The reasons for, and the extent of, misuse of prescribed substitution medication as well as parallel consumption of other drugs during substitution-based therapy have still not been adequately researched in Germany. Methods: This study examines the use of substitution medication in German substitution clinics utilizing a nationwide survey with anonymised questionnaires. Results: The analysis of the 605 questionnaires showed a 30-day consumption prevalence of 8.8% with regard to misuse of substitution substances. The lack of available heroin (38%) and the lack of open spots in treatment programs (21%) were quoted as being the main reasons for the misuse of substitution medication. Conclusion: Although the misuse of substitution medications is considered an important problem, our study showed that the current misuse was prevalent only among a minority of the patients. German regulations focused on the avoidance of misuse might be partially contributing to the problem.

Personality profile of binge drinking in university students is modulated by sex. A study using the Alternative Five Factor Model

BackgroundThe prevalence of binge drinking (BD), found especially among young people, is increasing worldwide and has become an important social and health concern. We studied, for the first time, the personality profile, using the Alternative Five Factor Model, among university students with BD and healthy controls, taking into account the possible influence of sex. Methods70 participants with BD (30 men) and 70 healthy controls (30 men) were included, selected to control for characteristics that are known to be related to BD (physical and mental disorders, consumption of other drugs, circadian rhythms), completed the Zuckerman-Kuhlman Personality Questionnaire (ZKPQ). ResultsThe scores on Neuroticism-Anxiety and Impulsive Sensation-Seeking were higher in the BD group compared to the controls (p<0.001 in both cases). The higher scores in the BD group in Neuroticism-Anxiety are due to higher scores in the women’s group (p=0.014), while those in Impulsive Sensation-Seeking are due to higher scores in the men’s group (p=0.009), both in the Impulsivity and in the Sensation-Seeking subscales (p<0.045). ConclusionsSex could be a factor that modulates the endophenotype of drug dependence (impulsive and anxious personality) and the prevention and/or treatment programs for BD should include not only the management of the personality risk factors but also different tailored approaches according to sex.