Introduction: Open sexual communication in the relationship is one of the main components of close partnership, as well as a key factor in maintaining sexual health, sexual satisfaction, but also a key element in achieving sexual goals and meeting the needs. The purpose of this paper is to review researches that determine psychosocial factors related to sexual communication. Materials and methods: A systematic review was conducted using GoogleScholar, PsycArticles, Academic Research Source eJournals, Healthsource – Consumer Edition and Medline. 22 quantitative and qualitative studies meeting the inclusion criteria were included. Results: Sexual communication was associated with: attachment, self-esteem, personality factors, awareness of risk and one’s sexuality, social anxiety, self-efficacy, self-acceptance, perceived threats to oneself, partner or relationship, assertiveness in sexual behavior, experience of use in childhood, stereotypes, cultural norms, parental communication about sexual topics, courage, a sense of comfort or broadly understood communication skills. Conclusions: The systematic review indicates the contribution of intra- and interpersonal factors, as well as communication competences in sexual communication. The importance of communication at various levels was emphasized: partnership, parental, communication with professionals. The results were discussed in an individual and relational perspective.