Construction Of System Research Articles

Construction of a novel mitochondrial oxidative stress-related genes prognostic system and molecular subtype characterization for breast cancer

PurposeBreast cancer (BRCA) is the most common malignant tumor among women, characterized by high incidence rates and mortality rates. Oxidative stress and immunity, particularly in relation to mitochondria, have emerged as pivotal factors in breast carcinogenesis. Nonetheless, limited research has explored the specific contribution of mitochondrial oxidative stress to the prognosis of BRCA.MethodIn this study, we conducted univariate and multivariate Cox regression analyses to pinpoint independent prognostic genes associated with mitochondrial oxidative stress (MOSRGs) and their correlation with BRCA clinical outcomes. Subsequently, we developed a robust and accurate MOS scoring system for BRCA patients based on these identified independent prognostic MOSRGs.ResultOur findings were further substantiated by immune infiltration and somatic mutation analyses, providing additional evidence that the MOS scoring system holds predictive value for clinical outcomes in patients and correlates directly with three subtypes of BRCA. In vitro experiments in the MCF7 cell and breast tissue further verified the mRNA and protein expression level of independent prognostic genes, validating the consistency of the MOS prognostic signatures in BRCA.ConclusionThis research has unveiled a novel prognostic scoring system, providing valuable insights for improving patient prognosis assessment and developing individualized treatment strategies in BRCA patients.

Analysis of the Economic Growth Effect of the National Free Trade Port Zones

In the dynamic landscape of globalization, the pivotal role of free trade zones in catalyzing openness and international trade has gained unprecedented prominence, drawing keen governmental interest worldwide. As China deepens its commitment to reform and openness, it ambitiously outlined plans for the establishment of national pilot free trade zones and free trade ports in 2018. The grand vision was to set a gold standard for openness in the new era and bolster international competitiveness. A thorough review and analysis of existing literature on national free trade ports reveal compelling insights. Evidence strongly suggests that the construction of these ports has not only significantly propelled economic growth but also triggered a ripple effect across various sectors. Mechanistic dissection elucidates that this growth can be attributed to heightened foreign investment attraction and accelerated technological innovation. This paper contributes robust empirical evidence to the discourse on refining and advancing the construction of the free trade system, thereby offering valuable guidance for policymakers and practitioners alike.

Construction of middle-phase microemulsion system and its micro-mechanism on displacing residual oil in low-permeability porous media

Construction of middle-phase microemulsion system and its micro-mechanism on displacing residual oil in low-permeability porous media

Construction and Application of an Evaluation System for Ocean Carbon Sink Trading

Construction and Application of an Evaluation System for Ocean Carbon Sink Trading

Xi'an Real Estate Financial Risk Early Warning System Construction

Xi'an Real Estate Financial Risk Early Warning System Construction

Enhancing the Encapsulation Performances of Liposomes for Amphiphilic Copolymers by Computer Simulations.

Liposomes, which encapsulate drugs into an inner aqueous core and demonstrate high drug-loading capacity, have attracted considerable interest in the field of drug delivery. Herein, the encapsulation processes for amphiphilic copolymers within liposomes have been investigated systematically to enhance the encapsulation capacity and optimize the structures using dissipative particle dynamics simulations. The results indicate that the physicochemical properties of lipids, receptors, and amphiphilic copolymers collectively determine the encapsulation behaviors of liposomes. Adjusting the hydrophobic interaction between hydrophobic tails of lipids (receptors) and hydrophobic blocks of copolymers, along with modulating the specific interaction between ligands and the functional head groups of receptors, can lead to various encapsulation capacities. Significantly, a medium hydrophobic interaction strength or a strong specific interaction is conducive to achieving a higher degree of encapsulation for amphiphilic copolymers. Furthermore, varying the key parameters, such as the hydrophobic interaction, the specific interaction, as well as the concentrations of lipids and receptors, can induce seven typical aggregate structures: heterogeneous, fully encapsulated, partially encapsulated, saturated-encapsulated, unsaturated-encapsulated, multilamellar, and column-like structures. The final phase diagrams are also constructed to provide a guideline for designing various structures of liposomes encapsulated with amphiphilic copolymers. These results significantly contribute to the illumination of strategies for the rational construction of the self-assembly system that facilitates the efficient encapsulation of amphiphilic copolymers within the inner aqueous core of liposomes, thereby providing valuable insights into the optimal design of liposome carriers for future biomedical applications.

Research on the Construction of Translation Technology Teaching and Language Service Talent Training System under the New Liberal Arts Context

The rise of technologies like machine-assisted translation and terminology management is transforming translation education and industry. The 2020 Teaching Guide for Undergraduate Translation Major formalized translation technology as a core course, supporting professionalization. However, research on translation technology teaching in China remains limited and often lacks practical application. Ethical issues, such as AI-related privacy and intellectual property concerns, are also growing. This study proposes a framework to enhance translation technology education, aiming to better align teaching with industry needs and cultivate skilled professionals.

Construction of Innovation System of College Physical Education Teaching Mode Facing Sunshine Physical Education

The goal of innovating sunshine physical education teaching mode is to promote the reform of traditional physical education teaching, ensure the all-round development of students physical and mental health, promote the improvement of students comprehensive quality, and create a good campus health culture. Therefore, for colleges and universities, we should pay attention to the reform and innovation of physical education teaching mode, enhance students physical and psychological quality, enhance their sense of collective honor and teamwork, and promote the further spread of campus sports culture. This paper analyzes the way of constructing physical education teaching system in colleges and universities under the background of sunshine sports, aiming at promoting students all-round development and improving their comprehensive quality.

Experiences and needs of older patients with stroke in China involved in rehabilitation decision-making: a qualitative study

BackgroundShared decision-making is recommended for stroke rehabilitation. However, the complexity of the rehabilitation modalities exposes patients to decision-making conflicts, exacerbates their disabilities, and diminishes their quality of life. This study aimed to explore the experiences and needs of older patients with stroke in China during rehabilitation decision-making, providing a reference for developing decision-support strategies.MethodsA qualitative phenomenological design was used to explore the experiences and needs of older patients with stroke in China. Purposive sampling was used to recruit 31 older Chinese patients with stroke. The participants participated in face-to-face, semi-structured, and in-depth interviews. Data were analyzed using inductive thematic analysis.ResultsThe key themes identified include (1) mixed feelings in shared decision-making, (2) multiple barriers hinder the possibility of participating in shared decision-making, (3) Delegating rehabilitation decisions to surrogates, (4) gaps between reality and expectation, and (5) decision fatigue from lack of continuity in the rehabilitation health care system.ConclusionsOlder patients with stroke in China have complex rehabilitation decision-making experiences and needs and face multiple obstacles when participating in shared decision-making. They lack an effective shared decision-making support system to assist them. Providing patients with comprehensive support (such as emotional and informational), strengthening the construction of a continuous rehabilitation system, alleviating economic pressure, and promoting patient participation in rehabilitation decision-making are necessary.

Kazakh nomads, social class transformations and Soviet power during the period of collectivization

ABSTRACT This research is devoted to the history of the political adaptation of tribal structures to the conditions of social class interactions in the Kazakh aul in the 1920s. Newly uncovered archival materials show how patrimonial and hierarchical institutions tried to adapt and adjust themselves to the system of socialist construction in the Kazakh steppe. The authors have identified three directions that most clearly demonstrated the behavioural motives and adaptation practices of Kazakh tribal cattle-breeding society: the formation of the Soviet apparatus of power in Kazakhstan; the participation of the tribal elite in elections to enter the Soviet institutions of power; and confiscation as a policy of struggle against ancestry and descent groups.

Exploration of Innovative Path of College Physical Education Teaching Based on Five Education Simultaneously

Five education simultaneously has become an important concept of educational reform in the new era. As an important part of higher education, college physical education plays a unique and important role in training the socialist builders and successors with all-round development of morality, intelligence, physical fitness, the United States and labor. From the perspective of five education simultaneously , this paper explores the innovative development path of college physical education teaching. The first is bacon casting soul, excavating sports moral education resources, cultivating patriotic feelings, enterprising spirit; The second is intelligent drive, promote sports informatization, and create a new ecology of smart teaching; The third is to shape aesthetic education, cultivate sports artistic temperament, and enhance aesthetic accomplishment; Fourth, labor education, sports labor into the whole teaching process, temper the quality of will; The fifth is to promote the integration of five education and achieve cross-penetration and coordination between sports and other disciplines. In the future, college sports should continue to deepen reform and innovation, strengthen the construction of systems, resources, scientific research, teachers and other aspects, and constantly improve the quality of physical education and education level, so as to contribute to accelerating the modernization of education, building a powerful education country, and realizing the great rejuvenation of the Chinese nation

A Study on the Practical Pathways of Aesthetic Education in Colleges and Universities from the Perspective of Aesthetic Education Infiltration

In recent years, practical approaches to aesthetic education have been continuously explored by various colleges and universities. The goal and pathway of infiltration have gradually integrated aesthetic education into all aspects of teaching activities. In this study, the practical exploration of college aesthetic education infiltration actions is taken as its starting point. By combining the actual situation of colleges, the concept of aesthetic education work is clarified, and detailed elaboration on advancing aesthetic education practices is conducted from three aspects: the improvement of the curriculum system construction, the deepening of the innovative practices of aesthetic education, and the expansion of the spaces for aesthetic education infiltration. Practical pathways for aesthetic education have also been proposed. Guided by theory, this research is significant for guiding the practical work of aesthetic education infiltration in colleges and universities in the new era.

College Students Career Planning Education System Construction Strategy

Career planning is an important foundation for college students to achieve high-quality employment. Entering the new era, college students are facing a brand new employment environment. To adapt to the changes in employment, colleges and universities should update the career planning education system promptly, enhance students’ employment competitiveness, and help students achieve high-quality employment. Based on this, this paper studies the construction strategies of the career planning education system in colleges and universities. The paper first analyzes the value of the construction of the career planning education system, and then expounds the main problems at present. On this basis, the paper puts forward specific strategies to help college students plan their careers scientifically and promote their good development.

Water Sensitive Urban Design Construction Systems Performance Due to Water Retention

Objectives: The main goal of this research is to analyze and quantify reduction of surface temperatures (Ts) in systems which retain and especially harvest water with the focus on blue roofs and to check if just infiltrating water is enough to reduce surface temperatures. Theoretical Framework: ODS13, Climate action; ODS11 Sustainable Cities and communities; Water Sensitive Urban Design construction systems thermal behavior and Cooling water effect implemented by Governments and Municipalities. Method: it’s experimental, based on the quantification of different WSUD construction systems which infiltrate, retain and harvest water during a first year and focused on a blue roof prototype during a second year. Tools used are a thermal camera, a hygrometer and an anemometer. Results and Discussion: Surface temperatures gradients were from 5.3ºC at the infiltration basin, to 6ºC in the blue roof prototype to 14.6ºC in the built blue roof. Construction systems which could retain and harvest water had a Ts underneath the environmental one. They also retain less heat during the night contributing less to UHI than those which can’t retain water. Research implications: this research provides the information about water powerful effect in construction systems which infiltrate and harvest water. They contribute to the decrease of UHI. Originality/value: results demonstrate water cooling effect in infiltrating surfaces which can retain it. Results offer one more construction systems choice criteria in urban design.

Cloud Network Collaborative SFC Deployment Under Heterogeneous Resource Of Power White Box Network

The construction of new electric power systems has led to a multiplication in the number of access nodes for electric power IoT information communication, accompanied by a deepening trend in business cloudification. However, due to the insufficient resource linkage and regulation capabilities of the electric power communication network on the cloud side, network side, and edge side, coupled with the lack of a convenient and unified cloud-network resource convergence and control mechanism, the existing electric power communication architecture is gradually finding it difficult to fully meet the demand for deterministic multi-service bearer. Therefore, it is necessary to evolve the original network equipment within the network toward a white box model, opening up interfaces for fine-grained sensing and full-area control, in order to provide more accurate and controllable network transmission services. In this paper, we first propose a cloud-network cooperative resource scheduling architecture for the electric power white box network. This architecture establishes a bearer network to achieve high consistency and cooperativeness of cloud-side end computing power through white box switches, uniformly schedules the global resources of the cloud-network convergence network, and improves the network service quality between cloud-side and side-side. Furthermore, we design a multi-dimensional re-source scheduling method for cloud-network synergy in the electric power white box network. This involves constructing a white box network virtualized heterogeneous resource (VHR) model and a heterogeneous resource control flow (HRCF) model. We transform the problem of merged deployment of service function chains (SFCs) into an SFC merger deployment problem by jointly controlling heterogeneous information, communication, storage, and arithmetic resources, along with the white box switch-specific pipelining resources in the white box network. We then carry out merger optimization of the same kind of function chains. Additionally, we propose a G-GS algorithm based on heuristic methods. Simulation results demonstrate that the method presented in this paper can significantly reduce the cost consumption of white box pipeline resources in the electric power white box network, thereby reducing the processing delay of SFC and improving the quality of electric power service bearing.

Construction of Sensory Evaluation System of Purple Sweet Potato Rice Steamed Sponge Cake Based on Fuzzy Mathematics

This paper presents the establishment of a sensory evaluation system for purple sweet potato rice steamed sponge cake (PSPRSSC) utilizing fuzzy mathematics. Initially, eight key sensory evaluation indices were identified through expert consultations. These indices were subsequently prioritized using fuzzy binary comparison, resulting in the following order: aroma, taste, crust color, elasticity, viscosity, chewiness, hardness, and brightness. The corresponding weight values assigned to each index were 23%, 18%, 16%, 13%, 12%, 8%, 6%, and 4%, respectively. Notably, aroma was found to have a more significant impact than visual attributes in the sensory evaluation of PSPRSSC. Based on this prioritization, comprehensive sensory evaluation criteria for PSPRSSC were formulated. Verification tests confirmed the efficacy of the proposed evaluation system. This study provides critical data and theoretical support for the sensory quality assessment of PSPRSSC, thereby facilitating its industrialization and enhancing its market viability.

Resource Efficiency and the Role of Renewable Energy in Miskolc: The City’s Journey Towards Becoming a Smart City

Miskolc, which is the focus of our investigation, is the fourth most populous city in Hungary and the center of one of the most underdeveloped NUTS2 (basic territorial category for the regional policy of the European Union) regions in the European Union. The socialist heavy industry played a decisive role in the development of the city, the decline of which also left deep traces in the city. In its current position, the city tries to manage its available resources as efficiently as possible, and the city management is open to the use of modern urban development tools. This is supported by the fact that Miskolc was the first Hungarian city to join the Green Cities for Sustainable Europe movement in 2011, and then in 2015, it joined the Triangulum project of the EU Smart Cities and Communities program as a follower city. In the process of becoming a smart city, the dimensions of environmental sustainability and energy efficiency were given a prominent role, which should not be surprising considering the traditions of the city. Within this, we must first mention the construction of the geothermal central heating system, with which the city really took significant steps in this field. The main goal of the study is to develop a new smart local concept closely linked to regional development and the key energy sector, through which the local adaptation of the defining elements of the internationally defined smart city in several forms for the city of Miskolc will be presented. In our study, we review how the results achieved by Miskolc so far and the development plans for the future fit in with the smart energy developments of smart cities. Before exploring the processes in Miskolc, we will deal in more detail with the possibilities inherent in district heating and geothermal energy utilization and Hungary’s capabilities.

Isobaric compressed air energy storage system: Water compensating cycle or CO2 compensating cycle?

Isobaric operation of air storage can remove the throttling losses existing in isochoric reservoir, making full use of the storage volume and lowering system construction cost. The water cycle and CO2 cycle are two of the most commonly configurations to stabilize the pressure in the air storage unit. The choice between the two cycles depends on whether the technical complexity and costs are justified by performance gains. This paper mainly focuses on developing the MAP design, a kindly selection diagram plotting the better value of performance indicators between the two systems, to determine the more favorable compensating cycle in the constant storage operation of the compressed air. The analysis results indicate that higher air storage pressure increases the system efficiency. The levelized cost of storage is provided with a valley value when the air storage pressure is at 6.6 MPa for the CO2 cycle and 14 MPa for the water cycle. The optimized systems can share a comparative efficiency of 68.04 % and 68.07 %, and the levelized cost of storage is 0.8237 ¥/kWh for the CO2 cycle and 0.7869 ¥/kWh for the water cycle. The water is suggested to be the compensating fluid for the isobaric system when the water machine efficiency is higher than 0.85 or else opting for CO2 proves to be a more economically viable choice.

Construction and Empirical Research of an Evaluation System for High-Quality Development of Small Towns in Guangxi Under the New Development Concept

The high-quality development of small towns in Guangxi is crucial for regional economic balance and sustainable development. This research conducts an in-depth exploration and systematic construction and validation analysis of the high-quality development of small towns in Guangxi. Guided by the new development concepts of innovation, coordination, green, openness, and sharing, a comprehensive evaluation system is established to assess the development levels of 70 small towns from 2005 to 2022. The research findings are as follows: 1. The analysis revealed significant growth in these dimensions over the study period, highlighting the unique characteristics of different types of small towns. 2. It was observed that small towns in southeastern Guangxi generally demonstrated higher development levels, while those in the northwestern regions exhibited considerable disparities, indicating regional imbalances. 3. The overall gap in the high-quality development level of small towns is gradually narrowing, but the difference is still relatively significant. 4. The findings underscore the advantages of the evaluation system developed, which effectively captures the multidimensional nature of high-quality development and serves as a robust framework for future research.

Design and Construction of Experimental System for Validation of a New Image Reconstruction Technique with Limited-view-angle Projection Data for BNCT-SPECT

Abstract. Boron Neutron Capture Therapy (BNCT) is expected to be a promising radiation therapy for cancer, and research on various issues associated with it is still in progress. One of the unsolved issues is the construction of a system for observing the effect of the treatment (local boron dose) in real time under high-background circumstances. Thus, we set out to establish a method for measuring gamma-rays emitted promptly from the body following the boron neutron capture reaction and reconstructing images in a SPECT-like manner. We call this method BNCT-SPECT. We have been developing a new image reconstruction method based on Bayesian estimation for the BNCT-SPECT method. In the present study, the aims were to design and construct an experimental system capable of validating BNCT-SPECT and its image reconstruction method and to confirm BNCT-SPECTs performance. The crucial takeaway from this study is that we should consider the use of extremely high background radiation during BNCT. For the validation of BNCT-SPECT, we attempted to reproduce these conditions, despite this being quite challenging. We first constructed an experimental system capable of reproducing such conditions. Theoretical investigation was carried out to facilitate the design of the system using the Monte Carlo transport calculation code MCNP. Finally, we performed experiments with some standard gamma-ray sources to complete the system.