Typhoons are frequent in coastal cities, and the vulnerability of road and bridge construction sites is high, but existing studies have not focused on the safety management of road and bridge construction sites under typhoon disasters. Traditional manual safety inspections suffer from problems such as low efficiency, high subjectivity, and incomplete coverage. Therefore, this study aims to develop an intelligent safety management system for road and bridge construction sites during the typhoon warning period, in order to achieve rapid and automated typhoon prevention and control. In this study, the automatic identification algorithm of potential safety hazards was developed based on the MATLAB platform, and then the system design of the MATLAB GUI was carried out, which ultimately forms the automatic safety hazard inspection and measure enquiry system during the typhoon warning period for road and bridge construction sites (RBS-TY). The system can realize the detection of vertical deformation, safety distance and safety height by using the point cloud data of the object to be measured. According to the identified safety hazards, it will automatically retrieve the database of typhoon safety measures in the road and bridge construction site and provide the countermeasures in the GUI interface. Experimentally verified results show that this system can assist safety management personnel to quickly guide typhoon prevention and control work during the 24-h typhoon warning period, improve the efficiency of safety management, and help to promote the development of intelligent typhoon emergency response technology at road and bridge construction sites.