ABSTRACT This paper aimed at determining the barriers preventing the extensive utilization of innovative materials in the construction sector. As a way of providing clear understanding of the complex interrelationship between the barriers, the literature review was supplemented by an expert-based survey to determine the barriers, whereas the hierarchical structure between the barriers was analyzed using the interpretive structural modelling (ISM) approach. Based on the outcome of the level partitioning of the ISM approach, it was found out that “reluctance to take responsibility for embodied carbon reduction (B14) was partitioned at the 8th level indicating that it is the most highly prioritized barrier considered to be the most crucial in preventing the use of low-carbon building materials in the construction industry. The paper produces vital knowledge and evidence that could be applied to encourage more sustainable construction practices by the wide adoption of alternative construction materials with lower embodied carbon in the construction sector. The implications inferred based on the findings of this paper seek to suggest remedies, strategies, and actions that could help to overcome the undesirable impact of the barriers that affect the utilization of low-carbon building materials, particularly amongst prominent stakeholders of construction projects.