Construction Of Heterocyclic Scaffolds Research Articles

Recent Advances in Iodosobenzene‐Mediated Construction of Heterocyclic Scaffolds: Transition‐Metal‐Free Approaches and Scope

Iodosobenzene (PhIO) is a well‐known hypervalent iodine reagent for its Lewis acidic oxidizing capability. In recent times it has been repeatedly proven to be a powerful tool for the development of toxic, costly transition‐metal‐free advanced and impressive methodologies to construct diverse array of different heterocycles. In this review some selected viable and innovative strategies from 2007 to 2016 have been contemplated. Sometimes mechanistic proposals were also taken as prime consideration since synthetic organic chemists are providing fresh stimuli to reinforce the theoretical predictions to grasp the unique nature of PhIO in dissimilar conditions. Convenient and environmentally friendly cyclization and cycloaddition protocols were delineated adequately to integrate the practical findings and mechanistic points of view.

ChemInform Abstract: Transition‐Metal‐Catalyzed Hydrogen‐Transfer Annulations: Access to Heterocyclic Scaffolds

AbstractReview: [47 refs.

Transition-metal-catalyzed hydrogen-transfer annulations: access to heterocyclic scaffolds.

The ability of hydrogen-transfer transition-metal catalysts, which enable increasingly rapid access to important structural scaffolds from simple starting materials, has led to a plethora of research efforts on the construction of heterocyclic scaffolds. Transition-metal-catalyzed hydrogen-transfer annulations are environmentally benign and highly atom-economical as they release of water and hydrogen as by-product and utilize renewable feedstock alcohols as starting materials. Recent advances in this field with respect to the annulations of alcohols with various nucleophilic partners, thus leading to the formation of heterocyclic scaffolds, are highlighted herein.

ChemInform Abstract: Construction of Heterocyclic Scaffolds via Transition Metal‐Catalyzed sp3 C—H Functionalization

AbstractReview: 52 refs.