Constant Alpha Research Articles

Follicular Fluid Proteomic Analysis to Identify Predictive Markers of Normal Embryonic Development.

Ageing populations, mass "baby-free" policies and children born to mothers at the age at which they are biologically expected to become grandmothers are growing problems in most developed societies. Therefore, any opportunity to improve the quality of infertility treatments seems important for the survival of societies. The possibility of indirectly studying the quality of developing oocytes by examining their follicular fluids (hFFs) offers new opportunities for progress in our understanding the processes of final oocyte maturation and, consequently, for predicting the quality of the resulting embryos and personalising their culture. Using mass spectrometry, we studied follicular fluids collected individually during in vitro fertilisation and compared their composition with the quality of the resulting embryos. We analysed 110 follicular fluids from 50 oocyte donors, from which we obtained 44 high-quality, 39 medium-quality, and 27 low-quality embryos. We identified 2182 proteins by Sequential Window Acquisition of all Theoretical Mass Spectra (SWATH-MS) using a TripleTOF 5600+ hybrid mass spectrometer, of which 484 were suitable for quantification. We were able to identify several proteins whose concentrations varied between the follicular fluids of different oocytes from the same patient and between patients. Among them, the most important appear to be immunoglobulin heavy constant alpha 1 (IgA1hc) and dickkopf-related protein 3. The first one is found at higher concentrations in hFFs from which oocytes develop into poor-quality embryos, the other one exhibits the opposite pattern. None of these have, so far, had any specific links to fertility disorders. In light of these findings, these proteins should be considered a primary target for research aimed at developing a diagnostic tool for oocyte quality control and pre-fertilisation screening. This is particularly important in cases where the fertilisation of each egg is not an option for ethical or other reasons, or in countries where it is prohibited by law.

The electromagnetic fine-structure constant in primordial nucleosynthesis revisited

We study the dependence of the primordial nuclear abundances as a function of the electromagnetic fine-structure constant alpha , keeping all other fundamental constants fixed. We update the leading nuclear reaction rates, in particular the electromagnetic contribution to the neutron-proton mass difference pertinent to beta -decays, and go beyond certain approximations made in the literature. In particular, we include the temperature-dependence of the leading nuclear reactions rates and assess the systematic uncertainties by using four different publicly available codes for Big Bang nucleosynthesis. Disregarding the unsolved so-called lithium-problem, we find that the current values for the observationally based {}^{2}text {H} and {}^{4}text {He} abundances restrict the fractional change in the fine-structure constant to less than 2% , which is a tighter bound than found in earlier works on the subject.

The Online Broadcast Range-Assignment Problem

Let P={p_0,ldots ,p_{n-1}} be a set of points in {mathbb R}^d, modeling devices in a wireless network. A range assignment assigns a range r(p_i) to each point p_iin P, thus inducing a directed communication graph mathcal {G}_r in which there is a directed edge (p_i,p_j) iff {{,textrm{dist},}}(p_i, p_j) leqslant r(p_i), where {{,textrm{dist},}}(p_i,p_j) denotes the distance between p_i and p_j. The range-assignment problem is to assign the transmission ranges such that mathcal {G}_r has a certain desirable property, while minimizing the cost of the assignment; here the cost is given by sum _{p_iin P} r(p_i)^{alpha }, for some constant alpha >1 called the distance-power gradient. We introduce the online version of the range-assignment problem, where the points p_j arrive one by one, and the range assignment has to be updated at each arrival. Following the standard in online algorithms, resources given out cannot be taken away—in our case this means that the transmission ranges will never decrease. The property we want to maintain is that mathcal {G}_r has a broadcast tree rooted at the first point p_0. Our results include the following.We prove that already in {mathbb R}^1, a 1-competitive algorithm does not exist. In particular, for distance-power gradient alpha =2 any online algorithm has competitive ratio at least 1.57.For points in {mathbb R}^1 and {mathbb R}^2, we analyze two natural strategies for updating the range assignment upon the arrival of a new point p_j. The strategies do not change the assignment if p_j is already within range of an existing point, otherwise they increase the range of a single point, as follows: Nearest-Neighbor (nn) increases the range of {{,textrm{nn},}}(p_j), the nearest neighbor of p_j, to {{,textrm{dist},}}(p_j, {{,textrm{nn},}}(p_j)), and Cheapest Increase (ci) increases the range of the point p_i for which the resulting cost increase to be able to reach the new point p_j is minimal. We give lower and upper bounds on the competitive ratio of these strategies as a function of the distance-power gradient alpha . We also analyze the following variant of nn in {mathbb R}^2 for alpha =2: 2-Nearest-Neighbor (2-nn) increases the range of {{,textrm{nn},}}(p_j) to 2cdot {{,textrm{dist},}}(p_j,{{,textrm{nn},}}(p_j)),We generalize the problem to points in arbitrary metric spaces, where we present an O(log n)-competitive algorithm.

Can a variation of fine structure constant influence the fate of gravitational collapse?

We show that it is possible to steer clear of a spacetime singularity during gravitational collapse by considering time-variation of a fundamental coupling, in this case, the fine structure constant alpha . We study a spherical distribution of cold dark matter coexisting with other fluid elements, collapsing under its own gravity. The dark matter is written as a scalar field interacting with electrically charged matter. This leads to a time variation of alpha and as a consequence, a breakdown of local charge conservation within the sphere. The exterior has no such field and therefore, Einstein’s GR and standard equivalence principles remain valid. We derive the lowest possible bound on the collapse of this sphere beyond which there is a bounce and dispersal of most of the accumulated matter. We discuss the critical behavior of the system around this point and show that the bound is connected to a length scale of the order of Planck, introduced in the theory for dimensional requirements.

Normalized solutions for the discrete Schrödinger equations

In the present paper, we consider the existence of solutions with a prescribed l^{2}-norm for the following discrete Schrödinger equations, {−Δ2uk−1−f(uk)=λukk∈Z,∑k∈Z|uk|2=α2,\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ \ extstyle\\begin{cases} -\\Delta ^{2} u_{k-1}-f(u_{k})= \\lambda u_{k} \\quad k\\in \\mathbb{Z}, \\\\ \\sum_{k\\in \\mathbb{Z}} \\vert u_{k} \\vert ^{2}=\\alpha ^{2}, \\end{cases} $$\\end{document} where Delta ^{2} u_{k-1}=u_{k+1}+u_{k-1}-2u_{k}, fin C(mathbb{R}) , α is a fixed constant, and lambda in mathbb{R} arises as a Lagrange multiplier. To get the solutions, we investigate the corresponding minimizing problem with the l^{2}-norm constraint: Eα=inf{12∑|Δuk−1|2−∑F(uk):∑|uk|2=α2}.\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ E_{\\alpha}=\\inf \\biggl\\{ \\frac{1}{2}\\sum \\vert \\Delta u_{k-1} \\vert ^{2}-\\sum F(u_{k}): \\sum \\vert u_{k} \\vert ^{2}=\\alpha ^{2} \\biggr\\} . $$\\end{document} An elaborative analysis on a minimizing sequence with respect to E_{alpha} is obtained. We prove that there is a constant alpha _{0}geq 0 such that there exists a global minimizer if alpha >alpha _{0}, and there exists no global minimizer if alpha <alpha _{0}. It seems that it is the first time to consider the solution with a prescribed l^{2}-norm of the discrete Schrödinger equations.

Exclusive dilepton production in photon-induced interactions at RHIC

The exclusive dilepton photoproduction in pp and pAu collisions at RHIC is investigated considering the contribution of the Bethe–Heitler (BH) and the timelike Compton scattering (TCS) processes. The TCS amplitude is estimated at next-to-leading-order of the strong running coupling constant alpha _s and assuming the Goloskokov–Kroll model for the quark and gluon generalized parton distributions. The TCS differential cross section is estimated as well the contribution associated to the interference between the TCS and BH amplitudes. Predictions for the TCS, BH and interference contributions are presented considering the kinematical range covered by the RHIC detectors.

Identification of serum biomarkers for necrotizing enterocolitis using aptamer-based proteomics.

Necrotizing enterocolitis (NEC) is a potentially fatal intestinal disease primarily affecting preterm infants. Early diagnosis of neonates with NEC is crucial to improving outcomes; however, traditional diagnostic tools remain inadequate. Biomarkers represent an opportunity to improve the speed and accuracy of diagnosis, but they are not routinely used in clinical practice. In this study, we utilized an aptamer-based proteomic discovery assay to identify new serum biomarkers of NEC. We compared levels of serum proteins in neonates with and without NEC and identified ten differentially expressed serum proteins between these groups. We detected two proteins, C-C motif chemokine ligand 16 (CCL16) and immunoglobulin heavy constant alpha 1 and 2 heterodimer (IGHA1 IGHA2), that were significantly increased during NEC and eight that were significantly decreased. Generation of receiver operating characteristic (ROC) curves revealed that alpha-fetoprotein (AUC = 0.926), glucagon (AUC = 0.860), and IGHA1 IGHA2 (AUC = 0.826) were the proteins that best differentiated patients with and without NEC. These findings indicate that further investigation into these serum proteins as a biomarker for NEC is warranted. In the future, laboratory tests incorporating these differentially expressed proteins may improve the ability of clinicians to diagnose infants with NEC rapidly and accurately.

Analysis of IGHA1 and other salivary proteins post half marathon in female participants.

High-intensity exercise (HIE), such as that in marathons and triathlons, suppresses transient local and systemic immunity. Serum and salivary immunoglobulin heavy constant alpha 1 (IGHA1) are major markers of immunosuppression by HIE. Although much is known about the systemic immunosuppressive response, little is known about its local response in the oral cavity, lungs, bronchial tubes, and skin. The oral cavity allows bacteria or viruses to enter the body. Saliva covers the epidermis of the oral cavity and plays an important role in the local stress response by preventing infection. In this study, we examined the properties of saliva secreted during the local stress response for half-marathon (HM) induced IGHA1 protein expression using quantitative proteomics. The Exercise Group (ExG) (19 healthy female university students) participated in a HM race. The Non-Exercise Group (NExG) (16 healthy female university students) did not participate in the ExG. The ExG saliva samples were collected 1 h pre and 2 h and 4 h post-HM. The NExG saliva samples were collected at the same time intervals. The saliva volume, protein concentration, and relative IGHA1 expression were analyzed. In addition, 1 h pre and 2 h post- HM saliva samples were analyzed by iTRAQ. The identified factors in iTRAQ were analyzed for the ExG and the NExG using western blotting. We identified kallikrein 1 (KLK1), immunoglobulin kappa chain (IgK), and cystatin S (CST4) as suppression factors, as well as IGHA1, which has been reported to be an immunological stress marker. IGHA1 (p = 0.003), KLK1 (p = 0.011), IGK (p = 0.002), and CST4 (p = 0.003) were suppressed 2 h post-HM compared with their levels pre HM, and IGHA1 (p < 0.001), KLK1 (p = 0.004), and CST4 (p = 0.006) were suppressed 4 h post-HM. There was also a positive correlation between IGHA1, IGK, and CST4 levels at 2 and 4 h post-HM. In addition, KLK1 and IGK levels at 2 h post-HM were positively correlated. Our study demonstrated that the salivary proteome is regulated, and antimicrobial proteins are suppressed post-HM. These results suggest that oral immunity was transiently suppressed post-HM. The positive correlation of each protein at 2 and 4 h post-HM suggests that the suppressed state was similarly regulated up to 4 h after a HM. The proteins identified in this study may have applications as stress markers for recreational runners and individuals who perform moderate to HIE on a regular basis.

Charged strange star model in Tolman–Kuchowicz spacetime in the background of 5D Einstein–Maxwell–Gauss–Bonnet gravity

In this article, we provide a new model of static charged anisotropic fluid sphere made of a charged perfect fluid in the context of 5D Einstein–Maxwell–Gauss–Bonnet (EMGB) gravity theory. To generate exact solutions of the EMGB field equations, we utilize the well-behaved Tolman–Kuchowicz (TK) ansatz together with a linear equation of state (EoS) of the form p_r=beta rho -gamma , (where beta and gamma are constants). Here the exterior space-time is described by the EGB Schwarzschild metric. The Gauss–Bonnet Lagrangian term mathcal {L}_{GB} is coupled with the Einstein–Hilbert action through the coupling constant alpha . When alpha rightarrow 0, we obtain the general relativity (GR) results. Here we present the solution for the compact star candidate EXO 1785-248 with mass=(1.3 pm 0.2)M_{odot }; radius = 10_{-1}^{+1} km. respectively. We analyze the effect of this coupling constant alpha on the principal characteristics of our model, such as energy density, pressure components, anisotropy factor, sound speed etc. We compare these results with corresponding GR results. Moreover, we studied the hydrostatic equilibrium of the stellar system by using a modified Tolman–Oppenheimer–Volkoff (TOV) equation and the dynamical stability through the critical value of the radial adiabatic index.The mass-radius relationship is also established to determine the compactness factor and surface redshift of our model. In this way, the stellar model obtained here is found to satisfy the elementary physical requirements necessary for a physically viable stellar object.

Summing up the Feynman diagrams: Toward quantum gluonodynamics

Summing up all Feynman diagrams describing an elementary particle can provide a measure of the energy and, with it, the mass of that particle. Moreover, a single mass quantum can be used to convert the Feynman sum into the particle mass. In the following, a mass formula for the calculation of the baryon and meson masses is introduced and explained. This formula involves calculating the number of possible Feynman diagrams and multiplying it by an elementary mass quantum. The mass formula results from a generalization of the connection between the electromagnetic coupling constant alpha (Sommerfelds constant) and the Rydberg constant. This mass formula adds an energy parametrization to the standard model, an important component that has been missing to date. Afterward, this mass formula is interpreted, leading to an interpretation of the elementary particles that is similar to the way in which molecules are interpreted. In this interpretation, gluons take the place of electrons in the case of elementary particles.

Approximate N^{3}LO parton distribution functions with theoretical uncertainties: MSHT20aN^3LO PDFs

We present the first global analysis of parton distribution functions (PDFs) at approximate N^{3}LO in the strong coupling constant alpha _{s}, extending beyond the current highest NNLO achieved in PDF fits. To achieve this, we present a general formalism for the inclusion of theoretical uncertainties associated with the perturbative expansion in the strong coupling. We demonstrate how using the currently available knowledge surrounding the next highest order (N^{3}LO) in alpha _{s} can provide consistent, justifiable and explainable approximate N^{3}LO (aN^{3}LO) PDFs. This includes estimates for uncertainties due the currently unknown N^{3}LO ingredients, but also implicitly some missing higher order uncertainties (MHOUs) beyond these. Specifically, we approximate the splitting functions, transition matrix elements, coefficient functions and K-factors for multiple processes to N^{3}LO. Crucially, these are constrained to be consistent with the wide range of already available information about N^{3}LO to match the complete result at this order as accurately as possible. Using this approach we perform a fully consistent approximate N^{3}LO global fit within the MSHT framework. This relies on an expansion of the Hessian procedure used in previous MSHT fits to allow for sources of theoretical uncertainties. These are included as nuisance parameters in a global fit, controlled by knowledge and intuition based prior distributions. We analyse the differences between our aN^{3}LO PDFs and the standard NNLO PDF set, and study the impact of using aN^{3}LO PDFs on the LHC production of a Higgs boson at this order. Finally, we provide guidelines on how these PDFs should be used in phenomenological investigations.

QCD improved top-quark decay at next-to-next-to-leading order

We analyse the top-quark decay at the next-to-next-to-leading order (NNLO) in QCD by using the Principle of Maximum Conformality (PMC) which provides a systematic way to eliminate renormalization scheme and scale ambiguities in perturbative QCD predictions. The PMC renormalization scales of the coupling constant alpha _s are determined by absorbing the non-conformal beta terms that govern the behavior of the running coupling by using the Renormalization Group Equation (RGE). We obtain the PMC scale Q_star =15.5 GeV for the top-quark decay, which is an order of magnitude smaller than the conventional choice mu _r=m_t, reflecting the small virtuality of the QCD dynamics of the top-quark decay process. Moreover, due to the non-conformal beta terms disappear in the pQCD series, there is no renormalon divergence and the NLO QCD correction term is greatly increased while the NNLO QCD correction term is suppressed compared to the conventional results obtained at mu _r=m_t. By further including the next-to-leading (NLO) electroweak corrections, the finite W boson width and the finite bottom quark mass, we obtain the top-quark total decay width Gamma ^{textrm{tot}}_t=1.3112^{+0.0190}_{-0.0189} GeV, where the error is the squared averages of the top-quark mass Delta m_t=pm 0.7 GeV, the coupling constant Delta alpha _s(M_Z)=pm 0.0009 and the estimation of unknown higher-order terms using the PAA method with [N/M]=[1/1]. The PMC improved predictions for the top-quark decay are complementary to the previous PMC calculations for top-quark pair production and helpful for detailed studies of properties of the top-quark.

Traffic Density Prediction using IoT-based Double Exponential Smoothing

The number of vehicles and currents that tend to increase causes traffic density. A system is proposed to calculate the number of vehicles and predict real-time traffic density. This research uses Haar Cascade to detect the number of cars and motorcycles and the Double Exponential Smoothing (DES) for forecasting the number of vehicles on the road. MAPE describes forecasting accuracy as a base for selecting the best smoothing constant (Alpha). The best test results from June 13 to 20, 2020, are cars on June 14, 2020 (alpha 0.5, MAPE 0%) and Motorcylecycles on June 18, 2020 (alpha 0.5, MAPE 0.1134% ). The most significant MAPE results of the car were on June 15, 2020, with alpha 0.5 and MAPE 2.1073%. The 3 minutes haar cascade detects 72.58% of cars and 81.90% of motorcycles.

A Comparison of the Smoothing Constant Values Among Exponential Smoothing Methods in Commodity Prices Forecasting

Commodity prices forecasting is one of the business functions to estimate future demand based on past data trend. This study aims to implement a trial and error technique of the constant (alpha α) value in the exponential smoothing method. Dealing with confusion that often researchers find in selecting an alpha (α) value among exponential smoothing families, which suits characteristics of the investigated case. As selection of the constant value precisely contributes to reduce the forecasting deviation. This paper used the alpha (α) value in the range 0,1 to 0,9 and utilized the mean absolute percentage error (MAPE) and Mean Absolute Error (MAE) as the parameter to know the grade of prediction. In data training, the authors used Single Exponential Smoothing (SES) and Brown’s Double Exponential Smoothing (B-DES) as methods to compare the results of prediction. It is addressed that forecasting with alpha (α) 0,1 is the most optimal values for Single Exponential Smoothing (SES) in this case with margin error 0,00036 of MAPE and 16,84 of MAE.&#x0D;

{textbf{D}}-dimensional dyonic AdS black holes with quasi-topological electromagnetism in Einstein Gauss–Bonnet gravity

Within Gauss–Bonnet gravity, we construct a solution endowed with dyonic matter fields in a higher dimension. The quasi-topological electromagnetism generates two kinds of contributions; one is the kinetic terms, and the second refers to the interactif terms. This overcomes the invariance topological problem. We investigate the thermodynamical proprieties of the obtained solution, namely, ADM mass, Hawking temperature, and entropy. To inspect the local stability, we examine the associated heat capacity. With regards to optical proprieties, we analyze the null geodesic in terms of the given parameter space. The shadow radius is a generating form with all the physical parameters that govern the shadow behavior. The study restricts only the taking of the effects of the D and alpha parameters. Finally, we examine the impact of the dimension D, GB coupling constant alpha , the cosmological constant Lambda , the electric q_e, the magnetic charge q_m and the coupling constant beta on the energy emission rate.

Parameterisation space for Cornell potential in a QCD potential model

We make a critical analysis on the free parameters of the Cornell potential -frac{4alpha _{s}}{3r}+br+c and provide a parameterisation space for the strong coupling constant alpha _{s} and the constant shift ‘c’ for choosing linear part as perturbation in the potential model. In the analysis of heavy-light mesons (D,D_{s},B,B_{s} text {and} B_{c}), we have found a wide range of values for the coupling constant i.e 0.20 le alpha _{s}le 0.64 with -1.2 le c le -0.66 which can be used to treat the confining part as perturbation.

Estimating evaporation rates and contaminant air concentrations due to small spills of non-ideal aqueous organic solvent mixtures in a controlled environment

Although small spills of non-ideal organic solvent mixtures are ubiquitous undesirable events in occupational settings, the potential risk of exposure associated with such scenarios remains insufficiently investigated. This study aimed to examine the impact of non-ideality on evaporation rates and contaminant air concentrations resulting from small spills of organic solvent mixtures. Evaporation rate constants alphas (α) were experimentally measured for five pure solvents using a gravimetric approach during solvent evaporation tests designed to simulate small spills of solvents. Two equations were used for estimating contaminants’ evaporation rates from aqueous mixtures assuming either ideal or non-ideal behavior based on the pure-chemical alpha values. A spill model also known as the well-mixed room model with exponentially decreasing emission rate was used to predict air concentrations during various spill scenarios based on the two sets of estimated evaporation rates. Model predictive performance was evaluated by comparing the estimates against real-time concentrations measured for the same scenarios. Evaluations for 12 binary non-ideal aqueous mixtures found that the estimated evaporation rates accounting for the correction by the activity coefficients of the solvents (median = 0.0318 min−1) were higher than the evaporation rates estimated without the correction factor (median = 0.00632 min−1). Model estimates using the corrected evaporation rates reasonably agreed with the measured values, with a median predicted peak concentrations-to-measured peak concentrations ratio of 0.92 (0.81 to 1.32) and a median difference between the predicted and the measured peak times of −5 min. By contrast, when the non-corrected evaporation rates were used, the median predicted peak concentrations-to-measured peak concentrations ratio was 0.31 (0.08 to 0.75) and the median difference between the predicted and the measured peak times was +33 min. Results from this study demonstrate the importance of considering the non-ideality effect for accurately estimating evaporation rates and contaminant air concentrations generated by solvent mixtures. Moreover, this study is a step further in improving knowledge of modeling exposures related to small spills of organic solvent mixtures.

Effective Mass of the Polaron: A Lower Bound

We show that the effective mass of the Fröhlich Polaron is bounded below by c alpha ^{2/5} for some constant c>0 and for all coupling constants alpha . The proof uses the point process representation of the path measure of the Fröhlich Polaron.

Anisotropic solution for polytropic stars in 4D Einstein–Gauss–Bonnet gravity

In the present work we have investigated a new anisotropic solution for polytropic stars in the framework of 4D Einstein–Gauss–Bonnet (EGB) gravity. The possibility of determining the masses and radii of compact stars which puts some limitations on equation of state (EoS) above the nuclear saturation density. For this purpose, the 4D EGB field equations are solved by taking a generalized polytropic equation of state (EoS) with Finch–Skea ansatz. The generalized solution for anisotropic model has been tested for different values of Gauss–Bonnet constant alpha which satisfies all the physical criteria including causality with static stability via mass vs central mass density (M-rho _c), Bondi and Abreu criterion. The adiabatic index shows a minor influence of the GB coupling constant whereas the central and surface redshifts in the EGB gravity always remain lower than the GR. We present the possibility of fitting the mass and radius for some known compact star via M-R curve which satisfies the recent gravitational wave observations from GW 170817 event.

Using anti-malondialdehyde-modified peptide adduct autoantibodies in serum of taiwanese women to diagnose primary Sjogren’s syndrome

BackgroundSjogren’s syndrome (SS) is a systemic autoimmune disease featured with a dry mouth and dry eyes. Several autoantibodies, including anti-SSA, anti-SSB, antinuclear antibodies can be detected in patients with SS. Oxidation-specific epitopes (OSEs) can be formed from malondialdehyde (MDA)-modified protein adducts and trigger chronic inflammation. In this study, our purposes were used serum levels of anti-MDA-modified peptide adducts autoantibodies to evaluate predictive performance by machine learning algorithms in primary Sjögren's syndrome (pSS) and assess the association between pSS and healthy controls. MethodsThree novel MDA-modified peptide adducts, including immunoglobulin (Ig) gamma heavy chain 1 (IGHG1)102–131, complement factor H (CFAH)1045–1062, and Ig heavy constant alpha 1 (IGHA1)307–327 were identified and validated. Serum levels of protein, MDA-modified protein adducts, MDA, and autoantibodies recognizing unmodified peptides and MDA-modified peptide adducts were measured. Statistically significance in correlations and odds ratios (ORs) were estimated. ResultsThe random forest classifier utilized autoantibodies combination composed of IgM anti-IGHG1102-131, IgM anti-IGHG1102-131 MDA and IgM anti-IGHA1307-327 achieved predictive performance as an accuracy of 88.0%, a sensitivity of 93.7%, and a specificity of 84.4% which may be as potential diagnostic biomarkers to differentiate patients with pSS from rheumatoid arthritis (RA), and secondary SS in RA and HCs. ConclusionsOur findings imply that low levels of IgA anti-IGHG1102-131 MDA (OR = 2.646), IgA anti-IGHG1102-131 (OR = 2.408), IgA anti-CFAH1045-1062 (OR = 2.571), and IgA anti-IGHA1307-327 (OR = 2.905) may denote developing risks of pSS, respectively.