Consistent Tendency Research Articles

Sjögren's syndrome positive for isolated anti-Ro52/SS-A antibody and anti-centromere antibody.

This current case report describes a Japanese woman in her 80s with xerostomia who presented with salivary gland dysfunction. She was positive for isolated anti-Ro52/SS-A antibody as determined by a chemiluminescent enzyme immunoassay and positive on a fluorescence enzyme immunoassay that recognizes both Ro52 and Ro60 antigens. A high serum concentration of anti-Ro52/SS-A antibody was determined by an enzyme-linked immunosorbent assay. A high anti-centromere antibodies (ACA) titre was also observed. Although Raynaud's phenomenon or a high serum immunoglobulin G concentration were not observed, Masson-trichrome staining of the patient's labial salivary glands showed considerable fibrosis. Her serum type I and type II interferon concentrations were normal. The present patient is the first with Sjögren's syndrome (SS) to exhibit isolated anti-Ro52/SS-A antibody and ACA without anti-Ro60/SS-A antibody. This current case report presents her case together with those of four other SS patients who were positive for isolated anti-Ro52/SS-A antibody. The SS literature also includes cases positive for ACA and describes clinical characteristics. The other four SS patients with isolated anti-Ro52/SS-A antibody described here had no ACA; interstitial pneumonia and polyneuropathy were observed in these cases, although there was no consistent tendency regarding types I and II interferon.

Study on the relationship between surface tension and dilational visco‐elasticity with foam stability

AbstractThe replacement of fluorine‐free foam is imminent, but to date, no fluorine‐free foam has reached comparable fire extinguishing performance to AFFF (aqueous film forming foam). The stability of firefighting foam significantly affects its extinguishing performance. In order to better understand the influence of foam formulation physical properties on foam stability, we correlate the foam stability with surface tension and dilational visco‐elasticity based on the AFFF formulation. The results show that, the foam stability rising steadily with the decrease of surface tension, which indicates that low surface tension favors the improvement of foam stability. However, when at the studied highest surface tension, the foam stability elevates slightly instead, demonstrating the surface tension is not the determinant of foam stability. By contrast, the dilational visco‐elasticity shows a closer correlation with foam stability for the consistent tendency. In the case of constantly changing disturbance frequency, the interface dilational elasticity shows a trend of first increasing and then decreasing with the rise of disturbance frequency, whereas the interface dilational viscosity is completely opposite. Different relaxation processes show up for different samples. More attention can be paid to the regulation of dilational visco‐elasticity in the development of fluorine‐free foams, so as to improve their extinguishing ability.

The decoupled effect of oxidizer mass flux and combustion pressure on turbulent combustion characteristics of finite-length solid fuel

Combustion pressure and oxidizer mass flux are key factors influencing the performance of hybrid rocket motors. In the present work, the decoupled effects of oxidizer mass flux and combustion pressure on turbulent combustion characteristics were investigated. First, a finite-length combustion theory of fuel grains was developed to identify the main sensitive parameters, including flame structure and the recirculation zone, which affect the combustion of solid fuel. Then, a two-dimensional transient numerical model, based on the coupling characteristics of the heat transfer process in solid fuel grains and dynamic combustion flow, was developed and validated through fire experiments under a wide range of inflow conditions. A quantitative analysis was conducted to assess the impact of flame structure and the recirculation zone on the dynamic combustion characteristics of finite-length solid fuel. The results showed that the fuel characteristic temperatures of the front and central parts are negatively correlated with flame height, while the characteristic temperature of the rear part is positively correlated with the recirculation zone temperature. Both the mass flow rate and combustion pressure are negatively correlated with flame height and positively correlated with the temperature of the recirculation zone. Compared to combustion pressure, the influence of mass flow rate is more significant. The transient processes of the solid fuel regression rate under different inflow conditions exhibit a consistent tendency: an increase in mass flow flux and combustion pressure results in faster attainment of peak regression rate and stabilization.

Analysis of lake changes and their influence factors in the three river regions from 2000 to 2020 in the Sanjiangyuan Region, China

An important factor for investigating climate change in the Sanjiangyuan is the evolution of the spatio-temporal pattern of lakes in this region. The present study used the Google Earth Engine (GEE) platform to extract lakes from 2000 to 2020. The present approach created a lake distribution dataset yearly and analyzed spatial and temporal patterns over 20 years. The analysis of lakes focused on the reaction of the Sanjiangyuan Lakes area to changes in climate, glaciers, and permafrost. The findings indicated that the Sanjiangyuan region contains 143 lakes, the majority of which are predominantly small, measuring 1–10 km2. The small lakes account for 60.14 % of the total and are primarily located in the source regions of the Yangtze River and Yellow River. The findings demonstrated that the Sanjiangyuan lakes experienced a significant expansion over the past two decades, particularly from 2011 to 2020. These lakes are divided into expanded, atrophic, and stable categories. Expanded lakes showed significant inter-annual trends in expansion, while atrophic lakes showed smaller fluctuations. The area of stable lakes experienced a consistent decline after 2010, despite a consistent expansion tendency from 2001 to 2010. Moreover, the results indicated that alterations in the size of glaciers and ice reserves in the Sanjiangyuan region have had the greatest influence on the fluctuation in lake area. Among the factors that affect the climate, temperature had the most significant effect on the change in lake area, followed by precipitation.

ACCELERATION OF DIGITAL-BASED PUBLIC SERVICES CASE STUDY AT THE INVESTMENT AND ONE-STOP INTEGRATED SERVICE OFFICE IN BELU DISTRICT

The objective of this study was to analyze and describe the acceleration of public services at the Investment and One-Stop Integrated Service Office, analyze supporting and inhibiting factors, and formulate a digital-based public service model. The collection techniques were used to obtain accurate, actual and comprehensive data in accordance with the problems and focus of the study, such as interview, observation, and documentation. The results of the study showed a consistent tendency (trend) in public services in improving the performance of public service delivery in Belu District.

Interplay of mobile phone dependency and catch-up sleep in South Korean youth: A seven-wave study of two nationally representative cohorts

This study investigated the reciprocal loop between catch-up sleep and mobile phone dependency from late childhood to late adolescence, distinguishing between inter-individual and intra-individual variations. Data from two nationally representative South Korean birth cohorts (N = 4,729, 48.8% female) were collected annually, assessing participants seven times from Grade 4 to Grade 10 or Grade 7 to post-high school. Findings from a cross-lagged panel model (CLPM) and a random-intercept CLPM showed that students who were more dependent on their mobile phones, either compared to others or to their own averages, were likely to report greater catch-up sleep from Grade 4 through Grade 7 in the younger cohort and from Grade 7 through Grade 10 in the older cohort. Likewise, students with greater catch-up sleep, compared to others or to their own averages, tended to rely more on their mobile phones from Grade 4 to Grade 5 in the younger cohort and from Grade 7 to Grade 8 in the older cohort. The CLPM findings further revealed that in the younger cohort, students with higher mobile phone dependency than their peers were more likely to increase catch-up sleep from Grade 7 to Grade 8, and in the older cohort, from Grade 10 to Grade 11. Similarly, higher catch-up sleep led to increased mobile phone dependency from Grade 9 to Grade 10 in the younger cohort, and from Grade 12 to the year post-high school in the older cohort. These patterns suggest consistent tendencies at both inter- and intra-adolescent levels.

Revealing irrigation uniformity with remote sensing: A comparative analysis of satellite-derived uniformity coefficient

This study investigates the use of satellite-derived Christiansen Uniformity Coefficient (SDCUC) values for evaluating irrigation uniformity. In the context of global water scarcity and the imperative for sustainable water management, we explore the potential of remote sensing methods to evaluate irrigation uniformity across large agricultural areas. The findings reveal a consistent tendency for SDCUC to overestimate irrigation uniformity, with an average overestimation rate of 7.83 %. However, accuracy improved with the appropriate method, vegetation index, or spectral band selection. Employing the entire satellite image for SDCUC (SDCUCTOT) assessment improved accuracy. For Sentinel-1 (S1), using the dual-band cross-polarization horizontal transmit/vertical receive band (VH), the bias confidence interval was −0.39–0.69 %, while for Sentinel-2 (S2), using the normalized difference red edge 3 index (NDRE3), it was −1.47–0.66 %, and for Landsat 8 (L8) and Landsat 9 (L9) using the shortwave infrared water stress index (SIWSI) it ranged from 0.36 % to 2.28 %. Improved results were also observed when the normalized difference vegetation index (NDVI) ranged between 0.4 and 0.8 or the evapotranspiration and potential evapotranspiration ratio (ET/PET) ranged between 0.30 and 0.55. In these conditions, SDCUCTOT for the S2, L8, and L9 using the simple ratio index (SR) ranged from 1.00 % to 2.33 %, 0.00–1.83 %, 0.23–2.00 %, respectively, and for S2, the normalized difference water index (NDWI) and NDRE3 ranged from −1.39–0.71 %, and −1.43–2.31 % respectively. These findings underscore the potential of remote sensing techniques to revolutionize water resource management and promote sustainable agriculture, emphasizing the synergistic role of ground-based measurements and the need for continued methodological refinements to improve accuracy. Further advancements and research are warranted to refine the methodology and enhance the accuracy and reliability of remote sensing-based irrigation uniformity assessment, ultimately contributing to more sustainable agricultural irrigation practices.

Comparison of kinetic energy conversion characteristics of two extreme precipitation episodes during persistent unusually heavy rainfall on 17–23 July 2021 in Henan, China

A persistent heavy rainfall event, contributed by two extreme episodes (P1 and P2), occurred in Henan province of China from 17 to 23 July 2021. An active mesoscale vortex was present in the lower troposphere, along with a shallow trough moving eastward in the upper troposphere. The budgets of rotational kinetic energy (KR) and divergent kinetic energy (KD) at distinct stages are investigated. The lower-level KR anomaly, related to the mesoscale vortex growth therein, was responsible for P1. However, the upper-troposphere KR was dominant and strong during the P2 stage, associated with an eastward-developing upper-level trough. Prior to both P1 and P2, active inner interaction between rotational and divergent winds presented, manifested as a rapid increase of KVRVD signals. KVRVD and precipitation had similar pattern distribution and consistent evolution tendency. Therefore, KVRVD might be a useful indicator for the occurrence and intensification of rainfall. Expect for two components of winds interaction, the external source feeding kinetic energy growth is also explored. For P1, APE (available potential energy)-> KD-> KR was the key path towards rotational kinetic energy, providing energy for mesoscale vortex growth in lower troposphere, which was favorable for the extreme episode of P1. Nevertheless, for P2 stage, APE acted as a direct energy source towards KR in upper troposphere, with higher efficiency (via APE-> KR) and thus stronger KR. This kind of difference in conversion path depended on the vertically-coupled degree between the lower-level mesoscale vortex and the upper-level trough, in addition to the rotational and divergent wind speed. Their tilting/upright configuration produced strong baroclinic/barotropic process, accelerating energy conversion of APE-> KD/APE-> KR via GD/GR (i.e., generating KD/KR by divergent/rotational winds crossing geopotential height contours, usually as a generator resulting from barotropic/baroclinic process). Therefore, kinetic energy budget may be a valuable tool for identifying key weather systems development and forecasting extreme rainfall episodes.

Intrapuparial stage aging and PMI estimation based on the developmental transcriptomes of forensically important Aldrichina grahami (Diptera: Calliphoridae) gene expression

BackgroundThe expression profiles of differentially expressed genes (DEGs) during pupal development have been demonstrated to be vital in age estimation of forensic entomological study. Here, using forensically important Aldrichina grahami (Diptera: Calliphoridae), we aimed to explore the potential of intrapuparial stage aging and postmortem interval (PMI) estimation based on characterization of successive developmental transcriptomes and gene expression patterns. MethodsWe collected A. grahami pupae at 11 successive intrapuparial stages at 20 °C and used the RNA-seq technique to build the transcriptome profiles of their intrapuparial stages. The DEGs were identified during the different intrapuparial stages using comparative transcriptome analysis. The selected marker DEGs were classified and clustered for intrapuparial stage aging and PMI estimation and then further verified for transcriptome data validation. Ultimately, we categorized the overall gene expression levels as the dependent variable and the age of intrapuparial A. grahami as the independent variable to conduct nonlinear regression analysis. ResultsWe redefined the intrapuparial stages of A. grahami into five key successive substages (I, II, III, IV, and V), based on the overall gene expression patterns during pupal development. We screened 99 specific time-dependent expressed genes (stage-specific DEGs) to determine the different intrapuparial stages based on comparison of the gene expression levels during the 11 developmental intrapuparial stages of A. grahami. We observed that 55 DEGs showed persistent upregulation during the development of intrapuparial A. grahami. We then selected four DEGs (act79b, act88f, up and ninac) which presented consistent upregulation using RT-qPCR (quantitative real-time PCR) analysis, along with consideration of the maximum fold changes during the pupal development. We conducted nonlinear regression analysis to simulate the calculations of the relationships between the expression levels of the four selected DEGs and the developmental time of intrapuparial A. grahami and constructed fitting curves. The curves demonstrated that act79b and ninac showed continuous relatively increasing levels. ConclusionsThis study redefined the intrapuparial stages of A. grahami based on expression profiles of developmental transcriptomes for the first time. The stage-specific DEGs and those with consistent tendencies of expression were found to have potential in age estimation of intrapuparial A. grahami and could be supplementary to a more accurate prediction of PMI.

Engineering the Mechanical Stability of a Therapeutic Affibody/PD-L1 Complex by Anchor Point Selection.

Protein-protein complexes can vary in mechanical stability depending on the direction from which force is applied. Here we investigated the anisotropic mechanical stability of a molecular complex between a therapeutic non-immunoglobulin scaffold called Affibody and the extracellular domain of the immune checkpoint protein PD-L1. We used a combination of single-molecule AFM force spectroscopy (AFM-SMFS) with bioorthogonal clickable peptide handles, shear stress bead adhesion assays, molecular modeling, and steered molecular dynamics (SMD) simulations to understand the pulling point dependency of mechanostability of the Affibody:(PD-L1) complex. We observed diverse mechanical responses depending on the anchor point. For example, pulling from residue #22 on Affibody generated an intermediate unfolding event attributed to partial unfolding of PD-L1, while pulling from Affibody's N-terminus generated force-activated catch bond behavior. We found that pulling from residue #22 or #47 on Affibody generated the highest rupture forces, with the complex breaking at up to ~ 190 pN under loading rates of ~104-105 pN/sec, representing a ~4-fold increase in mechanostability as compared with low force N-terminal pulling. SMD simulations provided consistent tendencies in rupture forces, and through visualization of force propagation networks provided mechanistic insights. These results demonstrate how mechanostability of therapeutic protein-protein interfaces can be controlled by informed selection of anchor points within molecules, with implications for optimal bioconjugation strategies in drug delivery vehicles.

Spatio-temporal pattern analysis of coastal zone in Nansha based on remote sensing technology

Among the most important and active areas of coastal cities is the coastal zone. Examining the changes in the coastal zone of Nansha District is helpful in identifying the spatiotemporal evolution pattern and driving force of this area, as well as serving as a guide for the preservation and exploitation of its resources. This is due to the fact that remote sensing's ability to collect and analyze coastlines can show minute variations in the way the water and land interact. The article uses drone orthophotos and Landsat and Quickbird paired with eight different sceneries from 1987 to 2021 to extract the coastline using remote sensing (RS) and geographic information system (GIS) techniques. The spatiotemporal features of the evolution of the Nansha shoreline are examined in order to guarantee correctness. and the motivating elements are talked about. The findings indicate that: 1) Over the previous 30 years, there has been a consistent upward tendency along Nansha District's shoreline. Among these, the percentage of artificial shoreline is growing annually, growing by about 56%, while the natural coastline is decreasing annually, decreasing by 70%. 2) There is a shift in the type of shoreline from natural to sea-reclamation, engineering construction, and aquaculture. 3) The modifications to the coastline have occurred in three phases: the first was the agricultural phase; the second was the port petrochemical phase; and the third was the reasonable restraint phase (quality construction). Wanqingsha, Longxue Island, and Nansha Bay's coastlines are all close to significant expansion areas of coastline. 4) The primary causes of the changes in the Nansha District shoreline are human activity, regional policy, and natural elements.

Chromosome-level genome assembly of Odontothrips loti Haliday (Thysanoptera: Thripidae)

As the predominant pest of alfalfa, Odontothrips loti Haliday causes great damages over the major alfalfa-growing regions of China. The characteristics of strong mobility and fecundity make them develop rapidly in the field and hard to be controlled. There is a shortage of bioinformation and limited genomic resources available of O. loti for us to develop novel pest management strategies. In this study, we constructed a chromosome-level reference genome assembly of O. loti with a genome size of 346.59 Mb and scaffold N50 length of 18.52 Mb, anchored onto 16 chromosomes and contained 20128 genes, of which 93.59% were functionally annotated. The results of 99.20% complete insecta_odb10 genes in BUSCO analysis, 91.11% short reads mapped to the ref-genome, and the consistent tendency among the thrips in the distribution of gene length reflects the quality of genome. Our study provided the first report of genome for the genus Odontothrips, which offers a genomic resource for further investigations on evolution and molecular biology of O. loti, contributing to pest management.

Deciphering the Spatial Stickiness, Co-occurrence, and Co-change of Industries at the Scale of City

This paper analyzes the location of industries in two metropolitan cities to investigate how firms are spatially distributed, and identify the prevailing trends in firm location choice. By defining a “Region Index” metric, we show how industries have concentrated in or diffused from the regions-of-interest over time. We apply this metric to the Central Area (CA) of Singapore and the London Region to decipher the relative tendency of industries to locate at CA as well as London. To analyze the spatial co-location of industries, we constructed a community network, which reveals subtle spatial relationships between firms. Extending this approach temporally to create a co-change network, we deduce the occurrences of industries in Singapore and London that move into or out of a spatial region synchronously. Based on this approach, we elucidate firm types that not only co-change but also co-occur in space and remain within a region-of-interest. Overall, we observe certain common and contrasting patterns of industry movements in the context of Singapore and London through the analysis. “Other Activities Auxiliary to Financial Services” is found to have the consistent tendency of diffusing out of CA and London throughout the period of study. Conversely, opposite movement patterns are observed where we see the proclivity of IT and digital service firms to locate in London but relocate out of CA, while the Media, Financial Services, and Life Insurance subsectors tend to diffuse out of London but concentrate in the CA of Singapore.

Verb Vocabulary Supports Event Probability Use in Developmental Language Disorder.

Children with developmental language disorder (DLD) tend to interpret noncanonical sentences like passives using event probability (EP) information regardless of structure (e.g., by interpreting "The dog was chased by the squirrel" as "The dog chased the squirrel"). Verbs are a major source of EP information in adults and children with typical development (TD), who know that "chase" implies an unequal relationship among participants. Individuals with DLD have poor verb knowledge and verb-based sentence processing. Yet, they also appear to rely more on EP information than their peers. This paradox raises two questions: (a) How do children with DLD use verb-based EP information alongside other information in online passive sentence interpretation? (b) How does verb vocabulary knowledge support EP information use? We created novel EP biases by showing animations of agents with consistent action tendencies (e.g., clumsy vs. helpful actions). We then used eye tracking to examine how this EP information was used during online passive sentence processing. Participants were 4- to 5-year-old children with DLD (n = 20) and same-age peers with TD (n = 20). In Experiment 1, children with DLD quickly integrated verb-based EP information with morphosyntax close to the verb but failed to do so with distant morphosyntax. In Experiment 2, the quality of children's sentence-specific verb vocabulary knowledge was positively associated with the use of EP information in both groups. Depending on the morphosyntactic context, children with DLD and TD used EP information differently, but verb vocabulary knowledge aided its use. https://doi.org/10.23641/asha.25491805.

Consistent Individual Tendencies in Motor Speed-Accuracy Trade-Off.

The literature on speed-accuracy trade-off (SAT) in motor control has evidenced individuality in how individuals trade moments (e.g.,mean and variance) of spatial and temporal errors. These individual tendencies could grasp tendencies of the system given previous experiences and constraints of the organism, a signature of the system control. Nonetheless, such tendency must be robust to small perturbations. Thirty participants performed nine conditions with different time and spatial criteria over 2days (scanning). In between these scanning conditions, individuals performed a practice condition that required modifications of the individuals' preferred spatial and temporal tendency in the SAT. Our results demonstrated that there were no systematic effects of practice in SAT preferences. However, individual analyses demonstrated significant changes for 25 out of 30 individuals. The latter either attests against a consistent preference or to a more complex characterization of individual SAT tendencies.

Do sexes differ in consistent individual differences and behavioural syndrome in an aposematic poison frog?

AbstractThere is a burgeoning interest in studying consistent individual differences in animal behaviour. Most studies consider mainly males, but sexes are subject to distinct selection pressures that may drive differences in life history and therefore lead to differences in a variety of behaviours. Here, we used Oophaga pumilio, a poison frog with sex differences in life‐history strategies (e.g., sex bias in space use and parental care), to explore whether sexes differ or share personality characteristics like behavioural consistency and behavioural syndromes. Based on the natural history of this species, we predicted sex differences in behavioural consistency in exploration but not in boldness, and a correlation between these behavioural traits. We found no sex differences in behavioural consistency in boldness and exploration, although, we observed a tendency of higher consistency in males than females in boldness. When pooling all individuals, we found a higher consistency in boldness than exploration, suggesting the presence of a bold personality in general. We observed a positive between‐individual correlation of boldness and exploration in both sexes indicating the presence of a behavioural syndrome. Our data suggest that selective mechanisms shaping individual behaviour act equally on both sexes in this poison frog.

Investigating twelve mainstream global precipitation datasets: Which one performs better on the Tibetan Plateau?

Acquiring precipitation information is a critical yet challenging task for the Tibetan Plateau (TP) with sparse gauges and high altitudes. Presently, there is a multitude of operational precipitation products merged from different data sources. A major concern within the TP science community is which one of these available precipitation datasets performs best on the TP. To address this concern, we selected and compared twelve widely used global precipitation datasets, including six satellite-based precipitation estimates (GSMaP-Gauge, IMERG-Final, TMPA-v7, CMORPH-BLD, PERSIANN-CDR, CHIRPS), five reanalysis data (ERA5, JRA-55, MERRA2, GLDAS, NCEP2), and one multi-source fusion product (MSWEP). Benchmarked against both automatic weather stations and independent field observations, we comprehensively investigate the spatiotemporal accuracy and regional applicability of these global precipitation products on the TP. The evaluation results indicate that almost all the datasets have a consistent tendency to overestimate lower precipitation rates and underestimate higher ones. However, four out of the twelve studied datasets (i.e., GSMaP-Gauge, IMERG-Final, ERA5, and MSWEP) significantly outperform others. Specifically, the two GPM-based satellite precipitation products, GSMaP-Gauge and IMERG-Final, can better reflect the difference between different rain intensities and perform better at moderate rain rates. In contrast, the reanalysis-based ERA5 exhibits a more clustered data series, with relatively higher accuracy at low precipitation rates. Moreover, ERA5 demonstrates a stable superiority in the mountainous areas characterized by complex local terrains. Furthermore, we find that the applicability of different precipitation datasets has an obvious region-related feature. Thus, a regional distribution map was made to clearly outline the optimal choice of current mainstream global precipitation datasets over different climate zones within the TP. This study can offer valuable insights for TP researchers, especially aiding them to select the appropriate precipitation data for their specific studies.

Transcriptomic and proteomic insights into the immune response of the intestine to Aeromonas veronii infection in koi carp (Cyprinus carpio var. koi)

Intestinal mucosal immunity serves as one of the primary barriers against pathogens. The immune mechanism involved in fish intestinal defense against bacterial infection still needs further investigation. To delve into the intestinal immune mechanisms of koi carp (Cyprinus carpio var. koi) against Aeromonas veronii infection, RNA-seq and isobaric tags for relative and absolute quantitation (iTRAQ)-coupled LC-MS/MS were employed. After A. veronii infection, 7224 differently expressed genes (DEGs) and 1482 differently expressed proteins (DEPs) were detected in the intestines of koi carp. Further, the integrated analysis of transcriptomic and proteomic data revealed that 471 DEGs were matched with the corresponding DEPs (named associated DEPs/DEGs). Among the 34 immune-related associated DEPs/DEGs, 21 were in the consistent expression tendency, whereas 13 were in the opposite tendency. Moreover, the immune-related associated DEPs/DEGs exhibiting consistent expression trends were predominantly enriched in nine pathways, with five of them being linked to innate immunity: ferroptosis, phagosome, complement and coagulation cascades, MAPK signaling pathway, and NLR signaling pathway. The expression patterns of tested genes detected using quantitative real-time PCR assay were consistent with the findings from RNA-Seq and iTRAQ. A potential offense and defense model between A. veronii and koi carp was established based on insights into the immune-related pathways, DEGs, and DEPs. Overall, our comprehensive transcriptome and proteome analysis allow us to better understand the intestinal mucosal immunity of teleost and the pathogenic mechanism of A. veronii.

Crystal structures of sixteen phosphane chalcogenide complexes of gold(I) chloride, bromide and iodide.

The structures of 16 phosphane chalcogenide complexes of gold(I) halides, with the general formula R 1 3- nR 2 nPEAuX (R 1 = t-butyl; R 2 = isopropyl; n = 0 to 3; E = S or Se; X = Cl, Br or I), are presented. The eight possible chlorido derivatives are: 1a, n = 3, E = S; 2a, n = 2, E = S; 3a, n = 1, E = S; 4a, n = 0, E = S; 5a, n = 3, E = Se; 6a, n = 2, E = Se; 7a, n = 1, E = Se; and 8a, n = 0, E = Se, and the corresponding bromido derivatives are 1b-8b in the same order. However, 2a and 2b were badly disordered and 8a was not obtained. The iodido derivatives are 2c, 6c and 7c (numbered as for the series a and b). All structures are solvent-free and all have Z' = 1 except for 6b and 6c (Z' = 2). All mol-ecules show the expected linear geometry at gold and approximately tetra-hedral angles P-E-Au. The presence of bulky ligands forces some short intra-molecular contacts, in particular H⋯Au and H⋯E. The Au-E bond lengths have a slight but consistent tendency to be longer when trans to a softer X ligand, and vice versa. The five compounds 1a, 5a, 6a, 1b and 5b form an isotypic set, despite the different alkyl groups in 6a. Compounds 3a/3b, 4b/8b and 6b/6c form isotypic pairs. The crystal packing can be analysed in terms of various types of secondary inter-actions, of which the most frequent are 'weak' hydrogen bonds from methine hydrogen atoms to the halogenido ligands. For the structure type 1a, H⋯X and H⋯E contacts combine to form a layer structure. For 3a/3b, the packing is almost featureless, but can be described in terms of a double-layer structure involving borderline H⋯Cl/Br and H⋯S contacts. In 4a and 4b/8b, which lack methine groups, Cmeth-yl-H⋯X contacts combine to form layer structures. In 7a/7b, short C-H⋯X inter-actions form chains of mol-ecules that are further linked by association of short Au⋯Se contacts to form a layer structure. The packing of compound 6b/6c can conveniently be analysed for each independent mol-ecule separately, because they occupy different regions of the cell. Mol-ecule 1 forms chains in which the mol-ecules are linked by a Cmethine⋯Au contact. The mol-ecules 2 associate via a short Se⋯Se contact and a short H⋯X contact to form a layer structure. The packing of compound 2c can be described in terms of two short Cmethine-H⋯I contacts, which combine to form a corrugated ribbon structure. Compound 7c is the only compound in this paper to feature Au⋯Au contacts, which lead to twofold-symmetric dimers. Apart from this, the packing is almost featureless, consisting of layers with only translation symmetry except for two very borderline Au⋯H contacts.

Effects of COVID-19-Associated Infection Control on the Pattern of Infections Imported by German Soldiers and Police Officers Returning from Predominantly Tropical Deployment Sites.

In response to the COVID-19 pandemic, German public health authorities launched various infection control procedures. In line with this, anti-pandemic infection control was also implemented for German military and police deployments. The presented study assessed the impact of this increased infection control effort on deployment-associated infections in a holistic approach. To do so, the results of post-deployment assessments offered to German soldiers and police officers at the Department of Tropical Medicine and Infectious Diseases of the Bundeswehr Hospital Hamburg obtained during the pandemic period were compared to the results recorded during the pre-pandemic period in an exploratory, hypothesis-forming comparative study. In total, data from 1010 military deployments and 134 police deployments, predominantly to the African or the Eastern Mediterranean WHO regions, were included in the analyses. In the main results, a significant decrease in gastroenteritis in deployed soldiers (20.1% versus 61.3%, p < 0.0001) and at least a trend in the same direction in deployed police officers (25.7% versus 35.4%, p = 0.4026) were shown for the pandemic period, while no consistent tendency into the one or the other direction was detectable for febrile illness on deployment. In contrast to the finding of less frequently reported deployment-associated gastroenteritis, the detection rates of enteric microorganisms after deployment, including poor hygiene-related colonization with apathogenic protozoa, remained unchanged. Regarding non-enteric infections, the numbers of serologically confirmed malaria cases on deployment and as expected, due to increased airway protection, Mycobacterium tuberculosis-specific immune-conversion dropped significantly with p = 0.0037 and p = 0.009, respectively. As a side finding, soldiers and police officers with post-deployment medical assessments were more likely to be older and male during the pandemic compared to the pre-pandemic period. In summary, only minor changes in deployment-associated infection and colonization rates were seen in response to the increased infection control procedures during the pandemic period, apart from respiratory infections. In particular, the clinical finding of less gastroenteritis on deployment was not matched by a concordant decline in poor hygiene-related enteric colonization with apathogenic protozoa in the soldiers' guts, indicating that the fecal-oral transmission risk remained basically the same.