Conservation tillage reduces the physical movement of soil to the minimum required for crop establishment and production. When consistently practiced as a soil and crop management system, it greatly reduces soil erosion and is recognized for the potential to improve soil quality and water conservation and plant available water. Adoption of conservation tillage increased dramatically with the advent of transgenic, glyphosate-resistant crops that permitted in-season, over-the-top use of glyphosate (N-[phosphonomethyl] glycine), a broad-spectrum herbicide with very low mammalian toxicity and minimal potential for off-site movement in soil or water. Glyphosate-resistant crops are currently grown on approximately 70 million ha (173 million ac) worldwide. The United States has the most hectares (45 million ha [99 million ac]) of transgenic, glyphosate-resistant cultivars and the greatest number of hectares (46 million ha [114 million ac]) in conservation tillage. The practice of conservation tillage is now threatened by the emergence and rapid spread of glyphosate-resistant Palmer amaranth (<i>Amaranthus palmeri</i> [S.] Wats.), one of several amaranths commonly called pigweeds. First identified in Georgia, it now has been reported in Alabama, Arkansas, Florida, Georgia, Louisiana, Mississippi, North Carolina, South Carolina, and Tennessee. Another closely related dioecious amaranth, or pigweed, common waterhemp (<i>Amaranthus rudis</i> Sauer), has also developed resistance to glyphosate in Illinois, Iowa, Minnesota, and Missouri. Hundreds of thousands of conservation tillage hectares, some currently under USDA Natural Resources Conservation Service conservation program contracts, are at risk of being converted to higher-intensity tillage systems due to the inability to control these glyphosate-resistant <i>Amaranthus</i> species in conservation tillage systems using traditional technologies. The decline of conservation tillage is inevitable without the development and rapid adoption of integrated, effective weed control strategies. Traditional and alternative weed control strategies, such as the utilization of crop and herbicide rotation and integration of high residue cereal cover crops, are necessary in order to sustain conservation tillage practices.